Objective and design: Primary aldosteronism (PA) represents the most common cause of secondary hypertension. A higher risk of cardiovascular events has been reported in patients with PA than in otherwise similar patients with essential hypertension (EH). So far, only a few studies investigated the electrocardiographic changes in PA patients compared to EH patients. Methods: To investigate the electrocardiographic changes and heart remodeling in PA, we enrolled 61 consecutive patients, 30 with PA [12 with aldosterone-producing adrenal cortical adenoma (APA) and 18 with bilateral adrenal hyperplasia-idiopathic adrenal hyperplasia] and 30 with EH. In all subjects, electrocardiographic parameters were evaluated from 12-lead electrocardiograms and heart remodeling with echocardiogram. Results: No significant differences in age, sex, body mass index, and blood pressure were found in two groups. The P wave and PR interval duration were significantly prolonged in patients with PA respect to EH (p < 0.003 and <0.002, respectively). A first degree atrioventricular block was present in 16% of the patients with PA and only in 3.2% of those with EH. In PA patients, the interventricular septum thickness (IVST) correlated with PR duration (r = 0.51; p < 0.03). Left ventricular hypertrophy was present in 53% of the patients with PA and in 26% of the patients with EH ( 2 χ , p < 0.03). Conclusion: In this case–control study, patients with PA show more anatomic and electrical heart remodeling than those with EH. We hypothesize that in patients with PA these cardiac changes may play a role for the increased risk of future cardiovascular events.

Electrical and myocardial remodeling in primary aldosteronism / Curione, Mario; Petramala, Luigi; Savoriti, C.; Verrenti, M.; Baiocco, E.; Salvatore, S.; Zinnamosca, Laura; Iannucci, G.; Sciomer, Susanna; Letizia, Claudio. - In: FRONTIERS IN CARDIOVASCULAR MEDICINE. - ISSN 2297-055X. - (2014). [10.3389/fcvm.2014.00007]

Electrical and myocardial remodeling in primary aldosteronism

CURIONE, Mario;PETRAMALA, LUIGI;ZINNAMOSCA, LAURA;G. Iannucci;SCIOMER, Susanna;LETIZIA, Claudio
2014

Abstract

Objective and design: Primary aldosteronism (PA) represents the most common cause of secondary hypertension. A higher risk of cardiovascular events has been reported in patients with PA than in otherwise similar patients with essential hypertension (EH). So far, only a few studies investigated the electrocardiographic changes in PA patients compared to EH patients. Methods: To investigate the electrocardiographic changes and heart remodeling in PA, we enrolled 61 consecutive patients, 30 with PA [12 with aldosterone-producing adrenal cortical adenoma (APA) and 18 with bilateral adrenal hyperplasia-idiopathic adrenal hyperplasia] and 30 with EH. In all subjects, electrocardiographic parameters were evaluated from 12-lead electrocardiograms and heart remodeling with echocardiogram. Results: No significant differences in age, sex, body mass index, and blood pressure were found in two groups. The P wave and PR interval duration were significantly prolonged in patients with PA respect to EH (p < 0.003 and <0.002, respectively). A first degree atrioventricular block was present in 16% of the patients with PA and only in 3.2% of those with EH. In PA patients, the interventricular septum thickness (IVST) correlated with PR duration (r = 0.51; p < 0.03). Left ventricular hypertrophy was present in 53% of the patients with PA and in 26% of the patients with EH ( 2 χ , p < 0.03). Conclusion: In this case–control study, patients with PA show more anatomic and electrical heart remodeling than those with EH. We hypothesize that in patients with PA these cardiac changes may play a role for the increased risk of future cardiovascular events.
2014
hyperaldosteronism; essential hypertension; electrocardiography; left ventricular hypertrophy; conduction disturbance
01 Pubblicazione su rivista::01a Articolo in rivista
Electrical and myocardial remodeling in primary aldosteronism / Curione, Mario; Petramala, Luigi; Savoriti, C.; Verrenti, M.; Baiocco, E.; Salvatore, S.; Zinnamosca, Laura; Iannucci, G.; Sciomer, Susanna; Letizia, Claudio. - In: FRONTIERS IN CARDIOVASCULAR MEDICINE. - ISSN 2297-055X. - (2014). [10.3389/fcvm.2014.00007]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/630552
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