Aim: Lactoferrin (Lf) is an antimicrobial and iron chelator glycoprotein contained in exocrine secretion, including saliva, and in secondary granules of neutrophil granulocytes. Lf performs its antibacterial and antiviral action through two pathways: the first deprives bacteria of the iron they need for their reproduction and for biofilm formation; the second contributes to restore the inflammatory homeostasis which is essential for tissue health modulating the level of cytokines, like IL-6. The study intends to propose the use of systemic and in situ Lf effectiveness in the healing of oral mucosa and bone tissue affected by medication-related ostenecrosis of the jaw (MRONJ), after surgical excision or spontaneous elimination of necrotic bone.
Use of systemic and in situ lactoferrin in MRONJ surgical management: proposal for a therapeutic solution / Montori, A.; Rocchetti, F.; Tenore, Gianluca; Gaimari, Gianfranco; Cassoni, A.; Palaia, Gaspare; Romeo, Umberto. - In: JOURNAL OF OSSEOINTEGRATION. - ISSN 2036-4121. - STAMPA. - 9:1(2017), pp. 184-184. (Intervento presentato al convegno XXIV Congresso Nazionale Collegio dei Docenti Universitari di Discipline Odontostomatologiche tenutosi a Milan; Italy nel 2017).
Use of systemic and in situ lactoferrin in MRONJ surgical management: proposal for a therapeutic solution
Montori, A.Primo
;Rocchetti, F.Secondo
;TENORE, GIANLUCA;GAIMARI, GIANFRANCO;Cassoni, A.;PALAIA, GASPAREPenultimo
;ROMEO, UmbertoUltimo
2017
Abstract
Aim: Lactoferrin (Lf) is an antimicrobial and iron chelator glycoprotein contained in exocrine secretion, including saliva, and in secondary granules of neutrophil granulocytes. Lf performs its antibacterial and antiviral action through two pathways: the first deprives bacteria of the iron they need for their reproduction and for biofilm formation; the second contributes to restore the inflammatory homeostasis which is essential for tissue health modulating the level of cytokines, like IL-6. The study intends to propose the use of systemic and in situ Lf effectiveness in the healing of oral mucosa and bone tissue affected by medication-related ostenecrosis of the jaw (MRONJ), after surgical excision or spontaneous elimination of necrotic bone.File | Dimensione | Formato | |
---|---|---|---|
Montori_Use-of-systemic_2017.pdf
accesso aperto
Note: https://www.journalofosseointegration.eu/index.php/jo/article/view/10
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Creative commons
Dimensione
40.09 kB
Formato
Adobe PDF
|
40.09 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.