The presence of Fc-receptor-blocking factors in the sera of normal and insulin-dependent diabetic pregnant women was investigated by means of an antibody-dependent cell-mediated cytotoxicity assay. Sera from normal pregnant women induced a significant depression of antibody dependent cell-mediated cytotoxicity when compared with sera from normal and diabetic non-pregnant women (p less than 0.0001; p less than 0.002, respectively). The effect of sera from diabetic pregnant women, however, was not different from that observed with sera from normal and diabetic non-pregnant women. Thus, we confirm the presence of Fc-receptor-blocking factors in the sera of normal pregnant women. The higher cytotoxicity levels measured in the presence of sera from pregnant women with insulin-dependent diabetes suggests that the titres of such factors are reduced in this condition

Sera from diabetic pregnant women contain reduced titres of inhibiting factors on killer cell activity / O., Zuccarini; M., Sensi; Gargiulo, Patrizia; P., Pozzilli; Tiberti, Claudio; A., Pachi; Fallucca, Francesco. - In: DIABETOLOGIA. - ISSN 0012-186X. - STAMPA. - 28:(1985), pp. 95-98. [10.1007/s00125-011-2204-7 .]

Sera from diabetic pregnant women contain reduced titres of inhibiting factors on killer cell activity.

GARGIULO, Patrizia;TIBERTI, Claudio;FALLUCCA, Francesco
1985

Abstract

The presence of Fc-receptor-blocking factors in the sera of normal and insulin-dependent diabetic pregnant women was investigated by means of an antibody-dependent cell-mediated cytotoxicity assay. Sera from normal pregnant women induced a significant depression of antibody dependent cell-mediated cytotoxicity when compared with sera from normal and diabetic non-pregnant women (p less than 0.0001; p less than 0.002, respectively). The effect of sera from diabetic pregnant women, however, was not different from that observed with sera from normal and diabetic non-pregnant women. Thus, we confirm the presence of Fc-receptor-blocking factors in the sera of normal pregnant women. The higher cytotoxicity levels measured in the presence of sera from pregnant women with insulin-dependent diabetes suggests that the titres of such factors are reduced in this condition
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/484057
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