Autism and intellectual disability may hinder any other coexisting psychiatric diagnosis. Diagnoses are often based on behavioral observations, directly ob- tained or reported by family members or operators in frequent contact with the patient, and non-verbal communications, as well as on the psychological and physical symptoms manifested by the patient. We describe the case of a 28-year-old Italian man, hospitalized in one of our long-term care wards for comorbid profound intellectual disability (IQ<25), autistic and psychotic disorders, and Gilbert syndrome, who manifested a severe exacerbation of psychosis, for which ziprasidone was prescribed. This condition para- doxically further deteriorated after the introduction of this drug. A subsequent switch to risperidone greatly and rapidly improved both psychosis-related and symp- toms emerging after the introduction of ziprasidone.

Effectiveness of switching from oral ziprasidone to risperidone in a patient with comorbid autistic disorder, profound intellectual disability, Gilbert syndrome, and exacerbation of psychosis / DEL CASALE, Antonio; Kotzalidis, Georgios D; Sacco, Michele; Rapinesi, Chiara; De Giorgi, Riccardo; Giardini, Marco; D'Andreagiovanni, Michele; Carlino, Nicola; Brugnoli, Roberto; Girardi, Paolo. - In: PSYCHIATRIA DANUBINA. - ISSN 0353-5053. - STAMPA. - 28:1(2016), pp. 91-94.

Effectiveness of switching from oral ziprasidone to risperidone in a patient with comorbid autistic disorder, profound intellectual disability, Gilbert syndrome, and exacerbation of psychosis

DEL CASALE, ANTONIO
;
RAPINESI, CHIARA;BRUGNOLI, ROBERTO;GIRARDI, Paolo
2016

Abstract

Autism and intellectual disability may hinder any other coexisting psychiatric diagnosis. Diagnoses are often based on behavioral observations, directly ob- tained or reported by family members or operators in frequent contact with the patient, and non-verbal communications, as well as on the psychological and physical symptoms manifested by the patient. We describe the case of a 28-year-old Italian man, hospitalized in one of our long-term care wards for comorbid profound intellectual disability (IQ<25), autistic and psychotic disorders, and Gilbert syndrome, who manifested a severe exacerbation of psychosis, for which ziprasidone was prescribed. This condition para- doxically further deteriorated after the introduction of this drug. A subsequent switch to risperidone greatly and rapidly improved both psychosis-related and symp- toms emerging after the introduction of ziprasidone.
2016
autism; intellectual disability; psychosis; Gilbert syndrome; treatment
01 Pubblicazione su rivista::01i Case report
Effectiveness of switching from oral ziprasidone to risperidone in a patient with comorbid autistic disorder, profound intellectual disability, Gilbert syndrome, and exacerbation of psychosis / DEL CASALE, Antonio; Kotzalidis, Georgios D; Sacco, Michele; Rapinesi, Chiara; De Giorgi, Riccardo; Giardini, Marco; D'Andreagiovanni, Michele; Carlino, Nicola; Brugnoli, Roberto; Girardi, Paolo. - In: PSYCHIATRIA DANUBINA. - ISSN 0353-5053. - STAMPA. - 28:1(2016), pp. 91-94.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/862571
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