The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini-Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85-0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery.

Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study / Babiloni, Claudio; DEL PERCIO, Claudio; Lizio, Roberta; Noce, Giuseppe; Cordone, Susanna; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, MARIA TERESA; Nobili, Flavio; Arnaldi, Dario; Aarsland, Dag; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Onofrj, Marco; Stocchi, Fabrizio; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Caravias, Georg; Garn, Heinrich; Sorpresi, Fabiola; Pievani, Michela; Frisoni, Giovanni B.; D'Antonio, Fabrizia; DE LENA, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Başar, Erol; Yener, Görsev; Emek Savaş, Derya Durusu; Triggiani, Antonio Ivano; Franciotti, Raffaella; De Pandis, Maria Francesca; Bonanni, Laura. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - (2017), pp. 143-158. [10.1016/j.neurobiolaging.2017.03.030]

Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study

BABILONI, CLAUDIO;DEL PERCIO, CLAUDIO;LIZIO, ROBERTA;NOCE, GIUSEPPE;CORDONE, SUSANNA;LOPEZ, SUSANNA;PASCARELLI, MARIA TERESA;ORZI, Francesco;BUTTINELLI, Carla;GIUBILEI, Franco;STOCCHI, FABRIZIO;D'ANTONIO, FABRIZIA;DE LENA, Carlo;
2017

Abstract

The aim of this retrospective exploratory study was that resting state eyes-closed electroencephalographic (rsEEG) rhythms might reflect brain arousal in patients with dementia due to Alzheimer's disease dementia (ADD), Parkinson's disease dementia (PDD), and dementia with Lewy body (DLB). Clinical and rsEEG data of 42 ADD, 42 PDD, 34 DLB, and 40 healthy elderly (Nold) subjects were available in an international archive. Demography, education, and Mini-Mental State Evaluation score were not different between the patient groups. Individual alpha frequency peak (IAF) determined the delta, theta, alpha 1, alpha 2, and alpha 3 frequency bands. Fixed beta 1, beta 2, and gamma bands were also considered. rsEEG cortical sources were estimated by means of the exact low-resolution brain electromagnetic source tomography and were then classified across individuals, on the basis of the receiver operating characteristic curves. Compared to Nold, IAF showed marked slowing in PDD and DLB and moderate slowing in ADD. Furthermore, all patient groups showed lower posterior alpha 2 source activities. This effect was dramatic in ADD, marked in DLB, and moderate in PDD. These groups also showed higher occipital delta source activities, but this effect was dramatic in PDD, marked in DLB, and moderate in ADD. The posterior delta and alpha sources allowed good classification accuracy (approximately 0.85-0.90) between the Nold subjects and patients, and between ADD and PDD patients. In quiet wakefulness, delta and alpha sources unveiled different spatial and frequency features of the cortical neural synchronization underpinning brain arousal in ADD, PDD, and DLB patients. Future prospective cross-validation studies should test these rsEEG markers for clinical applications and drug discovery.
Alzheimer's disease dementia (ADD); dementia with Lewy body (DLB); exact low-resolution brain electromagnetic source tomography (eLORETA); Parkinson's disease dementia (PDD); resting state electroencephalographic (rsEEG) rhythms; neuroscience ; aging; developmental biology; geriatrics and gerontology; neurology
01 Pubblicazione su rivista::01a Articolo in rivista
Abnormalities of cortical neural synchronization mechanisms in patients with dementia due to Alzheimer's and Lewy body diseases: an EEG study / Babiloni, Claudio; DEL PERCIO, Claudio; Lizio, Roberta; Noce, Giuseppe; Cordone, Susanna; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, MARIA TERESA; Nobili, Flavio; Arnaldi, Dario; Aarsland, Dag; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Onofrj, Marco; Stocchi, Fabrizio; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Caravias, Georg; Garn, Heinrich; Sorpresi, Fabiola; Pievani, Michela; Frisoni, Giovanni B.; D'Antonio, Fabrizia; DE LENA, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Başar, Erol; Yener, Görsev; Emek Savaş, Derya Durusu; Triggiani, Antonio Ivano; Franciotti, Raffaella; De Pandis, Maria Francesca; Bonanni, Laura. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - (2017), pp. 143-158. [10.1016/j.neurobiolaging.2017.03.030]
File allegati a questo prodotto
File Dimensione Formato  
Babiloni_Abnormalities_2017.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.15 MB
Formato Adobe PDF
2.15 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/954477
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 54
social impact