We investigated the anatomical correlates of chronic unilateral neglect in right brain damaged patients with no visual field defects. Independently from basal ganglia or thalamus involvement, neglect patients had a subcortical area of maximal lesion overlap (maxov) in the superior longitudinal fasciculus (SLF). Neglect patients without lesion of subcortical nuclei had an additional maxov area in the rostralmost limit of the supramarginal gyrus (SmG). Patients without neglect showed a maxov area in the corticospinal tract with no involvement of the SLF or SmG. These findings call attention to the role of parietal-frontal disconnection in the pathogenesis of neglect. This disconnection can make neglect generalised and enduring also in patients suffering only partial damage of the parietal-temporal cortex, and who would otherwise show more selective attentional impairments.

The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection? / Doricchi, Fabrizio; F., Tomaiuolo. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 14:(2003), pp. 2239-2243. [10.1097/01.wnr.0000091132.75061.64]

The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection?

DORICCHI, FABRIZIO;
2003

Abstract

We investigated the anatomical correlates of chronic unilateral neglect in right brain damaged patients with no visual field defects. Independently from basal ganglia or thalamus involvement, neglect patients had a subcortical area of maximal lesion overlap (maxov) in the superior longitudinal fasciculus (SLF). Neglect patients without lesion of subcortical nuclei had an additional maxov area in the rostralmost limit of the supramarginal gyrus (SmG). Patients without neglect showed a maxov area in the corticospinal tract with no involvement of the SLF or SmG. These findings call attention to the role of parietal-frontal disconnection in the pathogenesis of neglect. This disconnection can make neglect generalised and enduring also in patients suffering only partial damage of the parietal-temporal cortex, and who would otherwise show more selective attentional impairments.
2003
Aged, Analysis of Variance, Frontal Lobe; pathology, Hemianopsia; physiopathology, Humans, Middle Aged, Neural Pathways; pathology, Parietal Lobe; pathology, Perceptual Disorders; pathology/physiopathology
01 Pubblicazione su rivista::01a Articolo in rivista
The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection? / Doricchi, Fabrizio; F., Tomaiuolo. - In: NEUROREPORT. - ISSN 0959-4965. - STAMPA. - 14:(2003), pp. 2239-2243. [10.1097/01.wnr.0000091132.75061.64]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/472312
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