Objective: To determine the efficacy of combined L-carnitine and L-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. Design: Placebo-controlled double-blind randomized trial. Setting: University tertiary referral center. Patient(s): Sixty infertile patients (aged 20–40 years) with the following baseline sperm selection criteria: concentration, 10 to 40 106/mL; forward motility, 15%; total motility, 10% to 40%; and atypical forms, 80%. Fifty-six patients completed the study. Intervention(s): Patients were submitted to a combined treatment of L-carnitine (2 g/d) and L-acetyl-carnitine (1 g/d) or of placebo; the study design was 2 months’ wash-out, 6 months of therapy or of placebo, and 2 months’ follow-up. Main Outcome Measure(s): Variation in the semen parameters that were used for patient selection. Result(s): Even though increases were seen in all sperm parameters after combined carnitine treatment, the most significant improvement in sperm motility (both forward and total) was present in patients who had lower initial absolute values of motile sperm (4 106 forward or 5 106 total motile spermatozoa per ejaculate). Conclusion(s): Combined treatment with L-carnitine and L-acetyl-carnitine in a controlled study of efficacy was effective in increasing sperm motility, especially in groups with lower baseline levels.

A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia / Lenzi, Andrea; Sgro', P; Salacone, P; Paoli, Donatella; Gilio, B; Lombardo, Francesco; Santulli, Maria; Agarwal, A; Gandini, Loredana. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - STAMPA. - 81:(2004), pp. 1578-1584. [10.1016/j.fertnstert.2003.10.034]

A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia.

LENZI, Andrea;PAOLI, Donatella;LOMBARDO, Francesco;SANTULLI, Maria;GANDINI, Loredana
2004

Abstract

Objective: To determine the efficacy of combined L-carnitine and L-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. Design: Placebo-controlled double-blind randomized trial. Setting: University tertiary referral center. Patient(s): Sixty infertile patients (aged 20–40 years) with the following baseline sperm selection criteria: concentration, 10 to 40 106/mL; forward motility, 15%; total motility, 10% to 40%; and atypical forms, 80%. Fifty-six patients completed the study. Intervention(s): Patients were submitted to a combined treatment of L-carnitine (2 g/d) and L-acetyl-carnitine (1 g/d) or of placebo; the study design was 2 months’ wash-out, 6 months of therapy or of placebo, and 2 months’ follow-up. Main Outcome Measure(s): Variation in the semen parameters that were used for patient selection. Result(s): Even though increases were seen in all sperm parameters after combined carnitine treatment, the most significant improvement in sperm motility (both forward and total) was present in patients who had lower initial absolute values of motile sperm (4 106 forward or 5 106 total motile spermatozoa per ejaculate). Conclusion(s): Combined treatment with L-carnitine and L-acetyl-carnitine in a controlled study of efficacy was effective in increasing sperm motility, especially in groups with lower baseline levels.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/359226
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 51
  • Scopus 193
  • ???jsp.display-item.citation.isi??? 157
social impact