Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats

Prenatal Restraint Stress (PRS) in rats is a validated model of early stress resulting in permanent behavioral and neurobiological outcomes. Although sexual dimorphism in the effects of PRS has been hypothesized for more than 30 years, few studies in this long period have directly addressed the issue. Our group has uncovered a pronounced gender difference in the effects of PRS (stress delivered to the mothers 3 times per day during the last 10 days of pregnancy) on anxiety, spatial learning, and a series of neurobiological parameters classically associated with hippocampus-dependent behaviors. Adult male rats subjected to PRS ("PRS rats'') showed increased anxiety-like behavior in the elevated plus maze (EPM), a reduction in the survival of newborn cells in the dentate gyrus, a reduction in the activity of mGlu1/5 metabotropic glutamate receptors in the ventral hippocampus, and an increase in the levels of brain-derived neurotrophic factor (BDNF) and pro-BDNF in the hippocampus. In contrast, female PRS rats displayed reduced anxiety in the EPM, improved learning in the Morris water maze, an increase in the activity of mGlu1/5 receptors in the ventral and dorsal hippocampus, and no changes in hippocampal neurogenesis or BDNF levels. The direction of the changes in neurogenesis, BDNF levels and mGlu receptor function in PRS animals was not consistent with the behavioral changes, suggesting that PRS perturbs the interdependency of these particular parameters and their relation to hippocampus-dependent behavior. Our data suggest that the epigenetic changes in hippocampal neuroplasticity induced by early environmental challenges are critically sex-dependent and that the behavioral outcome may diverge in males and females. [Zuena, Anna Rita; Mairesse, Jerome; Morley-Fletcher, Sara; Maccari, Stefania] Univ Lille 1, Perinatal Stress Lab, F-59655 Villeneuve Dascq, France; [Zuena, Anna Rita; Mairesse, Jerome; Casolini, Paola; Cinque, Carlo; Alema, Giovanni Sebastiano; Chiodi, Valentina; Catalani, Assia; Nicoletti, Ferdinando; Maccari, Stefania] Univ Roma La Sapienza, Dept Human Physiol & Pharmacol, Rome, Italy; [Gradini, Roberto; Nicoletti, Ferdinando] Ist Neurol Mediterraneo Neuromed, Pozzilli, Italy; [Spagnoli, Luigi Giusto] Tor Vergata Univ, Inst Anatom Pathol, Rome, Italy; [Gradini, Roberto] Univ Roma La Sapienza, Dept Expt Med, Rome, Italy Zuena, AR (reprint author), Univ Lille 1, Perinatal Stress Lab, F-59655 Villeneuve Dascq, France. stefania.maccari@univ-lille1.fr Alema, Giovanni Sebastiano/D-2672-2009 Alema, Giovanni Sebastiano/0000-0003-2350-6365 University of Lille 1; Sapienza University of Rome; Ministere des Affaires Etrangers; Lavoisier, EGIDE This research was supported by the University of Lille 1 and the Sapienza University of Rome (under the framework of an agreement signed between the 2 universities on 15/02/2007). Anna Rita Zuena was funded by the Ministere des Affaires Etrangers. Jerome Mairesse was funded by the Lavoisier, EGIDE. 116 85 86 PUBLIC LIBRARY SCIENCE SAN FRANCISCO 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA 1932-6203 PLOS ONE PLoS One MAY 14 2008 3 5 e2170 10.1371/journal.pone.0002170 13 Multidisciplinary Sciences Science & Technology - Other Topics 390OE WOS:000262172800035 J Trezza, V; Cuomo, V; Vanderschuren, LJMJ Trezza, Viviana; Cuomo, Vincenzo; Vanderschuren, Louk J. M. J. Cannabis and the developing brain: Insights from behavior EUROPEAN JOURNAL OF PHARMACOLOGY English Review cannabis; behavior; development; pregnancy; adolescence PRENATAL MARIJUANA EXPOSURE; MESSENGER-RNA EXPRESSION; MU-OPIOID RECEPTORS; HUMAN FETAL-BRAIN; ILLICIT DRUG-USE; RAT-BRAIN; ADULT RATS; PERINATAL EXPOSURE; ENDOCANNABINOID SYSTEM; GENE-EXPRESSION The isolation and identification, in 1964, of delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, opened the door to a whole new field of medical research. The exploration of the therapeutic potential of THC and other natural and synthetic cannabinoid compounds was paralleled by the discovery of the endocannabinoid system, comprising cannabinoid receptors and their endogenous ligands, which offered exciting new insights into brain function. Besides its well-known involvement in specific brain functions, such as control of movement, memory and emotions, the endocannabinoid system plays an important role in fundamental developmental processes such as cell proliferation, migration and differentiation. For this reason, changes in its activity during stages of high neuronal plasticity, such as the perinatal and the adolescent period, can have long-lasting neurobehavioral consequences. Here, we summarize human and animal studies examining the behavioral and neurobiological effects of in utero and adolescent exposure to cannabis. Since cannabis preparations are widely used and abused by young people, including pregnant women, understanding how cannabinoid compounds affect the developing brain, leading to neurobehavioral alterations or neuropsychiatric disorders later in life, is a serious health issue. In addition, since the endocannabinoid system is emerging as a novel therapeutic target for the treatment of several neuropsychiatric diseases, a detailed investigation of possible adverse effects of cannabinoid compounds on the central nervous system (CNS) of immature individuals is warranted. (C) 2008 Elsevier B.V. All rights reserved. [Trezza, Viviana; Vanderschuren, Louk J. M. J.] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurosci & Pharmacol, NL-3584 CG Utrecht, Netherlands; [Cuomo, Vincenzo] Univ Rome Sapienza, Dept Human Physiool & Pharmacol, Rome, Italy Trezza, V (reprint author), Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurosci & Pharmacol, Univ Weg 100, NL-3584 CG Utrecht, Netherlands. vtrezza@umcutrecht.nl Cuomo, Vincenzo/D-2772-2009; cuomo, vincenzo/J-6777-2012 159 31 32 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0014-2999 EUR J PHARMACOL Eur. J. Pharmacol. MAY 13 2008 585 2-3 441 452 10.1016/j.ejphar.2008.01.058 12 Pharmacology & Pharmacy Pharmacology & Pharmacy 304ZD WOS:000256146700024 J Amato, MP; Goretti, B; Ghezzi, A; Lori, S; Zipoli, V; Portaccio, E; Moiola, L; Falautano, M; De Caro, MF; Lopez, M; Patti, F; Vecchio, R; Pozzilli, C; Bianchi, V; Roscio, M; Comi, G; Trojano, M Amato, M. P.; Goretti, B.; Ghezzi, A.; Lori, S.; Zipoli, V.; Portaccio, E.; Moiola, L.; Falautano, M.; De Caro, M. F.; Lopez, M.; Patti, F.; Vecchio, R.; Pozzilli, C.; Bianchi, V.; Roscio, M.; Comi, G.; Trojano, M. Italian Neurological Soc Cognitive and psychosocial features of childhood and juvenile MS NEUROLOGY English Article PEDIATRIC MULTIPLE-SCLEROSIS; IMPAIRMENT; CHILDREN; DYSFUNCTION; DIAGNOSIS; FATIGUE; DISABILITY; IMPACT; SCALE; LIFE Objective: To assess the impact of multiple sclerosis (MS) on cognitive and psychosocial functioning in childhood and juvenile cases. Methods: We used an extensive neuropsychological battery assessing IQ, memory, attention/concentration, executive functions, and language. Fatigue and depression were also measured. An interview on school and daily living activities was obtained from the parents. Performance of cases was compared with that of demographically matched healthy controls. Results: Sixty-three patients and 57 healthy controls were assessed. Five patients (8%) exhibited a particularly low IQ (< 70). Criteria for cognitive impairment (failure on at least three tests) were fulfilled in 19 patients (31%), whereas 32 patients (53%) failed at least two tests. Beyond deficits in memory, complex attention, and executive functions, the profile of deficits was characterized by involvement of linguistic abilities. In the regression analysis, the only significant predictor of cognitive impairment was an IQ score lower than 90 (odds ratio [OR] 18.2,95% CI 4.6-71.7, p < 0.001). Considering the IQ score as a dependent variable, the only significant predictor was represented by younger age at onset (OR 0.7, 95% CI 0.5-0.9, p = 0.009). Depressive symptoms were reported by 6% of the cases, and fatigue was reported by 73% of the cases. MS negatively affected school and everyday activities in 56% of the subjects. Conclusions: In childhood and juvenile cases, multiple sclerosis (MS) is associated with cognitive impairment and low IQ scores, the latter related to younger age at onset. These aspects are of critical importance in helping children and adolescents with MS to manage their difficulties and psychosocial challenges. [Amato, M. P.; Goretti, B.; Zipoli, V.; Portaccio, E.] Univ Florence, Dept Neurol, I-50134 Florence, Italy; [Lori, S.] Meyer Hosp, Neurol Unit, Florence, Italy; [Moiola, L.; Falautano, M.; Comi, G.] Ist Sci San Raffaele, Dept Neurol, I-20132 Milan, Italy; [De Caro, M. F.; Lopez, M.; Trojano, M.] Univ Bari, Dept Neurol, I-70121 Bari, Italy; [Patti, F.; Vecchio, R.] Univ Catania, Dept Neurol, I-95124 Catania, Italy; [Pozzilli, C.; Bianchi, V.] Univ Roma La Sapienza, Dept Neurol Sci, Rome, Italy Amato, MP (reprint author), Univ Florence, Dept Neurol, Viale Morgagni 85, I-50134 Florence, Italy. mariapia.amato@unifi.it Patti, Francesco/C-3300-2011 38 70 71 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0028-3878 NEUROLOGY Neurology MAY 13 2008 70 20 1891 1897 10.1212/01.wnl.0000312276.23177.fa 7 Clinical Neurology Neurosciences & Neurology 312YC WOS:000256707300005 J Domenici, F; Castellano, C; Congiu, A; Pompeo, G; Felici, R Domenici, F.; Castellano, C.; Congiu, A.; Pompeo, G.; Felici, R. Ordering and lyotropic behavior of a silicon-supported cationic and neutral lipid system studied by neutron reflectivity APPLIED PHYSICS LETTERS English Article DIOCTADECYLDIMETHYLAMMONIUM BROMIDE; X-RAY; MEMBRANES; BILAYERS; INTERFACES; VESICLES Self-assembling of amphipathic lipid films on solid support allows the structural investigation of important biological model systems, such as the vectorlike lipid membranes, in order to improve DNA transfection in nonviral gene therapy. We present a neutron reflectivity study of a binary lipid system composed of dioleoylphosphatidylcholine (DOPC) and dimethyldioctadecylammonium bromide (DDAB) deposited on [100] silicon support by means of spin coating technique. We underline their lyotropic behavior under saturated deuterium oxide (D(2)O) vapor thus pointing out that the lipid mixture is organized in ordered domains composed of plane lamellar bilayers of noninteractive DOPC and DDAB. (c) 2008 American Institute of Physics. [Domenici, F.; Castellano, C.; Congiu, A.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Pompeo, G.] Ist Struttura Mat, Sezione Tor Vergata, I-00133 Rome, Italy; [Felici, R.] European Synchrotron Radiat Facil, F-38043 Grenoble, France Domenici, F (reprint author), Univ Roma La Sapienza, Dipartimento Fis, Ple A Moro 2, I-00185 Rome, Italy. f.domenici@caspur.it; a.congiu@caspur.it 30 1 1 AMER INST PHYSICS MELVILLE CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA 0003-6951 APPL PHYS LETT Appl. Phys. Lett. MAY 12 2008 92 19 193901 10.1063/1.2917807 3 Physics, Applied Physics 310XN WOS:000256564200111 J Ribeiro, MCC; Scopigno, T; Ruocco, G Ribeiro, Mauro C. C.; Scopigno, Tullio; Ruocco, Giancarlo Fragility and glassy dynamics of 2Ca(NO(3))(2)center dot 3KNO(3) under pressure: Molecular dynamics simulations JOURNAL OF CHEMICAL PHYSICS English Article FORMING LIQUIDS; NITRATE MELTS; TRANSITION; RELAXATION; CA0.4K0.6(NO3)(1.4); TEMPERATURE; DEPENDENCE; TRANSPORT Molecular dynamics simulations of the glass-forming liquid 2Ca(NO(3))(2)center dot 3KNO(3) (CKN) were performed from high temperature liquid states down to low temperature glassy states at six different pressures from 10(-4) to 5.0 GPa. The temperature dependence of the structural relaxation time indicates that the fragility of liquid CKN changes with pressure. In line with recent proposal [Scopigno , Science 302, 849 (2003)], the change on liquid fragility is followed by a proportional change of the nonergodicity factor of the corresponding glass at low temperature. (c) 2008 American Institute of Physics. [Ribeiro, Mauro C. C.] Univ Sao Paulo, Inst Quim, Lab Espect Mol, BR-05513970 Sao Paulo, Brazil; [Scopigno, Tullio; Ruocco, Giancarlo] Univ Roma La Sapienza, Ist Nazl Fis Mat, I-00185 Rome, Italy; [Scopigno, Tullio; Ruocco, Giancarlo] Univ Roma La Sapienza, Dept Fis, I-00185 Rome, Italy Ribeiro, MCC (reprint author), Univ Sao Paulo, Inst Quim, Lab Espect Mol, CP 26077, BR-05513970 Sao Paulo, Brazil. mccribei@iq.usp.br Ruocco, Giancarlo/A-6245-2010; Scopigno, Tullio/A-1778-2010; Ribeiro, Mauro/C-4820-2012 Ruocco, Giancarlo/0000-0002-2762-9533; 26 7 7 AMER INST PHYSICS MELVILLE CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA 0021-9606 J CHEM PHYS J. Chem. Phys. MAY 12 2008 128 19 191104 10.1063/1.2931525 4 Physics, Atomic, Molecular & Chemical Physics 305VF WOS:000256205200004 J Celani, F; Isidori, A; Marconi, L Celani, F.; Isidori, A.; Marconi, L. A reduction paradigm for output regulation INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL English Article output regulation; nonlinear systems; linear systems; non-minimum-phase systems NONLINEAR INTERNAL-MODELS; SEMIGLOBAL STABILIZATION; FEEDBACK STABILIZATION; SYSTEMS; TOOL The goal of this paper is to provide a reduction paradigm for the design of output regulators which can be of interest for nonlinear as well as linear uncertain systems. The main motivation of the work is to provide a systematic design tool to deal with non-minimum-phase uncertain systems for which conventional high-gain stabilization methods are not effective. The contribution of the work is two-fold. First, this work extends a previous reduction paradigm for output regulation of nonlinear systems. Furthermore, in the case of the uncertain controlled dynamics being linear, we show how the proposed framework leads to a number of systematic design tools of interest for non-minimum-phase linear systems affected by severe uncertainties. A numerical control example of a linearized model of an inverted pendulum on a cart is presented. Copyright (c) 2007 John Wiley & Sons, Ltd. [Celani, F.; Isidori, A.] Univ Roma La Sapienza, Dipartimento Informat & Sistemist Antonio Ruberti, I-00185 Rome, Italy; [Isidori, A.] Washington Univ, Dept Elect & Syst Engn, St Louis, MO 63130 USA; [Isidori, A.; Marconi, L.] Univ Bologna, Dipartimento Elettr Informat & Sistemist, Ctr Res Complex Automated Syst Giuseppe Evangelis, I-40123 Bologna, Italy Celani, F (reprint author), Univ Roma La Sapienza, Dipartimento Informat & Sistemist Antonio Ruberti, Via Ariosto 25, I-00185 Rome, Italy. celani@dis.uniromal.it Celani, Fabio/F-1397-2011; Isidori, Alberto/F-5825-2011 19 3 3 WILEY-BLACKWELL MALDEN COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA 1049-8923 INT J ROBUST NONLIN Int. J. Robust Nonlinear Control MAY 10 2008 18 7 756 781 10.1002/rnc.1262 26 Automation & Control Systems; Engineering, Electrical & Electronic; Mathematics, Applied Automation & Control Systems; Engineering; Mathematics 294BP WOS:000255379400004 J Serrilli, AM; Ramunno, A; Amicucci, F; Chicarella, V; Santoni, S; Ballero, M; Serafini, M; Bianco, A Serrilli, Anna Maria; Ramunno, Alessia; Amicucci, Francesca; Chicarella, Valentina; Santoni, Sabrina; Ballero, Mauro; Serafini, Mauro; Bianco, Armandodoriano Iridoidic pattern in endemic Sardinian plants: the case of Galium species NATURAL PRODUCT RESEARCH English Article Rubiaceae; Galium corsicum; Galium schmidii; Galium glaucophyllum; monoterpenoids : iridoid glycosides; Sardinia GLUCOSIDES; SPECTROSCOPY; RUBIACEAE The monoterpenoid fractions of three endemic Galium ssp. (Rubiaceae) from Sardinia Island were examined and compared with the iridoidic pattern yet known in Galium species. This comparison evidenced theirs endemic characters. In particular, in G.corsicum and in G. glaucophyllum loganic acid was isolated and identified for the first time in Galium genus. In G. schmidii a rare iridoid is present, 10-hydroxy-loganin, whose presence in this genus was evidenced only in G. mollugo and loganin isolated for the first time. [Serrilli, Anna Maria; Ramunno, Alessia; Amicucci, Francesca; Chicarella, Valentina; Santoni, Sabrina; Bianco, Armandodoriano] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; [Ballero, Mauro] Univ Cagliari, Dipartimento Sci Bot, I-09124 Cagliari, Italy; [Serrilli, Anna Maria; Ramunno, Alessia; Amicucci, Francesca; Chicarella, Valentina; Santoni, Sabrina; Ballero, Mauro; Serafini, Mauro; Bianco, Armandodoriano] COSMESE Consorzio Interuniv Studio Metab Secondar, Cagliari, Italy Serrilli, AM (reprint author), Univ Roma La Sapienza, Dipartimento Chim, P A Moro 5, I-00185 Rome, Italy. annamaria.serrilli@uniroma1.it 14 1 1 TAYLOR & FRANCIS LTD ABINGDON 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND 1478-6419 NAT PROD RES Nat. Prod. Res. MAY 10 2008 22 7 618 622 10.1080/14786410701614135 5 Chemistry, Applied; Chemistry, Medicinal Chemistry; Pharmacology & Pharmacy 314JD WOS:000256804800009 J Zenchuk, AI; Santini, PM Zenchuk, A. I.; Santini, P. M. The remarkable relations among PDEs integrable by the inverse spectral transform method, by the method of characteristics and by the Hopf-Cole transformation JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL English Article KADOMTSEV-PETVIASHVILI EQUATION; NONLINEAR EVOLUTION EQUATIONS; DEPENDENT SCHRODINGER-EQUATION; PARTIAL-DIFFERENTIAL EQUATIONS; SCATTERING TRANSFORM; DRESSING METHOD; CAUCHY-PROBLEM; HIERARCHIES; ALGEBRAS; FIELDS We establish deep and remarkable connections among partial differential equations (PDEs) integrable by different methods: the inverse spectral transform method, the method of characteristics and the Hopf-Cole transformation. More concretely, (1) we show that the integrability properties (Lax pair, infinitely-many commuting symmetries, large classes of analytic solutions) of (2+1)-dimensional PDEs integrable by the inverse scattering transform method (S-integrable) can be generated by the integrability properties of the (1+1)-dimensional matrix Burgers hierarchy, integrable by the matrix Hopf-Cole transformation (C-integrable). (2) We show that the integrability properties (i) of S-integrable PDEs in (1+1) dimensions, (ii) of the multidimensional generalizations of the GL(M, C) self-dual Yang-Mills equations and (iii) of the multidimensional Calogero equations can be generated by the integrability properties of a recently introduced multidimensional matrix equation solvable by the method of characteristics. To establish the above links, we consider a block Frobenius matrix reduction of the relevant matrix fields, leading to integrable chains of matrix equations for the blocks of such a Frobenius matrix, followed by a systematic elimination procedure of some of these blocks. The construction of large classes of solutions of the soliton equations from solutions of the matrix Burgers hierarchy turns out to be intimately related to the construction of solutions in Sato theory. (3) Finally, we show that suitable generalizations of the block Frobenius matrix reduction of the matrix Burgers hierarchy generates PDEs exhibiting integrability properties in common with both S- and C-integrable equations. [Zenchuk, A. I.] Landau Inst Theoret Phys, Int Inst Nonlinear Sci, Ctr Nonlinear Studies, Moscow 119334, Russia; [Santini, P. M.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Santini, P. M.] Ist Nazl Fis Nucl, I-00185 Rome, Italy Zenchuk, AI (reprint author), Landau Inst Theoret Phys, Int Inst Nonlinear Sci, Ctr Nonlinear Studies, Kosygina 2, Moscow 119334, Russia. zenchuk@itp.ac.ru; paolo.santini@roma1.infn.it 52 6 6 IOP PUBLISHING LTD BRISTOL TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND 1751-8113 J PHYS A-MATH THEOR J. Phys. A-Math. Theor. MAY 9 2008 41 18 185209 10.1088/1751-8113/41/18/185209 28 Physics, Multidisciplinary; Physics, Mathematical Physics 298AZ WOS:000255659900016 J Aaltonen, T; Adelman, J; Akimoto, T; Albrow, MG; Gonzalez, BA; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Aoki, M; Apollinari, G; Apresyan, A; Arisawa, T; Artikov, A; Ashmanskas, W; Attal, A; Aurisano, A; Azfar, F; Azzi-Bacchetta, P; Azzurri, P; Bacchetta, N; Badgett, W; Barbaro-Galtieri, A; Barnes, VE; Barnett, BA; Baroiant, S; Bartsch, V; Bauer, G; Beauchemin, PH; Bedeschi, F; Bednar, P; Behari, S; Bellettini, G; Bellinger, J; Belloni, A; Benjamin, D; Beretvas, A; Beringer, J; Berry, T; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Blair, RE; Blocker, C; Blumenfeld, B; Bocci, A; Bodek, A; Boisvert, V; Bolla, G; Bolshov, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Bridgeman, A; Brigliadori, L; Bromberg, C; Brubaker, E; Budagov, J; Budd, HS; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Byrum, KL; Cabrera, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chang, SH; Chen, YC; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, JP; Choudalakis, G; Chuang, SH; Chung, K; Chung, WH; Chung, YS; Ciobanu, CI; Ciocci, MA; Clark, A; Clark, D; Compostella, G; Convery, ME; Conway, J; Cooper, B; Copic, K; Cordelli, M; Cortiana, G; Crescioli, F; Almenar, CC; Cuevas, J; Culbertson, R; Cully, JC; Dagenhart, D; Datta, M; Davies, T; de Barbaro, P; De Cecco, S; Deisher, A; De Lentdecker, G; De Lorenzo, G; Dell'Orso, M; Demortier, L; Deng, J; Deninno, M; De Pedis, D; Derwent, PF; Di Giovanni, GP; Dionisi, C; Di Ruzza, B; Dittmann, JR; D'Onofrio, M; Donati, S; Dong, P; Donini, J; Dorigo, T; Dube, S; Efron, J; Erbacher, R; Errede, D; Errede, S; Eusebi, R; Fang, HC; Farrington, S; Fedorko, WT; Feild, RG; Feindt, M; Fernandez, JP; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Forrester, S; Franklin, M; Freeman, JC; Furic, I; Gallinaro, M; Galyardt, J; Garberson, F; Garcia, JE; Garfinkel, AF; Genser, K; Gerberich, H; Gerdes, D; Giagu, S; Giakoumopolou, V; Giannetti, P; Gibson, K; Gimmell, JL; Ginsburg, CM; Giokaris, N; Giordani, M; Giromini, P; Giunta, M; Glagolev, V; Glenzinski, D; Gold, M; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; Gonzalez, O; Gorelov, I; Goshaw, AT; Goulianos, K; Gresele, A; Grinstein, S; Grosso-Pilcher, C; Group, RC; Grundler, U; da Costa, JG; Gunay-Unalan, Z; Haber, C; Hahn, K; Hahn, SR; Halkiadakis, E; Hamilton, A; Han, BY; Han, JY; Handler, R; Happacher, F; Hara, K; Hare, D; Hare, M; Harper, S; Harr, RF; Harris, RM; Hartz, M; Hatakeyama, K; Hauser, J; Hays, C; Heck, M; Heijboer, A; Heinemann, B; Heinrich, J; Henderson, C; Herndon, M; Heuser, J; Hewamanage, S; Hidas, D; Hill, CS; Hirschbuehl, D; Hocker, A; Hou, S; Houlden, M; Hsu, SC; Huffman, BT; Hughes, RE; Husemann, U; Huston, J; Incandela, J; Introzzi, G; Iori, M; Ivanov, A; Iyutin, B; James, E; Jayatilaka, B; Jeans, D; Jeon, EJ; Jindariani, S; Johnson, W; Jones, M; Joo, KK; Jun, SY; Jung, JE; Junk, TR; Kamon, T; Kar, D; Karchin, PE; Kato, Y; Kephart, R; Kerzel, U; Khotilovich, V; Kilminster, B; Kim, DH; Kim, HS; Kim, JE; Kim, MJ; Kim, SB; Kim, SH; Kim, YK; Kimura, N; Kirsch, L; Klimenko, S; Klute, M; Knuteson, B; Ko, BR; Koay, SA; Kondo, K; Kong, DJ; Konigsberg, J; Korytov, A; Kotwal, AV; Kraus, J; Kreps, M; Kroll, J; Krumnack, N; Kruse, M; Krutelyov, V; Kubo, T; Kuhlmann, SE; Kuhr, T; Kulkarni, NP; Kusakabe, Y; Kwang, S; Laasanen, AT; Lai, S; Lami, S; Lammel, S; Lancaster, M; Lander, RL; Lannon, K; Lath, A; Latino, G; Lazzizzera, I; LeCompte, T; Lee, J; Lee, J; Lee, YJ; Lee, SW; Lefevre, R; Leonardo, N; Leone, S; Levy, S; Lewis, JD; Lin, C; Lin, CS; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, DO; Liu, T; Lockyer, NS; Loginov, A; Loreti, M; Lovas, L; Lu, RS; Lucchesi, D; Lueck, J; Luci, C; Lujan, P; Lukens, P; Lungu, G; Lyons, L; Lys, J; Lysak, R; Lytken, E; Mack, P; MacQueen, D; Madrak, R; Maeshima, K; Makhoul, K; Maki, T; Maksimovic, P; Malde, S; Malik, S; Manca, G; Manousakis, A; Margaroli, F; Marino, C; Marino, CP; Martin, A; Martin, M; Martin, V; Martinez, M; Martinez-Ballarin, R; Maruyama, T; Mastrandrea, P; Masubuchi, T; Mattson, ME; Mazzanti, P; McFarland, KS; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzemer, S; Menzione, A; Merkel, P; Mesropian, C; Messina, A; Miao, T; Miladinovic, N; Miles, J; Miller, R; Mills, C; Milnik, M; Mitra, A; Mitselmakher, G; Miyake, H; Moed, S; Moggi, N; Moon, CS; Moore, R; Morello, M; Fernandez, PM; Mulmenstadt, J; Mukherjee, A; Muller, T; Mumford, R; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Nagano, A; Naganoma, J; Nakamura, K; Nakano, I; Napier, A; Necula, V; Neu, C; Neubauer, MS; Nielsen, J; Nodulman, L; Norman, M; Norniella, O; Nurse, E; Oh, SH; Oh, YD; Oksuzian, I; Okusawa, T; Oldeman, R; Orava, R; Osterberg, K; Griso, SP; Pagliarone, C; Palencia, E; Papadimitriou, V; Papaikonomou, A; Paramonov, AA; Parks, B; Pashapour, S; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, DE; Penzo, A; Phillips, TJ; Piacentino, G; Piedra, J; Pinera, L; Pitts, K; Plager, C; Pondrom, L; Portell, X; Poukhov, O; Pounder, N; Prakoshyn, F; Pronko, A; Proudfoot, J; Ptohos, F; Punzi, G; Pursley, J; Rademacker, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Reisert, B; Rekovic, V; Renton, P; Rescigno, M; Richter, S; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rossin, R; Roy, P; Ruiz, A; Russ, J; Rusu, V; Saarikko, H; Safonov, A; Sakumoto, WK; Salamanna, G; Salto, O; Santi, L; Sarkar, S; Sartori, L; Sato, K; Savoy-Navarro, A; Scheidle, T; Schlabach, P; Schmidt, EE; Schmidt, MA; Schmidt, MP; Schmitt, M; Schwarz, T; Scodellaro, L; Scott, AL; Scribano, A; Scuri, F; Sedov, A; Seidel, S; Seiya, Y; Semenov, A; Sexton-Kennedy, L; Sfyria, A; Shalhout, SZ; Shapiro, MD; Shears, T; Shepard, PF; Sherman, D; 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Wang, SM; Warburton, A; Waters, D; Weinberger, M; Wester, WC; Whitehouse, B; Whiteson, D; Wicklund, AB; Wicklund, E; Williams, G; Williams, HH; Wilson, P; Winer, BL; Wittich, P; Wolbers, S; Wolfe, C; Wright, T; Wu, X; Wynne, SM; Yagil, A; Yamamoto, K; Yamaoka, J; Yamashita, T; Yang, C; Yang, UK; Yang, YC; Yao, WM; Yeh, GP; Yoh, J; Yorita, K; Yoshida, T; Yu, GB; Yu, I; Yu, SS; Yun, JC; Zanello, L; Zanetti, A; Zaw, I; Zhang, X; Zheng, Y; Zucchelli, S Aaltonen, T.; Adelman, J.; Akimoto, T.; Albrow, M. G.; Gonzalez, B. Alvarez; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Aoki, M.; Apollinari, G.; Apresyan, A.; Arisawa, T.; Artikov, A.; Ashmanskas, W.; Attal, A.; Aurisano, A.; Azfar, F.; Azzi-Bacchetta, P.; Azzurri, P.; Bacchetta, N.; Badgett, W.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Baroiant, S.; Bartsch, V.; Bauer, G.; Beauchemin, P. -H.; Bedeschi, F.; Bednar, P.; Behari, S.; Bellettini, G.; Bellinger, J.; Belloni, A.; Benjamin, D.; Beretvas, A.; Beringer, J.; Berry, T.; Bhatti, A.; Binkley, M.; Bisello, D.; Bizjak, I.; Blair, R. E.; Blocker, C.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Boisvert, V.; Bolla, G.; Bolshov, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brau, B.; Bridgeman, A.; Brigliadori, L.; Bromberg, C.; Brubaker, E.; Budagov, J.; Budd, H. S.; Budd, S.; Burkett, K.; Busetto, G.; Bussey, P.; Buzatu, A.; Byrum, K. L.; Cabrera, S.; Campanelli, M.; Campbell, M.; Canelli, F.; Canepa, A.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Carron, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavalli-Sforza, M.; Cerri, A.; Cerrito, L.; Chang, S. H.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Chlebana, F.; Cho, K.; Chokheli, D.; Chou, J. P.; Choudalakis, G.; Chuang, S. H.; Chung, K.; Chung, W. H.; Chung, Y. S.; Ciobanu, C. I.; Ciocci, M. A.; Clark, A.; Clark, D.; Compostella, G.; Convery, M. E.; Conway, J.; Cooper, B.; Copic, K.; Cordelli, M.; Cortiana, G.; Crescioli, F.; Almenar, C. Cuenca; Cuevas, J.; Culbertson, R.; Cully, J. C.; Dagenhart, D.; Datta, M.; Davies, T.; de Barbaro, P.; De Cecco, S.; Deisher, A.; De Lentdecker, G.; De Lorenzo, G.; Dell'Orso, M.; Demortier, L.; Deng, J.; Deninno, M.; De Pedis, D.; Derwent, P. F.; Di Giovanni, G. P.; Dionisi, C.; Di Ruzza, B.; Dittmann, J. R.; D'Onofrio, M.; Donati, S.; Dong, P.; Donini, J.; Dorigo, T.; Dube, S.; Efron, J.; Erbacher, R.; Errede, D.; Errede, S.; Eusebi, R.; Fang, H. C.; Farrington, S.; Fedorko, W. T.; Feild, R. G.; Feindt, M.; Fernandez, J. P.; Ferrazza, C.; Field, R.; Flanagan, G.; Forrest, R.; Forrester, S.; Franklin, M.; Freeman, J. C.; Furic, I.; Gallinaro, M.; Galyardt, J.; Garberson, F.; Garcia, J. E.; Garfinkel, A. F.; Genser, K.; Gerberich, H.; Gerdes, D.; Giagu, S.; Giakoumopolou, V.; Giannetti, P.; Gibson, K.; Gimmell, J. L.; Ginsburg, C. M.; Giokaris, N.; Giordani, M.; Giromini, P.; Giunta, M.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldschmidt, N.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; Gonzalez, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gresele, A.; Grinstein, S.; Grosso-Pilcher, C.; Group, R. C.; Grundler, U.; da Costa, J. Guimaraes; Gunay-Unalan, Z.; Haber, C.; Hahn, K.; Hahn, S. R.; Halkiadakis, E.; Hamilton, A.; Han, B. -Y.; Han, J. Y.; Handler, R.; Happacher, F.; Hara, K.; Hare, D.; Hare, M.; Harper, S.; Harr, R. F.; Harris, R. M.; Hartz, M.; Hatakeyama, K.; Hauser, J.; Hays, C.; Heck, M.; Heijboer, A.; Heinemann, B.; Heinrich, J.; Henderson, C.; Herndon, M.; Heuser, J.; Hewamanage, S.; Hidas, D.; Hill, C. S.; Hirschbuehl, D.; Hocker, A.; Hou, S.; Houlden, M.; Hsu, S. -C.; Huffman, B. T.; Hughes, R. E.; Husemann, U.; Huston, J.; Incandela, J.; Introzzi, G.; Iori, M.; Ivanov, A.; Iyutin, B.; James, E.; Jayatilaka, B.; Jeans, D.; Jeon, E. J.; Jindariani, S.; Johnson, W.; Jones, M.; Joo, K. K.; Jun, S. Y.; Jung, J. E.; Junk, T. R.; Kamon, T.; Kar, D.; Karchin, P. E.; Kato, Y.; Kephart, R.; Kerzel, U.; Khotilovich, V.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. B.; Kim, S. H.; Kim, Y. K.; Kimura, N.; Kirsch, L.; Klimenko, S.; Klute, M.; Knuteson, B.; Ko, B. R.; Koay, S. A.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Korytov, A.; Kotwal, A. V.; Kraus, J.; Kreps, M.; Kroll, J.; Krumnack, N.; Kruse, M.; Krutelyov, V.; Kubo, T.; Kuhlmann, S. E.; Kuhr, T.; Kulkarni, N. P.; Kusakabe, Y.; Kwang, S.; Laasanen, A. T.; Lai, S.; Lami, S.; Lammel, S.; Lancaster, M.; Lander, R. L.; Lannon, K.; Lath, A.; Latino, G.; Lazzizzera, I.; LeCompte, T.; Lee, J.; Lee, J.; Lee, Y. J.; Lee, S. W.; Lefevre, R.; Leonardo, N.; Leone, S.; Levy, S.; Lewis, J. D.; Lin, C.; Lin, C. S.; Linacre, J.; Lindgren, M.; Lipeles, E.; Lister, A.; Litvintsev, D. O.; Liu, T.; Lockyer, N. S.; Loginov, A.; Loreti, M.; Lovas, L.; Lu, R. -S.; Lucchesi, D.; Lueck, J.; Luci, C.; Lujan, P.; Lukens, P.; Lungu, G.; Lyons, L.; Lys, J.; Lysak, R.; Lytken, E.; Mack, P.; MacQueen, D.; Madrak, R.; Maeshima, K.; Makhoul, K.; Maki, T.; Maksimovic, P.; Malde, S.; Malik, S.; Manca, G.; Manousakis, A.; Margaroli, F.; Marino, C.; Marino, C. P.; Martin, A.; Martin, M.; Martin, V.; Martinez, M.; Martinez-Ballarin, R.; Maruyama, T.; Mastrandrea, P.; Masubuchi, T.; Mattson, M. E.; Mazzanti, P.; McFarland, K. S.; McIntyre, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Menzemer, S.; Menzione, A.; Merkel, P.; Mesropian, C.; Messina, A.; Miao, T.; Miladinovic, N.; Miles, J.; Miller, R.; Mills, C.; Milnik, M.; Mitra, A.; Mitselmakher, G.