Although micrognathia and cleft palate have been reported in patients with Lymphedema-distichiasis syndrome (LDS), the classic Robin sequence with glossoptosis and airway obstruction has not been previously described in patients with genetically confirmed LDS. Here we report on two female siblings with LDS confirmed by a FOXC2 mutation who presented at birth with severe airway obstruction related to Robin sequence. Respiratory obstruction was successfully managed by early distraction osteogenesis. Our report highlights the unusual occurrence of Robin sequence in LDS patients and advises distraction osteogenesis to resolve breathing problems in LDS patients who present with Robin related severe airway obstruction.
Early mandibular distraction to relieve Robin severe airway obstruction in two siblings with lymphedema-distichiasis syndrome / Papoff, Paola; Castori, Marco; Manganaro, Lucia; Midulla, Fabio; Moretti, Corrado; Cascone, Piero. - In: JOURNAL OF MAXILLOFACIAL & ORAL SURGERY. - ISSN 0972-8279. - STAMPA. - 15:3(2016), pp. 384-389. [10.1007/s12663-015-0774-5]
Early mandibular distraction to relieve Robin severe airway obstruction in two siblings with lymphedema-distichiasis syndrome
PAPOFF, PAOLA
Primo
;CASTORI, MARCOSecondo
;MANGANARO, Lucia;MIDULLA, Fabio;MORETTI, CorradoPenultimo
;CASCONE, PIEROUltimo
2016
Abstract
Although micrognathia and cleft palate have been reported in patients with Lymphedema-distichiasis syndrome (LDS), the classic Robin sequence with glossoptosis and airway obstruction has not been previously described in patients with genetically confirmed LDS. Here we report on two female siblings with LDS confirmed by a FOXC2 mutation who presented at birth with severe airway obstruction related to Robin sequence. Respiratory obstruction was successfully managed by early distraction osteogenesis. Our report highlights the unusual occurrence of Robin sequence in LDS patients and advises distraction osteogenesis to resolve breathing problems in LDS patients who present with Robin related severe airway obstruction.File | Dimensione | Formato | |
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Papoff_Early-mandibular_2016.pdf
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Note: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048309/
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