Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlates with the deregulation of several long non-coding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development. The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches.
"Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs" / Amicone, Laura; Citarella, Franca; Cicchini, Carla. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - ELETTRONICO. - BioMed Research International, vol. 2015, Article ID 473942, 10 pages, 2015. doi:10.1155/2015/473942:(2015). [10.1155/2015/473942]
"Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs"
AMICONE, Laura;CITARELLA, Franca;CICCHINI, Carla
2015
Abstract
Recent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlates with the deregulation of several long non-coding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development. The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches.File | Dimensione | Formato | |
---|---|---|---|
Amicone_Epigenetic Regulation_2015.pdf
accesso aperto
Tipologia:
Documento in Post-print (versione successiva alla peer review e accettata per la pubblicazione)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
901.13 kB
Formato
Adobe PDF
|
901.13 kB | Adobe PDF |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.