Animal tissues produce 14CO2 when incubated with 14C-Lanthionine, rat and beef kidney cortices being the most active. pH optimum of this decarboxylase is 8, the Km for lanthionine is about 1.2 mM. The reaction is linear for the first hour then stops indicating inhibition by reaction products. The one-side decarboxylation of 14C-lanthionine yields 14C-aminoethylcysteine which is further degraded to 14C-cysteamine, 14C-hypotaurine and 14C-taurine all identified by paper and ion exchange chromatography. The lanthionine pathway is therefore another possible route for taurine biosynthesis. © 1979.
Lanthionine decarboxylation by animal tissues / Scandurra, Roberto; Consalvi, Valerio; DE MARCO, Carlo; Politi, Laura; D., Cavallini. - In: LIFE SCIENCES. - ISSN 0024-3205. - 24:21(1979), pp. 1925-1930.
Lanthionine decarboxylation by animal tissues
SCANDURRA, Roberto;CONSALVI, Valerio;DE MARCO, Carlo;POLITI, Laura;
1979
Abstract
Animal tissues produce 14CO2 when incubated with 14C-Lanthionine, rat and beef kidney cortices being the most active. pH optimum of this decarboxylase is 8, the Km for lanthionine is about 1.2 mM. The reaction is linear for the first hour then stops indicating inhibition by reaction products. The one-side decarboxylation of 14C-lanthionine yields 14C-aminoethylcysteine which is further degraded to 14C-cysteamine, 14C-hypotaurine and 14C-taurine all identified by paper and ion exchange chromatography. The lanthionine pathway is therefore another possible route for taurine biosynthesis. © 1979.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
