Calcitonin is the hallmark of medullary thyroid carcinoma. However, extrathyroidal neuroendocrine tumors can also release calcitonin.We report 2 cases of calcitonin-secreting pancreatic tumors found in asymptomatic patients with thyroid nodules referred to our center within 11 months.Case 1: A man initially referred for thyroid nodule characterization was found to have hypercalcitoninemia (>200 pg/mL) during non-neoplastic fine-needle aspiration.Case 2: A woman evaluated for liver metastasis was found to have hypercalcitoninemia and multinodular goiter.Our research emphasizes that marked hypercalcitoninemia in the presence of thyroid nodules is not necessarily due to medullary thyroid carcinoma; awareness of this could avoid unnecessary thyroidectomy. The lack of specific symptoms related to hypercalcitoninemia may be the reason that the prevalence of calcitonin-secreting pancreatic tumors is underestimated.

Extrathyroidal calcitonin secreting tumors: Pancreatic neuroendocrine tumors in patients with multinodular goiter: Two case reports / Giannetta, Elisa; Gianfrilli, Daniele; Pozza, Carlotta; Lauretta, Rosa; Graziadio, Chiara; Sbardella, Emilia; Baroli, Alberto; Caronna, Roberto; Chirletti, Piero; Lenzi, Andrea; Isidori, Andrea; Sbardella, Emilia. - In: MEDICINE. - ISSN 0025-7974. - ELETTRONICO. - 95:3(2016). [10.1097/MD.0000000000002419]

Extrathyroidal calcitonin secreting tumors: Pancreatic neuroendocrine tumors in patients with multinodular goiter: Two case reports

GIANNETTA, ELISA;GIANFRILLI, DANIELE;POZZA, CARLOTTA;GRAZIADIO, CHIARA;SBARDELLA, EMILIA;CARONNA, Roberto;CHIRLETTI, Piero;LENZI, Andrea;ISIDORI, Andrea;SBARDELLA, EMILIA
2016

Abstract

Calcitonin is the hallmark of medullary thyroid carcinoma. However, extrathyroidal neuroendocrine tumors can also release calcitonin.We report 2 cases of calcitonin-secreting pancreatic tumors found in asymptomatic patients with thyroid nodules referred to our center within 11 months.Case 1: A man initially referred for thyroid nodule characterization was found to have hypercalcitoninemia (>200 pg/mL) during non-neoplastic fine-needle aspiration.Case 2: A woman evaluated for liver metastasis was found to have hypercalcitoninemia and multinodular goiter.Our research emphasizes that marked hypercalcitoninemia in the presence of thyroid nodules is not necessarily due to medullary thyroid carcinoma; awareness of this could avoid unnecessary thyroidectomy. The lack of specific symptoms related to hypercalcitoninemia may be the reason that the prevalence of calcitonin-secreting pancreatic tumors is underestimated.
2016
Aged; Biomarkers; Tumor; Calcitonin; Diagnosis, Differential; Female; Goiter, Nodular; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroendocrine Tumors; Pancreatectomy; Pancreatic Neoplasms; Tomography, X-Ray Computed; Medicine (all)
01 Pubblicazione su rivista::01i Case report
Extrathyroidal calcitonin secreting tumors: Pancreatic neuroendocrine tumors in patients with multinodular goiter: Two case reports / Giannetta, Elisa; Gianfrilli, Daniele; Pozza, Carlotta; Lauretta, Rosa; Graziadio, Chiara; Sbardella, Emilia; Baroli, Alberto; Caronna, Roberto; Chirletti, Piero; Lenzi, Andrea; Isidori, Andrea; Sbardella, Emilia. - In: MEDICINE. - ISSN 0025-7974. - ELETTRONICO. - 95:3(2016). [10.1097/MD.0000000000002419]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/939334
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