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M.; Fernandez, P. Movilla; Mulmenstadt, J.; Mukherjee, A.; Muller, Th.; Mumford, R.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Nagano, A.; Naganoma, J.; Nakamura, K.; Nakano, I.; Napier, A.; Necula, V.; Neu, C.; Neubauer, M. S.; Nielsen, J.; Nodulman, L.; Norman, M.; Norniella, O.; Nurse, E.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Oldeman, R.; Orava, R.; Osterberg, K.; Griso, S. Pagan; Pagliarone, C.; Palencia, E.; Papadimitriou, V.; Papaikonomou, A.; Paramonov, A. A.; Parks, B.; Pashapour, S.; Patrick, J.; Pauletta, G.; Paulini, M.; Paus, C.; Pellett, D. E.; Penzo, A.; Phillips, T. J.; Piacentino, G.; Piedra, J.; Pinera, L.; Pitts, K.; Plager, C.; Pondrom, L.; Portell, X.; Poukhov, O.; Pounder, N.; Prakoshyn, F.; Pronko, A.; Proudfoot, J.; Ptohos, F.; Punzi, G.; Pursley, J.; Rademacker, J.; Rahaman, A.; Ramakrishnan, V.; Ranjan, N.; Redondo, I.; Reisert, B.; Rekovic, V.; Renton, P.; Rescigno, M.; Richter, S.; Rimondi, F.; Ristori, L.; Robson, A.; Rodrigo, T.; Rogers, E.; Rolli, S.; Roser, R.; Rossi, M.; Rossin, R.; Roy, P.; Ruiz, A.; Russ, J.; Rusu, V.; Saarikko, H.; Safonov, A.; Sakumoto, W. K.; Salamanna, G.; Salto, O.; Santi, L.; Sarkar, S.; Sartori, L.; Sato, K.; Savoy-Navarro, A.; Scheidle, T.; Schlabach, P.; Schmidt, E. E.; Schmidt, M. A.; Schmidt, M. P.; Schmitt, M.; Schwarz, T.; Scodellaro, L.; Scott, A. L.; Scribano, A.; Scuri, F.; Sedov, A.; Seidel, S.; Seiya, Y.; Semenov, A.; Sexton-Kennedy, L.; Sfyria, A.; Shalhout, S. Z.; Shapiro, M. D.; Shears, T.; Shepard, P. F.; Sherman, D.; Shimojima, M.; Shochet, M.; Shon, Y.; Shreyber, I.; Sidoti, A.; Sinervo, P.; Sisakyan, A.; Slaughter, A. J.; Slaunwhite, J.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Snihur, R.; Soderberg, M.; Soha, A.; Somalwar, S.; Sorin, V.; Spalding, J.; Spinella, F.; Spreitzer, T.; Squillacioti, P.; Stanitzki, M.; Denis, R. St.; Stelzer, B.; Stelzer-Chilton, O.; Stentz, D.; Strologas, J.; Stuart, D.; Suh, J. S.; Sukhanov, A.; Sun, H.; Suslov, I.; Suzuki, T.; Taffard, A.; Takashima, R.; Takeuchi, Y.; Tanaka, R.; Tecchio, M.; Teng, P. K.; Terashi, K.; Thom, J.; Thompson, A. S.; Thompson, G. A.; Thomson, E.; Tipton, P.; Tiwari, V.; Tkaczyk, S.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Tourneur, S.; Trischuk, W.; Tu, Y.; Turini, N.; Ukegawa, F.; Uozumi, S.; Vallecorsa, S.; van Remortel, N.; Varganov, A.; Vataga, E.; Vazquez, F.; Velev, G.; Vellidis, C.; Veszpremi, V.; Vidal, M.; Vidal, R.; Vila, I.; Vilar, R.; Vine, T.; Vogel, M.; Volobouev, I.; Volpi, G.; Wurthwein, F.; Wagner, P.; Wagner, R. G.; Wagner, R. L.; Wagner-Kuhr, J.; Wagner, W.; Wakisaka, T.; Wallny, R.; Wang, S. M.; Warburton, A.; Waters, D.; Weinberger, M.; Wester, W. C., III; Whitehouse, B.; Whiteson, D.; Wicklund, A. B.; Wicklund, E.; Williams, G.; Williams, H. H.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, C.; Wright, T.; Wu, X.; Wynne, S. M.; Yagil, A.; Yamamoto, K.; Yamaoka, J.; Yamashita, T.; Yang, C.; Yang, U. K.; Yang, Y. C.; Yao, W. M.; Yeh, G. P.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Yu, S. S.; Yun, J. C.; Zanello, L.; Zanetti, A.; Zaw, I.; Zhang, X.; Zheng, Y.; Zucchelli, S. CDF Collaboration Observation of the decay B(c)(+/-) -> J/psi pi(+/-) and measurement of the B(c)(+/-) mass PHYSICAL REVIEW LETTERS English Article B-C MESON; SEARCH The B(c)(+/-) meson is observed through the decay B(c)(+/-) -> J/psi pi(+/-), in data corresponding to an integrated luminosity of 2.4 fb(-1) recorded by the Collider Detector at Fermilab II detector at the Fermilab Tevatron. A signal of 108 +/- 15 candidates is observed, with a significance that exceeds 8 sigma. The mass of the B(c)(+/-) meson is measured to be 6275.6 +/- 2.9(stat) +/- 2.5(syst) MeV/c(2). [Aaltonen, T.; Maki, T.; Mehtala, P.; Orava, R.; Osterberg, K.; Saarikko, H.; van Remortel, N.] Univ Helsinki, Dept Phys, Div High Energy Phys, FIN-00014 Helsinki, Finland; [Aaltonen, T.; Maki, T.; Mehtala, P.; Orava, R.; Osterberg, K.; Saarikko, H.; van Remortel, N.] Helsinki Inst Phys, FIN-00014 Helsinki, Finland; [Chen, Y. C.; Hou, S.; Lu, R. -S.; Mitra, A.; Teng, P. K.; Wang, S. M.] Acad Sinica, Inst Phys, Taipei 11529, Taiwan; [Blair, R. E.; Byrum, K. L.; Kuhlmann, S. E.; LeCompte, T.; Nodulman, L.; Proudfoot, J.; Wagner, R. G.; Wicklund, A. B.] Argonne Natl Lab, Argonne, IL 60439 USA; [Attal, A.; Cavalli-Sforza, M.; De Lorenzo, G.; D'Onofrio, M.; Martinez, M.; Portell, X.; Salto, O.] Univ Autonoma Barcelona, Inst Fis Altes Energies, E-08193 Barcelona, Spain; [Dittmann, J. R.; Hewamanage, S.; Krumnack, N.] Baylor Univ, Waco, TX 76798 USA; [Brigliadori, L.; Castro, A.; Deninno, M.; Mazzanti, P.; Moggi, N.; Mussini, M.; Rimondi, F.] Univ Bologna, Ist Nazl Fis Nucl, I-40127 Bologna, Italy; [Blocker, C.; Clark, D.; Kirsch, L.; Miladinovic, N.] Brandeis Univ, Waltham, MA 02254 USA; [Baroiant, S.; Chertok, M.; Conway, J.; Almenar, C. Cuenca; Erbacher, R.; Forrest, R.; Forrester, S.; Ivanov, A.; Johnson, W.; Lander, R. L.; Lister, A.; Pellett, D. E.; Schwarz, T.; Smith, J. R.; Soha, A.] Univ Calif Davis, Davis, CA 95616 USA; [Dong, P.; Hauser, J.; Plager, C.; Stelzer, B.; Wallny, R.; Zheng, Y.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA; [Hsu, S. -C.; Lipeles, E.; Norman, M.; Wurthwein, F.; Yagil, A.] Univ Calif San Diego, La Jolla, CA 92093 USA; [Boveia, A.; Brau, B.; Garberson, F.; Hill, C. S.; Incandela, J.; Koay, S. A.; Krutelyov, V.; Rossin, R.; Scott, A. L.; Stuart, D.] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA; [Gonzalez, B. Alvarez; Casal, B.; Cuevas, J.; Gomez, G.; Menzemer, S.; Rodrigo, T.; Ruiz, A.; Scodellaro, L.; Vila, I.; Vilar, R.] Univ Cantabria, CSIC, Inst Fis Cantabria, E-39005 Santander, Spain; [Chung, K.; Galyardt, J.; Jun, S. Y.; Paulini, M.; Russ, J.; Tiwari, V.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA; [Adelman, J.; Brubaker, E.; Fedorko, W. T.; Grosso-Pilcher, C.; Kim, Y. K.; Kwang, S.; Levy, S.; Paramonov, A. A.; Schmidt, M. A.; Shochet, M.; Wolfe, C.; Yang, U. K.; Yorita, K.] Univ Chicago, Enrico Fermi Inst, Chicago, IL 60637 USA; [Antos, J.; Bednar, P.; Lovas, L.; Lysak, R.; Tokar, S.] Comenius Univ, Bratislava 84248, Slovakia; [Antos, J.; Bednar, P.; Lovas, L.; Lysak, R.; Tokar, S.] Inst Expt Phys, Kosice 04001, Slovakia; [Artikov, A.; Budagov, J.; Chokheli, D.; Giokaris, N.; Glagolev, V.; Manousakis, A.; Poukhov, O.; Prakoshyn, F.; Semenov, A.; Sisakyan, A.; Suslov, I.] Joint Inst Nucl Res, RU-141980 Dubna, Russia; [Benjamin, D.; Bocci, A.; Cabrera, S.; Deng, J.; Goshaw, A. T.; Hidas, D.; Jayatilaka, B.; Ko, B. R.; Kotwal, A. V.; Kruse, M.; Necula, V.; Oh, S. H.; Phillips, T. J.] Duke Univ, Durham, NC 27708 USA; [Albrow, M. G.; Apollinari, G.; Ashmanskas, W.; Badgett, W.; Beretvas, A.; Binkley, M.; Burkett, K.; Canelli, F.; Casarsa, M.; Chlachidze, G.; Chlebana, F.; Convery, M. E.; Culbertson, R.; Dagenhart, D.; Datta, M.; Derwent, P. F.; Eusebi, R.; Genser, K.; Ginsburg, C. M.; Glenzinski, D.; Golossanov, A.; Group, R. C.; Hahn, S. R.; Harris, R. M.; Hocker, A.; James, E.; Kephart, R.; Kim, M. J.; Lammel, S.; Lewis, J. D.; Lindgren, M.; Litvintsev, D. O.; Liu, T.; Lukens, P.; Madrak, R.; Maeshima, K.; Miao, T.; Moore, R.; Mukherjee, A.; Murat, P.; Nachtman, J.; Palencia, E.; Papadimitriou, V.; Patrick, J.; Pronko, A.; Ptohos, F.; Reisert, B.; Roser, R.; Rusu, V.; Sato, K.; Schlabach, P.; Schmidt, E. E.; Sexton-Kennedy, L.; Slaughter, A. J.; Snider, F. D.; Spalding, J.; Thom, J.; Tkaczyk, S.; Tonelli, D.; Torretta, D.; Velev, G.; Vidal, R.; Wagner, R. L.; Wester, W. C., III; Wicklund, E.; Wilson, P.; Wittich, P.; Wolbers, S.; Yeh, G. P.; Yoh, J.; Yu, S. S.; Yun, J. C.] Fermilab Natl Accelerator Lab, Batavia, IL 60510 USA; [Carrillo, S.; Field, R.; Furic, I.; Goldschmidt, N.; Jindariani, S.; Kar, D.; Klimenko, S.; Konigsberg, J.; Korytov, A.; Lungu, G.; Mitselmakher, G.; Oksuzian, I.; Pinera, L.; Sukhanov, A.] Univ Florida, Gainesville, FL 32611 USA; [Annovi, A.; Cordelli, M.; Giromini, P.; Happacher, F.; Torre, S.] Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy; [Clark, A.; Hamilton, A.; Lefevre, R.; Sfyria, A.; Shreyber, I.; Vallecorsa, S.; Wu, X.] Univ Geneva, CH-1211 Geneva, Switzerland; [Bussey, P.; Davies, T.; Martin, V.; Robson, A.; Denis, R. St.; Thompson, A. S.] Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland; [Belloni, A.; Chou, J. P.; Franklin, M.; Grinstein, S.; da Costa, J. Guimaraes; Mills, C.; Moed, S.; Sherman, D.; Zaw, I.] Harvard Univ, Cambridge, MA 02138 USA; [Aoki, M.; Bridgeman, A.; Budd, S.; Ciobanu, C. I.; Errede, D.; Errede, S.; Gerberich, H.; Grundler, U.; Junk, T. R.; Kraus, J.; Marino, C. P.; Neubauer, M. S.; Norniella, O.; Pitts, K.; Rogers, E.; Taffard, A.; Thompson, G. A.; Zhang, X.] Univ Illinois, Urbana, IL 61801 USA; [Barnett, B. A.; Behari, S.; Blumenfeld, B.; Maksimovic, P.; Martin, M.; Mumford, R.] Johns Hopkins Univ, Baltimore, MD 21218 USA; [Feindt, M.; Heck, M.; Heuser, J.; Hirschbuehl, D.; Kerzel, U.; Kreps, M.; Kuhr, T.; Lueck, J.; Mack, P.; Marino, C.; Milnik, M.; Muller, Th.; Papaikonomou, A.; Richter, S.; Scheidle, T.; Wagner-Kuhr, J.; Wagner, W.] Univ Karlsruhe, Inst Expt Kernphys, D-76128 Karlsruhe, Germany; [Chang, S. H.; Cho, K.; Jeon, E. J.; Joo, K. K.; Jung, J. E.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, S. B.; Kong, D. J.; Lee, J.; Lee, Y. J.; Moon, C. S.; Oh, Y. D.; Suh, J. S.; Yang, Y. C.; Yu, I.] Kyungpook Natl Univ, Ctr High Energy Phys, Taegu 702701, South Korea; [Chang, S. H.; Cho, K.; Jeon, E. J.; Joo, K. K.; Jung, J. E.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, S. B.; Kong, D. J.; Lee, J.; Lee, Y. J.; Moon, C. S.; Oh, Y. D.; Suh, J. S.; Yang, Y. C.; Yu, I.] Seoul Natl Univ, Seoul 151742, South Korea; [Chang, S. H.; Cho, K.; Jeon, E. J.; Joo, K. K.; Jung, J. E.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, S. B.; Kong, D. J.; Lee, J.; Lee, Y. J.; Moon, C. S.; Oh, Y. D.; Suh, J. S.; Yang, Y. C.; Yu, I.] Sungkyunkwan Univ, Suwon 440746, South Korea; [Chang, S. H.; Cho, K.; Jeon, E. J.; Joo, K. K.; Jung, J. E.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, S. B.; Kong, D. J.; Lee, J.; Lee, Y. J.; Moon, C. S.; Oh, Y. D.; Suh, J. S.; Yang, Y. C.; Yu, I.] Korea Inst Sci & Technol Informat, Taejon 305806, South Korea; [Chang, S. H.; Cho, K.; Jeon, E. J.; Joo, K. K.; Jung, J. E.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, S. B.; Kong, D. J.; Lee, J.; Lee, Y. J.; Moon, C. S.; Oh, Y. D.; Suh, J. S.; Yang, Y. C.; Yu, I.] Chonnam Natl Univ, Kwangju 500757, South Korea; [Barbaro-Galtieri, A.; Beringer, J.; Cerri, A.; Deisher, A.; Fang, H. C.; Freeman, J. C.; Haber, C.; Heinemann, B.; Lin, C. S.; Lujan, P.; Lys, J.; Fernandez, P. Movilla; Mulmenstadt, J.; Nielsen, J.; Shapiro, M. D.; Volobouev, I.; Yao, W. M.] Ernest Orlando Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA; [Berry, T.; Farrington, S.; Houlden, M.; Manca, G.; McNulty, R.; Mehta, A.; Oldeman, R.; Shears, T.; Wynne, S. M.] Univ Liverpool, Liverpool L69 7ZE, Merseyside, England; [Bartsch, V.; Bizjak, I.; Cerrito, L.; Cooper, B.; Lancaster, M.; Malik, S.; Nurse, E.; Vine, T.; Waters, D.] UCL, London WC1E 6BT, England; [Fernandez, J. P.; Gonzalez, O.; Martinez-Ballarin, R.; Redondo, I.; Vidal, M.] Ctr Invest Energet Medioambientales & Tecnol, E-28040 Madrid, Spain; [Bauer, G.; Bolshov, A.; Choudalakis, G.; Gomez-Ceballos, G.; Hahn, K.; Henderson, C.; Iyutin, B.; Klute, M.; Knuteson, B.; Leonardo, N.; Makhoul, K.; Miles, J.; Paus, C.] MIT, Cambridge, MA 02139 USA; [Beauchemin, P. -H.; Buzatu, A.; Carron, S.; Lai, S.; MacQueen, D.; Pashapour, S.; Roy, P.; Sinervo, P.; Snihur, R.; Spreitzer, T.; Trischuk, W.; Warburton, A.; Williams, G.] McGill Univ, Inst Particle Phys, Montreal, PQ H3A 2T8, Canada; [Beauchemin, P. -H.; Buzatu, A.; Carron, S.; Lai, S.; MacQueen, D.; Pashapour, S.; Roy, P.; Sinervo, P.; Snihur, R.; Spreitzer, T.; Trischuk, W.; Warburton, A.; Williams, G.] Univ Toronto, Toronto, ON M5S 1A7, Canada; [Amidei, D.; Campbell, M.; Copic, K.; Cully, J. C.; Gerdes, D.; Soderberg, M.; Tecchio, M.; Varganov, A.; Wright, T.] Univ Michigan, Ann Arbor, MI 48109 USA; [Bromberg, C.; Campanelli, M.; Gunay-Unalan, Z.; Huston, J.; Messina, A.; Miller, R.; Sorin, V.; Tollefson, K.] Michigan State Univ, E Lansing, MI 48824 USA; [Gold, M.; Gorelov, I.; Rekovic, V.; Seidel, S.; Strologas, J.; Vataga, E.; Vogel, M.] Univ New Mexico, Albuquerque, NM 87131 USA; [Schmitt, M.; Stentz, D.] Northwestern Univ, Evanston, IL 60208 USA; [Efron, J.; Hughes, R. E.; Kilminster, B.; Lannon, K.; Parks, B.; Slaunwhite, J.; Winer, B. L.] Ohio State Univ, Columbus, OH 43210 USA; [Nakano, I.; Takashima, R.; Tanaka, R.; Yamashita, T.] Okayama Univ, Okayama 7008530, Japan; [Kato, Y.; Okusawa, T.; Seiya, Y.; Wakisaka, T.; Yamamoto, K.; Yoshida, T.] Osaka City Univ, Osaka 588, Japan; [Azfar, F.; Harper, S.; Hays, C.; Huffman, B. T.; Linacre, J.; Lyons, L.; Malde, S.; Pounder, N.; Rademacker, J.; Renton, P.; Stelzer-Chilton, O.] Univ Oxford, Oxford OX1 3RH, England; [Amerio, S.; Azzi-Bacchetta, P.; Bacchetta, N.; Bisello, D.; Busetto, G.; Compostella, G.; Cortiana, G.; Donini, J.; Dorigo, T.; Gresele, A.; Lazzizzera, I.; Loreti, M.; Lucchesi, D.; Griso, S. Pagan] Univ Padua, Ist Nazl Fis Nucl, Sez Padova Trento, I-35131 Padua, Italy; [Di Giovanni, G. P.; Piedra, J.; Savoy-Navarro, A.] Univ Paris 06, CNRS, IN2P3, LPNHE,UMR7585, F-75252 Paris, France; [Canepa, A.; Heijboer, A.; Heinrich, J.; Kroll, J.; Lockyer, N. S.; Neu, C.; Thomson, E.; Tu, Y.; Wagner, P.; Whiteson, D.; Williams, H. H.] Univ Penn, Philadelphia, PA 19104 USA; [Azzurri, P.; Bedeschi, F.; Bellettini, G.; Carosi, R.; Catastini, P.; Chiarelli, G.; Ciocci, M. A.; Crescioli, F.; Dell'Orso, M.; Donati, S.; Ferrazza, C.; Garcia, J. E.; Giakoumopolou, V.; Giannetti, P.; Giunta, M.; Introzzi, G.; Lami, S.; Latino, G.; Leone, S.; Menzione, A.; Morello, M.; Pagliarone, C.; Piacentino, G.; Punzi, G.; Ristori, L.; Sartori, L.; Scribano, A.; Scuri, F.; Sidoti, A.; Spinella, F.; Squillacioti, P.; Turini, N.; Vellidis, C.; Volpi, G.] Univ Pisa, Ist Nazl Fis Nucl Pisa, Siena, Italy; [Azzurri, P.; Bedeschi, F.; Bellettini, G.; Carosi, R.; Catastini, P.; Chiarelli, G.; Ciocci, M. A.; Crescioli, F.; Dell'Orso, M.; Donati, S.; Ferrazza, C.; Garcia, J. E.; Giakoumopolou, V.; Giannetti, P.; Giunta, M.; Introzzi, G.; Lami, S.; Latino, G.; Leone, S.; Menzione, A.; Morello, M.; Pagliarone, C.; Piacentino, G.; Punzi, G.; Ristori, L.; Sartori, L.; Scribano, A.; Scuri, F.; Sidoti, A.; Spinella, F.; Squillacioti, P.; Turini, N.; Vellidis, C.; Volpi, G.] Scuola Normale Super Pisa, I-56127 Pisa, Italy; [Boudreau, J.; Gibson, K.; Hartz, M.; Rahaman, A.; Shepard, P. F.] Univ Pittsburgh, Pittsburgh, PA 15260 USA; [Apresyan, A.; Barnes, V. E.; Bolla, G.; Bortoletto, D.; Flanagan, G.; Garfinkel, A. F.; Jones, M.; Laasanen, A. T.; Lytken, E.; Margaroli, F.; Merkel, P.; Ranjan, N.; Sedov, A.; Veszpremi, V.] Purdue Univ, W Lafayette, IN 47907 USA; [Bodek, A.; Boisvert, V.; Budd, H. S.; Chung, Y. S.; de Barbaro, P.; De Lentdecker, G.; Gimmell, J. L.; Han, B. -Y.; Han, J. Y.; Lee, J.; McFarland, K. S.; Sakumoto, W. K.; Yu, G. B.] Univ Rochester, Rochester, NY 14627 USA; [Bhatti, A.; Demortier, L.; Gallinaro, M.; Goulianos, K.; Hatakeyama, K.; Mesropian, C.; Terashi, K.] Rockefeller Univ, New York, NY 10021 USA; [De Cecco, S.; De Pedis, D.; Dionisi, C.; Giagu, S.; Iori, M.; Jeans, D.; Luci, C.; Mastrandrea, P.; Rescigno, M.; Salamanna, G.; Sarkar, S.; Zanello, L.] Univ Roma La Sapienza, Ist Nazl Fis Nucl, Sez Roma 1, I-00185 Rome, Italy; [Anastassov, A.; Chuang, S. H.; Dube, S.; Halkiadakis, E.; Hare, D.; Lath, A.; Somalwar, S.; Yamaoka, J.] Rutgers State Univ, Piscataway, NJ 08855 USA; [Aurisano, A.; Goncharov, M.; Kamon, T.; Khotilovich, V.; Lee, S. W.; McIntyre, P.; Safonov, A.; Toback, D.] Texas A&M Univ, College Stn, TX 77843 USA; [Cauz, D.; Di Ruzza, B.; Giordani, M.; Pauletta, G.; Penzo, A.; Rossi, M.; Santi, L.; Zanetti, A.] Univ Trieste Udine, Ist Nazl Fis Nucl, Udine, Italy; [Akimoto, T.; Hara, K.; Kim, S. H.; Kimura, N.; Kubo, T.; Maruyama, T.; Masubuchi, T.; Miyake, H.; Nagai, Y.; Nagano, A.; Nakamura, K.; Shimojima, M.; Suzuki, T.; Takeuchi, Y.; Tomura, T.; Ukegawa, F.; Uozumi, S.] Univ Tsukuba, Tsukuba, Ibaraki 305, Japan; [Hare, M.; Napier, A.; Rolli, S.; Sliwa, K.; Sun, H.; Whitehouse, B.] Tufts Univ, Medford, MA 02155 USA; [Arisawa, T.; Kondo, K.; Kusakabe, Y.; Naganoma, J.] Waseda Univ, Tokyo 169, Japan; [Harr, R. F.; Karchin, P. E.; Kulkarni, N. P.; Mattson, M. E.; Shalhout, S. Z.] Wayne State Univ, Detroit, MI 48201 USA; [Bellinger, J.; Carlsmith, D.; Chung, W. H.; Handler, R.; Herndon, M.; Pondrom, L.; Pursley, J.; Ramakrishnan, V.; Shon, Y.] Univ Wisconsin, Madison, WI 53706 USA; [Feild, R. G.; Husemann, U.; Lin, C.; Loginov, A.; Martin, A.; Schmidt, M. P.; Stanitzki, M.; Tipton, P.; Yang, C.] Yale Univ, New Haven, CT 06520 USA Aaltonen, T (reprint author), Univ Helsinki, Dept Phys, Div High Energy Phys, FIN-00014 Helsinki, Finland. Ruiz, Alberto/E-4473-2011; Robson, Aidan/G-1087-2011; De Cecco, Sandro/B-1016-2012; Azzi, Patrizia/H-5404-2012; manca, giulia/I-9264-2012; Amerio, Silvia/J-4605-2012; Punzi, Giovanni/J-4947-2012; messina, andrea/C-2753-2013; Annovi, Alberto/G-6028-2012; Ivanov, Andrew/A-7982-2013; St.Denis, Richard/C-8997-2012; Warburton, Andreas/N-8028-2013 Ruiz, Alberto/0000-0002-3639-0368; Annovi, Alberto/0000-0002-4649-4398; Ivanov, Andrew/0000-0002-9270-5643; Warburton, Andreas/0000-0002-2298-7315 19 52 52 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 0031-9007 PHYS REV LETT Phys. Rev. Lett. 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Vasseur, G; Yeche, C; Zito, M; Purohit, MV; Weidemann, W; Wilson, JR; Yumiceva, FX; Abe, T; Allen, MT; Aston, D; Bartoldus, R; Berger, N; Boyarski, AM; Buchmueller, OL; Claus, R; Convery, MR; Cristinziani, M; Dingfelder, JC; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W; Fan, S; Field, RC; Glanzman, T; Gowdy, SJ; Hadig, T; Halyo, V; Hast, C; Hryn'ova, T; Innes, WR; Kelsey, MH; Kim, P; Kocian, ML; Leith, DWGS; Libby, J; Luitz, S; Luth, V; Lynch, HL; Marsiske, H; Messner, R; Muller, DR; O'Grady, CP; Ozcan, VE; Perazzo, A; Perl, M; Ratcliff, BN; Roodman, A; Salnikov, AA; Schindler, RH; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, MK; Suzuki, K; Swain, S; Thompson, JM; Va'vra, J; Weaver, M; Weinstein, AJR; Wisniewski, WJ; Wittgen, M; Wright, DH; Yarritu, AK; Yi, K; Young, CC; Burchat, PR; Edwards, AJ; Majewski, SA; Petersen, BA; Roat, C; Ahmed, M; Ahmed, S; Alam, MS; Ernst, JA; Saeed, MA; Wappler, FR; Zain, SB; Bugg, W; Krishnamurthy, M; Spanier, SM; Eckmann, R; Ritchie, JL; Satpathy, A; 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P.; Poireau, V.; Tisserand, V.; Zghiche, A.; Grauges, E.; Palano, A.; Pappagallo, M.; Pompili, A.; Chen, J. C.; Qi, N. D.; Rong, G.; Wang, P.; Zhu, Y. S.; Eigen, G.; Ofte, I.; Stugu, B.; Abrams, G. S.; Battaglia, M.; Breon, A. B.; Brown, D. N.; Button-Shafer, J.; Cahn, R. N.; Charles, E.; Day, C. T.; Gill, M. S.; Gritsan, A. V.; Groysman, Y.; Jacobsen, R. G.; Kadel, R. W.; Kadyk, J.; Kerth, L. T.; Kolomensky, Yu. G.; Kukartsev, G.; Lynch, G.; Mir, L. M.; Oddone, P. J.; Orimoto, T. J.; Pripstein, M.; Roe, N. A.; Ronan, M. T.; Wenzel, W. A.; Barrett, M.; Ford, K. E.; Harrison, T. J.; Hart, A. J.; Hawkes, C. M.; Morgan, S. E.; Watson, A. T.; Fritsch, M.; Goetzen, K.; Held, T.; Koch, H.; Lewandowski, B.; Pelizaeus, M.; Peters, K.; Schroeder, T.; Steinke, M.; Boyd, J. T.; Burke, J. P.; Chevalier, N.; Cottingham, W. N.; Kelly, M. P.; Cuhadar-Donszelmann, T.; Fulsom, B. G.; Hearty, C.; Knecht, N. S.; Mattison, T. S.; McKenna, J. A.; Khan, A.; Kyberd, P.; Saleem, M.; Teodorescu, L.; Blinov, A. E.; Blinov, V. E.; Bukin, A. D.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Yushkov, A. N.; Best, D.; Bondioli, M.; Bruinsma, M.; Chao, M.; Eschrich, I.; Kirkby, D.; Lankford, A. J.; Mandelkern, M.; Mommsen, R. K.; Roethel, W.; Stoker, D. P.; Buchanan, C.; Hartfiel, B. L.; Foulkes, S. D.; Gary, J. W.; Long, O.; Shen, B. C.; Wang, K.; Zhang, L.; Del Re, D.; Hadavand, H. K.; Hill, E. J.; Macfarlane, D. B.; Paar, H. P.; Rahatlou, S.; Sharma, V.; Berryhill, J. W.; Campagnari, C.; Cunha, A.; Dahmes, B.; Hong, T. M.; Mazur, M. A.; Richman, J. D.; Verkerke, W.; Beck, T. W.; Eisner, A. M.; Flacco, C. J.; Heusch, C. A.; Kroseberg, J.; Lockman, W. S.; Nesom, G.; Schalk, T.; Schumm, B. A.; Seiden, A.; Spradlin, P.; Williams, D. C.; Wilson, M. G.; Albert, J.; Chen, E.; Dubois-Felsmann, G. P.; Dvoretskii, A.; Hitlin, D. 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E.; Yi, J.; Arnaud, N.; Davier, M.; Giroux, X.; Grosdidier, G.; Hocker, A.; Le Diberder, F.; Lepeltier, V.; Lutz, A. M.; Oyanguren, A.; Petersen, T. C.; Pierini, M.; Plaszcynski, S.; Rodier, S.; Roudeau, P.; Schune, M. H.; Stocchi, A.; Wormser, G.; Cheng, C. H.; Lange, D. J.; Simani, M. C.; Wright, D. M.; Bevan, A. J.; Chavez, C. A.; Coleman, J. P.; Forster, I. J.; Fry, J. R.; Gabathuler, E.; Gamet, R.; George, K. A.; Hutchcroft, D. E.; Parry, R. J.; Payne, D. J.; Schofield, K. C.; Touramanis, C.; Cormack, C. M.; Di Lodovico, F.; Sacco, R.; Brown, C. L.; Cowan, G.; Flaecher, H. U.; Green, M. G.; Hopkins, D. A.; Jackson, P. S.; McMahon, T. R.; Ricciardi, S.; Salvatore, F.; Brown, D.; Davis, C. L.; Allison, J.; Barlow, N. R.; Barlow, R. J.; Hodgkinson, M. C.; Lafferty, G. D.; Naisbit, M. T.; Williams, J. C.; Chen, C.; Farbin, A.; Hulsbergen, W. D.; Jawahery, A.; Kovalskyi, D.; Lae, C. K.; Lillard, V.; Roberts, D. A.; Simi, G.; Blaylock, G.; Dallapiccola, C.; Hertzbach, S. S.; Kofler, R.; Koptchev, V. B.; Li, X.; Moore, T. B.; Saremi, S.; Staengle, H.; Willocq, S.; Cowan, R.; Koeneke, K.; Sciolla, G.; Sekula, S. J.; Spitznagel, M.; Taylor, F.; Yamamoto, R. K.; Kim, H.; Patel, P. M.; Robertson, S. H.; Lazzaro, A.; Lombardo, V.; Palombo, F.; Bauer, J. M.; Cremaldi, L.; Eschenburg, V.; Godang, R.; Kroeger, R.; Reidy, J.; Sanders, D. A.; Summers, D. J.; Zhao, H. W.; Brunet, S.; Cote, D.; Taras, P.; Viaud, B.; Nicholson, H.; Cavallo, N.; De Nardo, G.; Fabozzi, F.; Gatto, C.; Lista, L.; Monorchio, D.; Paolucci, P.; Piccolo, D.; Sciacca, C.; Baak, M.; Bulten, H.; Raven, G.; Snoek, H. L.; Wilden, L.; Jessop, C. P.; LoSecco, J. M.; Allmendinger, T.; Benelli, G.; Gan, K. K.; Honscheid, K.; Hufnagel, D.; Jackson, P. D.; Kagan, H.; Kass, R.; Pulliam, T.; Rahimi, A. M.; Ter-Antonyan, R.; Wong, Q. K.; Brau, J.; Frey, R.; Igonkina, O.; Lu, M.; Potter, C. T.; Sinev, N. B.; Strom, D.; Strube, J.; Torrence, E.; Dorigo, A.; Galeazzi, F.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Voci, C.; Benayoun, M.; Briand, H.; Chauveau, J.; David, P.; Del Buono, L.; De la Vaissiere, Ch.; Hamon, O.; John, M. J. J.; Leruste, Ph.; Malcles, J.; Ocariz, J.; Roos, L.; Therin, G.; Behera, P. K.; Gladney, L.; Guo, Q. H.; Panetta, J.; Biasini, M.; Covarelli, R.; Pacetti, S.; Pioppi, M.; Angelini, C.; Batignani, G.; Bettarini, S.; Bucci, F.; Calderini, G.; Carpinelli, M.; Cenci, R.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Morganti, M.; Neri, N.; Paoloni, E.; Rama, M.; Rizzo, G.; Walsh, J.; Haire, M.; Judd, D.; Wagoner, D. E.; Biesiada, J.; Danielson, N.; Elmer, P.; Lau, Y. P.; Lu, C.; Olsen, J.; Smith, A. J. S.; Telnov, A. V.; Bellini, F.; Cavoto, G.; D'Orazio, A.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Gioi, L. Li; Mazzoni, M. A.; Morganti, S.; Piredda, G.; Polci, F.; Tehrani, F. Safai; Voena, C.; Schroder, H.; Wagner, G.; Waldi, R.; Adye, T.; De Groot, N.; Franek, B.; Gopal, G. P.; Olaiya, E. O.; Wilson, F. F.; Aleksan, R.; Emery, S.; Gaidot, A.; Ganzhur, S. F.; Giraud, P. -F.; Graziani, G.; de Monchenault, G. Hamel; Kozanecki, W.; Legendre, M.; London, G. W.; Mayer, B.; Vasseur, G.; Yeche, Ch.; Zito, M.; Purohit, M. V.; Weidemann, W.; Wilson, J. R.; Yumiceva, F. X.; Abe, T.; Allen, M. T.; Aston, D.; Bartoldus, R.; Berger, N.; Boyarski, A. M.; Buchmueller, O. L.; Claus, R.; Convery, M. R.; Cristinziani, M.; Dingfelder, J. C.; Dong, D.; Dorfan, J.; Dujmic, D.; Dunwoodie, W.; Fan, S.; Field, R. C.; Glanzman, T.; Gowdy, S. J.; Hadig, T.; Halyo, V.; Hast, C.; Hryn'ova, T.; Innes, W. R.; Kelsey, M. H.; Kim, P.; Kocian, M. L.; Leith, D. W. G. S.; Libby, J.; Luitz, S.; Luth, V.; Lynch, H. L.; Marsiske, H.; Messner, R.; Muller, D. R.; O'Grady, C. P.; Ozcan, V. E.; Perazzo, A.; Perl, M.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Schwiening, J.; Snyder, A.; Stelzer, J.; Su, D.; Sullivan, M. K.; Suzuki, K.; Swain, S.; Thompson, J. M.; Va'vra, J.; Weaver, M.; Weinstein, A. J. R.; Wisniewski, W. J.; Wittgen, M.; Wright, D. H.; Yarritu, A. K.; Yi, K.; Young, C. C.; Burchat, P. R.; Edwards, A. J.; Majewski, S. A.; Petersen, B. A.; Roat, C.; Ahmed, M.; Ahmed, S.; Alam, M. S.; Ernst, J. A.; Saeed, M. A.; Wappler, F. R.; Zain, S. B.; Bugg, W.; Krishnamurthy, M.; Spanier, S. M.; Eckmann, R.; Ritchie, J. L.; Satpathy, A.; Schwitters, R. F.; Izen, J. M.; Kitayama, I.; Lou, X. C.; Ye, S.; Bianchi, F.; Bona, M.; Gallo, F.; Gamba, D.; Bomben, M.; Bosisio, L.; Cartaro, C.; Cossutti, F.; Della Ricca, G.; Dittongo, S.; Grancagnolo, S.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Pavini, R. S.; Banerjee, Sw.; Bhuyan, B.; Brown, C. M.; Fortin, D.; Hamano, K.; Kowalewski, R.; Roney, J. M.; Sobie, R. J.; Back, J. J.; Harrison, P. F.; Latham, T. E.; Mohanty, G. B.; Band, H. R.; Chen, X.; Cheng, B.; Dasu, S.; Datta, M.; Eichenbaum, A. M.; Flood, K. T.; Hollar, J. J.; Johnson, J. R.; Kutter, P. E.; Li, H.; Liu, R.; Mellado, B.; Mihalyi, A.; Pan, Y.; Prepost, R.; Tan, P.; von Wimmersperg-Toeller, J. H.; Wu, S. L.; Yu, Z.; Neal, H. Measurement of branching fractions and mass spectra of B -> K pi pi gamma (vol 98, art no 211804, 2007) PHYSICAL REVIEW LETTERS English Correction Peters, Klaus/C-2728-2008; de Groot, Nicolo/A-2675-2009; Patrignani, Claudia/C-5223-2009; Lista, Luca/C-5719-2008; Bellini, Fabio/D-1055-2009; Roe, Natalie/A-8798-2012; Neri, Nicola/G-3991-2012; Forti, Francesco/H-3035-2011; Rotondo, Marcello/I-6043-2012; de Sangro, Riccardo/J-2901-2012; Lo Vetere, Maurizio/J-5049-2012; Monge, Maria Roberta/G-9127-2012; Saeed, Mohammad/J-7455-2012; Della Ricca, Giuseppe/B-6826-2013; Cavallo, Nicola/F-8913-2012 Peters, Klaus/0000-0001-7133-0662; Patrignani, Claudia/0000-0002-5882-1747; Forti, Francesco/0000-0001-6535-7965; de Sangro, Riccardo/0000-0002-3808-5455; Lo Vetere, Maurizio/0000-0002-6520-4480; Monge, Maria Roberta/0000-0003-1633-3195; Saeed, Mohammad/0000-0002-3529-9255; Della Ricca, Giuseppe/0000-0003-2831-6982; 1 1 1 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 0031-9007 PHYS REV LETT Phys. Rev. Lett. MAY 9 2008 100 18 189903 10.1103/PhysRevLett.100.189903 2 Physics, Multidisciplinary Physics 299QZ WOS:000255771400078 J Bonaccorsi, I; Altieri, F; Sciamanna, I; Oricchio, E; Grillo, C; Contartese, G; Galati, EM Bonaccorsi, Irene; Altieri, Fabio; Sciamanna, Ilaria; Oricchio, Elisa; Grillo, Caterina; Contartese, Giuseppe; Galati, Enza Maria Endogenous reverse transcriptase as a mediator of ursolic acid's anti-proliferative and differentiating effects in human cancer cell lines CANCER LETTERS English Article ursolic acid; human tumor cell; reverse transcriptase; proliferation; differentiation EMBRYONAL CARCINOMA-CELLS; OLEANOLIC ACID; PROLIFERATION; THERAPY; APOPTOSIS; TRITERPENOIDS; INDUCTION; GROWTH; AGENTS; RNA Ursolic acid (UA) is a pentacyclic triterpenoid compound that is widely distributed in the plant kingdom and has a broad range of biological effects. Here, we examined the effects of UA on the proliferation and differentiation of human tumor cell lines from melanoma (A375), glioblastoma (U87) and thyroid anaplastic carcinoma (ARO), and on the proliferation of a non-transformed human fibroblast cell line (WI-38). The results show that UA inhibits tumor cell proliferation in a dose- and time-dependent manner. Consistent with this finding, UA treatment promotes differentiation of all of the analyzed tumor cell lines. Interestingly, we found that UA inhibits the endogenous reverse transcriptase (RT) activity in tumor cells, which has recently been shown to be involved in the control of proliferation and differentiation of neoplastic cells. Considering these findings, we suggest that the observed anti-proliferative and differentiating effects of UA may be related to this target. (C) 2008 Elsevier Ireland Ltd. All rights reserved. [Bonaccorsi, Irene; Contartese, Giuseppe; Galati, Enza Maria] Univ Messina, Sch Pharm, Pharmaco Biol Dept, I-98168 Messina, Italy; [Altieri, Fabio] Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, Rome, Italy; [Sciamanna, Ilaria; Oricchio, Elisa] Ist Super Sanita, I-00161 Rome, Italy Galati, EM (reprint author), Univ Messina, Sch Pharm, Pharmaco Biol Dept, I-98168 Messina, Italy. emgalati@unime.it Altieri, Fabio/D-2790-2009 31 18 22 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 0304-3835 CANCER LETT Cancer Lett. MAY 8 2008 263 1 130 139 10.1016/j.canlet.2007.12.026 10 Oncology Oncology 296VA WOS:000255572700015 J 't Hooft, G; Isidori, G; Maiani, L; Polosa, AD; Riquer, V 't Hooft, G.; Isidori, G.; Maiani, L.; Polosa, A. D.; Riquer, V. A theory of scalar mesons PHYSICS LETTERS B English Article CHIRAL PERTURBATION-THEORY; LARGE-N-C; PHENOMENOLOGICAL LAGRANGIANS; KLOE DETECTOR; PSEUDOPARTICLE; RESONANCES; F(0)(1500); BREAKING; GLUEBALL; LIGHT We discuss the effect of the instanton induced, six-fermion effective Lagrangian on the decays of the lightest scalar mesons in the diquark-antidiquark picture. This addition allows for a remarkably good description of light scalar meson decays. The same effective Lagrangian produces a mixing of the lightest scalars with the positive parity q (q) over bar states. Comparing with previous work where the q (q) over bar mesons are identified with the nonet at 1200-1700 MeV, we find that the mixing required to fit the mass spectrum is in good agreement with the instanton coupling obtained from light scalar decays. A coherent picture of scalar mesons as a mixture of tetraquark states (dominating in the lightest mesons) and heavy q (q) over bar states (dominating in the heavier mesons) emerges. (C) 2008 Published by Elsevier B.V. [Maiani, L.; Polosa, A. D.; Riquer, V.] Ist Nazl Fis Nucl, Sez Roma La Sapienza, I-00185 Rome, Italy; [Maiani, L.