Alzheimer’s disease is the most common neurodegenerative disorder characterized by the presence of β-amyloid aggregates deposited as senile plaques and by the presence of neurofibrillary tangles of tau protein. To date, there is a broad consensus on the idea that neuroinflammation is one of the most important component in Alzheimer’s disease pathogenesis. Chemokines and their receptors, beside the well-known role in the immune system, are widely expressed in the nervous system, where they play a significant role in the neuroinflammatory processes. Prokineticins are a new family of chemokine-like molecules involved in numerous physiological and pathological processes including immunity, pain, inflammation, and neuroinflammation. Prokineticin 2 (PROK2) and its receptors PKR1 and PKR2 are widely expressed in the central nervous system in both neuronal and glial cells. In Alzheimer’s disease, PROK2 sustains the neuroinflammatory condition and contributes to neurotoxicity, since its expression is strongly upregulated by amyloid-β peptide and reversed by the PKR antagonist PC1. This review aims to summarize the current knowledge on the neurotoxic and/or neuroprotective function of chemokines in Alzheimer’s disease, focusing on the prokineticin system: it represents a new field of investigation that can stimulate the research of innovative pharmacotherapeutic strategies.

Chemokines in alzheimer’s disease: new insights into prokineticins, chemokine-like proteins / Zuena, Anna Rita; Casolini, Paola; Lattanzi, Roberta; Maftei, Daniela. - In: FRONTIERS IN PHARMACOLOGY. - ISSN 1663-9812. - 10:(2019). [10.3389/fphar.2019.00622]

Chemokines in alzheimer’s disease: new insights into prokineticins, chemokine-like proteins

Zuena, Anna Rita
Primo
;
Casolini, Paola
Secondo
;
Lattanzi, Roberta
Penultimo
;
Maftei, Daniela
Ultimo
2019

Abstract

Alzheimer’s disease is the most common neurodegenerative disorder characterized by the presence of β-amyloid aggregates deposited as senile plaques and by the presence of neurofibrillary tangles of tau protein. To date, there is a broad consensus on the idea that neuroinflammation is one of the most important component in Alzheimer’s disease pathogenesis. Chemokines and their receptors, beside the well-known role in the immune system, are widely expressed in the nervous system, where they play a significant role in the neuroinflammatory processes. Prokineticins are a new family of chemokine-like molecules involved in numerous physiological and pathological processes including immunity, pain, inflammation, and neuroinflammation. Prokineticin 2 (PROK2) and its receptors PKR1 and PKR2 are widely expressed in the central nervous system in both neuronal and glial cells. In Alzheimer’s disease, PROK2 sustains the neuroinflammatory condition and contributes to neurotoxicity, since its expression is strongly upregulated by amyloid-β peptide and reversed by the PKR antagonist PC1. This review aims to summarize the current knowledge on the neurotoxic and/or neuroprotective function of chemokines in Alzheimer’s disease, focusing on the prokineticin system: it represents a new field of investigation that can stimulate the research of innovative pharmacotherapeutic strategies.
alzheimer’s disease; chemokines; prokineticin receptors; aß-peptide; prokineticins
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Chemokines in alzheimer’s disease: new insights into prokineticins, chemokine-like proteins / Zuena, Anna Rita; Casolini, Paola; Lattanzi, Roberta; Maftei, Daniela. - In: FRONTIERS IN PHARMACOLOGY. - ISSN 1663-9812. - 10:(2019). [10.3389/fphar.2019.00622]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1285292
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