Celiac Disease is a permanent intolerance to ingested gluten. The occurrence of liver impairment in CD is well described and can be regarded as one of the mainfold extra intestinal presentations of gluten-sensitive enteropathy. This increase is always mild or moderate, up to 5 times the upper limit of normal and transaminases decrease to normal range in most of patients on Gluten-free diet in maximum 12 months. We describe the case of a 16 months male addressed to our Operative Unit because of chronic diarrhea and poor weight growth with a severe increase of transaminases without a possible explanation. The case of our patient has highlighted the possibility of very high aminotransferase levels (up to 17 times the upper level normal of ALT) with a very slow decrease on a Gluten-free diet. It is necessary to study liver function in children at CD diagnosis and to seek celiac disease also in cases of severe hypertransaminasemia of unknown cause.

Transaminases and celiac disease: a relationship to be reassessed / Mennini, Maurizio; Ferrari, Federica; Valente, Michele; D'Amati, Giulia; Cucchiara, Salvatore. - In: PROGRESS IN NUTRITION. - ISSN 1129-8723. - 18:2(2016), pp. 190-192.

Transaminases and celiac disease: a relationship to be reassessed

MENNINI, MAURIZIO
Primo
Conceptualization
;
FERRARI, Federica
Secondo
Membro del Collaboration Group
;
VALENTE, MICHELE
Investigation
;
D'AMATI, Giulia
Penultimo
Investigation
;
CUCCHIARA, Salvatore
Ultimo
Conceptualization
2016

Abstract

Celiac Disease is a permanent intolerance to ingested gluten. The occurrence of liver impairment in CD is well described and can be regarded as one of the mainfold extra intestinal presentations of gluten-sensitive enteropathy. This increase is always mild or moderate, up to 5 times the upper limit of normal and transaminases decrease to normal range in most of patients on Gluten-free diet in maximum 12 months. We describe the case of a 16 months male addressed to our Operative Unit because of chronic diarrhea and poor weight growth with a severe increase of transaminases without a possible explanation. The case of our patient has highlighted the possibility of very high aminotransferase levels (up to 17 times the upper level normal of ALT) with a very slow decrease on a Gluten-free diet. It is necessary to study liver function in children at CD diagnosis and to seek celiac disease also in cases of severe hypertransaminasemia of unknown cause.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/866126
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