The exposure to stressful events during the early postnatal period with genetic vulnerability increases the risk for several neuropsychiatric and psychosocial disorders such as depression, anxiety and drug addiction. Moreover, several data points to dysfunctions of medial prefrontal cortex (mpFC) and nucleus accumbens (NAc) in development and expression of some stress-induced psychopathologies.Here, we investigate that an early postnatal stressful manipulation able to alter the mother-pups binding (Repeated Cross Fostering, RCF), in genetically at-risk subjects, increases adult vulnerability to disease by altering function of brain circuitry involved in processing of motivational stimuli. To test this hypothesis we used mice appertaining to C57BL/6J (C57) and DBA/2J (DBA) inbred strains that differ markedly in both stress response and anxiety or stress-induced depression-like behaviors and are characterized by differences in accumbal-DAergic and mpFC-monoaminergic functions.We find that the RCF cause an opposite effect in C57 and DBA mice on mpFC and NAc dopamine release and c-fos expression in response to acute stressful experience, paralleling behavioral pattern of stress coping evaluated by Forced Swimming Test and motivated behavior toward rewarding stimuli (Sucrose Preference Test).These data suggest that early postnatal stress experiences, in interaction with genetic liability, could represent a risk factor for some stress-induced psychopathological outcomes in adult life.
Early Environment Affects Stress Response in Adult Life Depending on Genotype / DI SEGNI, Matteo; Andolina, Diego; Pascucci, Tiziana; F., D'Amato; Babicola, Lucy; L. I., D'Apolito; Luchetti, Alessandra; Conversi, David; PUGLISI ALLEGRA, Stefano; Ventura, Rossella. - (2014). (Intervento presentato al convegno 9th FENS forum of Neuroscience tenutosi a Milam Italy nel 5-9 / 07 / 2014).