Hydroxyurea is a cytotoxic agent widely used in the treatment of myeloproliferative disorders. It is considered a-well-tolerated antineoplastic drug, with a dose-related bone marrow suppression as main adverse effect. This report describes a patient with essential thrombocythemia who developed an interstitial pneumonitis and respiratory failure within 4 years from beginning therapy with hydroxyurea (HU). After discontinuing of HU. both clinical and radiological resolution of pneumonitis occurred. In conclusion, HU-induced pulmonary toxicity is a potentially life-threatening side effect.

Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature / Internullo, Mattia; Giannelli, Valerio; Sardo, Liborio; Antonaglia, Caterina; Villani, Tullia; Angelici, Elena; Palange, Paolo. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 18:2(2014), p. 190-3.

Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature

INTERNULLO, MATTIA;GIANNELLI, VALERIO;SARDO, LIBORIO;ANTONAGLIA, CATERINA;VILLANI, TULLIA;ANGELICI, Elena;PALANGE, Paolo
2014

Abstract

Hydroxyurea is a cytotoxic agent widely used in the treatment of myeloproliferative disorders. It is considered a-well-tolerated antineoplastic drug, with a dose-related bone marrow suppression as main adverse effect. This report describes a patient with essential thrombocythemia who developed an interstitial pneumonitis and respiratory failure within 4 years from beginning therapy with hydroxyurea (HU). After discontinuing of HU. both clinical and radiological resolution of pneumonitis occurred. In conclusion, HU-induced pulmonary toxicity is a potentially life-threatening side effect.
Aged; Antineoplastic Agents; Female; Humans; Hydroxyurea; Lung Diseases, Interstitial; Respiratory Insufficiency; Thrombocytosis
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Hydroxyurea-induced interstitial pneumonitis: case report and review of the literature / Internullo, Mattia; Giannelli, Valerio; Sardo, Liborio; Antonaglia, Caterina; Villani, Tullia; Angelici, Elena; Palange, Paolo. - In: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. - ISSN 2284-0729. - 18:2(2014), p. 190-3.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/965459
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