Skeletal muscle has long been known as the target of several growth factors and hormones, including IGFs, steroids, thyroid and neurohypophyseal hormones, often regulating both muscle development and homeostasis in postnatal life, as summarized in classical as well as more recent reviews [1-4]. Such a complex hormonal regulation is not surprising, if one considers the many diverse functions muscle exerts: mechanical force production, body temperature regulation and metabolic storage due to its protein content. Active muscle accounts for over 90% of total body energy expenditure. Much more recent is the view of muscle as the source of several hormones [5-7] making skeletal muscle the largest endocrine gland of the organism and probably the most complex, due to the number (hundreds) of peptides constituting its secretome.
|Titolo:||Will exercise mimetics hold promise?|
|Data di pubblicazione:||2015|
|Appare nella tipologia:||01a Articolo in rivista|