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Isidori, G.] Ist Nazl Fis Nucl, Nazl Frascati Lab, I-00044 Frascati, Italy; [Isidori, G.] Scuola Normale Super Pisa, I-56126 Pisa, Italy; ['t Hooft, G.] Univ Utrecht, Inst Theoret Phys, NL-3508 TA Utrecht, Netherlands; ['t Hooft, G.] Spinoza Inst, NL-3508 TA Utrecht, Netherlands Polosa, AD (reprint author), Ist Nazl Fis Nucl, Sez Roma La Sapienza, P A Moro 2, I-00185 Rome, Italy. antonio.polosa@cern.ch 48 75 75 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0370-2693 PHYS LETT B Phys. Lett. B MAY 8 2008 662 5 424 430 10.1016/j.physletb.2008.03.036 7 Physics, Multidisciplinary Physics 303MT WOS:000256045300006 J De Luca, G; Suryapranata, H; Stone, GW; Antoniucci, D; Biondi-Zoccai, G; Kastrati, A; Chiariello, M; Marino, P De Luca, Giuseppe; Suryapranata, Harry; Stone, Gregg W.; Antoniucci, David; Biondi-Zoccai, Giuseppe; Kastrati, Adnan; Chiariello, Massimo; Marino, Paolo Coronary stenting versus balloon angioplasty for acute myocardial infarction: A meta-regression analysis of randomized trials INTERNATIONAL JOURNAL OF CARDIOLOGY English Article primary angioplasty; stenting; myocardial infarction; meta-analysis ELUTING STENT; THROMBOLYTIC THERAPY; CARDIOGENIC-SHOCK; CLINICAL-TRIALS; UNCOATED STENTS; IMPLANTATION; METAANALYSIS; ABCIXIMAB; ARTERY; INTERVENTION Introduction: Although stenting has been shown to reduce the need for target vessel revascularization (TVR) in acute myocardial infarction ( AMI), the benefits in terms of mortality and reinfarction are still unclear. Previous meta-analyses have failed to include all currently available randomized trials. The aim of the current study was to perform an updated meta-analysis to evaluate the benefits of coronary stenting for AMI in terms of mortality, reinfarction, and TVR, and whether these benefits correlated with the patient's risk profile. Methods: The literature was scanned by formal searches of electronic databases (MEDLINE and CENTRAL) from January 1990 to September 2006. We examined all completed, published, randomized trials of coronary stenting for AMI. The following key words were used for study selection: randomized trial, myocardial infarction, reperfusion, primary angioplasty, rescue angioplasty, stenting, and balloon angioplasty. Information on study design, type of stent, inclusion and exclusion criteria, primary endpoint, number of patients, angiographic and clinical outcome, were extracted by two investigators. Disagreements were resolved by consensus. Results: A total of 13 randomized trials were identified and analyzed involving 6922 patients (3460 or 50% randomized to stent and 3462 or 50% to balloon). Stenting was not associated with a significant reduction in 30-day (2.9% versus 3.0%, p = 0.81) and 1-year mortality (5.1% versus 5.2%, p = 0.81), as compared to balloon angioplasty. However, a significant relationship was observed between patient's risk profile and mortality benefits from coronary stenting at 30-day (beta -0.63 [-25.4; -2.45], p = 0.022) and 1-year follow-up (beta -0.61 [-15.9; -0.76], p = 0.034). Stenting was associated with benefits in terms of TVR at both 30-day (3.1% versus 5.1%, p < 0.0001) and 6 to 12 months (11.3% versus 18.4%, p < 0.0001) follow-up, without any difference in terms of reinfarction. Conclusions: Among AMI patients undergoing primary angioplasty, coronary stent implantation, when anatomically and technically feasible, may be considered, in addition to benefits in terms of TVR, to reduce mortality in high-risk patients, who may be identified by the use of validated risk scores. (c) 2007 Elsevier Ireland Ltd. All rights reserved. [De Luca, Giuseppe; Marino, Paolo] Eastern Piedmont Univ, Maggiore Carita Hosp, Div Cardiol, I-24100 Bergamo, Italy; [Suryapranata, Harry] Hosp Weezenlanden, Isala Klinieken, Zwolle, Netherlands; [Stone, Gregg W.] Lenox Hill Heart & Vasc Inst, Cardiovasc Res Fdn, New York, NY USA; [Antoniucci, David] Careggi Hosp, Div Cardiol, Florence, Italy; [Biondi-Zoccai, Giuseppe] Univ Turin, Div Cardiol, I-10124 Turin, Italy; [Kastrati, Adnan] Tech Univ Munich, Med Klin Rechts Isar 1, Munich, Germany; [Kastrati, Adnan] Tech Univ Munich, Deutsches Herzzent, Munich, Germany; [Chiariello, Massimo] Univ Naples Federico 2, Div Cardiol, Naples, Italy De Luca, G (reprint author), Eastern Piedmont Univ, Maggiore Carita Hosp, Div Cardiol, C So Mazzini 18, I-24100 Bergamo, Italy. giuseppe.deluca@maggioreosp.novara.it 47 46 50 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 0167-5273 INT J CARDIOL Int. J. Cardiol. MAY 7 2008 126 1 37 44 10.1016/j.ijcard.2007.03.112 8 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 301VI WOS:000255923500007 J Gianturco, FA; Sebastianelli, F; Lucchese, RR; Baccarelli, I; Sanna, N Gianturco, Franco A.; Sebastianelli, F.; Lucchese, R. R.; Baccarelli, I.; Sanna, N. Ring-breaking electron attachment to uracil: Following bond dissociations via evolving resonances JOURNAL OF CHEMICAL PHYSICS English Article LOW-ENERGY ELECTRONS; DNA-STRAND BREAKS; GAS-PHASE; POLYATOMIC-MOLECULES; NEGATIVE-IONS; THYMINE; SCATTERING; BASES; CLEAVAGE; 5-BROMOURACIL Calculations are carried out at various distinct energies to obtain both elastic cross sections and S-matrix resonance indicators (poles) from a quantum treatment of the electron scattering from gas-phase uracil. The low-energy region confirms the presence of pi* resonances as revealed by earlier calculations and experiments which are compared with the present findings. They turn out to be little affected by bond deformation, while the transient negative ions (TNIs) associated with sigma* resonances in the higher energy region (similar to 8 eV) indeed show that ring deformations which allow vibrational redistribution of the excess electron energy into the molecular target strongly affect these shape resonances: They therefore evolve along different dissociative pathways and stabilize different fragment anions. The calculations further show that the occurrence of conical intersections between sigma* and pi*-type potential energy surfaces (real parts) is a very likely mechanism responsible for energy transfers between different TNIs. The excess electron wavefunctions for such scattering states, once mapped over the molecular space, provide nanoscopic reasons for the selective breaking of different bonds in the ring region. (C) 2008 American Institute of Physics. [Gianturco, Franco A.; Sebastianelli, F.] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy; [Lucchese, R. R.] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA; [Baccarelli, I.; Sanna, N.] Supercomp Consortium Univ & Res, CASPUR, I-00185 Rome, Italy Gianturco, FA (reprint author), Univ Roma La Sapienza, Dept Chem, Piazzale A Moro 5, I-00185 Rome, Italy. fa.gianturco@caspur.it 38 21 21 AMER INST PHYSICS MELVILLE CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA 0021-9606 J CHEM PHYS J. Chem. Phys. MAY 7 2008 128 17 174302 10.1063/1.2913169 8 Physics, Atomic, Molecular & Chemical Physics 306EZ WOS:000256232400016 J Angeloni, S; Leboffe, C; Parente, A; Venditti, M; Giordano, A; Merli, M; Riggio, O Angeloni, Stefania; Leboffe, Cinzia; Parente, Antonella; Venditti, Mario; Giordano, Alessandra; Merli, Manuela; Riggio, Oliviero Efficacy of current guidelines for the treatment of spontaneous bacterial peritonitis in the clinical practice WORLD JOURNAL OF GASTROENTEROLOGY English Article spontaneous bacterial peritonitis; cefotaxime; antibiotic-resistant pathogens; ascitic polymorphonuclear count; cirrhosis CIRRHOTIC-PATIENTS; PREDICTIVE FACTORS; ACQUIRED INFECTIONS; RENAL IMPAIRMENT; CEFOTAXIME; PROPHYLAXIS; EPIDEMIOLOGY; PROGNOSIS; MORTALITY; DIAGNOSIS AIM: To verify the validity of the International Ascites Club guidelines for treatment of spontaneous bacterial peritonitis (SBP) in clinical practice. METHODS: All SBP episodes occurring in a group of consecutive cirrhotics were managed accordingly and included in the study. SBP was diagnosed when the ascitic fluid polymorphonuclear (PMN) cell count was > 250 cells/mm(3), and empirically treated with cefotaxime. RESULTS: Thirty-eight SBP episodes occurred in 32 cirrhotics (22 men/10 women; mean age: 58.6 +/- 11.2 years). Prevalence of SBP, in our population, was 17%. Ascitic fluid culture was positive in nine (24%) cases only. Eleven episodes were nosocomial and 71% community-acquired. Treatment with cefotaxime was successful in 59% of cases, while 41% of episodes required a modification of the initial antibiotic therapy because of a less-than 25% decrease in ascitic PMN count at 48 h. Change of antibiotic therapy led to the resolution of infection in 87% of episodes. Among the cases with positive culture, the initial antibiotic therapy with cefotaxime failed at a percentage (44%) similar to that of the whole series. In these cases, the isolated organisms were either resistant or with an inherent insufficient susceptibility to cefotaxime. CONCLUSION: In clinical practice, ascitic PMN count is a valid tool for starting a prompt antibiotic treatment and evaluating its efficacy. The initial treatment with cefotaxime failed more frequently than expected. An increase in healthcare-related infections with anti biotic-resistant pathogens may explain this finding. A different first-line antibiotic treatment should be investigated. (C) 2008 WJG. All rights reserved. [Angeloni, Stefania; Leboffe, Cinzia; Parente, Antonella; Venditti, Mario; Merli, Manuela; Riggio, Oliviero] Univ Roma La Sapienza, Dept Clin Med, I-00185 Rome, Italy; [Giordano, Alessandra] Univ Roma La Sapienza, Dept Publ Hlth, I-00185 Rome, Italy Riggio, O (reprint author), Univ Roma La Sapienza, Dept Clin Med, Viale Del Univ 37, I-00185 Rome, Italy. oliviero.riggio@uniromal.it Merli, Manuela/D-2311-2010 37 27 34 W J G PRESS BEIJING APT 1066, YISHOU GARDEN, NO 58, NORTH LANGXINZHUANG RD, PO BOX 2345, BEIJING 100023, PEOPLES R CHINA 1007-9327 WORLD J GASTROENTERO World J. Gastroenterol. MAY 7 2008 14 17 2757 2762 10.3748/wjg.14.2757 6 Gastroenterology & Hepatology Gastroenterology & Hepatology 299ST WOS:000255776000016 J Queyranne, M; Tardella, F Queyranne, Maurice; Tardella, Fabio Sublattices of product spaces: Hulls, representations and counting DISCRETE MATHEMATICS English Article lattices; sublattice hull; sublattice representation; counting sublattices; sublattice hull membership LATTICES The Cartesian product of lattices is a lattice, called a product space, with componentwise meet and join operations. A sublattice of a lattice L is a subset closed for the join and meet operations of L. The sublattice hull LQ of a subset Q of a lattice is the smallest sublattice containing Q. We consider two types of representations of sublattices and sublattice hulls in product spaces: representation by projections and representation with proper boundary epigraphs. We give sufficient conditions, on the dimension of the product space and/or on the sublattice hull of a subset Q, for LQ to be entirely defined by the sublattice hulls of the two-dimensional projections of Q. This extends results of Topkis (1978) and of Veinott [Representation of general and polyhedral subsemilattices and sublattices of product spaces, Linear Algebra Appl. 114/115 (1989) 681-704]. We give similar sufficient conditions for the sublattice hull LQ to be representable using the epigraphs of certain isotone (i.e., nondecreasing) functions defined on the one-dimensional projections of Q. This also extends results of Topkis and Veinott. Using this representation we show that LQ is convex when Q is a convex subset in a vector lattice (Riesz space), and is a polyhedron when Q is a polyhedron in R-n. We consider in greater detail the case of a finite product of finite chains (i.e., totally ordered sets). We use the representation with proper boundary epigraphs and provide upper and lower bounds on the number of sublattices, giving a partial answer to a problem posed by Birkhoff in 1937. These bounds are close to each other in a logarithmic sense. We define a corner representation of isotone functions and use it in conjunction with the representation with proper boundary epigraphs to define an encoding of sublattices. We show that this encoding is optimal (up to a constant factor) in terms of memory space. We also consider the sublattice hull membership problem of deciding whether a given point is in the sublattice hull LQ of a given subset Q. We present a good characterization and a polynomial time algorithm for this sublattice hull membership problem. We construct in polynomial time a data structure for the representation with proper boundary epigraphs, such that sublattice hull membership queries may be answered in time logarithmic in the size vertical bar Q vertical bar of the given subset. (c) 2007 Elsevier B.V. All rights reserved. [Tardella, Fabio] Fac Econ & Commercio, Dipartimento Matemat, I-00161 Rome, Italy; [Queyranne, Maurice] Univ British Columbia, Sauder Sch Business, Vancouver, BC V5Z 1M9, Canada Tardella, F (reprint author), Fac Econ & Commercio, Dipartimento Matemat, Via Castro Laurenziano 9, I-00161 Rome, Italy. Maurice.Queyranne@sauder.ubc.ca; fabio.tardella@uniromal.it 18 0 0 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 0012-365X DISCRETE MATH Discret. Math. MAY 6 2008 308 9 1508 1523 10.1016/j.disc.2007.03.080 16 Mathematics Mathematics 277RJ WOS:000254232100003 J Donzello, MP; Viola, E; Cai, X; Mannina, L; Rizzoli, C; Ricciardi, G; Ercolani, C; Kadish, KM; Rosa, A Donzello, Maria Pia; Viola, Elisa; Cai, Xiaohui; Mannina, Luisa; Rizzoli, Corrado; Ricciardi, Giampaolo; Ercolani, Claudio; Kadish, Karl M.; Rosa, Angela Tetra-2,3-pyrazinoporphyrazines with externally appended pyridine rings. 5. Synthesis, physicochemical and theoretical studies of a novel pentanuclear palladium(II) complex and related mononuclear species INORGANIC CHEMISTRY English Article ELECTRON-DEFICIENT PROPERTIES; ANNULATED DIAZEPINE RINGS; CRYSTAL-STRUCTURE; DIIMINE LIGANDS; X-RAY; SPECTRAL CHARACTERIZATION; HYDROTHERMAL SYNTHESIS; POLYPYRIDYL LIGANDS; STATISTICAL AVERAGE; METAL-COMPLEXES New palladium(II) complexes of the free-base tetrakis[2,3-(5,6-di-2-pyridylpyrazino)porphyrazine], [Py(8)TPyzPzH(2)], have been prepared and their physicochemical properties examined. The investigated compounds are the pentanuclear species [(PdCl2)(4)Py(8)TPyzPzPd], the monopalladated complex [Py(8)TPyzPzPd], and its corresponding octaiodide salt [(2-Mepy)(8)TPyzPzPd)(I)(8). All three Pd-II complexes have a common central pyrazinoporphyrazine core and differ only at the periphery of the macrocycle, where the simple dipyridinopyrazine fragments present in [Py(8)TPyzPzPd] bear four PdCl2 units coordinated at the pyridine N atoms in the pentanuclear complex, [(PdCl2)(4)Py(8)TPyzPzPd), or carry pyridine-N(CH3)(+) moieties in the iodide of the octacation [(2-Mepy)(8)TPyzPzPd](8+). The structural features of the pentanuclear complex [(PdCl2)(4)Py(8)TPyzPzPd], partly supported by X-ray data and solution H-1 NMR spectra of the [(CN)(2)Py(2)PyzPdCl(2)] precursor, were elucidated through one- and two-dimensional H-1 NMR spectra in solution and density functional theory (DFT) calculations. Structural information on the monopalladated complex [Py(8)TPyzPzPd] was also obtained from DFT calculations. It was found that in the complex [(PdCl2)(4)Py(8)TPyzPzPd] the peripheral PdCl2 units adopt a py-py coordination mode and the generated N2PdCl2 moieties are directed nearly perpendicular to the plane of the pyrazinoporphyrazine ring, strictly recalling the arrangement found for the palladated precursor [(CN)(2)Py(2)PyzPdCl(2)]. NMR and DFT results consistently indicate that of the four structural isomers predictable for [(PdCl2)(4)Py(8)TPyzPzPd], one having all four N2PdCl2 moieties pointing on the same side of the macrocyclic framework (i.e., isomer 4:0, plus the 3:1 and the 2:2-cis and 2:2-trans isomers), the 4:0 isomer (C-4v symmetry) is the predominant form present. According to cyclic voltammetry and spectroelectrochemical results in pyridine, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF), the monopalladated complex [Py(8)TPyzPzPd] undergoes four reversible or quasi-reversible one-electron ligand-centered reductions, similar to the behavior also observed for the pentanuclear complex [(PdCl2)(4)Py(8)TPyzPzPd], which shows an additional reduction peak attributable to the presence of PdCl2, Owing to the electron-withdrawing properties of the PdCl2 units, the pentanuclear complex is easier to reduce than the mononuclear complex [Py(8)TPyzPzPd], some related [Py(8)TPyzPzM] complexes, and their porphyrin or porphyrazine analogues, so much so that the corresponding monoanion radical is generated at potentials close to 0.0 V vs SCE in DMSO or DMF In turn, the monoanion of [(2-Mepy)(8)TPyzPzPd](I)(8) is also extremely easy to generate electrochemically. Indeed, because of the eight positively charged N-CH3+ groups in this complex the first reduction occurs at potentials close to +0. 10 V in DMSO or DMF The redox behavior of the mono- and pentapalladated complexes has been rationalized on the basis of a detailed DFT analysis of their gound-state electronic structure. [Donzello, Maria Pia; Viola, Elisa; Ercolani, Claudio] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; [Cai, Xiaohui; Kadish, Karl M.] Univ Houston, Dept Chem, Houston, TX 77204 USA; [Mannina, Luisa] Univ Molise, Dipartimento STAAM, I-8610 Campobasso, Italy; [Mannina, Luisa] CNR, Ist Metodol Chim, I-00016 Monterotondo, Italy; [Rizzoli, Corrado] Univ Parma, Dipartimento Chim Gen & Inorgan, I-43100 Parma, Italy; [Ricciardi, Giampaolo; Rosa, Angela] Univ Basilicata, Dipartimento Chim, I-85100 Potenza, Italy Ercolani, C (reprint author), Univ Roma La Sapienza, Dipartimento Chim, Piazzale Aldo Moro 5, I-00185 Rome, Italy. claudio.ercolani@uniromal.it 48 20 20 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 0020-1669 INORG CHEM Inorg. Chem. MAY 5 2008 47 9 3903 3919 10.1021/ic702430j 17 Chemistry, Inorganic & Nuclear Chemistry 294CA WOS:000255380500056 J Ascenzi, P; Imperi, F; Coletta, M; Fasano, M Ascenzi, Paolo; Imperi, Francesco; Coletta, Massimo; Fasano, Mauro Abacavir and warfarin modulate allosterically kinetics of NO dissociation from ferrous nitrosylated human serum heme-albumin BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS English Article ferrous nitrosylated human serum heme-albumin; drug-dependent denitrosylation kinetics; abacavir; warfarin; allostery IRON PROTOPORPHYRIN-IX; ANTI-HIV DRUGS; NITRIC-OXIDE; BINDING-PROPERTIES; MYCOBACTERIUM-TUBERCULOSIS; O-2-MEDIATED OXIDATION; TRUNCATED HEMOGLOBIN; ENZYMATIC-PROPERTIES; MEDIATED OXIDATION; CRYSTAL-STRUCTURE Human serum albumin (HSA) participates to heme scavenging, in turn HSA-heme binds gaseous diatomic ligands at the heme-Fe-atom. Here, the effect of abacavir and warfarin on denitrosylation kinetics of HSA-heme Fe(II)-NO (i.e., k(off)) is reported. In the absence of drugs, the value of k(off) is (1.3 +/- 0.2) x 10(-4) s(-1). Abacavir and warfarin facilitate NO dissociation from HSA-heme-Fe(II)-NO, the k(off) value increases to (8.6 +/- 0.9) x 10(-4) s(-1). From the dependence of k(off) on the drug concentration, values of the dissociation equilibrium constant for the abacavir and warfarin binding to HSA-heme-Fe(II)-NO (i.e., K = (1.2 +/- 0.2) x 10(-3) M and (6.2 +/- 0.7) x 10(-5) M, respectively) were determined. The increase of koff values reflects the stabilization of the basic form of HSA-heme-Fe by ligands (e.g., abacavir and warfarin) that bind to Sudlow's site I. This event parallels the stabilization of the six-coordinate derivative of the HSA-heme-Fe(II)-NO atom. Present data highlight the allosteric modulation of HSA heme-Fe(II) reactivity by heterotropic effectors. (c) 2008 Elsevier Inc. All rights reserved. [Ascenzi, Paolo; Imperi, Francesco] Univ Roma Tre, Dept Biol, I-00146 Rome, Italy; [Ascenzi, Paolo; Imperi, Francesco] Univ Roma Tre, Interdept Lab Electron Microscopy, I-00146 Rome, Italy; [Ascenzi, Paolo; Imperi, Francesco] IRCCS Lazzaro Spallanzani, Natl Inst Infect Dis, I-00149 Rome, Italy; [Coletta, Massimo] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy; [Fasano, Mauro] Univ Insubria, Dept Struct & Funct Biol, I-21052 Busto Arsizio, VA, Italy; [Fasano, Mauro] Univ Insubria, Ctr Neurosci, I-21052 Busto Arsizio, VA, Italy Ascenzi, P (reprint author), Univ Roma Tre, Dept Biol, Viale Guglielmo Marconi 446, I-00146 Rome, Italy. ascenzi@uniroma3.it Fasano, Mauro/A-7100-2008 Fasano, Mauro/0000-0003-0628-5871 54 14 14 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 0006-291X BIOCHEM BIOPH RES CO Biochem. Biophys. Res. Commun. MAY 2 2008 369 2 686 691 10.1016/j.bbrc.2008.02.077 6 Biochemistry & Molecular Biology; Biophysics Biochemistry & Molecular Biology; Biophysics 284AF WOS:000254676900066 J Alba, V; Pelissetto, A; Vicari, E Alba, Vincenzo; Pelissetto, Andrea; Vicari, Ettore The uniformly frustrated two-dimensional XY model in the limit of weak frustration JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL English Article PHASE-TRANSITIONS; MAGNETIC-FIELD; MONTE-CARLO; DEGENERACY; NETWORKS; SYSTEMS We consider the two-dimensional uniformly frustrated XY model in the limit of small frustration, which is equivalent to an XY system, for instance a Josephson junction array in a weak uniform magnetic field applied along a direction orthogonal to the lattice. We show that the uniform frustration (equivalently, the magnetic field) destabilizes the line of fixed points which characterize the critical behavior of theXY model for T <= T(KT), where T(KT) is the Kosterlitz-Thouless transition temperature: the system is paramagnetic at any temperature for sufficiently small frustration. We predict the critical behavior of the correlation length and of gauge-invariant magnetic susceptibilities as the frustration goes to zero. These predictions are fully confirmed by the numerical simulations. [Alba, Vincenzo] Scuola Normale Super Pisa, I-56126 Pisa, Italy; [Alba, Vincenzo] Ist Nazl Fis Nucl, I-56126 Pisa, Italy; [Pelissetto, Andrea] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Pelissetto, Andrea] Ist Nazl Fis Nucl, Sez Roma 1, I-00185 Rome, Italy; [Vicari, Ettore] Univ Pisa, Dipartimento Fis, I-56127 Pisa, Italy; [Vicari, Ettore] Ist Nazl Fis Nucl, Sez Pisa, I-56127 Pisa, Italy Alba, V (reprint author), Scuola Normale Super Pisa, I-56126 Pisa, Italy. Andrea.Pelissetto@roma1.infn.it; Ettore.Vicari@df.unipi.it vicari, ettore/F-9452-2012; Alba, Vincenzo/L-5319-2013 22 2 2 IOP PUBLISHING LTD BRISTOL TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND 1751-8113 J PHYS A-MATH THEOR J. Phys. A-Math. Theor. MAY 2 2008 41 17 175001 10.1088/1751-8113/41/17/175001 11 Physics, Multidisciplinary; Physics, Mathematical Physics 298AY WOS:000255659800003 J Bovo, G; Diani, E; Bisuilib, F; Di Bonaventura, C; Striano, P; Gambardella, A; Ferlazzo, E; Egeo, G; Mecarelli, O; Elia, M; Bianchi, A; Bortoluzzi, S; Vettori, A; Aguglia, U; Binelli, S; Falco, A; Coppola, G; Gobbi, G; Sofia, V; Striano, S; Tinuper, P; Giallonardo, AT; Michelucci, R; Nobile, C Bovo, Giorgia; Diani, Erica; Bisuilib, Francesca; Di Bonaventura, Carlo; Striano, Pasquale; Gambardella, Antonio; Ferlazzo, Edoardo; Egeo, Gabriella; Mecarelli, Oriano; Elia, Maurizio; Bianchi, Amedeo; Bortoluzzi, Stefania; Vettori, Andrea; Aguglia, Umberto; Binelli, Simona; De Falco, Arturo; Coppola, Giangennaro; Gobbi, Giuseppe; Sofia, Vito; Striano, Salvatore; Tinuper, Paolo; Giallonardo, Anna T.; Michelucci, Roberto; Nobile, Carlo Analysis of LGI1 promoter sequence, PDYN and GABBR1 polymorphisms in sporadic and familial lateral temporal lobe epilepsy NEUROSCIENCE LETTERS English Article lateral temporal epilepsy; LGI1 promoter; prodynorphin gene; GABBR1; association study DOMINANT PARTIAL EPILEPSY; IDIOPATHIC PARTIAL EPILEPSY; AUDITORY FEATURES; LGI1/EPITEMPIN GENE; MUTATIONS; G1465A; 10Q24 Autosomal dominant lateral temporal epilepsy (ADTLE) is a genetically transmitted epileptic syndrome characterized by focal seizures with predominant auditory symptoms likely originating from the lateral region of the temporal lobe, Mutations in coding region or exon splice site, of the leucine-rich, glioma-inactivated 1 (LGI1) gene account for about 50% of ADLTE families. De novo LGI1 mutations of the same kind have also been found in about 2.5% of non-familial cases with idiopathic partial epilepsy with auditory features (IPEAF). In both conditions, mutations in the LGI1 promoter region have not been reported. We sequenced the minimal promoter region of LGI1 in the probands of 16 ADLTE families and in 104 sporadic IPEAF patients and no mutations clearly linked to the disease were found. However, two polymorphisims, -500G >A and -507G > A, with potential functional implications were identified and analysed in the cohort of sporadic IPEAF patients but their frequencies did not differ from those found in a control population of similar age, gender and geographic origin. We also analysed in Our study population the GABA(B) receptor 1 c. 1465G > A and the prodynorphin promoter 68-bp repeat polymorphisms, previously associated with temporal lobe epilepsy. None of these polymorphisms showed a significant association with IPEAF, whereas a tendency towards association with the prodynorphin low expression (L) alleles was found in the small group of ADLTE index cases, in agreement with previous studies suggesting that this polymorphism is a susceptibility factor in familial forms of temporal lobe epilepsy. (C) 2008 Elsevier Ireland Ltd. All rights reserved. [Bovo, Giorgia; Diani, Erica; Nobile, Carlo] Univ Padua, Dept Biomed Sci, CNR, Inst Neurosci,Sect Padua, I-35121 Padua, Italy; [Bisuilib, Francesca; Tinuper, Paolo] Univ Bologna, Dept Neurol Sci, Bologna, Italy; [Di Bonaventura, Carlo; Egeo, Gabriella; Mecarelli, Oriano; Giallonardo, Anna T.] Univ Roma La Sapienza, Dept Neurol Sci, Rome, Italy; [Striano, Pasquale] Univ Genoa, Inst G Gaslini, Muscular & Neurodegenerat Dis Unit, Genoa, Italy; [Striano, Pasquale; Striano, Salvatore] Univ Naples Federico 2, Dept Neurol Sci, Naples, Italy; [Gambardella, Antonio] Magna Graecia Univ Catanzaro, Inst Neurol, Catanzaro, Italy; [Ferlazzo, Edoardo] Univ Messina, Dept Neurosci Psychiat & Anaestesiol Sci, I-98100 Messina, Italy; [Ferlazzo, Edoardo] RCCS Ctr Neurol Bonino Pulejo, Messina, Italy; [Elia, Maurizio] OASI Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy; [Bianchi, Amedeo] San Donato Hosp, Div Neurol, Arezzo, Italy; [Bortoluzzi, Stefania; Vettori, Andrea] Univ Padua, Dept Biol, Padua, Italy; [Aguglia, Umberto] Hosp Reggio Calabria, Reg Epilepsy Ctr, Reggio Di Calabria, Italy; [Binelli, Simona] Fdn Neurol Inst C Besta, Milan, Italy; [De Falco, Arturo] Loreto Nuovo Hosp, Div Neurol, Naples, Italy; [Coppola, Giangennaro] Univ Naples 2, Clin Child Neuropsychiat, Naples, Italy; [Gobbi, Giuseppe] Osped Maggiore CA Pizzardi, Unit Child Neuropsychiat, Bologna, Italy; [Sofia, Vito] Catania Univ, Dept Neurosci, Catania, Italy; [Michelucci, Roberto] Bellaria Hosp, Dept Neurosci, Bologna, Italy Nobile, C (reprint author), Univ Padua, Dept Biomed Sci, CNR, Inst Neurosci,Sect Padua, Viale G Colombo 3, I-35121 Padua, Italy. nobile@bio.unipd.it Bortoluzzi, Stefania/G-8211-2011 25 6 6 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 0304-3940 NEUROSCI LETT Neurosci. Lett. MAY 2 2008 436 1 23 26 10.1016/j.neulet.2008.02.045 4 Neurosciences Neurosciences & Neurology 298OG WOS:000255696400005 J Aubert, B; Bona, M; Boutigny, D; Karyotakis, Y; Lees, JP; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Tico, JG; Grauges, E; Lopez, L; Palano, A; Pappagallo, M; Eigen, G; Stugu, B; Sun, L; Abrams, GS; Battaglia, M; Brown, DN; Button-Shafer, J; Cahn, RN; Groysman, Y; Jacobsen, RG; Kadyk, JA; Kerth, LT; Kolomensky, YG; Kukartsev, G; Pegna, DL; Lynch, G; Mir, LM; Orimoto, TJ; Osipenkov, IL; Ronan, MT; Tackmann, K; Tanabe, T; Wenzel, WA; Sanchez, PDA; Hawkes, CM; Watson, AT; Koch, H; Schroeder, T; Walker, D; Asgeirsson, DJ; Cuhadar-Donszelmann, T; Fulsom, BG; Hearty, C; Mattison, TS; McKenna, JA; Barrett, M; Khan, A; Saleem, M; Teodorescu, L; Blinov, VE; Bukin, AD; Druzhinin, VP; Golubev, VB; Onuchin, AP; Serednyakov, SI; Skovpen, YI; Solodov, EP; Todyshev, KY; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, AJ; Lund, P; Mandelkern, M; Martin, EC; Stoker, DP; Abachi, S; Buchanan, C; Foulkes, SD; Gary, JW; Liu, F; Long, O; Shen, BC; Vitug, GM; Zhang, L; Paar, HP; Rahatlou, S; Sharma, V; Berryhill, JW; Campagnari, C; Cunha, A; Dahmes, B; Hong, TM; Kovalskyi, D; Richman, JD; Beck, TW; Eisner, AM; Flacco, CJ; Heusch, CA; Kroseberg, J; Lockman, WS; Schalk, T; Schumm, BA; Seiden, A; Wilson, MG; Winstrom, LO; Chen, E; Cheng, CH; Fang, F; Hitlin, DG; Narsky, I; Piatenko, T; Porter, FC; Andreassen, R; Mancinelli, G; Meadows, BT; Mishra, K; Sokoloff, MD; Blanc, F; Bloom, PC; Chen, S; Ford, WT; Hirschauer, JF; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, JG; Ulmer, KA; Wagner, SR; Zhang, J; Gabareen, AM; Soffer, A; Toki, WH; Wilson, RJ; Winklmeier, F; Altenburg, DD; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Klose, V; Kobel, MJ; Lacker, HM; Mader, WF; Nogowski, R; Schubert, J; Schubert, KR; Schwierz, R; Sundermann, JE; Volk, A; Bernard, D; Bonneaud, GR; Latour, E; Lombardo, V; Thiebaux, C; Verderi, M; Clark, PJ; Gradl, W; Muheim, F; Playfer, S; Robertson, AI; Watson, JE; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, IM; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo Vetere, M; Macri, MM; Monge, MR; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, KS; Morii, M; Wu, J; Dubitzky, RS; Marks, J; Schenk, S; Uwer, U; Bard, DJ; Dauncey, PD; Flack, RL; Nash, JA; Vazquez, WP; Tibbetts, M; Behera, PK; Chai, X; Charles, MJ; Mallik, U; Cochran, J; Crawley, HB; Dong, L; Eyges, V; Meyer, WT; Prell, S; Rosenberg, EI; Rubin, AE; Gao, YY; Gritsan, AV; Guo, ZJ; Lae, CK; Denig, AG; Fritsch, M; Schott, G; Arnaud, N; Bequilleux, J; D'Orazio, A; Davier, M; Grosdidier, G; Hocker, A; Lepeltier, V; Le Diberder, F; Lutz, AM; Pruvot, S; Rodier, S; Roudeau, P; Schune, MH; Serrano, J; Sordini, V; Stocchi, A; Wang, WF; Wormser, G; Lange, DJ; Wright, DM; Bingham, I; Burke, JP; Chavez, CA; Fry, JR; Gabathuler, E; Gamet, R; Hutchcroft, DE; Payne, DJ; Schofield, KC; Touramanis, C; Bevan, AJ; Clarke, C; George, KA; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flaecher, HU; Hopkins, DA; Paramesvaran, S; Salvatore, F; Wren, AC; Brown, DN; Davis, CL; Allison, J; Bailey, D; Barlow, NR; Barlow, RJ; Chia, YM; Edgar, CL; Lafferty, GD; West, TJ; Yi, JI; Anderson, J; Chen, C; Jawahery, A; Roberts, DA; Simi, G; Tuggle, JM; Blaylock, G; Dallapiccola, C; Hertzbach, SS; Li, X; Moore, TB; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, PH; Koeneke, K; Sciolla, G; Spitznagel, M; Taylor, F; Yamamoto, RK; Zhao, M; Zheng, Y; Mclachlin, SE; Patel, PM; Robertson, SH; Lazzaro, A; Palombo, F; Bauer, JM; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, DA; Summers, DJ; Zhao, HW; Brunet, S; Cote, D; Simard, M; Taras, P; Viaud, FB; Nicholson, H; De Nardo, G; Fabozzi, F; Lista, L; Monorchio, D; Sciacca, C; Baak, MA; Raven, G; Snoek, HL; Jessop, CP; Knoepfel, KJ; LoSecco, JM; Benelli, G; Corwin, LA; Honscheid, K; Kagan, H; Kass, R; Morris, JP; Rahimi, AM; Regensburger, JJ; Sekula, SJ; Wong, QK; Blount, NL; Brau, J; Frey, R; Igonkina, O; Kolb, JA; Lu, M; Rahmat, R; Sinev, NB; Strom, D; Strube, J; Torrence, E; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; de la Vaissiere, C; Hamon, O; Leruste, P; Malcles, J; Ocariz, J; Perez, A; Prendki, J; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cenci, R; Cervelli, A; Forti, F; Giorgi, MA; Lusiani, A; Marchiori, G; Mazur, MA; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, JJ; Biesiada, J; Elmer, P; Lau, YP; Lu, C; Olsen, J; Smith, AJS; Telnov, AV; Baracchini, E; Bellini, F; Cavoto, G; del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, PD; Gioi, LL; Mazzoni, MA; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schroder, H; Waldi, R; Adye, T; Castelli, G; Franek, B; Olaiya, EO; Roethel, W; Wilson, FF; Emery, S; Escalier, M; Gaidot, A; Ganzhur, SF; de Monchenault, GH; Kozanecki, W; Vasseur, G; Yeche, C; Zito, M; Chen, XR; Liu, H; Park, W; Purohit, MV; White, RM; Wilson, JR; Allen, MT; Aston, D; Bartoldus, R; Bechtle, P; Claus, R; Coleman, JP; Convery, MR; Dingfelder, JC; Dorfan, J; Dubois-Felsmann, GP; Dunwoodie, W; Field, RC; Glanzman, T; Gowdy, SJ; Graham, MT; Grenier, P; Hast, C; Innes, WR; Kaminski, J; Kelsey, MH; Kim, H; Kim, P; Kocian, ML; Leith, DWGS; Li, S; Luitz, S; Luth, V; Lynch, HL; MacFarlane, DB; Marsiske, H; Messner, R; Muller, DR; O'Grady, CP; Ofte, I; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, BN; Roodman, A; Salnikov, AA; Schindler, RH; Schwiening, J; Snyder, A; Su, D; Sullivan, MK; Suzuki, K; Swain, SK; Thompson, JM; Va'vra, J; Wagner, AP; Weaver, M; Wisniewski, WJ; Wittgen, M; Wright, DH; Yarritu, AK; Yi, K; Young, CC; Ziegler, V; Burchat, PR; Edwards, AJ; Majewski, SA; Miyashita, TS; Petersen, BA; Wilden, L; Ahmed, S; Alam, MS; Bula, R; Ernst, JA; Jain, V; Pan, B; Saeed, MA; Wappler, FR; Zain, SB; Krishnamurthy, M; Spanier, SM; Eckmann, R; Ritchie, JL; Ruland, AM; Schilling, CJ; Schwitters, RF; Izen, JM; Lou, XC; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, DA; Oyanguren, A; Albert, J; Banerjee, S; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, IM; Roney, JM; Sobie, RJ; Harrison, PF; Ilic, J; Latham, TE; Mohanty, GB; Band, HR; Chen, X; Dasu, S; Flood, KT; Hollar, JJ; Kutter, PE; Pan, Y; Pierini, M; Prepost, R; Wu, SL; Neal, H Aubert, B.; Bona, M.; Boutigny, D.; Karyotakis, Y.; Lees, J. P.; Poireau, V.; Prudent, X.; Tisserand, V.; Zghiche, A.; Tico, J. Garra; Grauges, E.; Lopez, L.; Palano, A.; Pappagallo, M.; Eigen, G.; Stugu, B.; Sun, L.; Abrams, G. S.; Battaglia, M.; Brown, D. N.; Button-Shafer, J.; Cahn, R. N.; Groysman, Y.; Jacobsen, R. G.; Kadyk, J. A.; Kerth, L. T.; Kolomensky, Yu. G.; Kukartsev, G.; Pegna, D. Lopes; Lynch, G.; Mir, L. M.; Orimoto, T. J.; Osipenkov, I. L.; Ronan, M. T.; Tackmann, K.; Tanabe, T.; Wenzel, W. A.; Sanchez, P. Del Amo; Hawkes, C. M.; Watson, A. T.; Koch, H.; Schroeder, T.; Walker, D.; Asgeirsson, D. J.; Cuhadar-Donszelmann, T.; Fulsom, B. G.