Migraine is a complex disorder caused by a combination of genetic and environmental factors. Although family and twin studies show that there is a genetic component in migraine, no genes predisposing to common forms of the disorder, migraine with and without aura, have been identified. Patients with migraine respond differently to a given drug administered. The efficacy of therapy and the occurrence of adverse drug response are a consequence of individual variability. Genetic profiling of predisposition to migraine should facilitate the development of more effective diagnostic and therapeutic applications. The development of International Hap Map project could provide a powerful tool for identification of the candidate genes in this complex disease and pharmacogenomics research could be the promise for individualized treatments and prevention of adverse drug response. © Springer-Verlag Italia 2007.

Genetics of migraine and pharmacogenomics: Some considerations / Piane, Maria; Lulli, Patrizia; Ivano, Farinelli; Simeoni, Simona; DE FILIPPIS, Sergio; Patacchioli, Francesca Romana; Martelletti, Paolo. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - STAMPA. - 8:6(2007), pp. 334-339. [10.1007/s10194-007-0427-2]

Genetics of migraine and pharmacogenomics: Some considerations

PIANE, Maria;LULLI, Patrizia;SIMEONI, SIMONA;DE FILIPPIS, Sergio;PATACCHIOLI, Francesca Romana;MARTELLETTI, Paolo
2007

Abstract

Migraine is a complex disorder caused by a combination of genetic and environmental factors. Although family and twin studies show that there is a genetic component in migraine, no genes predisposing to common forms of the disorder, migraine with and without aura, have been identified. Patients with migraine respond differently to a given drug administered. The efficacy of therapy and the occurrence of adverse drug response are a consequence of individual variability. Genetic profiling of predisposition to migraine should facilitate the development of more effective diagnostic and therapeutic applications. The development of International Hap Map project could provide a powerful tool for identification of the candidate genes in this complex disease and pharmacogenomics research could be the promise for individualized treatments and prevention of adverse drug response. © Springer-Verlag Italia 2007.
2007
migraine; non-responder patients; pharmacogenetics; pharmacogenomics
01 Pubblicazione su rivista::01a Articolo in rivista
Genetics of migraine and pharmacogenomics: Some considerations / Piane, Maria; Lulli, Patrizia; Ivano, Farinelli; Simeoni, Simona; DE FILIPPIS, Sergio; Patacchioli, Francesca Romana; Martelletti, Paolo. - In: THE JOURNAL OF HEADACHE AND PAIN. - ISSN 1129-2369. - STAMPA. - 8:6(2007), pp. 334-339. [10.1007/s10194-007-0427-2]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/360275
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