Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent-sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated to beta-amyloid deposition and impaired hippocampal memory consolidation. We hypothesize that the apparent contradiction may be explained by the partial overlap between 0.6-1 Hz EEG activity and K-Complex (KC). According to this view, we studied both frontal KCs and SWA in 20 AD patients and 20 healthy age-matched controls (HC) during nightly sleep, under the hypothesis that KCs better discriminate patients from healthy elderly than <= 1 Hz SWA. A drastic decrease of KC density during stage 2 NREM was found in AD compared to HC. Patients show more than 40% reduction of the KC density, allowing a correct classification of 80%. On the other hand, <= 1 Hz SWA of AD patients is slightly (not significantly) higher in most cortical areas compared to HC. Although no significant changes of <= 1 Hz SWA are detectable over frontal areas in AD, KC density decreases over the same location, and its decrease is related to the cognitive decline

The fall of Sleep K-Complex in Alzheimer disease / DE GENNARO, Luigi; Gorgoni, Maurizio; Reda, Flaminia; Lauri, Giulia; Truglia, Ilaria; Cordone, Susanna; Scarpelli, Serena; Mangiaruga, Anastasia; D'Atri, Aurora; Lacidogna, Giordano; Ferrara, Michele; Marra, Camillo; Rossini, Paolo Maria. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 7:(2017), p. 39688. [10.1038/srep39688]

The fall of Sleep K-Complex in Alzheimer disease

DE GENNARO, Luigi;GORGONI, MAURIZIO;REDA, FLAMINIA;LAURI, GIULIA;TRUGLIA, ILARIA;CORDONE, SUSANNA;SCARPELLI, SERENA;MANGIARUGA, ANASTASIA;D'ATRI, AURORA;
2017

Abstract

Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent-sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated to beta-amyloid deposition and impaired hippocampal memory consolidation. We hypothesize that the apparent contradiction may be explained by the partial overlap between 0.6-1 Hz EEG activity and K-Complex (KC). According to this view, we studied both frontal KCs and SWA in 20 AD patients and 20 healthy age-matched controls (HC) during nightly sleep, under the hypothesis that KCs better discriminate patients from healthy elderly than <= 1 Hz SWA. A drastic decrease of KC density during stage 2 NREM was found in AD compared to HC. Patients show more than 40% reduction of the KC density, allowing a correct classification of 80%. On the other hand, <= 1 Hz SWA of AD patients is slightly (not significantly) higher in most cortical areas compared to HC. Although no significant changes of <= 1 Hz SWA are detectable over frontal areas in AD, KC density decreases over the same location, and its decrease is related to the cognitive decline
2017
slow-wave sleep; closed-loop stimulation; delta waves; dementia patients; dependent memory; nucleus basalis; stage-2 sleep; eeg; frequency; brainMultidisciplinary
01 Pubblicazione su rivista::01a Articolo in rivista
The fall of Sleep K-Complex in Alzheimer disease / DE GENNARO, Luigi; Gorgoni, Maurizio; Reda, Flaminia; Lauri, Giulia; Truglia, Ilaria; Cordone, Susanna; Scarpelli, Serena; Mangiaruga, Anastasia; D'Atri, Aurora; Lacidogna, Giordano; Ferrara, Michele; Marra, Camillo; Rossini, Paolo Maria. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 7:(2017), p. 39688. [10.1038/srep39688]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/945275
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