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; Barrett, M.; Khan, A.; Saleem, M.; Teodorescu, L.; Blinov, V. E.; Bukin, A. D.; Druzhinin, V. P.; Golubev, V. B.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Bondioli, M.; Curry, S.; Eschrich, I.; Kirkby, D.; Lankford, A. J.; Lund, P.; Mandelkern, M.; Martin, E. C.; Stoker, D. P.; Abachi, S.; Buchanan, C.; Foulkes, S. D.; Gary, J. W.; Liu, F.; Long, O.; Shen, B. C.; Vitug, G. M.; Zhang, L.; Paar, H. P.; Rahatlou, S.; Sharma, V.; Berryhill, J. W.; Campagnari, C.; Cunha, A.; Dahmes, B.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; Beck, T. W.; Eisner, A. M.; Flacco, C. J.; Heusch, C. A.; Kroseberg, J.; Lockman, W. S.; Schalk, T.; Schumm, B. A.; Seiden, A.; Wilson, M. G.; Winstrom, L. O.; Chen, E.; Cheng, C. H.; Fang, F.; Hitlin, D. G.; Narsky, I.; Piatenko, T.; Porter, F. C.; Andreassen, R.; Mancinelli, G.; Meadows, B. T.; Mishra, K.; Sokoloff, M. D.; Blanc, F.; Bloom, P. C.; Chen, S.; Ford, W. T.; Hirschauer, J. F.; Kreisel, A.; Nagel, M.; Nauenberg, U.; Olivas, A.; Smith, J. G.; Ulmer, K. A.; Wagner, S. R.; Zhang, J.; Gabareen, A. M.; Soffer, A.; Toki, W. H.; Wilson, R. J.; Winklmeier, F.; Altenburg, D. D.; Feltresi, E.; Hauke, A.; Jasper, H.; Merkel, J.; Petzold, A.; Spaan, B.; Wacker, K.; Klose, V.; Kobel, M. J.; Lacker, H. M.; Mader, W. F.; Nogowski, R.; Schubert, J.; Schubert, K. R.; Schwierz, R.; Sundermann, J. E.; Volk, A.; Bernard, D.; Bonneaud, G. R.; Latour, E.; Lombardo, V.; Thiebaux, Ch.; Verderi, M.; Clark, P. J.; Gradl, W.; Muheim, F.; Playfer, S.; Robertson, A. I.; Watson, J. E.; Xie, Y.; Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Prencipe, E.; Santoro, V.; Anulli, F.; Baldini-Ferroli, R.; Calcaterra, A.; De Sangro, R.; Finocchiaro, G.; Pacetti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Buzzo, A.; Contri, R.; Lo Vetere, M.; Macri, M. M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Tosi, S.; Chaisanguanthum, K. S.; Morii, M.; Wu, J.; Dubitzky, R. S.; Marks, J.; Schenk, S.; Uwer, U.; Bard, D. J.; Dauncey, P. D.; Flack, R. L.; Nash, J. A.; Vazquez, W. Panduro; Tibbetts, M.; Behera, P. K.; Chai, X.; Charles, M. J.; Mallik, U.; Cochran, J.; Crawley, H. B.; Dong, L.; Eyges, V.; Meyer, W. T.; Prell, S.; Rosenberg, E. I.; Rubin, A. E.; Gao, Y. Y.; Gritsan, A. V.; Guo, Z. J.; Lae, C. K.; Denig, A. G.; Fritsch, M.; Schott, G.; Arnaud, N.; Bequilleux, J.; D'Orazio, A.; Davier, M.; Grosdidier, G.; Hoecker, A.; Lepeltier, V.; Le Diberder, F.; Lutz, A. M.; Pruvot, S.; Rodier, S.; Roudeau, P.; Schune, M. H.; Serrano, J.; Sordini, V.; Stocchi, A.; Wang, W. F.; Wormser, G.; Lange, D. J.; Wright, D. M.; Bingham, I.; Burke, J. P.; Chavez, C. A.; Fry, J. R.; Gabathuler, E.; Gamet, R.; Hutchcroft, D. E.; Payne, D. J.; Schofield, K. C.; Touramanis, C.; Bevan, A. J.; Clarke, C.; George, K. A.; Di Lodovico, F.; Menges, W.; Sacco, R.; Cowan, G.; Flaecher, H. U.; Hopkins, D. A.; Paramesvaran, S.; Salvatore, F.; Wren, A. C.; Brown, D. N.; Davis, C. L.; Allison, J.; Bailey, D.; Barlow, N. R.; Barlow, R. J.; Chia, Y. M.; Edgar, C. L.; Lafferty, G. D.; West, T. J.; Yi, J. I.; Anderson, J.; Chen, C.; Jawahery, A.; Roberts, D. A.; Simi, G.; Tuggle, J. M.; Blaylock, G.; Dallapiccola, C.; Hertzbach, S. S.; Li, X.; Moore, T. B.; Salvati, E.; Saremi, S.; Cowan, R.; Dujmic, D.; Fisher, P. H.; Koeneke, K.; Sciolla, G.; Spitznagel, M.; Taylor, F.; Yamamoto, R. K.; Zhao, M.; Zheng, Y.; Mclachlin, S. E.; Patel, P. M.; Robertson, S. H.; Lazzaro, A.; Palombo, F.; Bauer, J. M.; Cremaldi, L.; Eschenburg, V.; Godang, R.; Kroeger, R.; Sanders, D. A.; Summers, D. J.; Zhao, H. W.; Brunet, S.; Cote, D.; Simard, M.; Taras, P.; Viaud, F. B.; Nicholson, H.; De Nardo, G.; Fabozzi, F.; Lista, L.; Monorchio, D.; Sciacca, C.; Baak, M. A.; Raven, G.; Snoek, H. L.; Jessop, C. P.; Knoepfel, K. J.; LoSecco, J. M.; Benelli, G.; Corwin, L. A.; Honscheid, K.; Kagan, H.; Kass, R.; Morris, J. P.; Rahimi, A. M.; Regensburger, J. J.; Sekula, S. J.; Wong, Q. K.; Blount, N. L.; Brau, J.; Frey, R.; Igonkina, O.; Kolb, J. A.; Lu, M.; Rahmat, R.; Sinev, N. B.; Strom, D.; Strube, J.; Torrence, E.; Gagliardi, N.; Gaz, A.; Margoni, M.; Morandin, M.; Pompili, A.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Voci, C.; Ben-Haim, E.; Briand, H.; Calderini, G.; Chauveau, J.; David, P.; Del Buono, L.; de la Vaissiere, Ch.; Hamon, O.; Leruste, Ph.; Malcles, J.; Ocariz, J.; Perez, A.; Prendki, J.; Gladney, L.; Biasini, M.; Covarelli, R.; Manoni, E.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Cenci, R.; Cervelli, A.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Mazur, M. A.; Morganti, M.; Neri, N.; Paoloni, E.; Rizzo, G.; Walsh, J. J.; Biesiada, J.; Elmer, P.; Lau, Y. P.; Lu, C.; Olsen, J.; Smith, A. J. S.; Telnov, A. V.; Baracchini, E.; Bellini, F.; Cavoto, G.; del Re, D.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Jackson, P. D.; Gioi, L. Li; Mazzoni, M. A.; Morganti, S.; Piredda, G.; Polci, F.; Renga, F.; Voena, C.; Ebert, M.; Hartmann, T.; Schroeder, H.; Waldi, R.; Adye, T.; Castelli, G.; Franek, B.; Olaiya, E. O.; Roethel, W.; Wilson, F. F.; Emery, S.; Escalier, M.; Gaidot, A.; Ganzhur, S. F.; de Monchenault, G. Hamel; Kozanecki, W.; Vasseur, G.; Yeche, Ch.; Zito, M.; Chen, X. R.; Liu, H.; Park, W.; Purohit, M. V.; White, R. M.; Wilson, J. R.; Allen, M. T.; Aston, D.; Bartoldus, R.; Bechtle, P.; Claus, R.; Coleman, J. P.; Convery, M. R.; Dingfelder, J. C.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Field, R. C.; Glanzman, T.; Gowdy, S. J.; Graham, M. T.; Grenier, P.; Hast, C.; Innes, W. R.; Kaminski, J.; Kelsey, M. H.; Kim, H.; Kim, P.; Kocian, M. L.; Leith, D. W. G. S.; Li, S.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Marsiske, H.; Messner, R.; Muller, D. R.; O'Grady, C. P.; Ofte, I.; Perazzo, A.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Schwiening, J.; Snyder, A.; Su, D.; Sullivan, M. K.; Suzuki, K.; Swain, S. K.; Thompson, J. M.; Va'vra, J.; Wagner, A. P.; Weaver, M.; Wisniewski, W. J.; Wittgen, M.; Wright, D. H.; Yarritu, A. K.; Yi, K.; Young, C. C.; Ziegler, V.; Burchat, P. R.; Edwards, A. J.; Majewski, S. A.; Miyashita, T. S.; Petersen, B. A.; Wilden, L.; Ahmed, S.; Alam, M. S.; Bula, R.; Ernst, J. A.; Jain, V.; Pan, B.; Saeed, M. A.; Wappler, F. R.; Zain, S. B.; Krishnamurthy, M.; Spanier, S. M.; Eckmann, R.; Ritchie, J. L.; Ruland, A. M.; Schilling, C. J.; Schwitters, R. F.; Izen, J. M.; Lou, X. C.; Ye, S.; Bianchi, F.; Gallo, F.; Gamba, D.; Pelliccioni, M.; Bomben, M.; Bosisio, L.; Cartaro, C.; Cossutti, F.; Della Ricca, G.; Lanceri, L.; Vitale, L.; Azzolini, V.; Lopez-March, N.; Martinez-Vidal, F.; Milanes, D. A.; Oyanguren, A.; Albert, J.; Banerjee, Sw.; Bhuyan, B.; Hamano, K.; Kowalewski, R.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Harrison, P. F.; Ilic, J.; Latham, T. E.; Mohanty, G. B.; Band, H. R.; Chen, X.; Dasu, S.; Flood, K. T.; Hollar, J. J.; Kutter, P. E.; Pan, Y.; Pierini, M.; Prepost, R.; Wu, S. L.; Neal, H. Measurements of partial branching fractions for (B)over-bar -> X(u)l(nu)over-bar and determination of vertical bar V(ub)vertical bar PHYSICAL REVIEW LETTERS English Article MESON DECAYS; PHYSICS; MODEL We present partial branching fractions for inclusive charmless semileptonic B decays (B) over bar -> X(u)l (nu) over bar, and the determination of the Cabibbo-Kobayashi-Maskawa matrix element vertical bar V(ub)vertical bar. The analysis is based on a sample of 383 x 10(6) gamma(4S) decays into B (B) over bar pairs collected with the BABAR detector at the SLAC PEP-II e(+)e(-) storage rings. We select events using the invariant mass M(X) of the hadronic system, the invariant mass squared, q(2), of the lepton and neutrino pair, the kinematic variable P(+), or one of their combinations. We then determine partial branching fractions in limited regions of phase space: Delta B = (1.18 +/- 0.09(stat) +/- 0.07(syst) +/- 0.01(theor)) x 10(-3) (M(X) < 1.55 GeV/c(2)), Delta B = (0.95 +/- 0.10(stat) +/- 0.08(syst) +/- 0.01(theor)) x 10(-3) (P(+) < 0.66 GeV/c), and Delta B = (0.81 +/- 0.08(stat) +/- 0.07(syst) +/- 0.02(theor)) x 10(-3) (M(X) < 1.7 GeV/c(2), q(2) > 8 GeV(2)/c(4)). Corresponding values of vertical bar V(ub)vertical bar are extracted using several theoretical calculations. [Aubert, B.; Bona, M.; Boutigny, D.; Karyotakis, Y.; Lees, J. P.; Poireau, V.; Prudent, X.; Tisserand, V.; Zghiche, A.] CNRS, IN2P3, Phys Particules Lab, F-74941 Annecy Le Vieux, France; [Aubert, B.; Bona, M.; Boutigny, D.; Karyotakis, Y.; Lees, J. P.; Poireau, V.; Prudent, X.; Tisserand, V.; Zghiche, A.] Univ Savoie, F-74941 Annecy Le Vieux, France; [Tico, J. Garra; Grauges, E.] Univ Barcelona, Fac Fis, Dept ECM, E-08028 Barcelona, Spain; [Lopez, L.; Palano, A.; Pappagallo, M.] Univ Bari, Dipartimento Fis, I-70126 Bari, Italy; [Lopez, L.; Palano, A.; Pappagallo, M.] Ist Nazl Fis Nucl, I-70126 Bari, Italy; [Eigen, G.; Stugu, B.; Sun, L.] Univ Bergen, Dept Phys, N-5007 Bergen, Norway; [Abrams, G. S.; Battaglia, M.; Brown, D. N.; Button-Shafer, J.; Cahn, R. N.; Groysman, Y.; Jacobsen, R. G.; Kadyk, J. A.; Kerth, L. T.; Kolomensky, Yu. G.; Kukartsev, G.; Pegna, D. Lopes; Lynch, G.; Mir, L. M.; Orimoto, T. J.; Osipenkov, I. L.; Ronan, M. T.; Tackmann, K.; Tanabe, T.; Wenzel, W. A.] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA; [Sanchez, P. Del Amo; Hawkes, C. M.; Watson, A. T.] Univ Birmingham, Birmingham B15 2TT, W Midlands, England; [Koch, H.; Schroeder, T.] Ruhr Univ Bochum, Inst Expt Phys 1, D-44780 Bochum, Germany; [Walker, D.] Univ Bristol, Bristol BS8 1TL, Avon, England; [Asgeirsson, D. J.; Cuhadar-Donszelmann, T.; Fulsom, B. G.; Hearty, C.; Mattison, T. S.; McKenna, J. A.] Univ British Columbia, Vancouver, BC V6T 1Z1, Canada; [Barrett, M.; Khan, A.; Saleem, M.; Teodorescu, L.] Brunel Univ, Uxbridge UB8 3PH, Middx, England; [Blinov, V. E.; Bukin, A. D.; Druzhinin, V. P.; Golubev, V. B.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.] Budker Inst Nucl Phys, Novosibirsk 630090, Russia; [Bondioli, M.; Curry, S.; Eschrich, I.; Kirkby, D.; Lankford, A. J.; Lund, P.; Mandelkern, M.; Martin, E. C.; Stoker, D. P.] Univ Calif Irvine, Irvine, CA 92697 USA; [Abachi, S.; Buchanan, C.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA; [Foulkes, S. D.; Gary, J. W.; Liu, F.; Long, O.; Shen, B. C.; Vitug, G. M.; Zhang, L.] Univ Calif Riverside, Riverside, CA 92521 USA; [Paar, H. P.; Rahatlou, S.; Sharma, V.] Univ Calif San Diego, La Jolla, CA 92093 USA; [Berryhill, J. W.; Campagnari, C.; Cunha, A.; Dahmes, B.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA; [Beck, T. W.; Eisner, A. M.; Flacco, C. J.; Heusch, C. A.; Kroseberg, J.; Lockman, W. S.; Schalk, T.; Schumm, B. A.; Seiden, A.; Wilson, M. G.; Winstrom, L. O.] Univ Calif Santa Cruz, Inst Particle Phys, Santa Cruz, CA 95064 USA; [Chen, E.; Cheng, C. H.; Fang, F.; Hitlin, D. G.; Narsky, I.; Piatenko, T.; Porter, F. C.] CALTECH, Pasadena, CA 91125 USA; [Andreassen, R.; Mancinelli, G.; Meadows, B. T.; Mishra, K.; Sokoloff, M. D.] Univ Cincinnati, Cincinnati, OH 45221 USA; [Blanc, F.; Bloom, P. C.; Chen, S.; Ford, W. T.; Hirschauer, J. F.; Kreisel, A.; Nagel, M.; Nauenberg, U.; Olivas, A.; Smith, J. G.; Ulmer, K. A.; Wagner, S. R.; Zhang, J.] Univ Colorado, Boulder, CO 80309 USA; [Gabareen, A. M.; Soffer, A.; Toki, W. H.; Wilson, R. J.; Winklmeier, F.] Colorado State Univ, Ft Collins, CO 80523 USA; [Altenburg, D. D.; Feltresi, E.; Hauke, A.; Jasper, H.; Merkel, J.; Petzold, A.; Spaan, B.; Wacker, K.] Univ Dortmund, Inst Phys, D-44221 Dortmund, Germany; [Klose, V.; Kobel, M. J.; Lacker, H. M.; Mader, W. F.; Nogowski, R.; Schubert, J.; Schubert, K. R.; Schwierz, R.; Sundermann, J. E.; Volk, A.] Tech Univ Dresden, Inst Kern & Teilchenphys, D-01062 Dresden, Germany; [Bernard, D.; Bonneaud, G. R.; Latour, E.; Lombardo, V.; Thiebaux, Ch.] Ecole Polytech, CNRS, IN2P3, Lab Leprince Ringuet, F-91128 Palaiseau, France; [Verderi, M.; Clark, P. J.; Gradl, W.; Muheim, F.; Playfer, S.; Robertson, A. I.; Watson, J. E.; Xie, Y.] Univ Edinburgh, Edinburgh EH9 3JZ, Midlothian, Scotland; [Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Prencipe, E.; Santoro, V.] Univ Ferrara, Dipartmento Fis, I-44100 Ferrara, Italy; [Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Prencipe, E.; Santoro, V.] Ist Nazl Fis Nucl, I-44100 Ferrara, Italy; [Anulli, F.; Baldini-Ferroli, R.; Calcaterra, A.; De Sangro, R.; Finocchiaro, G.; Pacetti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.] Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy; [Buzzo, A.; Contri, R.; Lo Vetere, M.; Macri, M. M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Tosi, S.] Univ Genoa, Dipartimento Fis, I-16146 Genoa, Italy; [Buzzo, A.; Contri, R.; Lo Vetere, M.; Macri, M. M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Tosi, S.] Ist Nazl Fis Nucl, I-16146 Genoa, Italy; [Chaisanguanthum, K. S.; Morii, M.; Wu, J.] Harvard Univ, Cambridge, MA 02138 USA; [Dubitzky, R. S.; Marks, J.; Schenk, S.; Uwer, U.] Univ Heidelberg, Inst Phys, D-69120 Heidelberg, Germany; [Bard, D. J.; Dauncey, P. D.; Flack, R. L.; Nash, J. A.; Vazquez, W. Panduro; Tibbetts, M.] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England; [Behera, P. K.; Chai, X.; Charles, M. J.; Mallik, U.] Univ Iowa, Iowa City, IA 52242 USA; [Cochran, J.; Crawley, H. B.; Dong, L.; Eyges, V.; Meyer, W. T.; Prell, S.; Rosenberg, E. I.; Rubin, A. E.] Iowa State Univ, Ames, IA 50011 USA; [Gao, Y. Y.; Gritsan, A. V.; Guo, Z. J.; Lae, C. K.; Denig, A. G.] Johns Hopkins Univ, Baltimore, MD 21218 USA; [Fritsch, M.; Schott, G.] Univ Karlsruhe, Inst Expt Kernphys, D-76021 Karlsruhe, Germany; [Arnaud, N.; Bequilleux, J.; D'Orazio, A.; Davier, M.; Grosdidier, G.; Hoecker, A.; Lepeltier, V.; Le Diberder, F.; Lutz, A. M.; Pruvot, S.; Rodier, S.; Roudeau, P.; Schune, M. H.; Serrano, J.; Sordini, V.; Stocchi, A.; Wang, W. F.; Wormser, G.] Univ Paris 11, Ctr Sci Orsay, F-91898 Orsay, France; [Arnaud, N.; Bequilleux, J.; D'Orazio, A.; Davier, M.; Grosdidier, G.; Hoecker, A.; Lepeltier, V.; Le Diberder, F.; Lutz, A. M.; Pruvot, S.; Rodier, S.; Roudeau, P.; Schune, M. H.; Serrano, J.; Sordini, V.; Stocchi, A.; Wang, W. F.; Wormser, G.] CNRS, IN2P3, Lab Accelerateur Lineaire, F-91898 Orsay, France; [Lange, D. J.; Wright, D. M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA; [Bingham, I.; Burke, J. P.; Chavez, C. A.; Fry, J. R.; Gabathuler, E.; Gamet, R.; Hutchcroft, D. E.; Payne, D. J.; Schofield, K. C.; Touramanis, C.] Univ Liverpool, Liverpool L69 7ZE, Merseyside, England; [Bevan, A. J.; Clarke, C.; George, K. A.; Di Lodovico, F.; Menges, W.; Sacco, R.] Univ London, London E1 4NS, England; [Cowan, G.; Flaecher, H. U.; Hopkins, D. A.; Paramesvaran, S.; Salvatore, F.; Wren, A. C.] Univ London, Egham TW20 0EX, Surrey, England; [Cowan, G.; Flaecher, H. U.; Hopkins, D. A.; Paramesvaran, S.; Salvatore, F.; Wren, A. C.] Bedford New Coll, Egham TW20 0EX, Surrey, England; [Brown, D. N.; Davis, C. L.] Univ Louisville, Louisville, KY 40292 USA; [Allison, J.; Bailey, D.; Barlow, N. R.; Barlow, R. J.; Chia, Y. M.; Edgar, C. L.; Lafferty, G. D.; West, T. J.; Yi, J. I.] Univ Manchester, Manchester M13 9PL, Lancs, England; [Anderson, J.; Chen, C.; Jawahery, A.; Roberts, D. A.; Simi, G.; Tuggle, J. M.] Univ Maryland, College Pk, MD 20742 USA; [Blaylock, G.; Dallapiccola, C.; Hertzbach, S. S.; Li, X.; Moore, T. B.; Salvati, E.; Saremi, S.] Univ Massachusetts, Amherst, MA 01003 USA; [Cowan, R.; Dujmic, D.; Fisher, P. H.; Koeneke, K.; Sciolla, G.; Spitznagel, M.; Taylor, F.; Yamamoto, R. K.; Zhao, M.; Zheng, Y.] MIT, Nucl Sci Lab, Cambridge, MA 02139 USA; [Mclachlin, S. E.; Patel, P. M.; Robertson, S. H.] McGill Univ, Montreal, PQ H3A 2T8, Canada; [Lazzaro, A.; Palombo, F.] Univ Milan, Dipartimento Fis, I-20133 Milan, Italy; [Lazzaro, A.; Palombo, F.] Ist Nazl Fis Nucl, I-20133 Milan, Italy; [Bauer, J. M.; Cremaldi, L.; Eschenburg, V.; Godang, R.; Kroeger, R.; Sanders, D. A.; Summers, D. J.; Zhao, H. W.] Univ Mississippi, University, MS 38677 USA; [Brunet, S.; Cote, D.; Simard, M.; Taras, P.; Viaud, F. B.] Univ Montreal, Montreal, PQ H3C 3J7, Canada; [Nicholson, H.] Mt Holyoke Coll, S Hadley, MA 01075 USA; [De Nardo, G.; Fabozzi, F.; Lista, L.; Monorchio, D.; Sciacca, C.] Ist Nazl Fis Nucl, I-80126 Naples, Italy; [De Nardo, G.; Fabozzi, F.; Lista, L.; Monorchio, D.; Sciacca, C.] Univ Naples Federico 2, Dipartimento Sci Fisiche, I-80126 Naples, Italy; [Baak, M. A.; Raven, G.; Snoek, H. L.] NIKHEF H, Natl Inst Nucl Phys & High Energy Phys, NL-1009 DB Amsterdam, Netherlands; [Jessop, C. P.; Knoepfel, K. J.; LoSecco, J. M.] Univ Notre Dame, Notre Dame, IN 46556 USA; [Benelli, G.; Corwin, L. A.; Honscheid, K.; Kagan, H.; Kass, R.; Morris, J. P.; Rahimi, A. M.; Regensburger, J. J.; Sekula, S. J.; Wong, Q. K.] Ohio State Univ, Columbus, OH 43210 USA; [Blount, N. L.; Brau, J.; Frey, R.; Igonkina, O.; Kolb, J. A.; Lu, M.; Rahmat, R.; Sinev, N. B.; Strom, D.; Strube, J.; Torrence, E.] Univ Oregon, Eugene, OR 97403 USA; [Gagliardi, N.; Gaz, A.; Margoni, M.; Morandin, M.; Pompili, A.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Voci, C.] Ist Nazl Fis Nucl, I-35131 Padua, Italy; [Gagliardi, N.; Gaz, A.; Margoni, M.; Morandin, M.; Pompili, A.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Voci, C.] Univ Padua, Dipartimento Fis, I-35131 Padua, Italy; [Ben-Haim, E.; Briand, H.; Calderini, G.; Chauveau, J.; David, P.; Del Buono, L.; de la Vaissiere, Ch.; Hamon, O.; Leruste, Ph.; Malcles, J.; Ocariz, J.; Perez, A.; Prendki, J.] Univ Paris 07, Univ Paris 06, CNRS, IN2P3,Lab Phys Nucl & Hautes Energies, F-75252 Paris, France; [Gladney, L.] Univ Penn, Philadelphia, PA 19104 USA; [Biasini, M.; Covarelli, R.; Manoni, E.] Ist Nazl Fis Nucl, I-06100 Perugia, Italy; [Biasini, M.; Covarelli, R.; Manoni, E.] Univ Perugia, Dipartimento Fis, I-06100 Perugia, Italy; [Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Cenci, R.; Cervelli, A.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Mazur, M. A.; Morganti, M.; Neri, N.; Paoloni, E.; Rizzo, G.; Walsh, J. J.] Univ Pisa, Dipartimento Fis, Scuola Normale Super Pisa, I-56127 Pisa, Italy; [Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Cenci, R.; Cervelli, A.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Mazur, M. A.; Morganti, M.; Neri, N.; Paoloni, E.; Rizzo, G.; Walsh, J. J.] Ist Nazl Fis Nucl, I-56127 Pisa, Italy; [Biesiada, J.; Elmer, P.; Lau, Y. P.; Lu, C.; Olsen, J.; Smith, A. J. S.; Telnov, A. V.] Princeton Univ, Princeton, NJ 08544 USA; [Baracchini, E.; Bellini, F.; Cavoto, G.; del Re, D.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Jackson, P. D.; Gioi, L. Li; Mazzoni, M. A.; Morganti, S.; Piredda, G.; Polci, F.; Renga, F.; Voena, C.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Baracchini, E.; Bellini, F.; Cavoto, G.; del Re, D.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Jackson, P. D.; Gioi, L. Li; Mazzoni, M. A.; Morganti, S.; Piredda, G.; Polci, F.; Renga, F.; Voena, C.] Ist Nazl Fis Nucl, I-00185 Rome, Italy; [Ebert, M.; Hartmann, T.; Schroeder, H.; Waldi, R.] Univ Rostock, D-18051 Rostock, Germany; [Adye, T.; Castelli, G.; Franek, B.; Olaiya, E. O.; Roethel, W.; Wilson, F. F.] Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England; [Emery, S.; Escalier, M.; Gaidot, A.; Ganzhur, S. F.; de Monchenault, G. Hamel; Kozanecki, W.; Vasseur, G.; Yeche, Ch.; Zito, M.] CEA Saclay, DSM, F-91191 Gif Sur Yvette, France; [Chen, X. R.; Liu, H.; Park, W.; Purohit, M. V.; White, R. M.; Wilson, J. R.] Univ S Carolina, Columbia, SC 29208 USA; [Allen, M. T.; Aston, D.; Bartoldus, R.; Bechtle, P.; Claus, R.; Coleman, J. P.; Convery, M. R.; Dingfelder, J. C.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Field, R. C.; Glanzman, T.; Gowdy, S. J.; Graham, M. T.; Grenier, P.; Hast, C.; Innes, W. R.; Kaminski, J.; Kelsey, M. H.; Kim, H.; Kim, P.; Kocian, M. L.; Leith, D. W. G. S.; Li, S.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Marsiske, H.; Messner, R.; Muller, D. R.; O'Grady, C. P.; Ofte, I.; Perazzo, A.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Schwiening, J.; Snyder, A.; Su, D.; Sullivan, M. K.; Suzuki, K.; Swain, S. K.; Thompson, J. M.; Va'vra, J.; Wagner, A. P.; Weaver, M.; Wisniewski, W. J.; Wittgen, M.; Wright, D. H.; Yarritu, A. K.; Yi, K.; Young, C. C.; Ziegler, V.] Stanford Linear Accelerator Ctr, Stanford, CA 94309 USA; [Burchat, P. R.; Edwards, A. J.; Majewski, S. A.; Miyashita, T. S.; Petersen, B. A.; Wilden, L.] Stanford Univ, Stanford, CA 94305 USA; [Ahmed, S.; Alam, M. S.; Bula, R.; Ernst, J. A.; Jain, V.; Pan, B.; Saeed, M. A.; Wappler, F. R.; Zain, S. B.] SUNY Albany, Albany, NY 12222 USA; [Krishnamurthy, M.; Spanier, S. M.] Univ Tennessee, Knoxville, TN 37996 USA; [Eckmann, R.; Ritchie, J. L.; Ruland, A. M.; Schilling, C. J.; Schwitters, R. F.] Univ Texas Austin, Austin, TX 78712 USA; [Izen, J. M.; Lou, X. C.; Ye, S.] Univ Texas Dallas, Richardson, TX 75083 USA; [Bianchi, F.; Gallo, F.; Gamba, D.; Pelliccioni, M.] Ist Nazl Fis Nucl, I-10125 Turin, Italy; [Bianchi, F.; Gallo, F.; Gamba, D.; Pelliccioni, M.] Univ Turin, Dipartimento Fis Sperimentale, I-10125 Turin, Italy; [Khan, A.; Bomben, M.; Bosisio, L.; Cartaro, C.; Cossutti, F.; Della Ricca, G.; Lanceri, L.; Vitale, L.] Ist Nazl Fis Nucl, I-34127 Trieste, Italy; [Bomben, M.; Bosisio, L.; Cartaro, C.; Cossutti, F.; Della Ricca, G.; Lanceri, L.; Vitale, L.] Univ Trieste, Dipartimento Fis, I-34127 Trieste, Italy; [Azzolini, V.; Lopez-March, N.; Martinez-Vidal, F.; Milanes, D. A.; Oyanguren, A.] Univ Politecn Valencia, CSIC, IFIC, E-46071 Valencia, Spain; [Albert, J.; Banerjee, Sw.; Bhuyan, B.; Hamano, K.; Kowalewski, R.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.] Univ Victoria, Victoria, BC V8W 3P6, Canada; [Harrison, P. F.; Ilic, J.; Latham, T. E.; Mohanty, G. B.] Univ Warwick, Dept Phys, Coventry CV4 7AL, W Midlands, England; [Band, H. R.; Chen, X.; Dasu, S.; Flood, K. T.; Hollar, J. J.; Kutter, P. E.; Pan, Y.; Pierini, M.; Prepost, R.; Wu, S. L.] Univ Wisconsin, Madison, WI 53706 USA; [Neal, H.] Yale Univ, New Haven, CT 06511 USA Aubert, B (reprint author), CNRS, IN2P3, Phys Particules Lab, F-74941 Annecy Le Vieux, France. Patrignani, Claudia/C-5223-2009; Lista, Luca/C-5719-2008; Bellini, Fabio/D-1055-2009; Neri, Nicola/G-3991-2012; Monge, Maria Roberta/G-9127-2012; Forti, Francesco/H-3035-2011; Rotondo, Marcello/I-6043-2012; de Sangro, Riccardo/J-2901-2012; Lo Vetere, Maurizio/J-5049-2012; Saeed, Mohammad/J-7455-2012; Della Ricca, Giuseppe/B-6826-2013 Patrignani, Claudia/0000-0002-5882-1747; Monge, Maria Roberta/0000-0003-1633-3195; Forti, Francesco/0000-0001-6535-7965; de Sangro, Riccardo/0000-0002-3808-5455; Lo Vetere, Maurizio/0000-0002-6520-4480; Saeed, Mohammad/0000-0002-3529-9255; Della Ricca, Giuseppe/0000-0003-2831-6982 20 15 15 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 0031-9007 PHYS REV LETT Phys. Rev. Lett. 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Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, PD; Gioi, LL; Mazzoni, MA; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Der, HS; Waldi, R; Adye, T; Castelli, G; Franek, B; Olaiya, EO; Ricciardi, S; Roethel, W; Wilson, FF; Aleksan, R; Emery, S; Escalier, M; Gaidot, A; Ganzhur, SF; De Monchenault, GH; Kozanecki, W; Vasseur, G; Che, CY; Zito, M; Chen, XR; Liu, H; Park, W; Purohit, MV; Wilson, JR; Allen, MT; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, JP; Convery, MR; Dingfelder, JC; Dorfan, J; Dubois-Felsmann, GP; Dunwoodie, W; Field, RC; Glanzman, T; Gowdy, SJ; Graham, MT; Grenier, P; Hast, C; Hryn'ova, T; Innes, WR; Kaminski, J; Kelsey, MH; Kim, H; Kim, P; Kocian, ML; Leith, DWGS; Li, S; Luitz, S; Luth, V; Lynch, HL; MacFarlane, DB; Marsiske, H; Messner, R; Muller, DR; O'Grady, CP; Ofte, I; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, BN; Roodman, A; Salnikov, AA; Schindler, RH; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, MK; Suzuki, K; Swain, SK; Thompson, JM; Va'vra, J; Van Bakel, N; Wagner, AP; Weaver, M; Wisniewski, WJ; Wittgen, M; Wright, DH; Yarritu, AK; Yi, K; Young, CC; Burchat, PR; Edwards, AJ; Majewski, SA; Petersen, BA; Wilden, L; Ahmed, S; Alam, MS; Bula, R; Ernst, JA; Jain, V; Pan, B; Saeed, MA; Wappler, FR; Zain, SB; Bugg, W; Krishnamurthy, M; Spanier, SM; Eckmann, R; Ritchie, JL; Ruland, AM; Schilling, CJ; Schwitters, RF; Izen, JM; Lou, XC; Bianchi, SYF; Gallo, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, DA; Oyanguren, A; Albert, J; Banerjee, S; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, IM; Roney, JM; Sobie, RJ; Back, JJ; Harrison, PF; Ilic, J; Latham, TE; Mohanty, GB; Pappagallo, M; Band, HR; Chen, X; Dasu, S; Flood, KT; Hollar, JJ; Kutter, PE; Pan, Y; Pierini, M; Prepost, R; Wu, SL; Neal, H Aubert, B.; Bona, M.; Boutigny, D.; Karyotakis, Y.; Lees, J. P.; Poireau, V.; Prudent, X.; Tisserand, V.; Zghiche, A.; Tico, J. Garra; Grauges, E.; Lopez, L.; Palano, A.; Eigen, G.; Stugu, B.; Sun, L.; Abrams, G. S.; Battaglia, M.; Brown, D. N.; Button-Shafer, J.; Cahn, R. N.; Groysman, Y.; Jacobsen, R. G.; Kadyk, J. A.; Kerth, L. T.; Kolomensky, Yu. G.; Kukartsev, G.; Pegna, D. Lopes; Lynch, G.; Mir, L. M.; Orimoto, T. J.; Ronan, M. T.; Tackmann, K.; Wenzel, W. A.; Sanchez, P. Del Amo; Hawkes, C. M.; Watson, A. T.; Held, T.; Koch, H.; Lewandowski, B.; Pelizaeus, M.; Schroeder, T.; Steinke, M.; Walker, D.; Asgeirsson, D. J.; Cuhadar-Donszelmann, T.; Fulsom, B. G.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; Khan, A.; Saleem, M.; Teodorescu, L.; Blinov, V. E.; Bukin, A. D.; Druzhinin, V. P.; Golubev, V. B.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Bondioli, M.; Curry, S.; Eschrich, I.; Kirkby, D.; Lankford, A. J.; Lund, P.; Mandelkern, M.; Martin, E. C.; Stoker, D. P.; Abachi, S.; Buchanan, C.; Foulkes, S. D.; Gary, J. W.; Liu, F.; Long, O.; Shen, B. C.; Zhang, L.; Paar, H. P.; Rahatlou, S.; Sharma, V.; Berryhill, J. W.; Campagnari, C.; Cunha, A.; Dahmes, B.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; Beck, T. W.; Eisner, A. M.; Flacco, C. J.; Heusch, C. A.; Kroseberg, J.; Lockman, W. S.; Schalk, T.; Schumm, B. A.; Seiden, A.; Williams, D. C.; Wilson, M. G.; Winstrom, L. O.; Chen, E.; Cheng, C. H.; Fang, F.; Hitlin, D. G.; Narsky, I.; Piatenko, T.; Porter, F. C.; Andreassen, R.; Mancinelli, G.; Meadows, B. T.; Mishra, K.; Sokoloff, M. D.; Blanc, F.; Bloom, P. C.; Chen, S.; Ford, W. T.; Hirschauer, J. F.; Kreisel, A.; Nagel, M.; Nauenberg, U.; Olivas, A.; Smith, J. G.; Ulmer, K. A.; Wagner, S. R.; Zhang, J.; Gabareen, A. M.; Soffer, A.; Toki, W. H.; Wilson, R. J.; Winklmeier, F.; Zeng, Q.; Altenburg, D. D.; Feltresi, E.; Hauke, A.; Jasper, H.; Merkel, J.; Petzold, A.; Spaan, B.; Wacker, K.; Brandt, T.; Klose, V.; Kobel, M. J.; Lacker, H. M.; Mader, W. F.; Nogowski, R.; Schubert, J.; Schubert, K. R.; Schwierz, R.; Sundermann, J. E.; Volk, A.; Bernard, D.; Bonneaud, G. R.; Latour, E.; Lombardo, V.; Thiebaux, Ch.; Verderi, M.; Clark, P. J.; Gradl, W.; Muheim, F.; Playfer, S.; Robertson, A. I.; Xie, Y.; Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Prencipe, E.; Santoro, V.; Anulli, F.; Baldini-Ferroli, R.; Calcaterra, A.; De Sangro, R.; Finocchiaro, G.; Pacetti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Buzzo, A.; Contri, R.; Lo Vetere, M.; Macri, M. M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Tosi, S.; Chaisanguanthum, K. S.; Morii, M.; Wu, J.; Dubitzky, R. S.; Marks, J.; Schenk, S.; Uwer, U.; Bard, D. J.; Dauncey, P. D.; Flack, R. L.; Nash, J. A.; Nikolich, M. B.; Vazquez, W. Panduro; Tibbetts, M.; Behera, P. K.; Chai, X.; Charles, M. J.; Mallik, U.; Meyer, N. T.; Ziegler, V.; Cochran, J.; Crawley, H. B.; Dong, L.; Eyges, V.; Meyer, W. T.; Prell, S.; Rosenberg, E. I.; Rubin, A. E.; Gritsan, A. V.; Guo, Z. J.; Lae, C. K.; Denig, A. G.; Fritsch, M.; Schott, G.; Arnaud, N.; Bequilleux, J.; Davier, M.; Grosdidier, G.; Cker, A. Ho; Lepeltier, V.; Le Diberder, F.; Lutz, A. M.; Pruvot, S.; Rodier, S.; Roudeau, P.; Schune, M. H.; Serrano, J.; Sordini, V.; Stocchi, A.; Wang, W. F.; Wormser, G.; Lange, D. J.; Wright, D. M.; Bingham, I.; Chavez, C. A.; Forster, I. J.; Fry, J. R.; Gabathuler, E.; Gamet, R.; Hutchcroft, D. E.; Payne, D. J.; Schofield, K. C.; Touramanis, C.; Bevan, A. J.; George, K. A.; Di Lodovico, F.; Menges, W.; Sacco, R.; Cowan, G.; Flaecher, H. U.; Hopkins, D. A.; Paramesvaran, S.; Salvatore, F.; Wren, A. C.; Brown, D. N.; Davis, C. L.; Allison, J.; Barlow, N. R.; Barlow, R. J.; Chia, Y. M.; Edgar, C. L.; Lafferty, G. D.; West, T. J.; Yi, J. I.; Anderson, J.; Chen, C.; Jawahery, A.; Roberts, D. A.; Simi, G.; Tuggle, J. M.; Blaylock, G.; Dallapiccola, C.; Hertzbach, S. S.; Li, X.; Moore, T. B.; Salvati, E.; Saremi, S.; Cowan, R.; Dujmic, D.; Fisher, P. H.; Koeneke, K.; Sciolla, G.; Sekula, S. J.; Spitznagel, M.; Taylor, F.; Yamamoto, R. K.; Zhao, M.; Zheng, Y.; Mclachlin, S. E.; Patel, P. M.; Robertson, S. H.; Lazzaro, A.; Palombo, F.; Bauer, J. M.; Cremaldi, L.; Eschenburg, V.; Godang, R.; Kroeger, R.; Sanders, D. A.; Summers, D. J.; Zhao, H. W.; Brunet, S.; Cote, D.; Simard, M.; Taras, P.; Viaud, F. B.; Nicholson, H.; De Nardo, G.; Fabozzi, F.; Lista, L.; Monorchio, D.; Sciacca, C.; Baak, M. A.; Raven, G.; Snoek, H. L.; Jessop, C. P.; LoSecco, J. M.; Benelli, G.; Corwin, L. A.; Honscheid, K.; Kagan, H.; Kass, R.; Morris, J. P.; Rahimi, A. M.; Regensburger, J. J.; Wong, Q. K.; Blount, N. L.; Brau, J.; Frey, R.; Igonkina, O.; Kolb, J. A.; Lu, M.; Rahmat, R.; Sinev, N. B.; Strom, D.; Strube, J.; Torrence, E.; Gagliardi, N.; Gaz, A.; Margoni, M.; Morandin, M.; Pompili, A.