For the first time, grape seed extracts (GSEs), obtained from wine and table cultivars of Vitis vinifera L., cultured in experimental fields of Lazio and Puglia regions of Italy and grown in different agronomic conditions, have been tested on 43 Candida species strains. We demonstrated a significant correlation between the content of the flavan-3-ols in GSEs extracts, with a polymerization degree >= 4, and anti-Candida activity. Moreover, we demonstrated that GSEs, obtained from plants cultured with reduced irrigation, showed a content of polymeric flavan-3-ols > 250 mg/g with geometric mean MICvalues between 5.7 and 20.2 mg/L against Candida albicans reference strains. GSE, showing 573 mg/g of polymeric flavan-3-ols, has been tested in an experimental murine model of vaginal candidiasis by using noninvasive in vivo imaging technique. The results pointed out a significant inhibition of Candida albicans load 5 days after challenge. These findings indicate that GSEs with high content of polymeric flavan-3-ols can be used in mucosal infection as vaginal candidiasis.

Evaluation of Anti-Candida Activity of Vitis vinifera L. Seed Extracts Obtained from Wine and Table Cultivars / Simonetti, Giovanna; Anna Rita Santamaria, ; D'Auria, Felicia Diodata; Nadiamulinacci, ; Nadia, Mulinacci; Marzia, Innocenti; Francesca, Cecchini; Eva, Pericolini; Elena, Gabrielli; Panella, Simona; Donato, Antonacci; Palamara, ANNA TERESA; Anna, Vecchiarelli; Pasqua, Gabriella. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6133. - ELETTRONICO. - 2014:(2014), pp. 1-11. [10.1155/2014/127021]

Evaluation of Anti-Candida Activity of Vitis vinifera L. Seed Extracts Obtained from Wine and Table Cultivars

SIMONETTI, Giovanna;Felicia Diodata D'Auria;PANELLA, SIMONA;PALAMARA, ANNA TERESA;PASQUA, Gabriella
2014

Abstract

For the first time, grape seed extracts (GSEs), obtained from wine and table cultivars of Vitis vinifera L., cultured in experimental fields of Lazio and Puglia regions of Italy and grown in different agronomic conditions, have been tested on 43 Candida species strains. We demonstrated a significant correlation between the content of the flavan-3-ols in GSEs extracts, with a polymerization degree >= 4, and anti-Candida activity. Moreover, we demonstrated that GSEs, obtained from plants cultured with reduced irrigation, showed a content of polymeric flavan-3-ols > 250 mg/g with geometric mean MICvalues between 5.7 and 20.2 mg/L against Candida albicans reference strains. GSE, showing 573 mg/g of polymeric flavan-3-ols, has been tested in an experimental murine model of vaginal candidiasis by using noninvasive in vivo imaging technique. The results pointed out a significant inhibition of Candida albicans load 5 days after challenge. These findings indicate that GSEs with high content of polymeric flavan-3-ols can be used in mucosal infection as vaginal candidiasis.
2014
Vitis vinifera, Lazio, Puglia, Candida
01 Pubblicazione su rivista::01a Articolo in rivista
Evaluation of Anti-Candida Activity of Vitis vinifera L. Seed Extracts Obtained from Wine and Table Cultivars / Simonetti, Giovanna; Anna Rita Santamaria, ; D'Auria, Felicia Diodata; Nadiamulinacci, ; Nadia, Mulinacci; Marzia, Innocenti; Francesca, Cecchini; Eva, Pericolini; Elena, Gabrielli; Panella, Simona; Donato, Antonacci; Palamara, ANNA TERESA; Anna, Vecchiarelli; Pasqua, Gabriella. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6133. - ELETTRONICO. - 2014:(2014), pp. 1-11. [10.1155/2014/127021]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/556619
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