We analysed the long-term outcome of 35 children and adolescents (<20 years at diagnosis) with chronic myeloid leukaemia (CML) in chronic phase: 20 patients had received interferon-alpha and/or tyrosine kinase inhibitors (TKIs), and 15 underwent a haematopoietic stem cell transplant. The 10-year survival probabilities were similar in transplanted and non-transplanted patients (73·3% vs. 72·1%, respectively), whereas the survival probability was significantly lower in patients diagnosed before 1999 compared to those diagnosed afterwards (62·1% vs. 100%, P = 0·0384). The availability of TKIs and the standardized molecular monitoring have significantly improved treatment, management and outcome in children and adolescents with CML.

Can chronic myeloid leukaemia in children and adolescents be successfully treated without haematopoietic stem cell transplant? A single centre experience / Giona, Fiorina; Moleti, MARIA LUISA; De Benedittis, Daniela; Santopietro, Michelina; Nanni, Mauro; Testi, Anna Maria; Orlando, Sonia; Iori, ANNA PAOLA; Piciocchi, Alfonso; Gottardi, Enrico; Barberi, Walter; Diverio, Daniela; Saglio, Giuseppe; Foa, Roberto. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - 5:173(2016), pp. 749-753. [10.1111/bjh.13991]

Can chronic myeloid leukaemia in children and adolescents be successfully treated without haematopoietic stem cell transplant? A single centre experience

GIONA, Fiorina;MOLETI, MARIA LUISA;SANTOPIETRO, MICHELINA;TESTI, Anna Maria;IORI, ANNA PAOLA;BARBERI, Walter;FOA, Roberto
2016

Abstract

We analysed the long-term outcome of 35 children and adolescents (<20 years at diagnosis) with chronic myeloid leukaemia (CML) in chronic phase: 20 patients had received interferon-alpha and/or tyrosine kinase inhibitors (TKIs), and 15 underwent a haematopoietic stem cell transplant. The 10-year survival probabilities were similar in transplanted and non-transplanted patients (73·3% vs. 72·1%, respectively), whereas the survival probability was significantly lower in patients diagnosed before 1999 compared to those diagnosed afterwards (62·1% vs. 100%, P = 0·0384). The availability of TKIs and the standardized molecular monitoring have significantly improved treatment, management and outcome in children and adolescents with CML.
CML; childhood leukaemia; haematopoietic stem cell transplantation; interferon; tyrosine kinase inhibitors
01 Pubblicazione su rivista::01a Articolo in rivista
Can chronic myeloid leukaemia in children and adolescents be successfully treated without haematopoietic stem cell transplant? A single centre experience / Giona, Fiorina; Moleti, MARIA LUISA; De Benedittis, Daniela; Santopietro, Michelina; Nanni, Mauro; Testi, Anna Maria; Orlando, Sonia; Iori, ANNA PAOLA; Piciocchi, Alfonso; Gottardi, Enrico; Barberi, Walter; Diverio, Daniela; Saglio, Giuseppe; Foa, Roberto. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - 5:173(2016), pp. 749-753. [10.1111/bjh.13991]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/860490
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