We propose an advanced Raman spectroscopy (RS) study of nucleic acids. As known, nondisruptive optical techniques can allow for a qualitative investigation and for monitoring structural changes in molecules. These capabilities can also be improved, with the correlation of spectroscopic information with computational simulations. Furthermore, this approach can lead to a semi-quantitative analysis, e.g. in terms of nucleotide composition, of DNA or RNA. An important possibility is the employment of Surface- Enhanced Raman Spectroscopy (SERS) in enhancing the sensitivity of the technique.
Monitoring DNA oxidative damage: pushing the limits of Raman spectroscopy / Fasolato, Claudia; Ripanti, Francesca; Bignami, M.; Domenici, Fabio; Bordi, Federico; Dore, Paolo; Postorino, Paolo; Mazzei, F.. - STAMPA. - (2015). (Intervento presentato al convegno ESBP2015 - 8th European Symposium on Biopolymers tenutosi a Roma nel 16-18 Settembre 2015).
Monitoring DNA oxidative damage: pushing the limits of Raman spectroscopy
FASOLATO, CLAUDIA;RIPANTI, FRANCESCA;DOMENICI, FABIO;BORDI, FEDERICO;DORE, Paolo;POSTORINO, Paolo;
2015
Abstract
We propose an advanced Raman spectroscopy (RS) study of nucleic acids. As known, nondisruptive optical techniques can allow for a qualitative investigation and for monitoring structural changes in molecules. These capabilities can also be improved, with the correlation of spectroscopic information with computational simulations. Furthermore, this approach can lead to a semi-quantitative analysis, e.g. in terms of nucleotide composition, of DNA or RNA. An important possibility is the employment of Surface- Enhanced Raman Spectroscopy (SERS) in enhancing the sensitivity of the technique.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
