We report four HCV-HIV-coinfected patients who developed herpes zoster or muco-cutaneous herpes virus disease shortly after starting interferon-free antiviral treatment for HCV. We suggest that in our patients the prompt clearance of HCV following direct-acting antivirals leads to a paradoxical effect on the innate and adaptive immune system mediating the reactivation of herpetic infection.
Herpes virus reactivation after initiation of interferon-free antiviral agents in HIV-HCV-coinfected subjects: a new immune restoration disease? / Marocco, Raffaella; Lichtner, Miriam; Tieghi, Tiziana; Pozzetto, Irene; Mastroianni, Claudio Maria. - In: ANTIVIRAL THERAPY. - ISSN 1359-6535. - ELETTRONICO. - (2016), pp. 1-4. [10.3851/IMP3072]
Herpes virus reactivation after initiation of interferon-free antiviral agents in HIV-HCV-coinfected subjects: a new immune restoration disease?
MAROCCO, RAFFAELLA;LICHTNER, Miriam;TIEGHI, TIZIANA;POZZETTO, IRENE;MASTROIANNI, Claudio Maria
2016
Abstract
We report four HCV-HIV-coinfected patients who developed herpes zoster or muco-cutaneous herpes virus disease shortly after starting interferon-free antiviral treatment for HCV. We suggest that in our patients the prompt clearance of HCV following direct-acting antivirals leads to a paradoxical effect on the innate and adaptive immune system mediating the reactivation of herpetic infection.| File | Dimensione | Formato | |
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