Objective: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (<4 Hz) and alpha (8–13 Hz) electroencephalographic (EEG) rhythms with reference to a control group of sex-, age-, and education-matched healthy individuals. Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values were expected to show worse cognitive status. Methods: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys. ± 1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys. ± 2.2 SE). Lowresolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions. Results: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p < 0.05). Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values exhibited lower mini mental state evaluation (MMSE) score, higher CD4 count, and lower viral load (p < 0.05). Conclusions: This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.

Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: a statistical z-score index / Babiloni, Claudio; Pennica, Alfredo; DEL PERCIO, Claudio; Noce, Giuseppe; Cordone, Susanna; Muratori, Chiara; Ferracuti, Stefano; Donato, Nicole; Di Campli, Francesco; Gianserra, Laura; Teti, Elisabetta; Aceti, Antonio; Soricelli, Andrea; Viscione, Magdalena; Limatola, Cristina; Andreoni, Massimo; Onorati, Paolo. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1872-8952. - ELETTRONICO. - 127:3(2016), pp. 1803-1812. [10.1016/j.clinph.2015.12.007]

Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: a statistical z-score index

BABILONI, CLAUDIO;PENNICA, Alfredo;DEL PERCIO, CLAUDIO;NOCE, GIUSEPPE;CORDONE, SUSANNA;MURATORI, CHIARA;FERRACUTI, Stefano;GIANSERRA, LAURA;TETI, ELISABETTA;ACETI, Antonio;VISCIONE, MAGDALENA;LIMATOLA, Cristina;ONORATI, Paolo
2016

Abstract

Objective: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (<4 Hz) and alpha (8–13 Hz) electroencephalographic (EEG) rhythms with reference to a control group of sex-, age-, and education-matched healthy individuals. Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values were expected to show worse cognitive status. Methods: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys. ± 1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys. ± 2.2 SE). Lowresolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions. Results: Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p < 0.05). Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values exhibited lower mini mental state evaluation (MMSE) score, higher CD4 count, and lower viral load (p < 0.05). Conclusions: This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/899824
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