Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsiveness to therapy with EGFR inhibitors, as a consequence of the activation of Rasdependent intracellular signals. Here we report a colon cancer case carrying a novel combination of K-RAS mutations involving codon 13 (Gly to Asp) and codon 19 (Leu to Phe), on separate alleles. The double mutation was restricted to tumor cells bearing a mucinous-like phenotype.
Direct correlation between double K-RAS mutation and mucinous carcinoma. A case report / Pacini, Luca; Bastianelli, Daniela; Ponti, Donatella; Rosa, Paolo; Petrozza, Vincenzo; Giannini, Giuseppe; Ragona, Giuseppe; Calogero, Antonella. - In: APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR MORPHOLOGY. - ISSN 1541-2016. - 23:2(2015), pp. e4-e7. [10.1097/PAI.0000000000000176]
Direct correlation between double K-RAS mutation and mucinous carcinoma. A case report
PACINI, LUCA;BASTIANELLI, DANIELA;PONTI, Donatella;ROSA, PAOLO;PETROZZA, Vincenzo;GIANNINI, Giuseppe;RAGONA, Giuseppe;CALOGERO, ANTONELLA
2015
Abstract
Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsiveness to therapy with EGFR inhibitors, as a consequence of the activation of Rasdependent intracellular signals. Here we report a colon cancer case carrying a novel combination of K-RAS mutations involving codon 13 (Gly to Asp) and codon 19 (Leu to Phe), on separate alleles. The double mutation was restricted to tumor cells bearing a mucinous-like phenotype.| File | Dimensione | Formato | |
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