Nitrogen donor ligands and their coordination compounds as a tool for treatment of multi drug resistant tumors

In our previous work we prepared several libraries of compounds: organic ligands with N-donor atoms (in some cases with additional chalcogen donor atoms) and corresponding metal complexes. These compounds have been tested against various cancer and cancer stem cells (CSCs) and the most potent compounds have been identified. For selected compounds a detailed mechanistic study regarding antitumor activity has been performed together with in silico and experimental molecular target(s) identification. The most promising results will be presented. A novel line of our research represents building of drug delivery systems based on coordination polymers (CPs). CPs represent assembly of different building blocks - metals and organic linkers, with different porosities and dimensionalities (from 1D to 3D). CPs have demonstrated inimitable advantages in drug delivery systems. These advantages are nontoxicity, well-controlled drug release and stability, which can be the most pivotal characteristics of every efficient carrier. The mentioned properties make CPs one of the most applicable carriers in anticancer drug delivery systems. A novel class of Ag-based 1D-3D CPs with organic thiocyanates and substituted thiomorpholine ligands has been developed in collaboration of several groups. Studies of their drug delivery properties are in progress.