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Voci, C.; Ben-Haim, E.; Briand, H.; Calderini, G.; Chauveau, J.; David, P.; Del Buono, L.; Re, Ch. De la Vaissie; Hamon, O.; Leruste, Ph.; Malcles, J.; Ocariz, J.; Perez, A.; Gladney, L.; Biasini, M.; Covarelli, R.; Manoni, E.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Cenci, R.; Cervelli, A.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Mazur, M. A.; Morganti, M.; Neri, N.; Paoloni, E.; Rizzo, G.; Walsh, J. J.; Haire, M.; Biesiada, J.; Elmer, P.; Lau, Y. P.; Lu, C.; Olsen, J.; Smith, A. J. S.; Telnov, A. V.; Baracchini, E.; Bellini, F.; Cavoto, G.; D'Orazio, A.; Del Re, D.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Jackson, P. D.; Gioi, L. Li; Mazzoni, M. A.; Morganti, S.; Piredda, G.; Polci, F.; Renga, F.; Voena, C.; Ebert, M.; Hartmann, T.; Der, H. Schro; Waldi, R.; Adye, T.; Castelli, G.; Franek, B.; Olaiya, E. O.; Ricciardi, S.; Roethel, W.; Wilson, F. F.; Aleksan, R.; Emery, S.; Escalier, M.; Gaidot, A.; Ganzhur, S. F.; De Monchenault, G. Hamel; Kozanecki, W.; Vasseur, G.; Che, Ch. Ye; Zito, M.; Chen, X. R.; Liu, H.; Park, W.; Purohit, M. V.; Wilson, J. R.; Allen, M. T.; Aston, D.; Bartoldus, R.; Bechtle, P.; Berger, N.; Claus, R.; Coleman, J. P.; Convery, M. R.; Dingfelder, J. C.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Field, R. C.; Glanzman, T.; Gowdy, S. J.; Graham, M. T.; Grenier, P.; Hast, C.; Hryn'ova, T.; Innes, W. R.; Kaminski, J.; Kelsey, M. H.; Kim, H.; Kim, P.; Kocian, M. L.; Leith, D. W. G. S.; Li, S.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Marsiske, H.; Messner, R.; Muller, D. R.; O'Grady, C. P.; Ofte, I.; Perazzo, A.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Schwiening, J.; Snyder, A.; Stelzer, J.; Su, D.; Sullivan, M. K.; Suzuki, K.; Swain, S. K.; Thompson, J. M.; Va'vra, J.; Van Bakel, N.; Wagner, A. P.; Weaver, M.; Wisniewski, W. J.; Wittgen, M.; Wright, D. H.; Yarritu, A. K.; Yi, K.; Young, C. C.; Burchat, P. R.; Edwards, A. J.; Majewski, S. A.; Petersen, B. A.; Wilden, L.; Ahmed, S.; Alam, M. S.; Bula, R.; Ernst, J. A.; Jain, V.; Pan, B.; Saeed, M. A.; Wappler, F. R.; Zain, S. B.; Bugg, W.; Krishnamurthy, M.; Spanier, S. M.; Eckmann, R.; Ritchie, J. L.; Ruland, A. M.; Schilling, C. J.; Schwitters, R. F.; Izen, J. M.; Lou, X. C.; Bianchi, S. Ye F.; Gallo, F.; Gamba, D.; Pelliccioni, M.; Bomben, M.; Bosisio, L.; Cartaro, C.; Cossutti, F.; Della Ricca, G.; Lanceri, L.; Vitale, L.; Azzolini, V.; Lopez-March, N.; Martinez-Vidal, F.; Milanes, D. A.; Oyanguren, A.; Albert, J.; Banerjee, Sw.; Bhuyan, B.; Hamano, K.; Kowalewski, R.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Back, J. J.; Harrison, P. F.; Ilic, J.; Latham, T. E.; Mohanty, G. B.; Pappagallo, M.; Band, H. R.; Chen, X.; Dasu, S.; Flood, K. T.; Hollar, J. J.; Kutter, P. E.; Pan, Y.; Pierini, M.; Prepost, R.; Wu, S. L.; Neal, H. Observation of tree-level B decays with s(s)over-bar production from gluon radiation PHYSICAL REVIEW LETTERS English Article We report on our search for decays proceeding via a tree-level b -> c quark transition in which a gluon radiates into an s (s) over bar pair. We present observations of the decays B(-)-> D(s)(*)(+)K(-) pi(-) and (B) over bar (0) -> D(s)(+)K(S)(0)pi(-) and evidence for B(-)-> D(s)(+) K(-) K(-) and set upper limits on the branching fractions for (B) over bar (0) -> D(s)(*+)K(S)(0) pi(-) and B(-) -> D(s)(*+)K(-) K(-) using 383 x 10(6) gamma(4S)-> B (B) over bar events collected by the BABAR detector at SLAC. We present evidence that the invariant mass distributions of D(s)((*)+)K(-) pairs from B(-) -> D(s)(*)(+)K(-)pi(-) decays are inconsistent with the phase-space model, suggesting the presence of charm resonances lying below the D(s)(*)(+) K(-) threshold. [Aubert, B.; Bona, M.; Boutigny, D.; Karyotakis, Y.; Lees, J. P.; Poireau, V.; Prudent, X.; Tisserand, V.; Zghiche, A.] CNRS, IN2P3, Phys Particules Lab, F-74941 Annecy Le Vieux, France; [Aubert, B.; Bona, M.; Boutigny, D.; Karyotakis, Y.; Lees, J. P.; Poireau, V.; Prudent, X.; Tisserand, V.; Zghiche, A.] Univ Savoie, F-74941 Annecy Le Vieux, France; [Tico, J. Garra; Grauges, E.] Univ Barcelona, Fac Fis, Dept ECM, E-08028 Barcelona, Spain; [Lopez, L.; Palano, A.] Ist Nazl Fis Nucl, I-70126 Bari, Italy; [Lopez, L.; Palano, A.] Univ Bari, Dipartimento Fis, I-70126 Bari, Italy; [Eigen, G.; Stugu, B.; Sun, L.] Univ Bergen, Inst Phys, N-5007 Bergen, Norway; [Abrams, G. S.; Battaglia, M.; Brown, D. N.; Button-Shafer, J.; Cahn, R. N.; Groysman, Y.; Jacobsen, R. G.; Kadyk, J. A.; Kerth, L. T.; Kolomensky, Yu. G.; Kukartsev, G.; Pegna, D. Lopes; Lynch, G.; Mir, L. M.; Orimoto, T. J.; Ronan, M. T.; Tackmann, K.; Wenzel, W. A.] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA; [Sanchez, P. Del Amo; Hawkes, C. M.; Watson, A. T.] Univ Birmingham, Birmingham B15 2TT, W Midlands, England; [Held, T.; Koch, H.; Lewandowski, B.; Pelizaeus, M.; Schroeder, T.; Steinke, M.] Ruhr Univ Bochum, Inst Expt Phys 1, D-44780 Bochum, Germany; [Walker, D.] Univ Bristol, Bristol BS8 1TL, Avon, England; [Asgeirsson, D. J.; Cuhadar-Donszelmann, T.; Fulsom, B. G.; Hearty, C.; Mattison, T. S.; McKenna, J. A.] Univ British Columbia, Vancouver, BC V6T 1Z1, Canada; [Khan, A.; Saleem, M.; Teodorescu, L.] Brunel Univ, Uxbridge UB8 3PH, Middx, England; [Blinov, V. E.; Bukin, A. D.; Druzhinin, V. P.; Golubev, V. B.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.] Budker Inst Nucl Phys, Novosibirsk 630090, Russia; [Bondioli, M.; Curry, S.; Eschrich, I.; Kirkby, D.; Lankford, A. J.; Lund, P.; Mandelkern, M.; Martin, E. C.; Stoker, D. P.] Univ Calif Irvine, Irvine, CA 92697 USA; [Abachi, S.; Buchanan, C.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA; [Foulkes, S. D.; Gary, J. W.; Liu, F.; Long, O.; Shen, B. C.] Univ Calif Riverside, Riverside, CA 92521 USA; [Paar, H. P.; Rahatlou, S.; Sharma, V.] Univ Calif San Diego, La Jolla, CA 92093 USA; [Berryhill, J. W.; Campagnari, C.; Cunha, A.; Dahmes, B.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; Eisner, A. M.] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA; [Beck, T. W.; Eisner, A. M.; Flacco, C. J.; Heusch, C. A.; Kroseberg, J.; Lockman, W. S.; Schalk, T.; Schumm, B. A.; Seiden, A.; Williams, D. C.; Wilson, M. G.; Winstrom, L. O.] Univ Calif Santa Cruz, Inst Particle Phys, Santa Cruz, CA 95064 USA; [Chen, E.; Cheng, C. H.; Fang, F.; Hitlin, D. G.; Narsky, I.; Piatenko, T.; Porter, F. C.] CALTECH, Pasadena, CA 91125 USA; [Andreassen, R.; Mancinelli, G.; Meadows, B. T.; Mishra, K.; Sokoloff, M. D.] Univ Cincinnati, Cincinnati, OH 45221 USA; [Blanc, F.; Bloom, P. C.; Chen, S.; Ford, W. T.; Hirschauer, J. F.; Kreisel, A.; Nagel, M.; Nauenberg, U.; Olivas, A.; Smith, J. G.; Ulmer, K. A.; Wagner, S. R.; Zhang, J.] Univ Colorado, Boulder, CO 80309 USA; [Gabareen, A. M.; Soffer, A.; Toki, W. H.; Wilson, R. J.; Winklmeier, F.; Zeng, Q.] Colorado State Univ, Ft Collins, CO 80523 USA; [Altenburg, D. D.; Feltresi, E.; Hauke, A.; Jasper, H.; Merkel, J.; Petzold, A.; Spaan, B.; Wacker, K.] Univ Dortmund, Inst Phys, D-44221 Dortmund, Germany; [Brandt, T.; Klose, V.; Kobel, M. J.; Lacker, H. M.; Mader, W. F.; Nogowski, R.; Schubert, J.; Schubert, K. R.; Schwierz, R.; Sundermann, J. E.; Volk, A.] Tech Univ Dresden, Inst Kern & Teilchenphys, D-01062 Dresden, Germany; [Bernard, D.; Bonneaud, G. R.; Latour, E.; Lombardo, V.; Thiebaux, Ch.; Verderi, M.] Ecole Polytech, IN2P3, CNRS, Lab Leprince Ringuet, F-91128 Palaiseau, France; [Clark, P. J.; Gradl, W.; Muheim, F.; Playfer, S.; Robertson, A. I.; Xie, Y.] Univ Edinburgh, Edinburgh EH9 3JZ, Midlothian, Scotland; [Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Prencipe, E.; Santoro, V.] Univ Ferrara, Dipartmento Fis, I-44100 Ferrara, Italy; [Andreotti, M.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cecchi, A.; Cibinetto, G.; Franchini, P.; Luppi, E.; Negrini, M.; Petrella, A.; Piemontese, L.; Prencipe, E.; Santoro, V.] Ist Nazl Fis Nucl, I-44100 Ferrara, Italy; [Anulli, F.; Baldini-Ferroli, R.; Calcaterra, A.; De Sangro, R.; Finocchiaro, G.; Pacetti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.] Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy; [Anulli, F.; Baldini-Ferroli, R.; Calcaterra, A.; De Sangro, R.; Finocchiaro, G.; Pacetti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.] Ist Nazl Fis Nucl, I-16146 Genoa, Italy; [Buzzo, A.; Contri, R.; Lo Vetere, M.; Macri, M. M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Santroni, A.; Tosi, S.] Univ Genoa, Dipartimento Fis, I-16146 Genoa, Italy; [Chaisanguanthum, K. S.; Morii, M.; Wu, J.] Harvard Univ, Cambridge, MA 02138 USA; [Chaisanguanthum, K. S.; Morii, M.; Wu, J.] Univ Heidelberg, Inst Phys, D-69120 Heidelberg, Germany; [Dubitzky, R. S.; Marks, J.; Schenk, S.; Uwer, U.] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England; [Bard, D. J.; Dauncey, P. D.; Flack, R. L.; Nash, J. A.; Nikolich, M. B.; Vazquez, W. Panduro; Tibbetts, M.] Univ Iowa, Iowa City, IA 52242 USA; [Behera, P. K.; Chai, X.; Charles, M. J.; Mallik, U.; Meyer, N. T.; Ziegler, V.] Iowa State Univ, Ames, IA 50011 USA; [Cochran, J.; Crawley, H. B.; Dong, L.; Eyges, V.; Meyer, W. T.; Prell, S.; Rosenberg, E. I.; Rubin, A. E.; Gritsan, A. V.] Johns Hopkins Univ, Baltimore, MD 21218 USA; [Gritsan, A. V.; Guo, Z. J.; Lae, C. K.] Univ Karlsruhe, Inst Expt Kernphys, D-76021 Karlsruhe, Germany; [Denig, A. G.; Fritsch, M.; Schott, G.] Univ Paris 11, Ctr Sci Orsay, F-91898 Orsay, France; [Arnaud, N.; Bequilleux, J.; Davier, M.; Grosdidier, G.; Cker, A. Ho; Lepeltier, V.; Le Diberder, F.; Lutz, A. M.; Pruvot, S.; Rodier, S.; Roudeau, P.; Schune, M. H.; Serrano, J.; Sordini, V.; Stocchi, A.; Wang, W. F.; Wormser, G.] Univ Paris 11, CNRS, IN2P3, Lab Accelerateur Lineaire, F-91898 Orsay, France; [Lange, D. J.; Wright, D. M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA; [Bingham, I.; Chavez, C. A.; Forster, I. J.; Fry, J. R.; Gabathuler, E.; Gamet, R.; Hutchcroft, D. E.; Payne, D. J.; Schofield, K. C.; Touramanis, C.] Univ Liverpool, Liverpool L69 7ZE, Merseyside, England; [Bevan, A. J.; George, K. A.; Di Lodovico, F.; Menges, W.; Sacco, R.] Univ London, London E1 4NS, England; [Cowan, G.; Flaecher, H. U.; Hopkins, D. A.; Paramesvaran, S.; Salvatore, F.; Wren, A. C.] Univ London, Egham TW20 0EX, Surrey, England; [Cowan, G.; Flaecher, H. U.; Hopkins, D. A.; Paramesvaran, S.; Salvatore, F.; Wren, A. C.] Bedford New Coll, Egham TW20 0EX, Surrey, England; [Brown, D. N.; Davis, C. L.] Univ Louisville, Louisville, KY 40292 USA; [Allison, J.; Barlow, N. R.; Barlow, R. J.; Chia, Y. M.; Edgar, C. L.; Lafferty, G. D.; West, T. J.; Yi, J. I.] Univ Manchester, Manchester M13 9PL, Lancs, England; [Anderson, J.; Chen, C.; Jawahery, A.; Roberts, D. A.; Simi, G.; Tuggle, J. M.] Univ Maryland, College Pk, MD 20742 USA; [Blaylock, G.; Dallapiccola, C.; Hertzbach, S. S.; Li, X.; Moore, T. B.; Salvati, E.; Saremi, S.; Cowan, R.] Univ Massachusetts, Amherst, MA 01003 USA; [Cowan, R.; Dujmic, D.; Fisher, P. H.; Koeneke, K.; Sciolla, G.; Sekula, S. J.; Spitznagel, M.; Taylor, F.; Yamamoto, R. K.; Zhao, M.; Zheng, Y.] MIT, Nucl Sci Lab, Cambridge, MA 02139 USA; [Mclachlin, S. E.; Patel, P. M.; Robertson, S. H.] McGill Univ, Montreal, PQ H3A 2T8, Canada; [Lazzaro, A.; Palombo, F.] Univ Milan, Dipartimento Fis, I-20133 Milan, Italy; [Lazzaro, A.; Palombo, F.] Ist Nazl Fis Nucl, I-20133 Milan, Italy; [Bauer, J. M.; Cremaldi, L.; Eschenburg, V.; Godang, R.; Kroeger, R.; Sanders, D. A.; Summers, D. J.; Zhao, H. W.] Univ Mississippi, University, MS 38677 USA; [Brunet, S.; Cote, D.; Simard, M.; Taras, P.; Viaud, F. B.] Univ Montreal, Montreal, PQ H3C 3J7, Canada; [Nicholson, H.] Mt Holyoke Coll, S Hadley, MA 01075 USA; [De Nardo, G.; Fabozzi, F.; Lista, L.; Monorchio, D.; Sciacca, C.] Ist Nazl Fis Nucl, I-80126 Naples, Italy; [De Nardo, G.; Fabozzi, F.; Lista, L.; Monorchio, D.; Sciacca, C.] Univ Naples Federico 2, Dipartimento Sci Fis, I-80126 Naples, Italy; [Baak, M. A.; Raven, G.; Snoek, H. L.] NIKHEF H, Inst Nucl Phys & High Energy Phys, NL-1009 DB Amsterdam, Netherlands; [Jessop, C. P.; LoSecco, J. M.] Univ Notre Dame, Notre Dame, IN 46556 USA; [Jessop, C. P.; LoSecco, J. M.; Benelli, G.; Corwin, L. A.; Honscheid, K.; Kagan, H.; Kass, R.; Morris, J. P.; Rahimi, A. M.; Regensburger, J. J.; Wong, Q. K.] Ohio State Univ, Columbus, OH 43210 USA; [Blount, N. L.; Brau, J.; Frey, R.; Igonkina, O.; Kolb, J. A.; Rahmat, R.; Sinev, N. B.; Strom, D.; Strube, J.; Torrence, E.; Lu, C.] Univ Oregon, Eugene, OR 97403 USA; [Gagliardi, N.; Gaz, A.; Margoni, M.; Morandin, M.; Pompili, A.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Voci, C.] Univ Padua, Dipartimento Fis, I-35131 Padua, Italy; [Gagliardi, N.; Gaz, A.; Margoni, M.; Morandin, M.; Pompili, A.; Posocco, M.; Rotondo, M.; Simonetto, F.; Stroili, R.; Voci, C.] Ist Nazl Fis Nucl, I-35131 Padua, Italy; [Ben-Haim, E.; Briand, H.; Calderini, G.; Chauveau, J.; David, P.; Del Buono, L.; Re, Ch. De la Vaissie; Hamon, O.; Leruste, Ph.; Malcles, J.; Ocariz, J.; Perez, A.] Univ Paris 07, Univ Paris 06, CNRS, IN2P3,Lab Phys Nucl Hautes Energies, F-75252 Paris, France; [Gladney, L.] Univ Penn, Philadelphia, PA 19104 USA; [Biasini, M.; Covarelli, R.; Manoni, E.] Ist Nazl Fis Nucl, I-06100 Perugia, Italy; [Biasini, M.; Covarelli, R.; Manoni, E.] Univ Perugia, Dipartimento Fis, I-06100 Perugia, Italy; [Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Cenci, R.; Cervelli, A.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Mazur, M. A.; Morganti, M.; Neri, N.; Paoloni, E.; Rizzo, G.; Walsh, J. J.] Univ Pisa, Dipartimento Fis, Scuola Normale Super Pisa, I-56127 Pisa, Italy; [Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Cenci, R.; Cervelli, A.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Marchiori, G.; Mazur, M. A.; Morganti, M.; Neri, N.; Paoloni, E.; Rizzo, G.; Walsh, J. J.] Ist Nazl Fis Nucl, I-56127 Pisa, Italy; [Haire, M.] Praire View A&M Univ, Prairie View, TX 77446 USA; [Biesiada, J.; Elmer, P.; Lau, Y. P.; Lu, C.; Olsen, J.; Smith, A. J. S.; Telnov, A. V.] Princeton Univ, Princeton, NJ 08544 USA; [Buzzo, A.; Baracchini, E.; Bellini, F.; Cavoto, G.; D'Orazio, A.; Del Re, D.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Jackson, P. D.; Gioi, L. Li; Mazzoni, M. A.; Morganti, S.; Piredda, G.; Polci, F.; Renga, F.; Voena, C.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Baracchini, E.; Bellini, F.; Cavoto, G.; D'Orazio, A.; Del Re, D.; Di Marco, E.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Jackson, P. D.; Gioi, L. Li; Mazzoni, M. A.; Morganti, S.; Piredda, G.; Polci, F.; Renga, F.; Voena, C.] Ist Nazl Fis Nucl, I-00185 Rome, Italy; [Ebert, M.; Hartmann, T.; Der, H. Schro; Waldi, R.] Univ Rostock, D-18051 Rostock, Germany; [Adye, T.; Castelli, G.; Franek, B.; Olaiya, E. O.; Ricciardi, S.; Roethel, W.; Wilson, F. F.] Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England; [Aleksan, R.; Emery, S.; Escalier, M.; Gaidot, A.; Ganzhur, S. F.; De Monchenault, G. Hamel; Kozanecki, W.; Vasseur, G.; Che, Ch. Ye; Zito, M.] CEA Saclay, DSM Dapnia, F-91191 Gif Sur Yvette, France; [Chen, X. R.; Liu, H.; Park, W.; Purohit, M. V.; Wilson, J. R.] Univ S Carolina, Columbia, SC 29208 USA; [Allen, M. T.; Aston, D.; Bartoldus, R.; Bechtle, P.; Berger, N.; Claus, R.; Coleman, J. P.; Convery, M. R.; Dingfelder, J. C.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Field, R. C.; Glanzman, T.; Gowdy, S. J.; Graham, M. T.; Grenier, P.; Hast, C.; Hryn'ova, T.; Innes, W. R.; Kaminski, J.; Kelsey, M. H.; Kim, H.; Kim, P.; Kocian, M. L.; Leith, D. W. G. S.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Marsiske, H.; Messner, R.; Muller, D. R.; O'Grady, C. P.; Ofte, I.; Perazzo, A.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Schwiening, J.; Snyder, A.; Stelzer, J.; Su, D.; Sullivan, M. K.; Suzuki, K.; Swain, S. K.; Thompson, J. M.; Va'vra, J.; Van Bakel, N.; Wagner, A. P.; Weaver, M.; Wisniewski, W. J.; Wittgen, M.; Wright, D. H.; Yarritu, A. K.; Yi, K.; Young, C. C.] Stanford Linear Accelerator Ctr, Stanford, CA 94309 USA; [Burchat, P. R.; Edwards, A. J.; Majewski, S. A.; Petersen, B. A.; Wilden, L.] Stanford Univ, Stanford, CA 94305 USA; [Ahmed, S.; Alam, M. S.; Bula, R.; Ernst, J. A.; Jain, V.; Pan, B.; Saeed, M. A.; Wappler, F. R.; Zain, S. B.] SUNY Albany, Albany, NY 12222 USA; [Bugg, W.; Krishnamurthy, M.; Spanier, S. M.] Univ Tennessee, Knoxville, TN 37996 USA; [Eckmann, R.; Ritchie, J. L.; Ruland, A. M.; Schilling, C. J.; Schwitters, R. F.] Univ Texas Austin, Austin, TX 78712 USA; [Izen, J. M.; Lou, X. C.] Univ Texas Dallas, Richardson, TX 75083 USA; [Bianchi, S. Ye F.; Gallo, F.; Gamba, D.; Pelliccioni, M.] Ist Nazl Fis Nucl, I-10125 Turin, Italy; [Bianchi, S. Ye F.; Gallo, F.; Gamba, D.; Pelliccioni, M.] Univ Turin, Dipartimento Fis Sperimentale, I-10125 Turin, Italy; [Bomben, M.; Bosisio, L.; Cartaro, C.; Cossutti, F.; Della Ricca, G.; Lanceri, L.; Vitale, L.] Ist Nazl Fis Nucl, I-34127 Trieste, Italy; [Bomben, M.; Bosisio, L.; Cartaro, C.; Cossutti, F.; Della Ricca, G.; Lanceri, L.; Vitale, L.] Univ Trieste, Dipartimento Fis, I-34127 Trieste, Italy; [Azzolini, V.; Lopez-March, N.; Martinez-Vidal, F.; Milanes, D. A.; Oyanguren, A.] Univ Valencia, CSIC, IFIC, E-46071 Valencia, Spain; [Albert, J.; Banerjee, Sw.; Bhuyan, B.; Hamano, K.; Kowalewski, R.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.] Univ Victoria, Victoria, BC V8W 3P6, Canada; [Back, J. J.; Harrison, P. F.; Ilic, J.; Latham, T. E.; Mohanty, G. B.; Pappagallo, M.; Band, H. R.] Univ Warwick, Dept Phys, Coventry CV4 7AL, W Midlands, England; [Pan, B.; Band, H. R.; Chen, X.; Dasu, S.; Flood, K. T.; Hollar, J. J.; Kutter, P. E.; Pan, Y.; Pierini, M.; Prepost, R.; Wu, S. L.] Univ Wisconsin, Madison, WI 53706 USA; [Neal, H.] Yale Univ, New Haven, CT 06511 USA Aubert, B (reprint author), CNRS, IN2P3, Phys Particules Lab, F-74941 Annecy Le Vieux, France. Patrignani, Claudia/C-5223-2009; Lista, Luca/C-5719-2008; Bellini, Fabio/D-1055-2009; Neri, Nicola/G-3991-2012; Forti, Francesco/H-3035-2011; Rotondo, Marcello/I-6043-2012; de Sangro, Riccardo/J-2901-2012; Lo Vetere, Maurizio/J-5049-2012; Monge, Maria Roberta/G-9127-2012; Saeed, Mohammad/J-7455-2012; Della Ricca, Giuseppe/B-6826-2013 Patrignani, Claudia/0000-0002-5882-1747; Forti, Francesco/0000-0001-6535-7965; de Sangro, Riccardo/0000-0002-3808-5455; Lo Vetere, Maurizio/0000-0002-6520-4480; Monge, Maria Roberta/0000-0003-1633-3195; Saeed, Mohammad/0000-0002-3529-9255; Della Ricca, Giuseppe/0000-0003-2831-6982 11 4 4 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 0031-9007 PHYS REV LETT Phys. Rev. Lett. MAY 2 2008 100 17 171803 10.1103/PhysRevLett.100.171803 7 Physics, Multidisciplinary Physics 296DS WOS:000255524300024 J Jorg, T; Ricci-Tersenghi, F Jorg, Thomas; Ricci-Tersenghi, Federico Entropic effects in the very low temperature regime of diluted ising spin glasses with discrete couplings PHYSICAL REVIEW LETTERS English Article MONTE-CARLO; FRUSTRATED SYSTEMS; ORDER; DYNAMICS; SIMULATIONS; PERCOLATION; BEHAVIOR We study link-diluted +/- J Ising spin glass models on the hierarchical lattice and on a three-dimensional lattice close to the percolation threshold. We show that previously computed zero temperature fixed points are unstable with respect to temperature perturbations and do not belong to any critical line in the dilution-temperature plane. We discuss implications of the presence of such spurious unstable fixed points on the use of optimization algorithms, and we show how entropic effects should be taken into account to obtain the right physical behavior and critical points. [Jorg, Thomas] Univ Paris 11, LPTMS, F-91405 Orsay, France; [Jorg, Thomas] Equipe TAO INRIA Futurs, F-91405 Orsay, France; [Ricci-Tersenghi, Federico] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Ricci-Tersenghi, Federico] Univ Roma La Sapienza, INFM CNR, I-00185 Rome, Italy Jorg, T (reprint author), Univ Paris 11, LPTMS, Batiment 100, F-91405 Orsay, France. 30 10 10 AMER PHYSICAL SOC COLLEGE PK ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA 0031-9007 PHYS REV LETT Phys. Rev. Lett. MAY 2 2008 100 17 177203 10.1103/PhysRevLett.100.177203 4 Physics, Multidisciplinary Physics 296DS WOS:000255524300074 J Chiwiacowsky, LD; Gasbarri, P; Velho, HFD Chiwiacowsky, Leonardo D.; Gasbarri, Paolo; de Campos Velho, Haroldo F. Damage assessment of large space structures through the variational approach ACTA ASTRONAUTICA English Article large space structure; damage assessment; inverse vibration problems; structural dynamics The present investigation is focused on the solution of a dynamic inverse problem which is concerned with the assessment of damage in large space structures by means of measured vibration data. This inverse problem has been presented as an optimization problem and has been solved through the use of the conjugate gradient method with the adjoint equation, also called the variational approach. When a high number of damaged elements has to be found and these elements are also severely damaged, it is shown that the use of an additional method is necessary in order to provide a better initial guess for the conjugate gradient method. A stochastic method, represented by the genetic algorithm method, has been chosen because it provides robust search in complex spaces and also reduces the chance of converging to local optima. The application of this hybrid approach showed that better results can be achieved, although the computational time for the application analyzed here could increase. The damage estimation has been evaluated using noiseless and noisy synthetic experimental data, and the reported results are concerned with a space truss structure. (c) 2008 Elsevier Ltd. All rights reserved. [de Campos Velho, Haroldo F.] Inst Nacl Pesquisas Espaciais, Lab Associado Computacao & Matemat Aplicada, BR-12245970 Sao Jose Dos Campos, SP, Brazil; [Chiwiacowsky, Leonardo D.] Univ Vale Rio Sinos UNISINOS, Programa Interdisciplinar Posgaduacao Computacao, BR-93022000 Sao Leopoldo, RS, Brazil; [Gasbarri, Paolo] Univ Roma La Sapienza, Dipartimento Ingn Aerospaziale & Astronaut, I-00184 Rome, Italy Velho, HFD (reprint author), Inst Nacl Pesquisas Espaciais, Lab Associado Computacao & Matemat Aplicada, Av Astronautas 1758,POB 515, BR-12245970 Sao Jose Dos Campos, SP, Brazil. haroldo@lac.inpe.br 28 1 3 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0094-5765 ACTA ASTRONAUT Acta Astronaut. MAY-JUN 2008 62 10-11 592 604 10.1016/j.actaastro.2008.01.017 13 Engineering, Aerospace Engineering 315IS WOS:000256872600005 J Carrasco, F; Majone, M; Beccari, M Carrasco, F.; Majone, M.; Beccari, M. Full Scale Thermophilic Anaerobic Digestion of Sludge: Effect of Co-digestion with Agro-industrial Wastes AFINIDAD Spanish Article Thermophilic anaerobic digestion; Full scale digester; Sludge; Co-digestion; Agro-industrial wastes; Biogas; Empirical models MUNICIPAL SOLID-WASTE; OIL MILL EFFLUENTS; ORGANIC FRACTION; MATHEMATICAL-MODEL; WATER; PERSPECTIVES; REACTORS A full scale (2500 m) study has been performed to improve waste management in an agro-industrial factory of frozen food, by upgrading the thermophilic anaerobic digestion of sludges (from wastewater treatment) toward co-digestion of sludges and agro-industrial solid wastes (mainly wastage of pre-cooked food). The aim was to minimize the amount of wastes to be treated or disposed of out of the factory and to recover energy from wastes, so making the waste management less costly and more environmentally sound. Indeed, biogas flow rate remained quasi constant (1678 +/- 99 and 1623 +/- 147 m(3)/day (standard temperature and pressure, i.e. 0 degrees C and 1 bar), for digestion and co-digestion, respectively). On another hand, total solids removal yield increased from 58.8 to 65.0% and volatile solids removal yield from 66.9 to 72.8%. Therefore, the addition of agro-industrial wastes confirmed the good performance under thermophilic conditions. By means of multiple linear regression analysis it was possible to predict biogas flow rate and removal yield as a function of various process variables. [Carrasco, F.] Univ Girona, Dept Ingn Quim Agr & Tecnol Agroalimentaria, Girona 17071, Spain; [Majone, M.; Beccari, M.] Univ Roma La Sapienza, Dept Quim, I-00185 Rome, Italy Carrasco, F (reprint author), Univ Girona, Dept Ingn Quim Agr & Tecnol Agroalimentaria, Av Lluis Santalo S-N, Girona 17071, Spain. felix.carrasco@udg.edu 31 0 0 ASOC QUIMICOS BARCELONA INST QUIMICO SARRIA, 17 BARCELONA, SPAIN 0001-9704 AFINIDAD Afinidad MAY-JUN 2008 65 535 197 204 8 Chemistry, Multidisciplinary Chemistry 365TM WOS:000260430800003 J Carlsen, KH; Anderson, SD; Bjermer, L; Bonini, S; Brusasco, V; Canonica, W; Cummiskey, J; Delgado, L; Del Giacco, SR; Drobnic, F; Haahtela, T; Larsson, K; Palange, P; Popov, T; van Cauwenberge, P Carlsen, K. H.; Anderson, S. D.; Bjermer, L.; Bonini, S.; Brusasco, V.; Canonica, W.; Cummiskey, J.; Delgado, L.; Del Giacco, S. R.; Drobnic, F.; Haahtela, T.; Larsson, K.; Palange, P.; Popov, T.; van Cauwenberge, P. Treatment of exercise-induced asthma, respiratory and allergic disorders in sports and the relationship to doping: Part II of the report from the Joint Task Force of European Respiratory Society (ERS) and European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA(2)LEN ALLERGY English Review CROSS-COUNTRY SKIERS; INHALED IPRATROPIUM BROMIDE; ACTING BETA-AGONISTS; LONG-TERM TREATMENT; INDUCED BRONCHOCONSTRICTION; ENDURANCE PERFORMANCE; PHYSICAL PERFORMANCE; FLUTICASONE PROPIONATE; POWER OUTPUT; BECLOMETHASONE DIPROPIONATE Aim: The aims of part II is to review the current recommended treatment of exercise-induced asthma (EIA), respiratory and allergic disorders in sports, to review the evidence on possible improvement of performance in sports by asthma drugs and to make recommendations for their treatment. Methods: The literature cited with respect to the treatment of exercise induced asthma in athletes (and in asthma patients) is mainly based upon the systematic review given by Larsson et al. (Larsson K, Carlsen KH, Bonini S. Anti-asthmatic drugs: treatment of athletes and exercise-induced bronchoconstriction. In: Carlsen KH, Delgado L, Del Giacco S, editors. Diagnosis, prevention and treatment of exercise-related asthma, respiratory and allergic disorders in sports. Sheffield, UK: European Respiratory Journals Ltd, 2005:73-88) during the work of the Task Force. To assess the evidence of the literature regarding use of beta(2)-agonists related to athletic performance, the Task Force searched Medline for relevant papers up to November 2006 using the present search words: asthma, bronchial responsiveness, exercise-induced bronchoconstriction, athletes, sports, performance and beta(2)-agonists. Evidence level and grades of recommendation were assessed according to Sign criteria. Results: Treatment recommendations for EIA and bronchial hyper-responsiveness in athletes are set forth with special reference to controller and reliever medications. Evidence for lack of improvement of exercise performance by inhaled beta(2)-agonists in healthy athletes serves as a basis for permitting their use. There is a lack of evidence of treatment effects of asthma drugs on EIA and bronchial hyper-responsiveness in athletes whereas extensive documentation exists in treatment of EIA in patients with asthma. The documentation on lack of improvement on performance by common asthma drugs as inhaled beta(2)-agonists with relationship to sports in healthy individuals is of high evidence, level (1+). Conclusions: Exercise induced asthma should be treated in athletes along same principles as in ordinary asthma patients with relevance to controller and reliever treatment after careful diagnosis. There is very high level of evidence for the lack of improvement in athletic performance by inhaled beta 2-agonists. [Carlsen, K. H.] Univ Oslo, Rikshosp, Fac Med, Dept Paediat,Med Ctr,Norwegian Sch Sport Sci, NO-0791 Oslo, Norway; [Anderson, S. D.] Royal Prince Alfred Hosp, Dept Resp Med, Camperdown, NSW 2050, Australia; [Bjermer, L.] Univ Lund Hosp, Dept Resp Med & Allergol, S-22185 Lund, Sweden; [Bonini, S.] Univ Naples 2, Inst Neurobiol & Mol Med Rome Allergy & Clin Immu, Naples, Italy; [Brusasco, V.] Univ Genoa, Dipartimento Med Interna, Genoa, Italy; [Canonica, W.] Univ Genoa, Dept Internal Med, DIMI, I-16126 Genoa, Italy; [Cummiskey, J.] Blackrock Clin, Blackrock, County Dublin, Ireland; [Delgado, L.] Univ Porto, Hosp S Joao, Fac Med, Serv & Lab Imunol, P-4100 Oporto, Portugal; [Del Giacco, S. R.] Policlin Univ Cagliari, Cagliari, Italy; [Drobnic, F.] Olymp Training Ctr CAR, Sports Physiol Dept, Barcelona, Spain; [Haahtela, T.] Univ Helsinki, Cent Hosp, Skin & Allergy Hosp, Dept Allergy, Helsinki, Finland; [Larsson, K.] Karolinska Inst, Lung & Allergy Res Div Physiol IMM, S-10401 Stockholm, Sweden; [Palange, P.] Dipartimento Med Clin, Rome, Italy; [Popov, T.] Med Univ Sofia, Clin Ctr Allergol, Sofia, Bulgaria; [van Cauwenberge, P.] Univ Ghent, Dept Otorhinolaryngol, B-9000 Ghent, Belgium Carlsen, KH (reprint author), Univ Oslo, Rikshosp, Fac Med, Dept Paediat,Med Ctr,Norwegian Sch Sport Sci, Ullveien 14, NO-0791 Oslo, Norway. Delgado, Luis/L-8035-2013 Delgado, Luis/0000-0003-2375-9071 95 33 35 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 0105-4538 ALLERGY Allergy MAY 2008 63 5 492 505 10.1111/j.1398-9995.2008.01663.x 14 Allergy; Immunology Allergy; Immunology 283LW WOS:000254638700002 J Spoletini, I; Marra, C; Di Iulio, F; Gianni, W; Sancesario, G; Giubilei, F; Trequattrini, A; Bria, P; Caltagirone, C; Spalletta, G Spoletini, Ilaria; Marra, Camillo; Di Iulio, Fulvia; Gianni, Walter; Sancesario, Giuseppe; Giubilei, Franco; Trequattrini, Alberto; Bria, Pietro; Caltagirone, Carlo; Spalletta, Gianfranco Facial emotion recognition deficit in amnestic mild cognitive impairment and Alzheimer disease AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY