Gu et al.1 proposed an investigation to determine the approximate solubility products of some calcium salt of bile salts. In this comunication the solubility of calcium (II) deoxycholate is studied at 25°C. To minimize the activity coefficients change in spite of the concentration of the reagent variation, the constant ionic medium was adopted. All the investagetd solutions were 0.5 mol dm-3 NaCl or N(CH3)4Cl. The solid calcium (II) deoxycholate was prepared by adding a slight excess of calcium (II) chloride to a sodium deoxycholate solution. The obtained solid was analysed by thermogramimetry for the stochiometric composition. The solid was equilibrated with solutions in the selected ionic medium at different concentration of calcium (II), deoxycholate and in the range 7.5 –log cH 11.3. Solubility was evaluated by analysing filtrated solutions by determining calcium (II) by means of Atomic Absorption Spectrophotometry. Experimental data could be explained by assuming the presence of a complex between calcium (II) and deoxycholate (log = 5.46), beside to the solubility product (-log Ks = 9.15). 1. Gu, J-J; Hofmann, A.F.; Ton-Nu, H.-T.; Schteingart, D.; Mysels, K.J. J.Lip. Res. 1992, 33, 635
Solubility of calcium deoxycholate / M., Antonilli; Bottari, Emilio Giovanni; Festa, Maria Rosa; L., Gentile. - STAMPA. - (2009), pp. 103-103. (Intervento presentato al convegno XXIII Congresso Nazionale della Società Chimica Italiana tenutosi a SORRENTO (Na) nel 5 – 10 LUGLIO 2009).
Solubility of calcium deoxycholate
BOTTARI, Emilio Giovanni;FESTA, Maria Rosa;
2009
Abstract
Gu et al.1 proposed an investigation to determine the approximate solubility products of some calcium salt of bile salts. In this comunication the solubility of calcium (II) deoxycholate is studied at 25°C. To minimize the activity coefficients change in spite of the concentration of the reagent variation, the constant ionic medium was adopted. All the investagetd solutions were 0.5 mol dm-3 NaCl or N(CH3)4Cl. The solid calcium (II) deoxycholate was prepared by adding a slight excess of calcium (II) chloride to a sodium deoxycholate solution. The obtained solid was analysed by thermogramimetry for the stochiometric composition. The solid was equilibrated with solutions in the selected ionic medium at different concentration of calcium (II), deoxycholate and in the range 7.5 –log cH 11.3. Solubility was evaluated by analysing filtrated solutions by determining calcium (II) by means of Atomic Absorption Spectrophotometry. Experimental data could be explained by assuming the presence of a complex between calcium (II) and deoxycholate (log = 5.46), beside to the solubility product (-log Ks = 9.15). 1. Gu, J-J; Hofmann, A.F.; Ton-Nu, H.-T.; Schteingart, D.; Mysels, K.J. J.Lip. Res. 1992, 33, 635I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
