We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.
Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles / LA REGINA, Giuseppe; Gatti, Valerio; Famiglini, Valeria; Piscitelli, Francesco; Silvestri, Romano. - In: ACS COMBINATORIAL SCIENCE. - ISSN 2156-8952. - 14:4(2012), pp. 258-262. [10.1021/co200165j]
Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles
LA REGINA, GIUSEPPE
;GATTI, VALERIO;FAMIGLINI, VALERIA;PISCITELLI, FRANCESCO;SILVESTRI, Romano
2012
Abstract
We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