English Article facial emotion recognition; Alzheimer disease; amnestic mild cognitive impairment; cognition MEDIAL TEMPORAL ATROPHY; HUMAN AMYGDALA; NEUROFIBRILLARY TANGLES; DEMENTIA; MEMORY; EXPRESSIONS; FEARFUL; PSYCHOPATHOLOGY; PERCEPTION; SYMPTOMS Objectives: A deficit in facial emotion recognition was described in patients with Alzheimer disease ( AD). However, this issue has been underexplored in subjects with amnestic mild cognitive impairment ( a- MCI). Thus, the authors aimed to determine whether a deficit in facial emotion recognition is present in a- MCI phase and whether this is intensity dependent. A secondary aim was to investigate relationships between facial emotion recognition and cognitive performances. Design: Case-control study. Setting: Memory clinic. Participants: Fifty a- MCI patients, 50 mild AD patients, and 50 comparison subjects ( COM) were enrolled. Measurements: Information about facial emotion recognition was obtained from Penn Emotion Recognition Test. The Mental Deterioration Battery was used to measure cognitive impairment. Results: Mild AD patients were more impaired in the recognition of almost all emotional stimuli of all intensities than a- MCI and COM subjects. However, there was an increased progression only in lowintensity facial emotion recognition deficit from COM to a- MCI to mild AD patients. In particular, a- MCI subjects differed significantly from COM in low-intensity fearful face recognition performance. This deficit in a- MCI patients was explained by the short-term verbal memory impairment, whereas the same deficit in mild AD patients was explained by the long-term verbal memory impairment. Conclusions: Emotion recognition progresses from a deficit in low-intensity fearful facial recognition in a- MCI phase to a deficit in all intensities and emotions in mild AD. This could be an effect of the progressive degeneration of brain structures modulating emotional processing. An early detection of emotional impairment in MCI phases of dementia may have clinical implications. [Spoletini, Ilaria; Di Iulio, Fulvia; Caltagirone, Carlo; Spalletta, Gianfranco] IRCCS Santa Lucia Fdn, Lab Clin & Behav Neurol, I-00179 Rome, Italy; [Marra, Camillo] Univ Cattolica Sacro Cuore, Dept Neurol, I-00168 Rome, Italy; [Gianni, Walter] IRCCS INRCA, Rome, Italy; [Sancesario, Giuseppe; Caltagirone, Carlo; Spalletta, Gianfranco] Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy; [Giubilei, Franco] Univ Roma La Sapienza, Fac Med 2, Dept Neurol, Rome, Italy; [Trequattrini, Alberto] ASL Gitta Castello, Perugia, Italy; [Bria, Pietro] Univ Cattolica Sacro Cuore, Inst Psychiat, I-00168 Rome, Italy Spalletta, G (reprint author), IRCCS Santa Lucia Fdn, Lab Clin & Behav Neurol, Via Ardeatina 306, I-00179 Rome, Italy. g.spalletta@hsantalucia.it Caltagirone, Carlo/B-4930-2013 49 26 27 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1064-7481 AM J GERIAT PSYCHIAT Am. J. Geriatr. Psychiatr. MAY 2008 16 5 389 398 10.1097/JGP.0b013e318165dbce 10 Geriatrics & Gerontology; Gerontology; Psychiatry Geriatrics & Gerontology; Psychiatry 294PN WOS:000255418100007 J Behar, DM; Villems, R; Soodyall, H; Blue-Smith, J; Pereira, L; Metspalu, E; Scozzari, R; Makkan, H; Tzur, S; Comas, D; Bertranpetit, J; Quintana-Murci, L; Tyler-Smith, C; Wells, RS; Rosset, S Behar, Doron M.; Villems, Richard; Soodyall, Himla; Blue-Smith, Jason; Pereira, Luisa; Metspalu, Ene; Scozzari, Rosaria; Makkan, Heeran; Tzur, Shay; Comas, David; Bertranpetit, Jaume; Quintana-Murci, Lluis; Tyler-Smith, Chris; Wells, R. Spencer; Rosset, Saharon Genographic Consortium The dawn of human matrilineal diversity AMERICAN JOURNAL OF HUMAN GENETICS English Article HUMAN MITOCHONDRIAL-DNA; MODERN HUMAN-BEHAVIOR; FALSE DISCOVERY RATE; MTDNA VARIATION; Y-CHROMOSOME; AFRICAN POPULATIONS; EVOLUTION; HAPLOGROUP; PHYLOGEOGRAPHY; SEQUENCES The quest to explain demographic history during the early part of human evolution has been limited because of the scarce paleoanthropological record from the Middle Stone Age. To shed light on the structure of the mitochondrial DNA (mtDNA) phylogeny at the dawn of Homo sapiens, we constructed a matrilineal tree composed of 624 complete mtDNA genomes from sub-Saharan Hg L lineages. We paid particular attention to the Khoi and San (Khoisan) people of South Africa because they are considered to be a unique relic of hunter-gatherer lifestyle and to carry paternal and maternal lineages belonging to the deepest clades known among modern humans. Both the tree phylogeny and coalescence calculations suggest that Khoisan matrilineal ancestry diverged from the rest of the human mtDNA pool 90,000-150,000 years before present (ybp) and that at least five additional, currently extant maternal lineages existed during this period in parallel. Furthermore, we estimate that a minimum of 40 other evolutionarily successful lineages flourished in sub-Saharan Africa during the period of modern human dispersal out of Africa approximately 60,000-70,000 ybp. Only much later, at the beginning of the Late Stone Age, about 40,000 ybp, did introgression of additional lineages occur into the Khoisan mtDNA pool. This process was further accelerated during the recent Bantu expansions. Our results suggest that the early settlement of humans in Africa was already matrilineally structured and involved small, separately evolving isolated populations. [Behar, Doron M.; Tzur, Shay] Rambam Hlth Care Campus, Mol Med Lab, IL-31096 Haifa, Israel; [Villems, Richard; Metspalu, Ene] Univ Tartu, Dept Evolut Biol, EE-51010 Tartu, Estonia; [Villems, Richard; Metspalu, Ene] Univ Tartu, Dept Evolut Biol, Estonian Bioctr, EE-51010 Tartu, Estonia; [Soodyall, Himla; Makkan, Heeran] Univ Witwatersrand, ZA-2000 Johannesburg, South Africa; [Soodyall, Himla; Makkan, Heeran] Univ Witwatersrand, Natl Hlth Lab Serv, Div Human Genet, Sch Pathol, ZA-2000 Johannesburg, South Africa; [Blue-Smith, Jason; Wells, R. Spencer] Natl Geog Soc, Mission Program, Washington, DC 20036 USA; [Pereira, Luisa] Univ Porto, Inst Pathol & Immunol Mol, P-4200465 Oporto, Portugal; [Pereira, Luisa] Univ Porto, Fac Med, P-4200319 Oporto, Portugal; [Scozzari, Rosaria] Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy; [Comas, David; Bertranpetit, Jaume] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Evolut Biol Unit, Barcelona 08003, Catalonia, Spain; [Quintana-Murci, Lluis] Inst Pasteur, CNRS, URA 3012, Unit Human Evolut Genet, F-75724 Paris, France; [Tyler-Smith, Chris] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England; [Rosset, Saharon] IBM Corp, Thomas J Watson Res Ctr, Data Analyt Res Grp, Yorktown Hts, NY 10598 USA; [Rosset, Saharon] Tel Aviv Univ, Sch Math Sci, Dept Stat & Operat Res, IL-69978 Tel Aviv, Israel Behar, DM (reprint author), Rambam Hlth Care Campus, Mol Med Lab, IL-31096 Haifa, Israel. behardm@usernet.com Pereira, Luisa /H-3050-2011; Cooper, Alan/E-8171-2012; Bertranpetit, Jaume/F-8550-2012; Santos, Fabricio/H-2370-2011 Pereira, Luisa /0000-0002-4271-1527; Cooper, Alan/0000-0002-7738-7851; Santos, Fabricio/0000-0001-9088-1750 48 156 158 CELL PRESS CAMBRIDGE 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA 0002-9297 AM J HUM GENET Am. J. Hum. Genet. MAY 2008 82 5 1130 1140 10.1016/j.ajhg.2008.04.002 11 Genetics & Heredity Genetics & Heredity 301VJ WOS:000255923600012 J Santoni, A; Carlino, C; Stabile, H; Gismondi, A Santoni, Angela; Carlino, Claudia; Stabile, Helena; Gismondi, Angela Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY English Review adhesion molecules; chemokines; decidual endothelial cells; decidual stromal cells; NK cell migration; uterine NK cells NATURAL-KILLER-CELLS; PERIPHERAL-BLOOD LYMPHOCYTES; HUMAN ENDOMETRIUM; ADHESION MOLECULES; ENDOTHELIAL-CELLS; MENSTRUAL-CYCLE; DIFFERENTIAL EXPRESSION; LEUKOCYTE RECRUITMENT; VASCULAR ENDOTHELIUM; EMBRYO IMPLANTATION Natural killer (NK) cells represent the most prominent immune cell type found in the uterus in the first trimester of human pregnancy and in the secretory phase of menstrual cycle. The role of NK cells in pregnancy has been largely discussed over the past years and it is now becoming increasingly clear that they may influence pregnancy outcome at several levels. In normal pregnancy, it appears that the major function of NK cells is to provide benefit by secreting a number of cytokines, chemokines and angiogenic factors rather than to exert a cytotoxic activity. However, the origin of decidual NK cells is still debated and it remains unclear whether they can derive from NK cell populations recruited from peripheral blood and/or other tissues or from self renewal of NK cell progenitors present in the uterus prior to pregnancy or recruited from other tissues. Here, we review the molecular mechanisms underlying peripheral blood NK cell recruitment and its role in the accumulation of NK cells in the decidua during early pregnancy. [Santoni, Angela; Carlino, Claudia; Stabile, Helena; Gismondi, Angela] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy; [Santoni, Angela] Univ Roma La Sapienza, Ist Pasteur Fdn Cenci Bolognetti, Rome, Italy Gismondi, A (reprint author), Univ Roma La Sapienza, Dept Expt Med, Viale Regina Elena 324, I-00161 Rome, Italy. angela.santoni@uniroma1.it 65 24 26 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1046-7408 AM J REPROD IMMUNOL Am. J. Reprod. Immunol. MAY 2008 59 5 417 424 10.1111/j.1600-0897.2008.00598.x 8 Immunology; Reproductive Biology Immunology; Reproductive Biology 286OR WOS:000254855800005 J Casciani, E; Polettini, E; Carmenini, E; Floriani, I; Masselli, G; Bertini, L; Gualdi, GF Casciani, Emanuele; Polettini, Elisabetta; Carmenini, Enrico; Floriani, Irene; Masselli, Gabriele; Bertini, Luca; Gualdi, Gian Franco Endorectal and dynamic contrast-enhanced MRI for detection of local recurrence after radical prostatectomy AMERICAN JOURNAL OF ROENTGENOLOGY English Article contrast-enhanced MRI; MRI; prostate neoplasm; recurrence RADIATION-THERAPY; PROSTATIC FOSSA; INITIAL-EXPERIENCE; PATHOLOGICAL STAGE; CANCER; ANTIGEN; BIOPSY; MANAGEMENT; NEOVASCULARITY; SPECTROSCOPY OBJECTIVE. The objective of our study was to evaluate the sensitivity and specificity of endorectal MRI combined with dynamic contrast-enhanced MRI to detect local recurrence after radical prostatectomy. MATERIALS and METHODS. A total of 51 patients who had undergone radical prostatectomy for prostatic adenocarcinoma 10 months to 6 years before underwent a combined endorectal coil MRI and dynamic gadolinium- enhanced MRI before endorectal sonographically guided biopsy of the prostatic fossa. The MRI combined with MR dynamic imaging results were correlated with the presence of recurrence defined as a positive biopsy result or reduction in prostate-specific antigen level after radiation therapy. RESULTS. Overall data of 46 ( 25 recurred, 21 nonrecurred) out of 51 evaluated patients were analyzed. All recurrences showed signal enhancement after gadolinium administration and, in particular, 22 of 24 patients ( 91%) showed rapid and early signal enhancement. The overall sensitivity and specificity of MR dynamic imaging was higher compared with MRI alone ( 88%, [ 95% CI] 69 - 98% and 100%, 84 - 100% compared with 48%, 28 - 69% and 52%, 30 - 74%). MRI combined with dynamic imaging allowed better identification of recurrences compared with MRI alone ( McNemar test: chi-square 1 = 16.67; p = < 0.0001). CONCLUSION. MRI combined with dynamic contrast-enhanced MRI showed a higher sensitivity and specificity compared with MRI alone in detecting local recurrences after radical prostatectomy. [Casciani, Emanuele; Polettini, Elisabetta; Masselli, Gabriele; Bertini, Luca; Gualdi, Gian Franco] Univ Roma La Sapienza, Dept Radiol, I-00166 Rome, Italy; [Carmenini, Enrico] Osped MG Vannini, UOC Osservaz Med, Rome, Italy; [Floriani, Irene] Ist Ric Farmacol Mario Negri, Milan, Italy Casciani, E (reprint author), Univ Roma La Sapienza, Dept Radiol, Via Policlin 155, I-00166 Rome, Italy. emanuelecasciani@hotmail.com 28 44 44 AMER ROENTGEN RAY SOC RESTON 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA 0361-803X AM J ROENTGENOL Am. J. Roentgenol. MAY 2008 190 5 1187 1192 10.2214/AJR.07.3032 6 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging 291HH WOS:000255185100012 J Marques, MPM; Gil, FPSC; Calheiros, R; Battaglia, V; Brunati, AM; Agostinelli, E; Toninello, A Marques, M. P. M.; Gil, F. P. S. C.; Calheiros, R.; Battaglia, V.; Brunati, A. M.; Agostinelli, E.; Toninello, A. Biological activity of antitumoural MGBG: the structural variable AMINO ACIDS English Article MGBG; SAMDC; structure-activity relationships; DFT calculations; physiological structures; mitochondrial permeability transition (MPT) RAT-LIVER MITOCHONDRIA; METHYL GLYOXAL BIS(GUANYLHYDRAZONE); L1210 LEUKEMIA-CELLS; PERMEABILITY TRANSITION; METHYLGLYOXAL BIS(GUANYLHYDRAZONE); OXIDATIVE-PHOSPHORYLATION; MOLECULAR-STRUCTURES; TUMOR-CELLS; METHYLGLYOXAL-BIS(GUANYLHYDRAZONE); INHIBITION The present study aims at determining the structure-activity relationships (SAR's) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-L-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activity, MGBG's structural preferences at physiological conditions were ascertained, by quantum mechanical (DFT) calculations. [Marques, M. P. M.] Univ Coimbra, Fac Sci & Technol, Dept Biochem, P-3001401 Coimbra, Portugal; [Marques, M. P. M.; Gil, F. P. S. C.; Calheiros, R.] Univ Coimbra, Res Unit Quim Fis Mol, Coimbra, Portugal; [Gil, F. P. S. C.] Univ Coimbra, Dept Phys, CEMDRX, Coimbra, Portugal; [Battaglia, V.; Brunati, A. M.; Toninello, A.] Univ Padua, Inst Neurosci, CNR, Dept Biol Chem, Padua, Italy; [Agostinelli, E.] Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, Inst Mol Biol & Pathol, Rome, Italy Marques, MPM (reprint author), Univ Coimbra, Fac Sci & Technol, Dept Biochem, Ap 3126, P-3001401 Coimbra, Portugal. pmc@ci.uc.pt agostinelli, enzo/D-3374-2009 55 5 5 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0939-4451 AMINO ACIDS Amino Acids MAY 2008 34 4 555 564 10.1007/s00726-007-0009-2 10 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 297JP WOS:000255613300007 J Angelini, C; Antonelli, D; Utzeri, C Angelini, Claudio; Antonelli, Damiano; Utzeri, Carlo Multi-year and multi-site population study on the life history of Salamandrina perspicillata (Savi, 1821) (Amphibia, Urodela) AMPHIBIA-REPTILIA English Article body-size correlates; inter-population variability; population study; Salamandrina CALIFORNIA TIGER SALAMANDER; BODY SIZE; DECLINES We studied nine populations of Salamandrina perspicillata for two to nine years and described the life history variation among these population. Despite experiencing similar climatic conditions, populations differed in mean body size: populations using still water bodies for oviposition were larger body-sized than those using brooks. One semi-natural pond was used by particularly small individuals and was probably recently colonised. The mean body size of ovipositing females varied from year to year. Measurements of individuals in successive years showed that the tail grew more than the trunk and this differential growth increased with age. Females did not oviposit every year and, within a given population, the number of ovipositing females varied widely from year to year. [Angelini, Claudio; Utzeri, Carlo] Univ Roma La Sapienza, Dipartimento Biol Anim & Uomo, I-00185 Rome, Italy Angelini, C (reprint author), Univ Roma La Sapienza, Dipartimento Biol Anim & Uomo, Viale Univ 32, I-00185 Rome, Italy. oppela@tin.it 31 8 8 BRILL ACADEMIC PUBLISHERS LEIDEN PLANTIJNSTRAAT 2, P O BOX 9000, 2300 PA LEIDEN, NETHERLANDS 0173-5373 AMPHIBIA-REPTILIA Amphib. Reptil. MAY 2008 29 2 161 170 10.1163/156853808784125072 10 Zoology Zoology 304GV WOS:000256098900002 J Caruso, G; Cavaliere, C; Guarino, C; Gubbiotti, R; Foglia, P; Lagana, A Caruso, Giuseppe; Cavaliere, Chiara; Guarino, Chiara; Gubbiotti, Riccardo; Foglia, Patrizia; Lagana, Aldo Identification of changes in Triticum durum L. leaf proteome in response to salt stress by two-dimensional electrophoresis and MALDI-TOF mass spectrometry ANALYTICAL AND BIOANALYTICAL CHEMISTRY English Article Matrix-assisted laser desorption/ionization time of flight; proteomics; salt stress; Triticum durum; wheat; two-dimensional electrophoresis BETA-GLUCOSIDASE; SIGNAL-TRANSDUCTION; OXIDATIVE STRESS; WATER-DEFICIT; PISUM-SATIVUM; AESTIVUM L.; PROTEINS; WHEAT; ARABIDOPSIS; SALINITY In order to understand the molecular basis of salt stress response, a proteomic approach, employing two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS), was used to identify proteins affected by salinity in wheat (Triticum durum 'Ofanto'). Identification of proteins, whose levels were altered, was performed by comparing protein patterns of salt-treated and control plants. A set of control plants was grown without NaCl addition under the same conditions as the salt-treated plants. Proteins were extracted from the leaves of untreated and NaCl-treated plants, and resolved using 24-cm immobilized pH gradient strips with a pH 4-7 linear gradient in the first dimension and a 12.5% sodium dodecyl sulphate polyacrylamide gel electrophoresis in the second dimension; the gels were stained with Coomassie and image analysis was performed. Quantitative evaluation, statistical analyses and MALDI-TOF MS characterization of the resolved spots in treated and untreated samples enabled us to identify 38 proteins whose levels were altered in response to salt stress. In particular, ten proteins were downregulated and 28 were upregulated. A possible role of these proteins in response to salinity is discussed. [Lagana, Aldo] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; [Caruso, Giuseppe; Cavaliere, Chiara; Guarino, Chiara; Gubbiotti, Riccardo; Foglia, Patrizia; Lagana, Aldo] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy Lagana, A (reprint author), Univ Roma La Sapienza, Dipartimento Chim, Box 34,Roma 62,Piazzale Aldo Moro 5, I-00185 Rome, Italy. aldo.lagana@uniromal.it Lagana, Aldo/F-7390-2010; Foglia, Patrizia/B-5057-2010; Cavaliere, Chiara/D-2757-2009 Cavaliere, Chiara/0000-0003-1332-682X 54 31 38 SPRINGER HEIDELBERG HEIDELBERG TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY 1618-2642 ANAL BIOANAL CHEM Anal. Bioanal. Chem. MAY 2008 391 1 381 390 10.1007/s00216-008-2008-x 10 Biochemical Research Methods; Chemistry, Analytical Biochemistry & Molecular Biology; Chemistry 291HJ WOS:000255185300037 J Cozza, P; Marino, A; Franchi, L Cozza, Paola; Marino, Alessandra; Franchi, Lorenzo A nonsurgical approach to treatment of high-angle Class II malocclusion ANGLE ORTHODONTIST English Article Class II malocclusion; vertical growth pattern; nonsurgical approach DIVISION-1 MALOCCLUSION; NONEXTRACTION TREATMENT; PULL HEADGEAR; GROWTH; IMPLANT Malocclusions with a hyperdivergent vertical facial pattern are often difficult to treat without a combined surgical/orthodontic approach. The aim of this article is to describe a nonsurgical approach to the treatment of a high-angle Class II malocclusion in a growing patient. Some fundamental aspects, such as correct diagnosis, treatment timing, favorable mandibular growth pattern, and patient compliance, proved to be critical to correct the severe dentoskeletal disharmony. [Franchi, Lorenzo] Univ Florence, Dept Orthodont, I-50127 Florence, Italy; [Marino, Alessandra] Univ Roma La Sapienza, Dept Orthodont, Rome, Italy; [Cozza, Paola] Univ Roma Tor Vergata, Dept Orthodont, Rome, Italy Franchi, L (reprint author), Univ Florence, Dept Orthodont, Via Ponte Mezzo 46-48, I-50127 Florence, Italy. lorenzo.franchi@unifi.it Franchi, Lorenzo/B-2730-2009 17 1 2 E H ANGLE EDUCATION RESEARCH FOUNDATION, INC NEWTON N 1615 BEACON ST, NEWTON N, MA 02468-1507 USA 0003-3219 ANGLE ORTHOD Angle Orthod. MAY 2008 78 3 553 560 10.2319/052307-248.1 8 Dentistry, Oral Surgery & Medicine Dentistry, Oral Surgery & Medicine 292ZW WOS:000255305600027 J Bettini, R; Boninsegna, L; Mantovani, W; Capelli, P; Bassi, C; Pederzoli, P; Delle Fave, GF; Panzuto, F; Scarpa, A; Falconi, M Bettini, R.; Boninsegna, L.; Mantovani, W.; Capelli, P.; Bassi, C.; Pederzoli, P.; Delle Fave, G. F.; Panzuto, F.; Scarpa, A.; Falconi, M. Prognostic factors at diagnosis and value of WHO classification in a mono-institutional series of 180 non-functioning pancreatic endocrine tumours ANNALS OF ONCOLOGY English Article pancreatic endocrine tumours; pancreatic neoplasm; pancreatic surgery; prognostic factors; survival ISLET-CELL CARCINOMA; NEUROENDOCRINE TUMORS; PREDICTIVE FACTORS; SURVIVAL Background: Non- functioning pancreatic endocrine tumours ( NF- PETs) are an aggressive gastroenteropancreatic neoplasm. The present study assessed survival, value of World Health Organisation ( WHO) classification and prognostic utility of clinicopathological parameters at diagnosis. Patients and methods: From 1990 to 2004, 180 patients with NF- PETs were entered in a prospective database, and predictors of prognosis were tested in uni- and multivariate models. Results: There were 25 ( 14%) benign lesions, 38 ( 21%) neoplasms of uncertain behaviour, 100 well- differentiated carcinomas ( 56%) and 17 poorly differentiated carcinomas ( 9%). Radical resection was possible in 93 cases ( 51.6%). Overall 5-, 10- and 15- year survival rates were 67%, 49.3% and 32.8%, respectively, and were significantly higher in radically resected patients ( 93%, 80.8% and 65.2%, respectively; P < 0.00001). By multivariate analysis, poor differentiation [ hazard ratio ( HR) 7.3; P = 0.0001], nodal metastases ( HR 3.05; P = 0.02), liver metastases ( HR 3.29; P = 0.003), K(i)- 67 > 5% ( HR 2.5; P = 0.012) and weight loss ( HR 3.06; P = 0.001) were significantly associated with mortality. Conclusion: This study confirms the good long- term survival of patients with NF- PETs and the prognostic value of WHO classification, liver metastases, poor differentiation, Ki- 67, nodal metastases and weight loss. These latter two parameters have a prognostic value similar to that of liver metastases and Ki- 67. [Bettini, R.; Boninsegna, L.; Bassi, C.; Pederzoli, P.; Falconi, M.] Univ Verona, Dept Surg & Gastroenterol Sci, I-37100 Verona, Italy; [Mantovani, W.] Univ Verona, Dept Med & Publ Hlth, I-37100 Verona, Italy; [Capelli, P.] Univ Verona, Dept Pathol, I-37100 Verona, Italy; [Delle Fave, G. F.; Panzuto, F.] Univ Roma La Sapienza, Sch Med 2, Dept Digest & Liver Dis, Rome, Italy Falconi, M (reprint author), Policlin GB Rossi, Dipartimento Sci Chirurg & Gastroenterol, Chirurg Gen B, P Le LA Scuro 10, I-37134 Verona, Italy. massimo.falconi@univr.it 26 69 75 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0923-7534 ANN ONCOL Ann. Oncol. MAY 2008 19 5 903 908 10.1093/annonc/mdm552 6 Oncology Oncology 296DU WOS:000255524500012 J Altieri, F; Grillo, C; Maceroni, M; Chichiarelli, S Altieri, Fabio; Grillo, Caterina; Maceroni, Manola; Chichiarelli, Silvia DNA damage and repair: From molecular mechanisms to health implications ANTIOXIDANTS & REDOX SIGNALING English Review NUCLEOTIDE-EXCISION-REPAIR; STRAND BREAK REPAIR; HUMAN MISMATCH REPAIR; TRANSCRIPTION-COUPLED REPAIR; RNA-POLYMERASE-II; SEVERE COMBINED IMMUNODEFICIENCY; NONPOLYPOSIS COLORECTAL-CANCER; PROMOTES BRANCH MIGRATION; DEPENDENT PROTEIN-KINASE; FACIO-SKELETAL SYNDROME DNA is subjected to several modifications, resulting from endogenous and exogenous sources. The cell has developed a network of complementary DNA-repair mechanisms, and in the human genome, > 130 genes have been found to be involved. Knowledge about the basic mechanisms for DNA repair has revealed an unexpected complexity, with overlapping specificity within the same pathway, as well as extensive functional interactions between proteins involved in repair pathways. Unrepaired or improperly repaired DNA lesions have serious potential consequences for the cell, leading to genomic instability and deregulation of cellular functions. A number of disorders or syndromes, including several cancer predispositions and accelerated aging, are linked to an inherited defect in one of the DNA-repair pathways. Genomic instability, a characteristic of most human malignancies, can also arise from acquired defects in DNA repair, and the specific pathway affected is predictive of types of mutations, tumor drug sensitivity, and treatment outcome. Although DNA repair has received little attention as a determinant of drug sensitivity, emerging knowledge of mutations and polymorphisms in key human DNA-repair genes may provide a rational basis for improved strategies for therapeutic interventions on a number of tumors and degenerative disorders. [Altieri, Fabio; Grillo, Caterina; Maceroni, Manola; Chichiarelli, Silvia] Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, Rome, Italy Altieri, F (reprint author), Univ Roma La Sapienza, Dept Biochem Sci A Rossi Fanelli, Rome, Italy. Altieri, Fabio/D-2790-2009; Chichiarelli, Silvia/F-1226-2011 270 46 47 MARY ANN LIEBERT INC NEW ROCHELLE 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA 1523-0864 ANTIOXID REDOX SIGN Antioxid. Redox Signal. MAY 2008 10 5 891 937 10.1089/ars.2007.1830 47 Biochemistry & Molecular Biology; Endocrinology & Metabolism Biochemistry & Molecular Biology; Endocrinology & Metabolism 276GP WOS:000254129600002 J Chambolle, A; Giacomini, A; Ponsiglione, M Chambolle, Antonin; Giacomini, Alessandro; Ponsiglione, Marcello Crack initiation in brittle materials ARCHIVE FOR RATIONAL MECHANICS AND ANALYSIS English Article QUASI-STATIC GROWTH; VARIATIONAL-PROBLEMS; COMPACTNESS THEOREM; ELLIPTIC-EQUATIONS; DIVERGENCE FORM; EXISTENCE; MINIMIZATION; FRACTURES; SYSTEMS; PROOF In this paper we study the crack initiation in a hyper-elastic body governed by a Griffith-type energy. We prove that, during a load process through a time-dependent boundary datum of the type t -> tg(x) and in the absence of strong singularities (e.g., this is the case of homogeneous isotropic materials) the crack initiation is brutal, that is, a big crack appears after a positive time t(i) > 0. Conversely, in the presence of a point x of strong singularity, a crack will depart from x at the initial time of loading and with zero velocity. We prove these facts for admissible cracks belonging to the large class of closed one-dimensional sets with a finite number of connected components. The main tool we employ to address the problem is a local minimality result for the functional epsilon(upsilon, Gamma) := integral(Omega)f(x, del upsilon)dx + kH(1)(Gamma), where Omega subset of R-2, k > 0 and f is a suitable Caratheodory function. We prove that if the uncracked configuration u of Omega relative to a boundary displacement psi has at most uniformly weak singularities, then configurations (u(Gamma), Gamma) with H-1(Gamma) small enough are such that epsilon(u, empty set) < epsilon(u(Gamma), Gamma). [Chambolle, Antonin] Ecole Polytech, CNRS, CMAP, F-91128 Palaiseau, France; [Giacomini, Alessandro] Univ Brescia, Dipartimento Matemat, Fac Ingn, I-25133 Brescia, Italy; [Ponsiglione, Marcello] Max Planck Inst Math Sci, D-04103 Leipzig, Germany Chambolle, A (reprint author), Ecole Polytech, CNRS, CMAP, F-91128 Palaiseau, France. antonin.chambolle@polytechnique.fr; alessandro.giacomini@ing.unibs.it; marcello.ponsiglione@mis.mpg.de Giacomini, Alessandro/H-8268-2012 31 20 20 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0003-9527 ARCH RATION MECH AN Arch. Ration. Mech. Anal. MAY 2008 188 2 309 349 10.1007/s00205-007-0080-6 41 Mathematics, Interdisciplinary Applications; Mechanics Mathematics; Mechanics 276XJ WOS:000254176700005 J Amici, A; Baratta, A; Linguanti, A; Giudice, G; Servello, A; Scalise, C; Tafaro, L; Cicconetti, P; Marigliano, V; Cacciafesta, M Amici, A.; Baratta, A.; Linguanti, A.; Giudice, G.; Servello, A.; Scalise, C.; Tafaro, L.; Cicconetti, P.; Marigliano, V.; Cacciafesta, M. The Marigliano-Cacciafesta polypathological scale: A tool for assessing fragility ARCHIVES OF GERONTOLOGY AND GERIATRICS English Article MGA; frailty of the elderly; comorbidity in elderly; prevention of disability in elderly GERIATRIC EVALUATION UNIT; FRAILTY; PEOPLE; INDEX; ADL The aim of our studies was to establish a standard method of assessment that allows an early identification of frailty in the elderly, i.e., to predict who are at risk of developing disabilities, in order to be able to intervene with preventive global and individualized measures. A new multidimensional scale called Marigliano-Cacciafesta polypathological scale (MCPS) was used on 180 elderly people, together with the Barthel index (BI), the global evaluation functional index (GEFI), the geriatric depression scale (GDS), the mini mental state examination (MMSE), the mini nutritional assessment (MNA), and the Tinetti test. A strongly significant statistical correlation was found between the MCPS and the nutritional state, mood level, motor functionality, level of disability and global functionality. As the fragile patients are at a risk to develop disabilities, we think that our scale can be a significant contribution to the multidimensional geriatric assessment (MGA), aimed at identifying and quantifying the parameter of fragility of each patient, an information which should be known, if we intend to introduce preventive measures. (c) 2007 Elsevier Ireland Ltd. All rights reserved. [Amici, A.; Baratta, A.; Linguanti, A.; Giudice, G.; Servello, A.; Scalise, C.; Tafaro, L.; Cicconetti, P.; Marigliano, V.; Cacciafesta, M.] Univ Roma La Sapienza, Policlin Umberto I, Dept Aging Sci, I-00161 Rome, Italy Cacciafesta, M (reprint author), Via Panama 102, I-00198 Rome, Italy. mauro.cacciafesta@uniromal.it 20 10 11 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 0167-4943 ARCH GERONTOL GERIAT Arch. Gerontol. Geriatr. MAY-JUN 2008 46 3 327 334 10.1016/j.archger.2007.05.007 8 Geriatrics & Gerontology Geriatrics & Gerontology 296SZ WOS:000255567400007 J Hullah, E; Turok, Y; Nauta, M; Yoong, W Hullah, Esther; Turok, Yaroslava; Nauta, Maud; Yoong, Wai Self-reported oral hygiene habits, dental attendance and attitudes to dentistry during pregnancy in a sample of immigrant women in North London ARCHIVES OF GYNECOLOGY AND OBSTETRICS English Article oral hygiene; dental attendance; pregnancy; immigrants PERIODONTAL-DISEASE; BIRTH; RISK Aims The aim of this study was to describe self-reported oral health, oral hygiene habits, frequency of visits to a dentist and factors associated with dental attendance among pregnant women at a North London Hospital, the majority of whom are immigrants. Background Peridontal disease is associated with an increased risk of adverse pregnancy outcomes. The aim of this study is to describe self-reported oral health, oral hygiene habits, frequency of visits to a dentist and factors associated with dental attendance among pregnant women at a North London Hospital, the majority of whom are immigrants. Materials and methods A questionnaire