There is evidence that certain psychopathological conditions are accompanied by a dysfunction in both the hypothalamo-pituitary-adrenal axis and dopaminergic systems, although the relationship between these two systems is as yet unclear. In the present study we investigated the effect of a specific lesion of dopamine mesencephalic neurons (Ventral Tegmental Area) on basal and stress-induced corticosterone secretion. Three weeks after injection of 6-OHDA, there was a depletion in dopamine in the frontal cortex and in the ventral and dorsal striatum, whereas norepinephrine and serotonin levels were unchanged. The dopamine-lesioned rats exhibited a lower basal and stress-induced corticosterone secretion than the sham-lesioned animals. The results indicate that the dopaminergic system may have a stimulatory influence on the hypothalamo-pituitary-adrenal axis.

Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons / Casolini, Paola; Kabbaj, M.; Leprat, F.; Piazza, P. V.; ROUGE PONT, F.; Angelucci, Luciano; Simon, H.; LE MOAL, M.; Maccari, S.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 622:(1993), pp. 311-314. [10.1016/0006-8993(93)90836-C]

Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons.

CASOLINI, Paola;ANGELUCCI, Luciano;
1993

Abstract

There is evidence that certain psychopathological conditions are accompanied by a dysfunction in both the hypothalamo-pituitary-adrenal axis and dopaminergic systems, although the relationship between these two systems is as yet unclear. In the present study we investigated the effect of a specific lesion of dopamine mesencephalic neurons (Ventral Tegmental Area) on basal and stress-induced corticosterone secretion. Three weeks after injection of 6-OHDA, there was a depletion in dopamine in the frontal cortex and in the ventral and dorsal striatum, whereas norepinephrine and serotonin levels were unchanged. The dopamine-lesioned rats exhibited a lower basal and stress-induced corticosterone secretion than the sham-lesioned animals. The results indicate that the dopaminergic system may have a stimulatory influence on the hypothalamo-pituitary-adrenal axis.
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Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neurons / Casolini, Paola; Kabbaj, M.; Leprat, F.; Piazza, P. V.; ROUGE PONT, F.; Angelucci, Luciano; Simon, H.; LE MOAL, M.; Maccari, S.. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 622:(1993), pp. 311-314. [10.1016/0006-8993(93)90836-C]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/45082
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