A radio-guided surgery technique exploiting beta- emitters is under development. It aims at a higher target-to-background activity ratio implying both a smaller radiopharma- ceutical activity and the possibility of extending the technique to cases with a large uptake of surrounding healthy organs. Such technique requires a dedicated intraoperative probe detecting beta- radiation. A first prototype has been developed relying on the low density and high light yield of the diphenylbutadiene doped para-therphenyl organic scintillator. The scintillation light produced in a cylindrical crystal, 5 mm in diameter and 3 mm in height, is guided to a photo-multiplier tube by optical bres. The custom readout electronics is designed to optimize its usage in terms of feedback to the surgeon, portability and remote monitoring of the signal. Tests show that with a radiotracer activity comparable to those administered for diagnostic purposes the developed probe can detect a 0.1 ml cancerous residual of meningioma in a few seconds.

Polycrystalline para-terphenyl scintillator adopted in a β<sup>-</sup> Detecting probe for radio-guided surgery / SOLFAROLI CAMILLOCCI, Elena; Bellini, Fabio; Bocci, V.; Collamati, Francesco; De Lucia, E.; Faccini, Riccardo; Marafini, M.; Mattei, I.; Morganti, S.; Paramatti, Riccardo; Patera, Vincenzo; Pinci, Davide; Recchia, L.; Russomando, Andrea; Sarti, Alessio; Sciubba, Adalberto; Senzacqua, Martina; Voena, Cecilia. - In: JOURNAL OF PHYSICS. CONFERENCE SERIES. - ISSN 1742-6588. - 620:(2015), p. 012009. ((Intervento presentato al convegno Workshop on the Applications of Novel Scintillators in Research and Industry, ANSRI 2015 tenutosi a University College Dublin, irl nel 2015 [10.1088/1742-6596/620/1/012009].

Polycrystalline para-terphenyl scintillator adopted in a β- Detecting probe for radio-guided surgery

SOLFAROLI CAMILLOCCI, ELENA;BELLINI, Fabio;COLLAMATI, FRANCESCO;FACCINI, Riccardo;PARAMATTI, Riccardo;PATERA, Vincenzo;PINCI, davide;RUSSOMANDO, ANDREA;SARTI, ALESSIO;SCIUBBA, Adalberto;SENZACQUA, MARTINA;VOENA, Cecilia
2015

Abstract

A radio-guided surgery technique exploiting beta- emitters is under development. It aims at a higher target-to-background activity ratio implying both a smaller radiopharma- ceutical activity and the possibility of extending the technique to cases with a large uptake of surrounding healthy organs. Such technique requires a dedicated intraoperative probe detecting beta- radiation. A first prototype has been developed relying on the low density and high light yield of the diphenylbutadiene doped para-therphenyl organic scintillator. The scintillation light produced in a cylindrical crystal, 5 mm in diameter and 3 mm in height, is guided to a photo-multiplier tube by optical bres. The custom readout electronics is designed to optimize its usage in terms of feedback to the surgeon, portability and remote monitoring of the signal. Tests show that with a radiotracer activity comparable to those administered for diagnostic purposes the developed probe can detect a 0.1 ml cancerous residual of meningioma in a few seconds.
Workshop on the Applications of Novel Scintillators in Research and Industry, ANSRI 2015
Physics and Astronomy (all)
04 Pubblicazione in atti di convegno::04c Atto di convegno in rivista
Polycrystalline para-terphenyl scintillator adopted in a β<sup>-</sup> Detecting probe for radio-guided surgery / SOLFAROLI CAMILLOCCI, Elena; Bellini, Fabio; Bocci, V.; Collamati, Francesco; De Lucia, E.; Faccini, Riccardo; Marafini, M.; Mattei, I.; Morganti, S.; Paramatti, Riccardo; Patera, Vincenzo; Pinci, Davide; Recchia, L.; Russomando, Andrea; Sarti, Alessio; Sciubba, Adalberto; Senzacqua, Martina; Voena, Cecilia. - In: JOURNAL OF PHYSICS. CONFERENCE SERIES. - ISSN 1742-6588. - 620:(2015), p. 012009. ((Intervento presentato al convegno Workshop on the Applications of Novel Scintillators in Research and Industry, ANSRI 2015 tenutosi a University College Dublin, irl nel 2015 [10.1088/1742-6596/620/1/012009].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/931282
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