Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications. (C) 2013 Published by Elsevier B.V.
Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells / Christian, Celia; Elena, Trapasso; Marcello, Locatelli; Michele, Navarra; Cinzia Anna, Ventura; Joy, Wolfram; Carafa, Maria; Valeria Maria, Morittu; Domenico, Britti; Luisa Di, Marzio; Donatella, Paolino. - In: COLLOIDS AND SURFACES. B, BIOINTERFACES. - ISSN 0927-7765. - STAMPA. - 112:112(2013), pp. 548-553. [10.1016/j.colsurfb.2013.09.017]
Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells
CARAFA, Maria;
2013
Abstract
Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications. (C) 2013 Published by Elsevier B.V.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
