Purpose: A radio-guided surgery technique with b!-emitting radio-tracers was suggested to overcome the effect of the large penetration of c radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection. Methods: A patient affected by meningioma was administered 300 MBq of 90Y-DOTATOC. Several samples extracted from the meningioma and the nearby Dura Mater were analyzed with a b! probe designed specifically for this radio-guided surgery technique. The observed signals were compared both with the evaluation from the histology and with the Monte Carlo simulation. Results: we obtained a large signal on the bulk tumor (105 cps) and a significant signal on residuals of "0.2 ml (28 cps). We also show that simulations predict correctly the observed yields and this allows us to estimate that the healthy tissues would return negligible signals (#1 cps). This test also demonstrated that the exposure of the medical staff is negligible and that among the biological wastes only urine has a significant activity. Conclusions: This proof-of-principle test on a patient assessed that the technique is feasible with negligible background to medical personnel and confirmed that the expectations obtained with Monte Carlo simulations starting from diagnostic PET images are correct.

First ex vivo validation of a radioguided surgery technique with β-radiation / SOLFAROLI CAMILLOCCI, Elena; Schiariti, M.; Bocci, V.; Carollo, A.; Chiodi, G.; Colandrea, M.; Collamati, Francesco; Cremonesi, M.; Donnarumma, Raffaella; Ferrari, M. E.; Ferroli, P.; Ghielmetti, F.; Grana, C. M.; MANCINI TERRACCIANO, Carlo; Marafini, M.; Morganti, S.; Patanè, M.; Pedroli, G.; Pollo, B.; Recchia, L.; Russomando, Andrea; Toppi, Marco; Traini, Giacomo; Faccini, Riccardo. - In: PHYSICA MEDICA. - ISSN 1120-1797. - STAMPA. - 32:9(2016), pp. 1139-1144. [10.1016/j.ejmp.2016.08.018]

First ex vivo validation of a radioguided surgery technique with β-radiation

SOLFAROLI CAMILLOCCI, ELENA;COLLAMATI, FRANCESCO;DONNARUMMA, RAFFAELLA;MANCINI TERRACCIANO, CARLO;RUSSOMANDO, ANDREA;TOPPI, Marco;TRAINI, GIACOMO;FACCINI, Riccardo
2016

Abstract

Purpose: A radio-guided surgery technique with b!-emitting radio-tracers was suggested to overcome the effect of the large penetration of c radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection. Methods: A patient affected by meningioma was administered 300 MBq of 90Y-DOTATOC. Several samples extracted from the meningioma and the nearby Dura Mater were analyzed with a b! probe designed specifically for this radio-guided surgery technique. The observed signals were compared both with the evaluation from the histology and with the Monte Carlo simulation. Results: we obtained a large signal on the bulk tumor (105 cps) and a significant signal on residuals of "0.2 ml (28 cps). We also show that simulations predict correctly the observed yields and this allows us to estimate that the healthy tissues would return negligible signals (#1 cps). This test also demonstrated that the exposure of the medical staff is negligible and that among the biological wastes only urine has a significant activity. Conclusions: This proof-of-principle test on a patient assessed that the technique is feasible with negligible background to medical personnel and confirmed that the expectations obtained with Monte Carlo simulations starting from diagnostic PET images are correct.
File allegati a questo prodotto
File Dimensione Formato  
PhysicaMedica32-9_Solfaroli2016_FirstExVivo.pdf

solo gestori archivio

Tipologia: Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.17 MB
Formato Adobe PDF
1.17 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/905383
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 27
social impact