Anomalous diffusion (AD) stretched-exponential gamma-imaging model, was applied to investigate a fixed mouse spinal cord by using gradient strength varying PGSTE sequence at 9.4T. To highlight the new additional information provided by AD approach, we compared AD images with results obtained by using conventional DTI, relaxometry and histological data. Mean gamma , gamma-anisotropy , gammapar and gammaortho are able to detect microstructural information of white matter (WM) in spinal cord more specific and complementary to those provided by DTI. Specifically, the correlation between gamma-anisotropy and myelin fraction is in agreement with the anisotropic rearrangement of myelin along White Matter fibers.
Anomalous diffusion gamma-imaging to assess spinal cord white matter microstructure #2907 / Caporale, Alessandra; Palombo, Marco; Capuani, Silvia. - ELETTRONICO. - (2015). (Intervento presentato al convegno ISMRM 23rd Annual Meeting & Exhibition tenutosi a Toronto, Ontario, Canada nel 30/05/2015 - 05/06/2015).
Anomalous diffusion gamma-imaging to assess spinal cord white matter microstructure #2907
CAPUANI, Silvia
2015
Abstract
Anomalous diffusion (AD) stretched-exponential gamma-imaging model, was applied to investigate a fixed mouse spinal cord by using gradient strength varying PGSTE sequence at 9.4T. To highlight the new additional information provided by AD approach, we compared AD images with results obtained by using conventional DTI, relaxometry and histological data. Mean gamma , gamma-anisotropy , gammapar and gammaortho are able to detect microstructural information of white matter (WM) in spinal cord more specific and complementary to those provided by DTI. Specifically, the correlation between gamma-anisotropy and myelin fraction is in agreement with the anisotropic rearrangement of myelin along White Matter fibers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
