A large outbreak of New Delhi metallo-beta-lactamase (NDM)-1-producing Klebsiella pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020, ST147 NDM-9-producing K. pneumoniae were detected at the University Hospital of Pisa, Tuscany, in two critically ill patients; one developed bacteraemia. Genomic and phylogenetic analyses suggest relatedness of 2018–2019 and 2020 strains, with a change from NDM-1 to NDM-9 in the latter and evolution by colistin, tigecycline and fosfomycin resistance acquisition
Extremely-drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020 / Falcone, Marco; Giordano, Cesira; Barnini, Simona; Tiseo, Giusy; Leonildi, Alessandro; Malacarne, Paolo; Menichetti, Francesco; Carattoli, Alessandra. - In: EUROSURVEILLANCE. - ISSN 1560-7917. - (2020). [10.2807/1560-7917.ES.2020.25.48.2001779]
Extremely-drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
Alessandra Carattoli
2020
Abstract
A large outbreak of New Delhi metallo-beta-lactamase (NDM)-1-producing Klebsiella pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020, ST147 NDM-9-producing K. pneumoniae were detected at the University Hospital of Pisa, Tuscany, in two critically ill patients; one developed bacteraemia. Genomic and phylogenetic analyses suggest relatedness of 2018–2019 and 2020 strains, with a change from NDM-1 to NDM-9 in the latter and evolution by colistin, tigecycline and fosfomycin resistance acquisition| File | Dimensione | Formato | |
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