designed by the authors was completed by postnatal women within 3 days of delivery. Data collected included past dental attendance, reasons for attendance and information about age, parity and socio-economic group. Results In total, 206 women completed the questionnaires within 3 days of delivery; 74.2% of the mothers were not born in the UK and 38.3% were Black African. The mean age of was 28.19 +/- 6.07 years. The majority reported good oral hygiene habits such as brushing their teeth twice a day (73.7%) and using mouthwash (51%). However, their dental attendance was poor and the average time since their last visit to a dentist was 1.8 +/- 1.61 years. Over a third of the women questioned did not know about the availability of free dental care during pregnancy and for 12 months after; 33% visited a dentist in pregnancy and half of them needed and received treatment; 15% of mothers had more than one pregnancy and yet were still unaware of free dental care provided during pregnancy and 12 months after birth. Only 36% of questioned women regularly visited a dentist. Pregnancy did little to change their attitudes to dental care. There appears no difference in attitudes to dental care between immigrant and British born pregnant women. Conclusion Efforts to improve the uptake of dental care should be directed towards immigrant groups in order to promote better maternal health. Further research is required into the provision of dental care during pregnancy, as the high level of non-attendance demonstrated by mothers is undesirable. [Hullah, Esther; Turok, Yaroslava; Nauta, Maud; Yoong, Wai] N Middlesex Univ Hosp, Dept Obstet & Gynaecol, London N18 1QX, England Yoong, W (reprint author), N Middlesex Univ Hosp, Dept Obstet & Gynaecol, London N18 1QX, England. wai.yoong@nmh.nhs.uk 10 9 9 SPRINGER HEIDELBERG HEIDELBERG TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY 0932-0067 ARCH GYNECOL OBSTET Arch. Gynecol. Obstet. MAY 2008 277 5 405 409 10.1007/s00404-007-0480-8 5 Obstetrics & Gynecology Obstetrics & Gynecology 283FY WOS:000254623300005 J Scrivo, R; Spadaro, A; Spinelli, FR; Valesini, G Scrivo, Rossana; Spadaro, Antonio; Spinelli, Francesca Romana; Valesini, Guido Uveitis following the use of tumor necrosis factor alpha inhibitors: comment on the article by Lim et al ARTHRITIS AND RHEUMATISM English Letter ETANERCEPT [Scrivo, Rossana; Spadaro, Antonio; Spinelli, Francesca Romana; Valesini, Guido] Sapienza Univ Roma, Rome, Italy Scrivo, R (reprint author), Sapienza Univ Roma, Rome, Italy. Spinelli, Francesca Romana/F-1475-2013 6 8 8 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 0004-3591 ARTHRITIS RHEUM Arthritis Rheum. MAY 2008 58 5 1555 1556 10.1002/art.23440 2 Rheumatology Rheumatology 300TP WOS:000255848400045 J Buttari, B; Profumo, E; Tagliani, A; Ippoliti, F; Businaro, R; Rigano, R Buttari, B.; Profumo, E.; Tagliani, A.; Ippoliti, F.; Businaro, R.; Rigano, R. FREE HEMOGLOBIN: A CHEMOTACTIC STIMULUS FOR THE INNATE IMMUNITY ATHEROSCLEROSIS SUPPLEMENTS English Meeting Abstract [Buttari, B.; Profumo, E.] Ist Super Sanita, Dipartimento Malattie Infett Parassitarie Immun, I-00161 Rome, Italy; [Tagliani, A.; Businaro, R.; Rigano, R.] Univ Di Roma Sapienza, Dipartimento Di Sci Cardiovasc, Rome, Italy; [Ippoliti, F.] Univ Di Roma Sapienza, Dipartimento Di Med Sperimentale, Rome, Italy 0 0 1 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 1567-5688 ATHEROSCLEROSIS SUPP Atheroscler. Suppl. MAY 2008 9 1 14 14 10.1016/S1567-5688(08)70053-9 1 Peripheral Vascular Disease Cardiovascular System & Cardiology V12PI WOS:000207610700054 J Zampi, G; Fini, F; Placanica, A; Illuminati, G; Torromeo, C; Barilla, F; Paravati, V Zampi, G.; Fini, F.; Placanica, A.; Illuminati, G.; Torromeo, C.; Barilla, F.; Paravati, V. EVALUATION OF CEREBROVASCULAR RISK BY ECOCOLORDOPPLER IN PATIENTS WITH ACUTE CORONARY SYNDROME (ACS) ATHEROSCLEROSIS SUPPLEMENTS English Meeting Abstract [Zampi, G.; Fini, F.; Placanica, A.; Torromeo, C.; Barilla, F.; Paravati, V.] Univ Roma La Sapienza, Policlin Umberto 1, Dipartimento Cuore & Grossi Vasi, Rome, Italy; [Illuminati, G.] Univ Roma La Sapienza, Policlin Umberto 1, Dipartimento Chirurgia F Durante, Rome, Italy 0 0 0 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 1567-5688 ATHEROSCLEROSIS SUPP Atheroscler. Suppl. MAY 2008 9 1 236 236 10.1016/S1567-5688(08)70942-5 1 Peripheral Vascular Disease Cardiovascular System & Cardiology V12PI WOS:000207610701661 J Mathieu, A; Cauli, A; Fiorillo, MT; Sorrentino, R Mathieu, Alessandro; Cauli, Alberto; Fiorillo, Mania Teresa; Sorrentino, Rosa HLA-B27 and Ankylosing Spondylitis geographic distribution as the result of a genetic selection induced by malaria endemic? A review supporting the hypothesis AUTOIMMUNITY REVIEWS English Article HLA-B27; HLA-B27 subtypes; Ankylosing Spondylitis; malaria; genetic selection PAPUA-NEW-GUINEA; NECROSIS-FACTOR-ALPHA; CEREBRAL MALARIA; SELF-PEPTIDE; CLASS-I; HLA-B; SUSCEPTIBILITY; POLYMORPHISM; ASSOCIATION; POPULATION The geographic distribution of HLA-B27 shows a latitude-related gradient inverse to that of malaria endemic. An apparent exception occurs in New Guinea, a region where malaria is present, but where HLA-B27 frequency shows, however, an orographic gradient antithetic to that of malaria incidence. We therefore suggest that Plasmodium falciparum may have exerted a negative selection on this gene. This might be due to a higher susceptibility to severe forms of malaria, associated with HLA-B27 or other close gene(s). In addition, we suggest here that the same selective pressure that has contributed to reduce the HLA-B27 frequency in some regions has favoured the fixing of newly generated B27 subtypes included in more advantageous HLA haplotypes. In some cases, as for B*2709 in Sardinia and B*2706 in Southeast Asia, these haplotypes may harbour factors that protect from Ankylosing Spondylitis, an autoimmune disease strongly associated with HLA-B27, thus offering a novel, powerful tool to dissect disease pathogenesis, and to identify additional genetic factors of susceptibility. (C) 2008 Elsevier B.V. All rights reserved. [Mathieu, Alessandro] Univ Cagliari, Univ Clin, Dept Med Sci, Chair Rheumatol 2, I-09042 Cagliari, Italy; [Fiorillo, Mania Teresa; Sorrentino, Rosa] Univ Roma La Sapienza, Dept Cell Biol & Dev, I-00185 Rome, Italy Mathieu, A (reprint author), Univ Cagliari, Univ Clin, Dept Med Sci, Chair Rheumatol 2, SS 554, I-09042 Cagliari, Italy. mathieu@pacs.unica.it Sorrentino, Rosa/G-5472-2012 40 11 11 ELSEVIER SCIENCE BV AMSTERDAM PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 1568-9972 AUTOIMMUN REV Autoimmun. Rev. MAY 2008 7 5 398 403 10.1016/j.autrev.2008.03.013 6 Immunology Immunology 313CZ WOS:000256720000009 J Camilli, M; Nacchia, R; Terenzi, M; Di Nocera, F Camilli, Marco; Nacchia, Roberto; Terenzi, Michela; Di Nocera, Francesco ASTEF: A stmple tool for emmAnn'ng timations BEHAVIOR RESEARCH METHODS English Article EYE-MOVEMENTS In human factors and ergonomics research, the analysis of eye movements has gained popularity as a method for obtaining information concerning the operator's cognitive strategies and for drawing inferences about the cognitive state of an individual. For example, recent studies have shown that the distribution of eye fixations is sensitive to variations in mental workload-dispersed when workload is high, and clustered when workload is low. Spatial statistics algorithms can be used to obtain information about the type of distribution and can be applied over fixations recorded during small epochs of time to assess online changes in the level of mental load experienced by the individuals. In order to ease the computation of the statistical index and to encourage research on the spatial properties of visual scanning, A Simple Tool for Examining Fixations has been developed. The software application implements functions for fixation visualization, management, and analysis, and includes a tool for fixation identification from raw gaze point data. Updated information can be obtained online at www.astef.info, where the installation package is freely downloadable. [Di Nocera, Francesco] Univ Roma La Sapienza, Dept Psychol, Cognit Ergon Lab, Rome, Italy Di Nocera, F (reprint author), Univ Roma La Sapienza, Dept Psychol, Cognit Ergon Lab, Via Marsi 78-00185, Rome, Italy. dinocera@uniromal.it 36 6 6 PSYCHONOMIC SOC INC AUSTIN 1710 FORTVIEW RD, AUSTIN, TX 78704 USA 1554-351X BEHAV RES METHODS Behav. Res. Methods MAY 2008 40 2 373 382 10.3758/BRM.40.2.373 10 Psychology, Mathematical; Psychology, Experimental Psychology 320IN WOS:000257227000001 J Masotti, A; Vicennati, P; Boschi, F; Calderan, L; Sbarbati, A; Ortaggi, G Masotti, Andrea; Vicennati, Paola; Boschi, Federico; Calderan, Laura; Sbarbati, Andrea; Ortaggi, Giancarlo A novel near-infrared indocyanine dye - Polyethylenimine conjugate allows DNA delivery imaging in vivo BIOCONJUGATE CHEMISTRY English Article HEPTAMETHINE CYANINE DYES; RESTRICTED AZA-BODIPY; HIGHLY FLUORESCENT; QUANTUM DOTS; GENE-EXPRESSION; ABSORBING DYES; LIVING MICE; TUMORS; LIPOSOMES; PROBES Near-infrared (NIR) fluorescence light has been applied to monitor several biological events in vivo since it penetrates tissues more efficiently than visible light. Dyes exhibiting NIR fluorescence and having large Stokes shift are key elements for this promising optical imaging technology. Here, we report the synthesis of a novel conjugate between a near-infrared indocyanine dye and an organic polyamine polymer (polyethylenimine, PEI) (IR820-PEI) with high chemical stability and good optical properties. IR820-PEI absorbs at 665 nm, emits at 780 nm, and displays a large Stokes shift (115 nm). Moreover, the reported conjugate is able to bind DNA, and the delivery process can be monitored in vivo with noninvasive optical imaging techniques. These characteristics make IR820-PEI one of the most effective and versatile indocyanine dye polymeric-conjugate reported so far. [Masotti, Andrea; Vicennati, Paola; Ortaggi, Giancarlo] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy; [Boschi, Federico; Calderan, Laura; Sbarbati, Andrea] Univ Verona, Sect Anat & Histol, Dept Morphol Biomed Sci, I-37134 Verona, Italy Masotti, A (reprint author), Univ Roma La Sapienza, Dept Chem, P Le Aldo Moro 5, I-00185 Rome, Italy. andrea.masotti@uniromal.it Masotti, Andrea/D-5306-2009 Masotti, Andrea/0000-0002-2511-5088 36 37 37 AMER CHEMICAL SOC WASHINGTON 1155 16TH ST, NW, WASHINGTON, DC 20036 USA 1043-1802 BIOCONJUGATE CHEM Bioconjugate Chem. MAY 2008 19 5 983 987 10.1021/bc700356f 5 Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Multidisciplinary; Chemistry, Organic Biochemistry & Molecular Biology; Chemistry 304JF WOS:000256105100001 J Carola, V; Frazzetto, G; Pascucci, T; Audero, E; Puglisi-Allegra, S; Cabib, S; Lesch, KP; Gross, C Carola, Valeria; Frazzetto, Giovanni; Pascucci, Tiziana; Audero, Enrica; Puglisi-Allegra, Stefano; Cabib, Simona; Lesch, Klaus-Peter; Gross, Cornelius Identifying molecular substrates in a mouse model of the serotonin transporter x environment risk factor for anxiety and depression BIOLOGICAL PSYCHIATRY English Article 5-HTT; anxiety; depression; gene x environment; maternal behavior TAIL SUSPENSION TEST; NEUROTROPHIC FACTOR; MICE LACKING; MATERNAL-BEHAVIOR; GENETIC-VARIATION; RAT-BRAIN; POLYMORPHISM; EXPRESSION; STRESS; BDNF Background: A polymorphism in the serotonin transporter (5-HTT) gene modulates the association between adverse early experiences and risk for major depression in adulthood. Although human imaging studies have begun to elucidate the neural circuits involved in the 5-HTT x environment risk factor, a molecular understanding of this phenomenon is lacking. Such an understanding might help to identify novel targets for the diagnosis and therapy of mood disorders. To address this need, we developed a gene-environment screening paradigm in the mouse. Methods: We established a mouse model in which a heterozygous null mutation in 5-HTT moderates the effects of poor maternal care on adult anxiety and depression-related behavior. Biochemical analysis of brains from these animals was performed to identify molecular substrates of the gene, environment, and gene x environment effects. Results: Mice experiencing low maternal care showed deficient gamma-aminobutyric acid-A receptor binding in the amygdala and 5-HTT heterozygous null mice showed decreased serotonin turnover in hippocampus and striatum. Strikingly, levels of brain-derived neurotrophic factor (BDNF) messenger RNA in hippocampus were elevated exclusively in 5-HTT heterozygous null mice experiencing poor maternal care, suggesting that developmental programming of hippocampal circuits might underlie the 5-HTT x environment risk factor. Conclusions: These findings demonstrate that serotonin plays a similar role in modifying the long-term behavioral effects of rearing environment in diverse mammalian species and identifies BDNF as a molecular substrate of this risk factor. [Carola, Valeria; Frazzetto, Giovanni; Audero, Enrica; Gross, Cornelius] EMBL, Mouse Biol Unit, I-00015 Monterotondo, Italy; [Pascucci, Tiziana; Puglisi-Allegra, Stefano; Cabib, Simona] Univ Roma La Sapienza, Dept Psychol, Rome, Italy; [Pascucci, Tiziana; Puglisi-Allegra, Stefano; Cabib, Simona] Univ Roma La Sapienza, Ctr Daniel Bovet, Rome, Italy; [Puglisi-Allegra, Stefano; Cabib, Simona] European Ctr Brain Res CERC, Santa Lucia Fdn, Rome, Italy; [Lesch, Klaus-Peter] Univ Wurzburg, Dept Psychiat & Psychotherapy, D-97070 Wurzburg, Germany Gross, C (reprint author), EMBL, Mouse Biol Unit, Via Ramarini 32, I-00015 Monterotondo, Italy. gross@embl.it Lesch, Klaus-Peter/J-4906-2013 Lesch, Klaus-Peter/0000-0001-8348-153X 41 66 66 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 0006-3223 BIOL PSYCHIAT Biol. Psychiatry MAY 1 2008 63 9 840 846 10.1016/j.biopsych.2007.08.013 7 Neurosciences; Psychiatry Neurosciences & Neurology; Psychiatry 287VU WOS:000254945400004 J Sbardella, G; Castellano, S; Vicidomini, C; Rotili, D; Nebbioso, A; Miceli, M; Altucci, L; Mai, A Sbardella, Gianluca; Castellano, Sabrina; Vicidomini, Caterina; Rotili, Dante; Nebbioso, Angela; Miceli, Marco; Altucci, Lucia; Mai, Antonello Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases BIOORGANIC & MEDICINAL CHEMISTRY LETTERS English Article epigenetics; histone acetyltransferase modulators; HAT; antitumor agents; anacardic acid BINDING MODE ANALYSIS; CELL-DIFFERENTIATION; DEACETYLASE INHIBITORS; ACETYLATION; PROLIFERATION; P300; CANCER; PCAF; GENE; EXPRESSION Pentadecylidenemalonate 1b, a simplified analogue of anacardic acid, was identified as the first mixed activator/inhibitor of histone acetyltransferases (HATs). It potentiates PCAF HAT activity while inhibiting those of p300/CBP and recombinant CBP. The remarkable apoptotic effect together with the ability to selectively acetylate histone versus non-histone substrates appoint 1b as a lead for the development of anticancer drugs. (c) 2008 Elsevier Ltd. All rights reserved. [Sbardella, Gianluca; Castellano, Sabrina; Vicidomini, Caterina] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy; [Rotili, Dante; Mai, Antonello] Univ Roma La Sapienza, Dipartimento Studi Farmaceut, Ist Pasteur Fondaz Cenci Bolognetti, I-00185 Rome, Italy; [Nebbioso, Angela; Miceli, Marco; Altucci, Lucia] Univ Naples 2, Dipartimento Patol Gen, I-80138 Naples, Italy Sbardella, G (reprint author), Univ Salerno, Dipartimento Sci Farmaceut, Via Ponte Don Melillo, I-84084 Fisciano, SA, Italy. gsbardella@unisa.it; lucia.altucci@unina2.it; antonello.mai@uniromal.it Castellano, Sabrina/B-7635-2011; Sbardella, Gianluca/E-2823-2010 Sbardella, Gianluca/0000-0003-0748-1145 36 36 37 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0960-894X BIOORG MED CHEM LETT Bioorg. Med. Chem. Lett. MAY 1 2008 18 9 2788 2792 10.1016/j.bmcl.2008.04.017 5 Chemistry, Medicinal; Chemistry, Organic Pharmacology & Pharmacy; Chemistry 294ZH WOS:000255444300005 J Ortar, G; Moriello, AS; Cascio, MG; De Petrocellis, L; Ligresti, A; Morera, E; Nalli, M; Di Marzo, V Ortar, Giorgio; Moriello, Aniello Schiano; Cascio, Maria Grazia; De Petrocellis, Luciano; Ligresti, Alessia; Morera, Enrico; Nalli, Marianna; Di Marzo, Vincenzo New tetrazole-based selective anandamide uptake inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS English Article endocannabinoids; anandamide uptake; anandamide uptake inhibitors; tetrazoles ACID AMIDE HYDROLASE; CANNABINOID RECEPTORS; ENDOCANNABINOID SYSTEM; MOLECULAR CHARACTERIZATION; COVALENT MODIFICATION; TRANSPORT; INACTIVATION; MEMBRANE; BRAIN; IDENTIFICATION A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC(50) = 2.3-5.1 mu M) and selectively over other proteins involved in endocannabinoid action and metabolism. (c) 2008 Elsevier Ltd. All rights reserved. [Ortar, Giorgio; Morera, Enrico; Nalli, Marianna] Sapienza Univ Roma, Dipartimento Studi Farmaceut, I-00185 Rome, Italy; [Moriello, Aniello Schiano; Cascio, Maria Grazia; Ligresti, Alessia; Di Marzo, Vincenzo] Consiglio Nazl Ricerche, Ist Chim Biomol, I-80078 Naples, Italy; [De Petrocellis, Luciano] Consiglio Nazl Ricerche, Ist Cibernet, I-80078 Naples, Italy Ortar, G (reprint author), Sapienza Univ Roma, Dipartimento Studi Farmaceut, Piazzale Aldo Moro 5, I-00185 Rome, Italy. giorgio.ortar@uniroma1.it 41 13 14 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0960-894X BIOORG MED CHEM LETT Bioorg. Med. Chem. Lett. MAY 1 2008 18 9 2820 2824 10.1016/j.bmcl.2008.04.003 5 Chemistry, Medicinal; Chemistry, Organic Pharmacology & Pharmacy; Chemistry 294ZH WOS:000255444300011 J Bisegna, P; Caruso, G; Andreucci, D; Shen, L; Gurevich, VV; Hamm, HE; DiBenedetto, E Bisegna, Paolo; Caruso, Giovanni; Andreucci, Daniele; Shen, Lixin; Gurevich, Vsevolod V.; Hamm, Heidi E.; DiBenedetto, Emmanuele Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single photon response in vertebrate phototransduction BIOPHYSICAL JOURNAL English Review ROD OUTER SEGMENTS; MULTIPLE PHOSPHORYLATION SITES; RHODOPSIN KNOCKOUT MICE; CA-K EXCHANGE; RETINAL RODS; CYCLIC-GMP; G-PROTEIN; FREE CALCIUM; DARK NOISE; WILD-TYPE The single photon response in vertebrate phototransduction is highly reproducible despite a number of random components of the activation cascade, including the random activation site, the random walk of an activated receptor, and its quenching in a random number of steps. Here we use a previously generated and tested spatiotemporal mathematical and computational model to identify possible mechanisms of variability reduction. The model permits one to separate the process into modules, and to analyze their impact separately. We show that the activation cascade is responsible for generation of variability, whereas diffusion of the second messengers is responsible for its suppression. Randomness of the activation site contributes at early times to the coefficient of variation of the photoresponse, whereas the Brownian path of a photoisomerized rhodopsin (Rh*) has a negligible effect. The major driver of variability is the turnoff mechanism of Rh*, which occurs essentially within the. first 2 - 4 phosphorylated states of Rh*. Theoretically increasing the number of steps to quenching does not significantly decrease the corresponding coefficient of variation of the effector, in agreement with the biochemical limitations on the phosphorylated states of the receptor. Diffusion of the second messengers in the cytosol acts as a suppressor of the variability generated by the activation cascade. Calcium feedback has a negligible regulatory effect on the photocurrent variability. A comparative variability analysis has been conducted for the phototransduction in mouse and salamander, including a study of the effects of their anatomical differences such as incisures and photoreceptors geometry on variability generation and suppression. [Shen, Lixin; Hamm, Heidi E.; DiBenedetto, Emmanuele] Vanderbilt Univ, Med Ctr, Biomath Study Grp, Nashville, TN 37203 USA; [DiBenedetto, Emmanuele] Vanderbilt Univ, Dept Math, Nashville, TN USA; [Bisegna, Paolo] Univ Rome, Dept Civil Engn, Tor Vergata, Italy; [Caruso, Giovanni] CNR, Construct Technol Inst, Rome, Italy; [Andreucci, Daniele] Univ Rome, Dept Math Methods & Models, La Sapienza, Italy; [Shen, Lixin; Gurevich, Vsevolod V.; Hamm, Heidi E.] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN USA DiBenedetto, E (reprint author), Vanderbilt Univ, Med Ctr, Biomath Study Grp, Nashville, TN 37203 USA. em.diben@vanderbilt.edu Bisegna, Paolo/G-7569-2011; Gurevich, Vsevolod/A-3236-2008 Gurevich, Vsevolod/0000-0002-3950-5351 101 22 23 BIOPHYSICAL SOC BETHESDA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA 0006-3495 BIOPHYS J Biophys. J. MAY 1 2008 94 9 3363 3383 10.1529/biophysj.107.114058 21 Biophysics Biophysics 286EW WOS:000254829700002 J Santonicola, MG; Lenhoff, AM; Kaler, EW Santonicola, M. Gabriella; Lenhoff, Abraham M.; Kaler, Eric W. Binding of alkyl polyglucoside Surfactants to bacteriorhodopsin and its relation to protein stability BIOPHYSICAL JOURNAL English Article SMALL-ANGLE SCATTERING; LIPIDIC CUBIC PHASES; MEMBRANE-PROTEINS; PURPLE MEMBRANE; QUATERNARY STRUCTURE; DETERGENT COMPLEXES; ANGSTROM RESOLUTION; NEUTRON-SCATTERING; THERMAL-STABILITY; HYDROGEN-EXCHANGE The binding of alkyl polyglucoside surfactants to the integral membrane protein bacteriorhodopsin ( BR) and the formation of protein-surfactant complexes are investigated by sedimentation equilibrium via analytical ultracentrifugation and by small-angle neutron scattering ( SANS). Contrast variation techniques in SANS enable measurement of the composition of the protein-surfactant complexes and determination of the thickness of the surfactant shell bound to the protein. The results indicate that alkyl polyglucosides can bind to BR as single surfactant layers or as a thicker shell. The thickness of the surfactant shell increases with increasing surfactant tail length, and it is generally unrelated to the aggregation number of the micelles even for a small and predominantly hydrophobic membrane protein such as BR. The aggregation numbers determined by sedimentation equilibrium methods match those measured by SANS, which also allows reconstruction of the shape of the protein-detergent complex. When the surfactant is present as a single layer, the BR loses activity, as measured by absorption spectroscopy, more quickly than it does when the surfactant forms a thicker shell. [Santonicola, M. Gabriella; Lenhoff, Abraham M.; Kaler, Eric W.] Univ Delaware, Dept Chem Engn, Ctr Mol & Engn Thermodynam, Newark, DE 19716 USA Kaler, EW (reprint author), Univ Delaware, Dept Chem Engn, Ctr Mol & Engn Thermodynam, Newark, DE 19716 USA. kaler@udel.edu Santonicola, Mariagabriella/E-6355-2010 Santonicola, Mariagabriella/0000-0002-2736-8580 61 9 10 BIOPHYSICAL SOC BETHESDA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA 0006-3495 BIOPHYS J Biophys. J. MAY 1 2008 94 9 3647 3658 10.1529/biophysj.107.113258 12 Biophysics Biophysics 286EW WOS:000254829700026 J Margutti, P; Matarrese, P; Conti, F; Colasanti, T; Delunardo, F; Capozzi, A; Garofalo, T; Profurno, E; Rigano, R; Siracusano, A; Alessandri, C; Salvati, B; Valesini, G; Malorni, W; Sorice, M; Ortonal, E Margutti, Paola; Matarrese, Paola; Conti, Fabrizio; Colasanti, Tania; Delunardo, Federica; Capozzi, Antonella; Garofalo, Tina; Profurno, Elisabetta; Rigano, Rachele; Siracusano, Alessandra; Alessandri, Cristiano; Salvati, Bruno; Valesini, Guido; Malorni, Walter; Sorice, Maurizio; Ortonal, Elena Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis BLOOD English Article SYSTEMIC-LUPUS-ERYTHEMATOSUS; CONNECTIVE-TISSUE DISEASE; LIPID-PEROXIDATION; PSYCHIATRIC MANIFESTATIONS; AUTOIMMUNE-DISEASES; DRUG-RESISTANCE; GLUTATHIONE; ANTIBODIES; PROTEIN; AUTOANTIGEN Although detection of autoantibodies in the peripheral blood from patients with immune-mediated endothelial dysfunctions has so far failed to provide tools of diagnostic or pathogenetic value, putative bioindicators include anti-endothelial cell antibodies, a heterogeneous family of antibodies that react with autoantigens expressed by endothelial cells. In this study, to identify endothelial autoantigens involved in the autoimmune processes causing endothelial damage, we screened a human microvascular endothelial cell cDNA library with sera from patients with Behcet's disease. We identified antibodies to the C-terminus of Ral binding protein1 (RLIP76), a protein that catalyzes the ATP-dependent transport of glutathione (GSH) conjugates including GSH-4-hydroxy-t-2,3-nonenal, in the serum of a significant percentage of patients with various diseases characterized by immune-mediated endothelial dysfunction, including Behcet disease, systemic sclerosis, systemic lupus erythematosus and carotid atherosclerosis. These autoantibodies increased intracellular levels of 4-hydroxy-t-2,3-nonenal, decreased levels of GSH and activated C-Jun NH2 Kinase signaling (JNK), thus inducing oxidative stress-mediated endothelial cell apoptosis. The dietary antioxidant alpha-tocopherol counteracted endothelial cell demise. These findings suggest that autoantibodies to RLIP76 play a pathogenetic role in immune-mediated vascular diseases and represent a valuable peripheral blood bioindicator of atherosclerosis and immune-mediated vascular diseases. [Margutti, Paola; Colasanti, Tania; Delunardo, Federica; Profurno, Elisabetta; Rigano, Rachele; Siracusano, Alessandra; Ortonal, Elena] Ist Super Sanita, Dipartimento Malattie Infett Parassitarie & Immun, I-00161 Rome, Italy; [Matarrese, Paola; Malorni, Walter] Ist Super Sanita, Dipartimento Farmaco, I-00161 Rome, Italy; [Conti, Fabrizio; Alessandri, Cristiano; Valesini, Guido] Univ Roma La Sapienza, Dipartimento Clin & Terapia Med, Rome, Italy; [Capozzi, Antonella; Garofalo, Tina; Sorice, Maurizio] Univ Roma La Sapienza, Dipartimento Med Sperimentale, I-00185 Rome, Italy; [Salvati, Bruno] Univ Roma La Sapienza, Dipartimento Sci Chirurg, Rome, Italy Ortonal, E (reprint author), Ist Super Sanita, Sect Immune Mediat dis, Dept Infect Parasit & Immune Mediat Dis, Viale Regina Elena 299, I-00161 Rome, Italy. elena.ortona@iss.it Salvati, Bruno/A-4010-2011 57 29 29 AMER SOC HEMATOLOGY WASHINGTON 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA 0006-4971 BLOOD Blood MAY 1 2008 111 9 4559 4570 10.1182/blood-2007-05-092825 12 Hematology Hematology 294EO WOS:000255387400024 J Doricchi, F; Guariglia, P; Figliozzi, F; Silvetti, M; Gasparini, M; Merola, S; Macci, E; Binetti, N; Bruschini, M; Bueti, D Doricchi, Fabrizio; Guariglia, Paola; Figliozzi, Francesca; Silvetti, Massimo; Gasparini, Marina; Merola, Sheila; Macci, Enrica; Binetti, Nicola; Bruschini, Michela; Bueti, Domenica No reversal of the Oppel-Kundt illusion with short stimuli: confutation of the space anisometry interpretation of neglect and 'cross-over' in line bisection BRAIN English Letter spatial neglect; line bisection; crossover; space anisometry; Oppel-Kundt illusion UNILATERAL SPATIAL NEGLECT; HEMIANOPIA; FIXATION; PATTERNS [Doricchi, Fabrizio; Guariglia, Paola; Figliozzi, Francesca; Silvetti, Massimo; Merola, Sheila; Macci, Enrica; Binetti, Nicola; Bruschini, Michela; Bueti, Domenica] IRCCS, Fdn Santa Lucia, Ctr Ric Neuropsicol, I-00179 Rome, Italy; [Doricchi, Fabrizio; Guariglia, Paola; Figliozzi, Francesca; Silvetti, Massimo; Merola, Sheila; Macci, Enrica; Binetti, Nicola] Univ Roma La Sapienza, Dipartimento Psicol, Rome, Italy; [Gasparini, Marina] Univ Roma La Sapienza, Dipartimento Sci Neurol, Va Cattedra, Rome, Italy; [Bueti, Domenica] UCL, Inst Cognit Neurosci, London, England Doricchi, F (reprint author), IRCCS, Fdn Santa Lucia, Ctr Ric Neuropsicol, Via Ardeatina 306, I-00179 Rome, Italy. fabrizio.doricchi@uniroma1.it 15 4 4 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0006-8950 BRAIN Brain MAY 2008 131 5 e94 10.1093/brain/awm273 4 Clinical Neurology; Neurosciences Neurosciences & Neurology 296DN WOS:000255523800001 J Leggio, MG; Tedesco, AM; Chiricozzi, FR; Clausi, S; Orsini, A; Molinari, M Leggio, M. G.; Tedesco, A. M.; Chiricozzi, F. R.; Clausi, S.; Orsini, A.; Molinari, M. Cognitive sequencing impairment in patients with focal or atrophic cerebellar damage BRAIN English Article cerebellum; executive function; picture arrangement; script BASAL GANGLIA OUTPUT; PARKINSONS-DISEASE; ACQUISITION; DEFICIT; LESIONS; BRAIN; DEGENERATION; INFORMATION; VISUOMOTOR; DISORDERS Although cognitive impairment after cerebellar damage has been widely reported, the mechanisms of cerebro-cerebellar interactions are still a matter of debate. The cerebellum is involved in sequence detection and production in both motor and sensory domains, and sequencing has been proposed as the basic mechanism of cerebellar functioning. Furthermore, it has been suggested that knowledge of sequencing mechanisms may help to define cerebellar predictive control processes. In spite of its recognized importance, cerebellar sequencing has seldom been investigated in cognitive domains. Cognitive sequencing functions are often analysed by means of action/script elaboration. Lesion and activation studies have localized this function in frontal cortex and basal ganglia circuits. The present study is the first to report deficits in script sequencing after cerebellar damage. We employed a card-sequencing test, developed ad hoc, to evaluate the influence of the content to be sequenced. Stimuli consisted of sets of sentences that described actions with a precise logical and temporal sequence (Verbal Factor), sets of cartoon-like drawings that reproduced behavioural sequences (Behavioural Factor) or abstract figures (Spatial Factor). The influence of the lesion characteristics was analysed by grouping patients according to lesion-type (focal or atrophic) and lesion-side (right or left). The results indicated that patients with cerebellar damage present a cognitive sequencing impairment independently of lesion type or localization. A correlation was also shown between lesion side and characteristics of the material to be sequenced. Namely, patients with left lesions perform defectively only on script sequences based on pictorial material and patients with right lesions only on script sequences requiring verbal elaboration. The present data support the hypothesis that sequence processing is the cerebellar mode of operation also in the cognitive domain. In addition, the presence of right/left and pictorial/verbal differences is in agreement with the idea that cerebro-cerebellar interactions are organized in segregated cortico-cerebellar loops in which specificity is not related to the mode of functioning, but to the characteristics of the information processed. [Leggio, M. G.; Tedesco, A. M.; Chiricozzi, F. R.; Clausi, S.; Orsini, A.; Molinari, M.] Univ Roma La Sapienza, Dept Psychol, Head Ataxia Lab Santa Lucia Fdn, I-00185 Rome, Italy Leggio, MG (reprint author), Univ Roma La Sapienza, Dept Psychol, Head Ataxia