Nowadays there is a growing interest in particle therapy treatments exploiting light ion beams against tumors due to their enhanced relative biological effectiveness and high space selectivity. In particular promising results are obtained by the use of 4He projectiles. Unlike the treatments performed using protons, the beam ions can undergo a fragmentation process when interacting with the atomic nuclei in the patient body. In this paper the results of measurements performed at the Heidelberg Ion-Beam Therapy center are reported. For the first time the absolute fluxes and the energy spectra of the fragments—protons, deuterons, and tritons—produced by 4He ion beams of 102, 125 and 145 MeV u−1 energies on a poly-methyl methacrylate target were evaluated at different angles. The obtained results are particularly relevant in view of the necessary optimization and review of the treatment planning software being developed for clinical use of 4He beams in clinical routine and the relative bench-marking of Monte Carlo algorithm predictions.

Secondary radiation measurements for particle therapy applications: Nuclear fragmentation produced by 4He ion beams in a PMMA target / Marafini, M.; Paramatti, Riccardo; Pinci, Davide; Battistoni, G.; Collamati, Francesco; DE LUCIA, Erika; Faccini, Riccardo; Frallicciardi, P. M.; MANCINI TERRACCIANO, Carlo; Mattei, I.; Muraro, S.; Piersanti, Luca; Rovituso, M.; Rucinski, A.; Russomando, Andrea; Sarti, Alessio; Sciubba, Adalberto; SOLFAROLI CAMILLOCCI, Elena; Toppi, Marco; Traini, Giacomo; Voena, Cecilia; Patera, Vincenzo. - In: PHYSICS IN MEDICINE AND BIOLOGY. - ISSN 0031-9155. - STAMPA. - 62:4(2017), pp. 1291-1309. [10.1088/1361-6560/aa5307]

Secondary radiation measurements for particle therapy applications: Nuclear fragmentation produced by 4He ion beams in a PMMA target

PARAMATTI, Riccardo;PINCI, davide;COLLAMATI, FRANCESCO;DE LUCIA, Erika;FACCINI, Riccardo;MANCINI TERRACCIANO, CARLO;PIERSANTI, LUCA;RUSSOMANDO, ANDREA;SARTI, ALESSIO;SCIUBBA, Adalberto;SOLFAROLI CAMILLOCCI, ELENA;TOPPI, Marco;TRAINI, GIACOMO;VOENA, Cecilia;PATERA, Vincenzo
2017

Abstract

Nowadays there is a growing interest in particle therapy treatments exploiting light ion beams against tumors due to their enhanced relative biological effectiveness and high space selectivity. In particular promising results are obtained by the use of 4He projectiles. Unlike the treatments performed using protons, the beam ions can undergo a fragmentation process when interacting with the atomic nuclei in the patient body. In this paper the results of measurements performed at the Heidelberg Ion-Beam Therapy center are reported. For the first time the absolute fluxes and the energy spectra of the fragments—protons, deuterons, and tritons—produced by 4He ion beams of 102, 125 and 145 MeV u−1 energies on a poly-methyl methacrylate target were evaluated at different angles. The obtained results are particularly relevant in view of the necessary optimization and review of the treatment planning software being developed for clinical use of 4He beams in clinical routine and the relative bench-marking of Monte Carlo algorithm predictions.
2017
differential yield; helium beam; nuclear fragmentation; PMMA target; Radiological and Ultrasound Technology; Radiology, Nuclear Medicine and Imaging
01 Pubblicazione su rivista::01a Articolo in rivista
Secondary radiation measurements for particle therapy applications: Nuclear fragmentation produced by 4He ion beams in a PMMA target / Marafini, M.; Paramatti, Riccardo; Pinci, Davide; Battistoni, G.; Collamati, Francesco; DE LUCIA, Erika; Faccini, Riccardo; Frallicciardi, P. M.; MANCINI TERRACCIANO, Carlo; Mattei, I.; Muraro, S.; Piersanti, Luca; Rovituso, M.; Rucinski, A.; Russomando, Andrea; Sarti, Alessio; Sciubba, Adalberto; SOLFAROLI CAMILLOCCI, Elena; Toppi, Marco; Traini, Giacomo; Voena, Cecilia; Patera, Vincenzo. - In: PHYSICS IN MEDICINE AND BIOLOGY. - ISSN 0031-9155. - STAMPA. - 62:4(2017), pp. 1291-1309. [10.1088/1361-6560/aa5307]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/949761
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