Argonaute are a conserved class of proteins central to the microRNA pathway. We have highlighted a novel and non-redundant function of Ago1 versus Ago2; the two core factors of the miRNA-associated RISC complex. Stable overexpression of Ago1 in neuroblastoma cells causes the cell cycle to slow down, a decrease in cellular motility and a stronger apoptotic response upon UV irradiation. These effects, together with a significant increase in p53 levels, suggest that Ago1 may act as a tumor-suppressor factor, a function also supported by GEO Profiles microarrays that inversely correlate Ago1 expression levels with cell proliferation rates. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Ago1 and Ago2 differentially affect cell proliferation, motility and apoptosis when overexpressed in SH-SY5Y neuroblastoma cells / Chiara, Parisi; Corinna, Giorgi; Enrico Maria, Batassa; Laura, Braccini; Giovanna, Maresca; Igea, D'Agnano; Caputo, Viviana; A., Salvatore; Flavia, Pietrolati; Cogoni, Carlo; Catalanotto, Caterina. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 585:19(2011), pp. 2965-2971. [10.1016/j.febslet.2011.08.003]

Ago1 and Ago2 differentially affect cell proliferation, motility and apoptosis when overexpressed in SH-SY5Y neuroblastoma cells

CAPUTO, VIVIANA;COGONI, Carlo;CATALANOTTO, Caterina
2011

Abstract

Argonaute are a conserved class of proteins central to the microRNA pathway. We have highlighted a novel and non-redundant function of Ago1 versus Ago2; the two core factors of the miRNA-associated RISC complex. Stable overexpression of Ago1 in neuroblastoma cells causes the cell cycle to slow down, a decrease in cellular motility and a stronger apoptotic response upon UV irradiation. These effects, together with a significant increase in p53 levels, suggest that Ago1 may act as a tumor-suppressor factor, a function also supported by GEO Profiles microarrays that inversely correlate Ago1 expression levels with cell proliferation rates. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
2011
argonaute; cancer; cell proliferation; mirna; sh-sy5y
01 Pubblicazione su rivista::01a Articolo in rivista
Ago1 and Ago2 differentially affect cell proliferation, motility and apoptosis when overexpressed in SH-SY5Y neuroblastoma cells / Chiara, Parisi; Corinna, Giorgi; Enrico Maria, Batassa; Laura, Braccini; Giovanna, Maresca; Igea, D'Agnano; Caputo, Viviana; A., Salvatore; Flavia, Pietrolati; Cogoni, Carlo; Catalanotto, Caterina. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 585:19(2011), pp. 2965-2971. [10.1016/j.febslet.2011.08.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/427944
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