The nitration of tyrosine derivatives with nitrogen monoxide (nitric oxide) occurs only in the presence of dioxygen, and the hypothesized mechanism involves nitrogen dioxide (NO2). For better understanding of the reaction mechanism, the nitration of model compounds - such as 1- and 2-naphthols and their corresponding 2- and 1-nitroso derivatives with nitrogen monoxide in the presence and in the absence of dioxygen was studied. The results described here show that tyrosine and naphthols do not undergo nitrosation when they react with (NO)-N-., and so nitrosation of tyrosine in biological systems is highly unlikely. In addition, the oxidation of nitrosonaphthols reversible arrow isonitrosonaphthols by nitric oxide and its derivatives to the corresponding nitro derivatives does not involve the oxoammonium ion, as reported previously. The mechanistic proposals are supported mainly by ESR investigation and electrochemical data.
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|Titolo:||On the Role of Nitrogen Monoxide (Nitric Oxide) in the Nitration of a Tyrosine Derivative and Model Compounds|
|Data di pubblicazione:||2002|
|Appartiene alla tipologia:||01a Articolo in rivista|