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EnglishChronic lymphocytic leukemia of T-cell origin (T-CLL), a rare variant of CLL, appears to be a clonal proliferation of mature T cells of one of several subsets. In the cells of 7 T-CLL patients, surface markers (including those reacting with a panel of monoclonal antibodies), functional activities, and electron microscopic morphology were evaluated. The phenotypic patterns of circulating T-CLL cells correspond to those of normal mature T-cell subsets. The cells of three patients demonstrated at least one marker reported to be expressed by suppressor/cytotoxic T cells; those of three patients expressed markers apparently linked with T-helper activity. Cells from one patient appeared to be a heterogeneous proliferation of more than one T-cell subset. These T-CLL cells may also retain some of the functional activity of the normal T subpopulations. Our data indicate that a combination of several tests should be used to characterize the proliferating cells in T-CLL.
Immunologic evaluation of T chronic lymphocyte leukemia cells: Correlations among phenotype, functional activities, and morphology / F., Pandolfi; G., De Rossi; G., Semenzato; Quinti, Isabella; A., Ranucci; G., De Sanctis; M., Lopez; G., Gasparotto; Aiuti, Fernando. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 59:4(1982), pp. 688-695.
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| Titolo: | Immunologic evaluation of T chronic lymphocyte leukemia cells: Correlations among phenotype, functional activities, and morphology | |
| Autori: | ||
| Data di pubblicazione: | 1982 | |
| Rivista: | ||
| Citazione: | Immunologic evaluation of T chronic lymphocyte leukemia cells: Correlations among phenotype, functional activities, and morphology / F., Pandolfi; G., De Rossi; G., Semenzato; Quinti, Isabella; A., Ranucci; G., De Sanctis; M., Lopez; G., Gasparotto; Aiuti, Fernando. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 59:4(1982), pp. 688-695. | |
| Handle: | http://hdl.handle.net/11573/418776 | |
| Appartiene alla tipologia: | 01a Articolo in rivista |
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