Coarse-graining polymer solutions: A critical appraisal of single- and multi-site models

We critically discuss and review the general ideas behind single- andmulti-site coarse-grained(CG) models asapplied tomacro- molecular solutions in the dilute and semi-dilute regime. We first con- sider single-site models with zero-density and density-dependent pair potentials. We highlight advantages and limitations of each option in reproducingthethermodynamicbehaviorandthelarge-scalestructure of the underlying reference model. As a case study we consider solu- tions of linear homopolymers in a solvent of variable quality. Secondly, we extend the discussion to multi-component systems presenting, as a test case, results for mixtures of colloids and polymers. Specifically, we found the CG model with zero-density potentials to be unable to pre- dict fluid-fluid demixing in a reasonable range of densities for mixtures of colloids and polymers of equal size. For larger colloids, the polymer volume fractions at which phase separation occurs are largely overes- timated. CG models with density-dependent potentials are somewhat less accurate than models with zero-density potentials in reproducing the thermodynamics of the system and, although they present a phase separation, they significantly underestimate the polymer volume frac- tionsalongthebinodal.Finally,wediscussageneralmulti-sitestrategy, which is thermodynamically consistent and fully transferable with the numberofsites,andthatallowsustoovercomemostofthelimitations discussed for single-site models.