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Labeling and assessment of energy and sustainability performances in the civil sector: The case study of ESA-ESRIN in Rome

The continuous improvement of the energy and sustainability performances of buildings is stimulated by mandatory rules, economic incentives and voluntary sustainability pathway of which energy efficiency is one of the most important components. The tools to evaluate the energy, sustainability, automation and energy metering performances of buildings, to check the status and lead the investments, are often complex, slow, expensive and related to the specific Countries, making difficult the job...

Correlation, response and entropy approaches to allosteric behaviors: a critical comparison on the ubiquitin case

Correlation analysis and its close variant principal component analysis are tools widely applied to predict the biological functions of macromolecules in terms of the relationship between fluctuation dynamics and structural properties. However, since this kind of analysis does not necessarily imply causation links among the elements of the system, its results run the risk of being biologically misinterpreted. By using as a benchmark the structure of ubiquitin, we report a critical comparison ...

Resveratrol and resveratrol-loaded galactosylated liposomes. Anti-adherence and cell wall damage effects on Staphylococcus aureus and MRSA

Antibiotic resistance due to bacterial biofilm formation is a major global health concern that makes the search for new therapeutic approaches an urgent need. In this context,, trans-resveratrol (RSV), a polyphenolic natural substance, seems to be a good candidate for preventing and eradicating biofilm-associated infections but its mechanism of action is poorly understood. In addition, RSV suffers from low bioavailability and chemical instability in the biological media that make its encapsul...

Rooting depth and xylem vulnerability are independent woody plant traits jointly selected by aridity, seasonality, and water table depth

Evolutionary radiations of woody taxa within arid environments were made possible bymultiple trait innovations including deep roots and embolism-resistant xylem, but little isknown about how these traits have coevolved across the phylogeny of woody plants or howthey jointly influence the distribution of species. We synthesized global trait and vegetation plot datasets to examine how rooting depth and xylem vulnerability across 188 woody plant species interact with aridity, precipitation seaso...

Dynamical changes of SARS-CoV-2 spike variants in the highly immunogenic regions impact the viral antibodies escaping

The prolonged circulation of the SARS-CoV-2 virus resulted in the emergence of several viral variants, with different spreading features. Moreover, the increased number of recovered and/or vaccinated people introduced a selective pressure toward variants able to evade the immune system, developed against the former viral versions. This process results in reinfections. Aiming to study the latter process, we first collected a large structural dataset of antibodies in complex with the original v...

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