C. difficile (C. d.) is the main cause of antibiotic-associated diarrhea and colitis. It is shown in literature a high asymptomatic carriage rate of C. d. in patients with cystic fibrosis (CF), though C. d.-related colitis is an uncommon complication in these patients, despite the use of multiple high-dose antibiotic regimes and the frequency of hospital admissions. Lung transplantation with the associated immunosuppression and aggressive antibiotic therapy may increase the risk of the clinical manifestation of C. d. In this paper, we describe three cases of severe C. d. colitis in patients with CF following lung transplantation and illustrate our experience in the diagnosis and management of these patients. © 2010 John Wiley & Sons A/S.

Clostridium difficile-related pancolitis in lung-transplanted patients with cystic fibrosis / Patriarchi, Francesca; M., Rolla; Maccioni, Francesca; Menichella, Alessandra; Scacchi, Cristina; A., Ambrosini; Costantino, Annarita; Quattrucci, Serena. - In: CLINICAL TRANSPLANTATION. - ISSN 0902-0063. - 25:1(2011), pp. E46-E51. [10.1111/j.1399-0012.2010.01316.x]

Clostridium difficile-related pancolitis in lung-transplanted patients with cystic fibrosis

PATRIARCHI, FRANCESCA;MACCIONI, Francesca;MENICHELLA, ALESSANDRA;SCACCHI, CRISTINA;COSTANTINO, ANNARITA;QUATTRUCCI, Serena
2011

Abstract

C. difficile (C. d.) is the main cause of antibiotic-associated diarrhea and colitis. It is shown in literature a high asymptomatic carriage rate of C. d. in patients with cystic fibrosis (CF), though C. d.-related colitis is an uncommon complication in these patients, despite the use of multiple high-dose antibiotic regimes and the frequency of hospital admissions. Lung transplantation with the associated immunosuppression and aggressive antibiotic therapy may increase the risk of the clinical manifestation of C. d. In this paper, we describe three cases of severe C. d. colitis in patients with CF following lung transplantation and illustrate our experience in the diagnosis and management of these patients. © 2010 John Wiley & Sons A/S.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/413952
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