Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.
4-aminopyridine derivatives with anticholinesterase and antiamnesic activity / Scipione, Luigi; DE VITA, Daniela; Alessandra, Musella; Lisa, Flammini; Simona, Bertoni; Elisabetta, Barocelli. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 18:1(2008), pp. 309-312. [10.1016/j.bmcl.2007.10.077]
4-aminopyridine derivatives with anticholinesterase and antiamnesic activity
SCIPIONE, Luigi;DE VITA, DANIELA;
2008
Abstract
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
