Background: Nonallergic rhinitis with eosinophilic syndrome (NARES) is persistent, without atopy, but with ≥25% nasal eosinophilia. Hypereosinophilia seems to contribute to nasal mucosa dysfunction. Objectives: This analytical case-control study aimed at assessing the presence and severity of nonspecific nasal hyperactivity and at finding out whether eosinophilia may be correlated with the respiratory and mucociliary clearance functions. Materials: The symptom score was assessed in 38 patients and 15 controls whose nasal smear was also tested for eosinophils and mucociliary transport (MCT). Nonspecific nasal provocation tests (NSNPT) with histamine were also carried out, and total nasal resistance (TNR) was determined. Results: The symptom score of NARES after NSNPT were not significantly different from the control group, and there was poor or no correlation among the single symptoms and the differences studied for every nasal reactivity class. This correlation improved when using the composite symptom score. The most severe eosinophilia was observed in high reactivity groups, and it was correlated with an increase in TNR. MCT worsened as eosinophilia and nasal reactivity increased. Unlike controls, a significant correlation was observed between the increase in MCT and TNR. Conclusions: In NARES, nonspecific nasal hyperreactivity is the result of epithelial damage produced by eosinophilic inflammation, which causes MCT slow down, an increase in TNR, and nasal reactivity classes, with possible impact on classification, prognosis, and treatment control.

Nasal histamine responses in nonallergic rhinitis with eosinophilic syndrome / Zambetti, Giampietro; Ciofalo, Andrea; Romeo, Raffaello; Soldo, Pietro; Fusconi, Massimo; Greco, Antonio; Magliulo, Giuseppe; de Vincentiis, Marco. - In: ALLERGY & RHINOLOGY. - ISSN 2152-6575. - STAMPA. - 6:2(2015), pp. 94-100. [10.2500/ar.2015.6.0125]

Nasal histamine responses in nonallergic rhinitis with eosinophilic syndrome

Zambetti, Giampietro
Primo
;
Ciofalo, Andrea
Secondo
;
Soldo, Pietro;Fusconi, Massimo;Greco, Antonio;Magliulo, Giuseppe
Penultimo
;
de Vincentiis, Marco
Ultimo
2015

Abstract

Background: Nonallergic rhinitis with eosinophilic syndrome (NARES) is persistent, without atopy, but with ≥25% nasal eosinophilia. Hypereosinophilia seems to contribute to nasal mucosa dysfunction. Objectives: This analytical case-control study aimed at assessing the presence and severity of nonspecific nasal hyperactivity and at finding out whether eosinophilia may be correlated with the respiratory and mucociliary clearance functions. Materials: The symptom score was assessed in 38 patients and 15 controls whose nasal smear was also tested for eosinophils and mucociliary transport (MCT). Nonspecific nasal provocation tests (NSNPT) with histamine were also carried out, and total nasal resistance (TNR) was determined. Results: The symptom score of NARES after NSNPT were not significantly different from the control group, and there was poor or no correlation among the single symptoms and the differences studied for every nasal reactivity class. This correlation improved when using the composite symptom score. The most severe eosinophilia was observed in high reactivity groups, and it was correlated with an increase in TNR. MCT worsened as eosinophilia and nasal reactivity increased. Unlike controls, a significant correlation was observed between the increase in MCT and TNR. Conclusions: In NARES, nonspecific nasal hyperreactivity is the result of epithelial damage produced by eosinophilic inflammation, which causes MCT slow down, an increase in TNR, and nasal reactivity classes, with possible impact on classification, prognosis, and treatment control.
2015
nonspecific nasal provocation test with histamine; symptom score; mucociliary clearance; eosinophils; total nasal resistance; nonspecific nasal hyperactivity; NARES
01 Pubblicazione su rivista::01a Articolo in rivista
Nasal histamine responses in nonallergic rhinitis with eosinophilic syndrome / Zambetti, Giampietro; Ciofalo, Andrea; Romeo, Raffaello; Soldo, Pietro; Fusconi, Massimo; Greco, Antonio; Magliulo, Giuseppe; de Vincentiis, Marco. - In: ALLERGY & RHINOLOGY. - ISSN 2152-6575. - STAMPA. - 6:2(2015), pp. 94-100. [10.2500/ar.2015.6.0125]
File allegati a questo prodotto
File Dimensione Formato  
Zambetti_Nasal_2015.pdf

accesso aperto

Note: https://journals.sagepub.com/doi/10.2500/ar.2015.6.0125
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 345.79 kB
Formato Adobe PDF
345.79 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/810029
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 8
social impact