Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water. Continual exposure to dialysis solutions, as well as episodes of peritonitis and hemoperitoneum, can cause acute/chronic inflammation and injury to the peritoneal membrane, which undergoes progressive fibrosis, angiogenesis, and vasculopathy, eventually leading to discontinuation of the peritoneal dialysis. Among the different events controlling this pathological process, epithelial to mesenchymal transition of mesothelial cells plays a main role in the induction of fibrosis and in subsequent functional deterioration of the peritoneal membrane. Here, the main extracellular inducers and cellular players are described. Moreover, signaling pathways acting during this process are elucidated, with emphasis on signals delivered by TGF-β family members and by Toll-like/IL-1β receptors. The understanding of molecular mechanisms underlying fibrosis of the peritoneal membrane has both a basic and a translational relevance, since it may be useful for setup of therapies aimed at counteracting the deterioration as well as restoring the homeostasis of the peritoneal membrane.

Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis / Strippoli, Raffaele; Moreno Vicente, Roberto; Battistelli, Cecilia; Cicchini, Carla; Noce, Valeria; Amicone, Laura; Marchetti, Alessandra; Del Pozo, Miguel Angel; Tripodi, Marco. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-9678. - ELETTRONICO. - 2016:(2016). [10.1155/2016/3543678]

Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis

STRIPPOLI, RAFFAELE;BATTISTELLI, CECILIA;CICCHINI, Carla;NOCE, VALERIA;AMICONE, Laura;MARCHETTI, ALESSANDRA;TRIPODI, Marco
2016

Abstract

Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis. During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water. Continual exposure to dialysis solutions, as well as episodes of peritonitis and hemoperitoneum, can cause acute/chronic inflammation and injury to the peritoneal membrane, which undergoes progressive fibrosis, angiogenesis, and vasculopathy, eventually leading to discontinuation of the peritoneal dialysis. Among the different events controlling this pathological process, epithelial to mesenchymal transition of mesothelial cells plays a main role in the induction of fibrosis and in subsequent functional deterioration of the peritoneal membrane. Here, the main extracellular inducers and cellular players are described. Moreover, signaling pathways acting during this process are elucidated, with emphasis on signals delivered by TGF-β family members and by Toll-like/IL-1β receptors. The understanding of molecular mechanisms underlying fibrosis of the peritoneal membrane has both a basic and a translational relevance, since it may be useful for setup of therapies aimed at counteracting the deterioration as well as restoring the homeostasis of the peritoneal membrane.
2016
Cell Biology; Molecular Biology
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis / Strippoli, Raffaele; Moreno Vicente, Roberto; Battistelli, Cecilia; Cicchini, Carla; Noce, Valeria; Amicone, Laura; Marchetti, Alessandra; Del Pozo, Miguel Angel; Tripodi, Marco. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-9678. - ELETTRONICO. - 2016:(2016). [10.1155/2016/3543678]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/867038
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