During HIV disease an increased in vitro apoptosis of peripheral blood mononuclear cells has been demonstrated. This can be reversed in vitro by interleukin (IL)-2. Recent trials with highly active antiretroviral therapy (HAART) and IL-2 in HIV-1-infected patients showed promising immunological and clinical results. Here we investigated the effects of subcutaneous low-dose IL-2 administration in combination with HAART on in vitro apoptosis and the relationship between apoptosis, CD4(+) counts, and HIV replication. Twenty-two asymptomatic HIV patients were randomized for HAART (arm I) and HAART plus IL-2 (arm II). Spontaneous apoptosis was decreased in both arms after 28 weeks of therapy but the reduction was highly significant only in arm II (P = 0.05 vs P = 0.001), As the percentage of apoptosis decreased, there was a significantly higher increase of both CD4(+) and CD4(+) naive T cells in arm II vs arm I. HIV plasma viremia was reduced in all patients after therapy. Our data suggest that intermittent therapy with low-dose subcutaneous IL-2 in addition to HAART induces a positive immunomodulation in asymptomatic HIV-infected patients. (C) 2000 Academic Press.

Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART / Franco, Pandolfi; Marina, Pierdominici; Marco, Marziali; Maria Livia, Bernardi; Antonelli, Guido; Vincenzo, Galati; Gianpiero, D'Offizi; Aiuti, Fernando. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - STAMPA. - 94:3(2000), pp. 153-159. [10.1006/clim.2000.4837]

Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART

ANTONELLI, Guido;AIUTI, Fernando
2000

Abstract

During HIV disease an increased in vitro apoptosis of peripheral blood mononuclear cells has been demonstrated. This can be reversed in vitro by interleukin (IL)-2. Recent trials with highly active antiretroviral therapy (HAART) and IL-2 in HIV-1-infected patients showed promising immunological and clinical results. Here we investigated the effects of subcutaneous low-dose IL-2 administration in combination with HAART on in vitro apoptosis and the relationship between apoptosis, CD4(+) counts, and HIV replication. Twenty-two asymptomatic HIV patients were randomized for HAART (arm I) and HAART plus IL-2 (arm II). Spontaneous apoptosis was decreased in both arms after 28 weeks of therapy but the reduction was highly significant only in arm II (P = 0.05 vs P = 0.001), As the percentage of apoptosis decreased, there was a significantly higher increase of both CD4(+) and CD4(+) naive T cells in arm II vs arm I. HIV plasma viremia was reduced in all patients after therapy. Our data suggest that intermittent therapy with low-dose subcutaneous IL-2 in addition to HAART induces a positive immunomodulation in asymptomatic HIV-infected patients. (C) 2000 Academic Press.
2000
apoptosis; cd4 t cells; hiv viremia; interleukin-2
01 Pubblicazione su rivista::01a Articolo in rivista
Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART / Franco, Pandolfi; Marina, Pierdominici; Marco, Marziali; Maria Livia, Bernardi; Antonelli, Guido; Vincenzo, Galati; Gianpiero, D'Offizi; Aiuti, Fernando. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - STAMPA. - 94:3(2000), pp. 153-159. [10.1006/clim.2000.4837]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/436420
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