Radio-guided surgery (RGS) is a technique to intraoperatively detect tumour remnants, favouring a ra- dical resection. Exploiting β emitting tracers provides a higher signal to background ratio compared to the established technique with γ radiation, allowing the extension of the RGS applicability range. We developed and tested a detector based on para-terphenyl scintillator with high sensitivity to low energy electrons and almost transparent to γs to be used as intraoperative probe for RGS with β emitting tracer. Portable read out electronics was customised to match the surgeon needs. This probe was used for preclinical test on specific phantoms and a test on “ex vivo” specimens from patients affected by me- ningioma showing very promising results for the application of this new technique on brain tumours. In this paper, the prototype of the intraoperative probe and the tests are discussed; then, the results on meningioma are used to make predictions on the performance of the probe detecting residuals of a more challenging and more interesting brain tumour: the glioma.

Intraoperative probe detecting β- decays in brain tumour radio-guided surgery / SOLFAROLI CAMILLOCCI, Elena; Bocci, Valerio; Collamati, Francesco; Donnarumma, Raffaella; Faccini, Riccardo; MANCINI TERRACCIANO, Carlo; Marafini, Michela; Mattei, Ilaria; Morganti, Silvio; Muraro, Silvio; Recchia, Luigi; Rucinski, Antoni; Russomando, Andrea; Toppi, Marco; Traini, Giacomo. - In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. - ISSN 0168-9002. - (2016). [http://dx.doi.org/10.1016/j.nima.2016.04.107]

Intraoperative probe detecting β- decays in brain tumour radio-guided surgery

SOLFAROLI CAMILLOCCI, ELENA;COLLAMATI, FRANCESCO;FACCINI, Riccardo;MANCINI TERRACCIANO, CARLO;RUSSOMANDO, ANDREA;TOPPI, Marco;TRAINI, GIACOMO
2016

Abstract

Radio-guided surgery (RGS) is a technique to intraoperatively detect tumour remnants, favouring a ra- dical resection. Exploiting β emitting tracers provides a higher signal to background ratio compared to the established technique with γ radiation, allowing the extension of the RGS applicability range. We developed and tested a detector based on para-terphenyl scintillator with high sensitivity to low energy electrons and almost transparent to γs to be used as intraoperative probe for RGS with β emitting tracer. Portable read out electronics was customised to match the surgeon needs. This probe was used for preclinical test on specific phantoms and a test on “ex vivo” specimens from patients affected by me- ningioma showing very promising results for the application of this new technique on brain tumours. In this paper, the prototype of the intraoperative probe and the tests are discussed; then, the results on meningioma are used to make predictions on the performance of the probe detecting residuals of a more challenging and more interesting brain tumour: the glioma.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/867902
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