Lab Santa Lucia Fdn, Via Dei Marsi 78, I-00185 Rome, Italy. maria.leggio@uniromal.it Molinari, Marco/A-9624-2010; Leggio, Maria/D-1269-2010 Molinari, Marco/0000-0001-9808-9688; 60 42 43 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 0006-8950 BRAIN Brain MAY 2008 131 5 1332 1343 10.1093/brain/awn040 12 Clinical Neurology; Neurosciences Neurosciences & Neurology 296DN WOS:000255523800020 J Bossu, P; Ciaramella, A; Salani, F; Bizzoni, F; Varsi, E; Di Julio, F; Giubilei, F; Gianni, W; Trequattrini, A; Moro, ML; Bernardini, S; Caltagirone, C; Spalletta, G Bossu, Paola; Ciaramella, Antonio; Salani, Francesca; Bizzoni, Federica; Varsi, Erika; Di Julio, Fulvia; Giubilei, Franco; Gianni, Walter; Trequattrini, Alberto; Moro, Maria Luisa; Bernardini, Sergio; Caltagirone, Carlo; Spalletta, Gianfranco Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment BRAIN BEHAVIOR AND IMMUNITY English Article interleukin-18; Alzheimer's disease; cognitive decline MICROGLIAL ACTIVATION; INFLAMMATORY MARKERS; IL-18; DEMENTIA; BRAIN; RISK; MICE A body of evidence indicates that inflammation plays a pivotal role in AD pathogenesis. IL-18 is a pro-inflammatory cytokine produced in the brain, emerging to be implicated in AD. Although no differences in circulating IL-18 levels were measured between AD patients and controls, a significant increased production of IL-18 was obtained from stimulated blood mononuclear cells of AD patients. This was true particularly in AD subjects carrying the C/C genotype at the -607 position of IL-18 gene promoter. Furthermore, a significant correlation between IL-18 production and cognitive decline was observed in AD patients. Overall, these data indicate that IL-18-related inflammatory pathways, probably also in virtue of polymorphic IL-18 gene influence, are exacerbated in AD patients, and that this cytokine may indeed participate in pathogenic processes leading to dementia. (c) 2007 Elsevier Inc. All rights reserved. [Bossu, Paola; Ciaramella, Antonio; Salani, Francesca; Bizzoni, Federica; Varsi, Erika; Di Julio, Fulvia; Moro, Maria Luisa; Caltagirone, Carlo; Spalletta, Gianfranco] IRCCS, Santa Lucia Fdn, Dept Clin & Behav Neurol, I-00179 Rome, Italy; [Giubilei, Franco] Univ Roma La Sapienza, Dept Neurol, Rome, Italy; [Giubilei, Franco] IRCCS, INRCA, Rome, Italy; [Bernardini, Sergio] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy; [Bernardini, Sergio] Univ Roma Tor Vergata, Dept Lab Med, Rome, Italy; [Caltagirone, Carlo] Univ Roma Tor Vergata, Dept Neurosci, Rome, Italy; [Spalletta, Gianfranco] Univ Roma Tor Vergata, Tor Vergata Hosp, Neuropsychol Outpatient Clin, Rome, Italy Bossu, P (reprint author), IRCCS, Santa Lucia Fdn, Dept Clin & Behav Neurol, Via Ardeatina 306, I-00179 Rome, Italy. p.bossu@hsantalucia.it Ciaramella, Antonio/F-1170-2011; SALANI, FRANCESCA/I-1314-2012; Caltagirone, Carlo/B-4930-2013 Ciaramella, Antonio/0000-0001-9888-8156; 21 30 31 ACADEMIC PRESS INC ELSEVIER SCIENCE SAN DIEGO 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA 0889-1591 BRAIN BEHAV IMMUN Brain Behav. Immun. MAY 2008 22 4 487 492 10.1016/j.bbi.2007.10.001 6 Immunology; Neurosciences Immunology; Neurosciences & Neurology 298ZE WOS:000255724800009 J Adami, S; Bianchi, G; Brandi, ML; Giannini, S; Ortolani, S; DiMunno, O; Frediani, B; Rossini, M Adami, Silvano; Bianchi, Gerolamo; Brandi, Maria Luisa; Giannini, Sandro; Ortolani, Sergio; DiMunno, Ombretta; Frediani, Bruno; Rossini, Maurizio BONTURNO Study Grp Determinants of bone turnover markers in healthy premenopausal women CALCIFIED TISSUE INTERNATIONAL English Article bone turnover marker; normative value; contraceptive pill; body weight; serum phosphate POSTMENOPAUSAL OSTEOPOROSIS; PARATHYROID-HORMONE; VERTEBRAL FRACTURE; MINERAL DENSITY; RISK-FACTORS; ALENDRONATE; SERUM; RISEDRONATE; RESORPTION; REDUCTION Bone turnover markers (BTMs) are widely used for the management of osteoporosis, and the premenopausal reference range is the target value for the treatment of postmenopausal osteoporosis with antiresorbing agents. Three serum BTMs (serum C-telopeptide of type I collagen [CTX], osteocalcin [OC], and N-terminal propeptide of type I procollagen [P1NP]), serum calcium, creatinine, phosphate, magnesium, and follicle-stimulating hormone (FSH) were measured in 638 healthy premenopausal women aged 20-50 years. In 83 women on the contraceptive pill (CP), the levels of the three BTMs adjusted for all confounding factors were 14-26% lower (P < 0.005) than in non-CP users. In 18 women considered perimenopausal for serum FSH levels > 30 IU/mL despite having regular menses, BTM levels were significantly higher than in age-matched women. This group of subjects and the women on the CP were excluded from further analysis. The three BTMs significantly decreased with advancing age and were negatively and independently correlated with body mass index (P < 0.001) and serum phosphate. In conclusion, we confirm that CP use is associated with significantly lower BTM values. An increase in BTM concentrations can be observed in perimenopausal women, i.e., women with normal menses but FSH levels > 30 IU/mL. BTMs decrease substantially with advancing age, and this appears to be associated with changes in body weight and serum phosphate. New normative ranges for serum OC, CTX, and P1NP were identified; and our findings in general impose a redefinition of the criteria for establishing the normal ranges for BTMs. [Adami, Silvano; Rossini, Maurizio] Univ Verona, Osped Valeggio, Rheumatol Unit, I-37067 Verona, Italy; [Bianchi, Gerolamo] Rheumatol Unit, Genoa, Italy; [Brandi, Maria Luisa] Univ Florence, Endocrine Unit, Florence, Italy; [Giannini, Sandro] Univ Padua, Padua, Italy; [Ortolani, Sergio] Osped Auxol, Ist Auxol Italiano Irccs, Unita Operat Reumatol & Malattie Metab Osseo, Milan, Italy; [DiMunno, Ombretta] Univ Pisa, Rhematol Unit, Pisa, Italy; [Frediani, Bruno] Univ Siena, Rhematol Unit, I-53100 Siena, Italy Adami, S (reprint author), Univ Verona, Osped Valeggio, Rheumatol Unit, I-37067 Verona, Italy. silvano.adami@univr.it; gerolamo_bianchi@tin.it; m.brandi@DMI.UNIFI.IT; sandro.giannini@unipd.it; ortolani@auxologico.it; odimunno@int.med.unipi.it; fredianibruno@tiscali.it; maurizio.rossini@libero.it 27 38 38 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 0171-967X CALCIFIED TISSUE INT Calcif. Tissue Int. MAY 2008 82 5 341 347 10.1007/s00223-008-9126-5 7 Endocrinology & Metabolism Endocrinology & Metabolism 315VW WOS:000256909300003 J Appleton, DL; Abbate, A; Biondi-Zoccai, GGL Appleton, Darryn L.; Abbate, Antonio; Biondi-Zoccai, Giuseppe G. L. Late percutaneous coronary intervention for the totally occluded infarct-related artery: A meta-analysis of the effects on cardiac function and remodeling CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS English Article meta-analysis; myocardial infarction; late; revascularization; percutaneous coronary intervention; total occlusion; remodeling ACUTE MYOCARDIAL-INFARCTION; POSITRON EMISSION TOMOGRAPHY; RANDOMIZED CONTROLLED-TRIAL; LEFT-VENTRICULAR FUNCTION; RESCUE ANGIOPLASTY; LATE REPERFUSION; CONSERVATIVE MANAGEMENT; TOTAL OCCLUSION; THERAPY; THROMBOLYSIS (Background) under bar: Late percutaneous coronary intervention (PCI) of a totally occluded infarct-related artery (IRA) in stable patients is currently not recommended based on the lack of clear clinical benefits in randomized controlled trials. We sought to perform a systematic review and meta-analysis of randomized controlled trials comparing PCI with optimal medical therapy in patients with IRA occlusion more than 12 hr after onset of acute myocardial infarction (AMI), focusing on left ventricular function and remodeling. (Methods and Results) under bar: PubMed, CENTRAL, and mRCT were searched for eligible studies. Studies were included in the analysis if they were randomized controlled trials comparing conservative medical management with PCI performed at least 12 hr after the onset of symptoms of AMI, and data on left ventricular ejection fraction (LVEF) at baseline and follow-up were available. Studies were excluded if randomization occurred less than 12 hr after symptom onset, or if patients were hemodynamically unstable. Change in LVEF was the primary outcome of interest, with changes in left ventricular end-diastolic volume index (LVEDVI) and end-systolic volume index (LVESVI) analyzed as secondary endpoints. We retrieved five studies in which baseline and follow up LVEF data were available enrolling a total of 648 patients: 342 patients randomized to PCI and 306 to medical treatment. There was a statistically significant difference in LVEF changes over time favoring PCI (+3.1%, 95% CI +1.0 to +5.2, P = 0.0004). In addition, there were statistically significant differences changes in both LVEDVI (-5.1 ml in favor of PCI, 95% CI of -9.4 to -0.8, P = 0.020) and LVESVI (-5.3 ml in favor in PCI, 95% CI of -8.3 to -2.4, P = 0.0005). (Conclusions) under bar: This meta-analysis suggests that late revascularization of an occluded IRA may improve left ventricular systolic function and remodeling, supporting the "open artery hypothesis." The reason why these changes have not resulted in clinical benefits in large clinical trials is subject to debate. (C) 2008 Wiley-Liss, Inc. [Biondi-Zoccai, Giuseppe G. L.] Univ Turin, Div Cardiol, Turin, Italy; [Appleton, Darryn L.; Abbate, Antonio] Virginia Commonwealth Univ, VCU Pauley Heart Ctr, Richmond, VA USA Biondi-Zoccai, GGL (reprint author), Univ Turin, Div Cardiol, Turin, Italy. gbiondizoccai@gmail.com Abbate, Antonio/C-2388-2008 42 14 16 WILEY-LISS HOBOKEN DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA 1522-1946 CATHETER CARDIO INTE Catheter. Cardiovasc. Interv. MAY 1 2008 71 6 772 781 10.1002/ccd.21468 10 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 291ZB WOS:000255235000014 J Brunetti, M; Della Penna, S; Ferretti, A; Del Gratta, C; Cianflone, F; Belardinelli, P; Caulo, M; Pizzella, V; Belardinelli, MO; Romani, GL Brunetti, M.; Della Penna, S.; Ferretti, A.; Del Gratta, C.; Cianflone, F.; Belardinelli, P.; Caulo, M.; Pizzella, V.; Belardinelli, M. Olivetti; Romani, G. L. A frontoparietal network for spatial attention reorienting in the auditory domain: A human fMRI/MEG study of functional and temporal dynamics CEREBRAL CORTEX English Article auditory processing; fMRI; MEG; reorienting response; vertical meridian CORTICAL NETWORK; HUMAN BRAIN; CORTEX; LOCALIZATION; ACTIVATION; MECHANISMS; EVENTS; MEG Several studies have identified a supramodal network critical to the reorienting of attention toward stimuli at novel locations and which involves the right temporoparietal junction and the inferior frontal areas. The present functional magnetic resonance imaging (fMRI)magnetoencephalography (MEG) study investigates: 1) the cerebral circuit underlying attentional reorienting to spatially varying sound locations; 2) the circuit related to the regular change of sound location in the same hemifield, the change of sound location across hemifields, or sounds presented randomly at different locations on the azimuth plane; 3) functional temporal dynamics of the observed cortical areas exploiting the complementary characteristics of the fMRI and MEG paradigms. fMRI results suggest 3 distinct roles: the supratemporal plane appears modulated by variations of sound location; the inferior parietal lobule is modulated by the cross-meridian effect; and the inferior frontal cortex is engaged by the inhibition of a motor response. MEG data help to elucidate the temporal dynamics of this network by providing high-resolution time series with which to measure latency of neural activation manipulated by the reorienting of attention. [Brunetti, M.; Della Penna, S.; Ferretti, A.; Del Gratta, C.; Cianflone, F.; Belardinelli, P.; Caulo, M.; Pizzella, V.; Romani, G. L.] Univ G Annunzio Chieti, Inst Adv Biomed Technol, I-66013 Chieti, CH, Italy; [Brunetti, M.; Della Penna, S.; Ferretti, A.; Del Gratta, C.; Cianflone, F.; Belardinelli, P.; Caulo, M.; Pizzella, V.; Romani, G. L.] Univ G Annunzio Chieti, Dept Clin Sci & Biomed Imaging, I-66013 Chieti, CH, Italy; [Belardinelli, P.; Belardinelli, M. Olivetti] Univ Roma La Sapienza, ECONA Interuniv Ctr Res Cognit Proc Nat & Artific, I-00185 Rome, Italy; [Belardinelli, M. Olivetti] Univ Roma La Sapienza, Dept Psychol, I-00185 Rome, Italy Brunetti, M (reprint author), Univ G Annunzio Chieti, Inst Adv Biomed Technol, Via Dei Vestini 33, I-66013 Chieti, CH, Italy. mbrunetti@itab.unich.it 31 18 18 OXFORD UNIV PRESS INC CARY JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA 1047-3211 CEREB CORTEX Cereb. Cortex MAY 2008 18 5 1139 1147 10.1093/cercor/bhm145 9 Neurosciences Neurosciences & Neurology 287ZD WOS:000254955100013 J De Falco, M; Nardella, P; Marrelli, L; Di Paola, L; Basile, A; Gallucci, F De Falco, M.; Nardella, P.; Marrelli, L.; Di Paola, L.; Basile, A.; Gallucci, F. The effect of heat-flux profile and of other geometric and operating variables in designing industrial membrane methane steam reformers CHEMICAL ENGINEERING JOURNAL English Article methane steam reforming; membrane reactor; hydrogen production; design variables WATER-GAS SHIFT; PACKED-BEDS; 2-DIMENSIONAL MODEL; PALLADIUM MEMBRANE; REACTOR; SIMULATION; HYDROGEN; TRANSPORT; DENSE; FLOW The performance of an original membrane methane reformer is analyzed by a two-dimensional mathematical model. The reactor is a bundle of four coaxial double tubes inserted in a shell in which a heating fluid flows. The annular region of each tube is the reaction zone, whereas the inner tube is the selective membrane for hydrogen removal. Many simulations have been carried out in order to find a suitable set of values of geometric and operating design variables. The effect of pressure and sweeping gas flow rate at permeation side, of membrane diameter and of axial profile of heat flux supplied to the reactor is analyzed in 81 virtual experiments. Suitable operating conditions are found: over 58% methane conversion can be reached, within a proper membrane temperature range and extra methane consumption for thermal duty. (C) 2007 Elsevier B.V. All rights reserved. [De Falco, M.; Nardella, P.; Marrelli, L.; Di Paola, L.] Univ Roma La Sapienza, Dept Chem Engn, I-00184 Rome, Italy; [Basile, A.; Gallucci, F.] Univ Calabria, CNR, ITM, Inst Membrane Technol, I-87030 Arcavacata Di Rende, CS, Italy De Falco, M (reprint author), Univ Roma La Sapienza, Dept Chem Engn, Via Eudossiana 18, I-00184 Rome, Italy. marcello.defalco@uniromal.it gallucci, fausto/E-7375-2013 gallucci, fausto/0000-0001-6379-773X 27 19 19 ELSEVIER SCIENCE SA LAUSANNE PO BOX 564, 1001 LAUSANNE, SWITZERLAND 1385-8947 CHEM ENG J Chem. Eng. J. MAY 1 2008 138 1-3 442 451 10.1016/j.cej.2007.06.026 10 Engineering, Environmental; Engineering, Chemical Engineering 290CK WOS:000255100300048 J Cerbelli, S; Giona, M Cerbelli, Stefano; Giona, Massimiliano On the estimate of mixing length in interdigital micromixers CHEMICAL ENGINEERING JOURNAL English Article fluid mixing; interdigital micromixers; laminar flows; homogenization; lamination MICROFLUIDICS The multilamination process that characterizes interdigital micromixers is an efficient and technologically feasible method for maximizing and controlling mass and/or heat transfer between two or more segregated fluid streams. We analyze the dynamics of mixing that takes place in the mixing channel downstream the interdigital apparatus. Specifically, we investigate, for different flow profiles, how the channel length necessary to achieve a prescribed level of mixedness depends on the degree of lamination (number and thickness of lamellae) of the feed stream. As a case study, we consider plug, shear and Poiseuille flow, and compare steady-state profiles resulting from the numerical simulation of the full advection-diffusion problem with the analytical solution stemming from the one-dimensional Sturm-Liouville eigenvalue problem along the spanwise coordinate, obtained neglecting streamwise diffusion. We find that (i) the mixing length can be significantly affected by the flow profile, especially at high degree of lamination of the feed stream, and (ii) in general, no obvious scaling between mixing length and lamellar thickness can be assumed. A rigorous way to approach the design of these micromixers is proposed. (C) 2007 Elsevier B.V. All rights reserved. [Cerbelli, Stefano; Giona, Massimiliano] Univ Roma La Sapienza, Fac Ingn, Dipartimento Ingn Chim, I-00184 Rome, Italy Giona, M (reprint author), Univ Roma La Sapienza, Fac Ingn, Dipartimento Ingn Chim, Via Eudossiana 18, I-00184 Rome, Italy. max@giona.ing.uniromal.it 21 3 3 ELSEVIER SCIENCE SA LAUSANNE PO BOX 564, 1001 LAUSANNE, SWITZERLAND 1385-8947 CHEM ENG J Chem. Eng. J. MAY 1 2008 138 1-3 523 537 10.1016/j.cej.2007.07.067 15 Engineering, Environmental; Engineering, Chemical Engineering 290CK WOS:000255100300056 J Valerio, M; Porcelli, F; Zbilut, JP; Giuliani, A; Manetti, C; Conti, F Valerio, Mariacristina; Porcelli, Fernando; Zbilut, Joseph P.; Giuliani, Alessandro; Manetti, Cesare; Conti, Filippo pH effects on the conformational preferences of amyloid beta-peptide (1-40) in HFIP aqueous solution by NMR spectroscopy CHEMMEDCHEM English Review Alzheimer's disease; amyloid beta-peptides; conformational flexibility; NMR spectroscopy; principal component analysis AMYLOID-BETA-PROTEIN; ALZHEIMERS-DISEASE; FIBRIL FORMATION; SECONDARY STRUCTURE; PLAQUE-COMPETENCE; MEMBRANE INTERACTION; CIRCULAR-DICHROISM; TERMINAL FRAGMENT; PRECURSOR PROTEIN; STRUCTURAL MODEL The structure and aggregation state of amyloid beta-peptide (A beta) in membrane-like environments ore important determinants of pathological events in Alzheimer's disease. In fact, the neurotoxic nature of amyloid-forming peptides and proteins is associated with specific conformational transitions proximal to the membrane. Under certain conditions, the A beta peptide undergoes a conformational change that brings the peptide in solution to a "competent state" for aggregation. Conversion can be obtained at medium pH (5.0-6.0), and in vivo this appears to take place in the endocytic pathway. The combined use of (1)H NMR spectroscopy and molecular dynamics-simulated annealing calculations in aqueous hexafluoroisoproponol simulating the membrane environment, at different pH conditions, enabled us to get some insights into the aggregation process of A beta, confirming our previous hypotheses of a relationship between conformational flexibility and aggregation propensity. The conformational space of the peptide was explored by means of an innovative use of principal component analysis as applied to residue-by-residue root-mean-square deviations values from a reference structure. This procedure allowed us to identify the aggregation-prone regions of the peptide. [Valerio, Mariacristina; Manetti, Cesare; Conti, Filippo] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy; [Porcelli, Fernando] Univ Tuscia, Dipartimento Sci Ambientali, I-01100 Viterbo, Italy; [Zbilut, Joseph P.] Rush Univ, Med Ctr, Dept Physiol & Mol Biophys, Chicago, IL 60612 USA; [Giuliani, Alessandro] Ist Super Sanita, Dipartimento Ambiente & Connessa Prevenz Primaria, I-00161 Rome, Italy Valerio, M (reprint author), Univ Roma La Sapienza, Dipartimento Chim, P A Moro 5, I-00185 Rome, Italy. filippo.conti@uniroma1.it 109 6 7 WILEY-BLACKWELL MALDEN COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA 1860-7179 CHEMMEDCHEM ChemMedChem MAY 2008 3 5 833 843 10.1002/cmdc.200700324 11 Chemistry, Medicinal; Pharmacology & Pharmacy Pharmacology & Pharmacy 305MU WOS:000256183300018 J Navarrini, W; Scrosati, B; Panero, S; Sanguineti, A; Alessandro, G; Paolo, F Navarrini, Walter; Scrosati, Bruno; Panero, Stefania; Sanguineti, Aldo; Alessandro, Ghielmi; Paolo, Fossati Propylene carbonate uptake and conductivity of lithiated short side chain perfluorinated sulfonic ionomeric membranes CHIMICA OGGI-CHEMISTRY TODAY English Article Short Side Chain (SSC) ion-conducting polymers have revealed a better electrochemical behaviour compared to the long-side-chain (LSC) NAFION (R)-like polymers in the Polymer Electrolyte Membrane Fuel Cell (PEMFC) application (1). The relevance of the lithium form of HYFLON (R) ION as polymer electrolyte for lithium ion batteries has also been investigated. Starting from these SSC ionomers and utilising a particularly straightforward methodology for the preparation and dehydration of the lithium ion membrane in nonaqueous media, it has been possible to achieve a high ionic conductivity in the range of 10-3 S/cm at room temperature(2). The high concentration of lithium ions and the high polymer swelling in propylene carbonate solvent are not sufficient to explain the high ionic conductivity observed. [Navarrini, Walter] Politecn Milan, Dipartimento Chim Mat & Ingn Chim Giulio Natta, I-20133 Milan, Italy; [Scrosati, Bruno; Panero, Stefania] Univ Roma La Sapienza, Rome, Italy; [Sanguineti, Aldo; Alessandro, Ghielmi; Paolo, Fossati] CRS Solvay Solexis, Bollate Milano, Italy Navarrini, W (reprint author), Politecn Milan, Dipartimento Chim Mat & Ingn Chim Giulio Natta, Via Mancinelli 7, I-20133 Milan, Italy. Panero, Stefania/G-9761-2011; Navarrini, walter/L-7505-2013 13 1 1 TEKNOSCIENZE PUBL MILANO VIALE BRIANZA 22, 20127 MILANO, ITALY 0392-839X CHIM OGGI Chim. Oggi-Chem. Today MAY-JUN 2008 26 3 1 22 25 4 Biotechnology & Applied Microbiology; Chemistry, Multidisciplinary Biotechnology & Applied Microbiology; Chemistry 311VG WOS:000256627900008 J Ortore, E; Francione, V Ortore, Emiliano; Francione, Valerio On the aerosols monitoring by satellite observations CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY English Article Aerosols; Satellite; Monitoring; Atmosphere; Earth; Sensor Particulate matter is the general term used to identify a complex mixture of organic and inorganic particles (aerosols) that can be found suspended in the atmosphere in solid, liquid or both physical states. The presence of particulate of non-natural origin is linked to important climatic and environmental effects. The interactions of these particles with the solar radiation, the Earth and the atmospheric gases, can modify the atmosphere physical and chemical characteristics, the temperature vertical profile and other thermodynamic variables, as well as the Earth surface characteristics and its temperature. Studies on the particles have furthermore demonstrated the existence of a link between the presence of fine and ultra-fine particulate of non-natural origin and some effects on the health of human and other living being. The aerosols can contaminate a wide area of the region surrounding the source of particulate. Based upon all these reasons it is considered the utmost importance to develop a satellite-based system capable of monitoring the presence of particulate on very large areas. This paper provides methodologies to identify atmospheric particles by means of satellite-based sensors operating both in the reflective and in the thermal infrared part of the electromagnetic spectrum. [Ortore, Emiliano] Univ Roma La Sapienza, Sch Aerosp Engn, I-00184 Rome, Italy Ortore, E (reprint author), Univ Roma La Sapienza, Sch Aerosp Engn, Via Eudossiana 16, I-00184 Rome, Italy. ortore@psm.uniroma1.it 11 3 3 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 1618-954X CLEAN TECHNOL ENVIR Clean Technol. Environ. Policy MAY 2008 10 2 137 145 10.1007/s10098-007-0134-3 9 Engineering, Environmental; Environmental Sciences Engineering; Environmental Sciences & Ecology 371IX WOS:000260826100007 J Morano, S; Cipriani, R; Santangelo, C; Fallarino, M; Camovale, A; Mandosi, E; Gatti, A; Sensi, M; Di Mario, U Morano, S.; Cipriani, R.; Santangelo, C.; Fallarino, M.; Camovale, A.; Mandosi, E.; Gatti, A.; Sensi, M.; Di Mario, U. Angiotensin blockade and matrix synthesis by glomerular epithelial cells in high glucose: A further experimental insight into the pathophysiology of diabetic nephropathy CLINICA TERAPEUTICA English Article angiotensin converting enzyme inhibitor; angiotensin II receptor-1 antagonist; extracellular matrix; glomerular epithelial cells; diabetic nephropathy GROWTH-FACTOR-BETA; GENE-EXPRESSION; MESANGIAL CELLS; FACTOR-I; SYSTEM; KIDNEY; INHIBITORS; RECEPTORS; PODOCYTES; DISEASE Aims. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor-1 (AT-1) antagonists are used in the treatment of proteinuria of diabetic nephropathy. One of the major pathogenic events in this condition is represented by the alteration of the extracellular matrix protein synthesis by glomerular epithelial cells. Materials and Methods. We evaluated the effects of the angiotensin converting enzyme inhibitor, Enalaprilat, and the AT-I receptor antagonist, Losartan, on mRNA fibronectin and laminin synthesis by glomerular epithelial cells, in conditions mimicking hyperglycemia. Results. In high glucose conditions, Enalaprilat reduced significantly the mRNA expression of fibronectin (p <0.03), but not significantly that of laminin. Losartan addition to high glucose incubated cells reduced (-30%) mRNA expression of fibronectin, and significantly (p <0.05) the mRNA expression of laminin. Conclusions. In addition to the known hemodynamic effects, the improvement of renal function in diabetic patients treated with these compounds may also be due to a modulator effect on extracellular matrix content and composition. [Morano, S.; Cipriani, R.; Santangelo, C.; Fallarino, M.; Camovale, A.; Mandosi, E.; Gatti, A.; Sensi, M.; Di Mario, U.] Univ Roma La Sapienza, Dept Clin Sci, I-00161 Rome, Italy Morano, S (reprint author), Univ Roma La Sapienza, Dept Clin Sci, Viale Policlin, I-00161 Rome, Italy. susanna.morano@uniroma1.it 28 3 3 SOC EDITRICE UNIV ROME VIA G B MORGAGNI 1, ROME, 10061, ITALY 0009-9074 CLIN TER Clin. Ter. MAY-JUN 2008 159 3 151 154 4 Pharmacology & Pharmacy Pharmacology & Pharmacy 326ST WOS:000257679900002 J Monacelli, G; Cascioli, I; Prezzemolo, G; Spagnoli, A; Irace, S Monacelli, G.; Cascioli, I.; Prezzemolo, G.; Spagnoli, A.; Irace, S. Surgical treatment of Morton's neuroma: our experience and literature review CLINICA TERAPEUTICA Italian Article neurolysis; Morton's neuromas is METATARSALGIA; NERVE Objective. Morton's neuroma is a common foot problem associated with pain. Materials and Methods. In 52 patients intermetatarsal spaces were operated on for Morton's neuralgia Gautier surgical treatment. The procedure included dorsal incision, division of the deep intermetatarsal ligament, and resection of the common digital nerve including the neuroma. Results. The outcome of the operation was excellent in 47 patients. Conclusions: The results show the efficacy of the surgical treatment of Morton's neuralgia with a dorsal incision, over a long follow-up period. [Cascioli, I.; Prezzemolo, G.; Spagnoli, A.; Irace, S.] Univ Roma La Sapienza, UOC Chirurg Plast Ricostruttiva Urgenza, Azienda Policlin Umberto 1, Rome, Italy; [Monacelli, G.] NEUROMED IRCCS Pozzilli, Isernia, Italy Monacelli, G (reprint author), Via G Penta 44, I-00100 Rome, Italy. giampaolo.monacelli@uniroma1.it 14 0 0 SOC EDITRICE UNIV ROME VIA G B MORGAGNI 1, ROME, 10061, ITALY 0009-9074 CLIN TER Clin. Ter. MAY-JUN 2008 159 3 165 167 3 Pharmacology & Pharmacy Pharmacology & Pharmacy 326ST WOS:000257679900004 J Delle Sediel, A; Riente, L; Filippucci, E; Iagnocco, A; Meenagh, G; Epis, O; Grassi, W; Valesini, G; Montecucco, C; Bombardieri, S Delle Sediel, A.; Riente, L.; Filippucci, E.; Iagnocco, A.; Meenagh, G.; Epis, O.; Grassi, W.; Valesini, G.; Montecucco, C.; Bombardieri, S. Ultrasound imaging for the rheumatologist - XV. Ultrasound imaging in vasculitis CLINICAL AND EXPERIMENTAL RHEUMATOLOGY English Editorial Material ultrasound; vasculitis; polymyalgia rheumatica; Takayasu's arteritis; temporal arteritis GIANT-CELL ARTERITIS; B-MODE ULTRASONOGRAPHY; POLYMYALGIA-RHEUMATICA; TAKAYASU-ARTERITIS; DUPLEX ULTRASONOGRAPHY; TEMPORAL ARTERITIS; DOPPLER ULTRASONOGRAPHY; BEHCETS-SYNDROME; DIAGNOSIS; ARTHRITIS Over the last few years, a large number of studies have emphasized the fundamental role of ultrasonography (US) in the clinical evaluation of patients affected by rheumatic disorders. However, not all rheumatic diseases have been studied by US. To date, very few reports exist on the use of US in the assessment of articular, periarticular structures and blood vessels in vasculitis. In this review we provide an overview of the current data regarding the role of US in vasculitis. Sonographic evaluation of cardiac or renal involvement in these disorders will not be covered. [Delle Sediel, A.] Univ Pisa, Dipartimento Med Interna, UO Reumatol, Cattedra Reumatol, I-56126 Pisa, Italy; [Filippucci, E.; Grassi, W.] Univ Politecn Marche, Cattedra Reumatol, Jesi, Italy; [Iagnocco, A.; Valesini, G.] Sapienza Univ Roma, Cattedra Reumatol, Rome, Italy; [Epis, O.; Montecucco, C.] Univ Pavia, Cattedra Reumatol, IRCCS Policlin S Matteo, I-27100 Pavia, Italy Delle Sediel, A (reprint author), Univ Pisa, Dipartimento Med Interna, UO Reumatol, Cattedra Reumatol, Via Roma 67, I-56126 Pisa, Italy. adellese@lycos.com 46 15 15 CLINICAL & EXPER RHEUMATOLOGY PISA VIA SANTA MARIA 31, 56126 PISA, ITALY 0392-856X CLIN EXP RHEUMATOL Clin. Exp. Rheumatol. MAY-JUN 2008 26 3 391 394 4 Rheumatology Rheumatology 323AI WOS:000257416000001 J Lugaresi, A; Durastanti, V; Gasperini, C; Lai, M; Pozzilli, C; Orefice, G; Sotgiu, S; Pucci, E; Ardito, B; Millefiorini, E Lugaresi, Alessandra; Durastanti, Valentina; Gasperini, Claudio; Lai, Marina; Pozzilli, Carlo; Orefice, Giuseppe; Sotgiu, Stefano; Pucci, Eugenio; Ardito, Bruno; Millefiorini, Enrico CoSa Study Grp Safety and tolerability in relapsing-remitting multiple sclerosis patients treated with high-dose subcutaneous interferon-beta by Rebiject autoinjection over a 1-year period: The CoSA study CLINICAL NEUROPHARMACOLOGY English Review multiple sclerosis; interferon beta; patient satisfaction; autoinjection system; rebiject DOUBLE-BLIND; SATISFACTION; TRIAL; MS; GUIDELINES; REGIMENS; EFFICACY; DEVICE Objectives: Approved multiple sclerosis (MS) treatments include subcutaneous and intramuscular interferon beta (IFN-beta) Patient satisfaction during long-term IFN-beta treatment is crucial. This study investigated the satisfaction of patients with relapsing-remitting MS treated with IFN-beta-1a (Rebif) by the autoinjection system, Rebiject. Materials and Methods: This prospective observational study recruited subjects with relapsing-remitting MS (n = 76) from 19 neurological centers in Italy who were eligible for subcutaneous IFN-beta-1a treatment either as a first immunomodulatory therapy or as a switch from other treatments. Patients received IFN-beta-1a 44 mu g 3 times weekly via the Rebiject system. A questionnaire on the use of Rebiject and the most common adverse effects related to IFN-beta-1a administration was completed monthly under the supervision of trained nurses. Results: Satisfaction with treatment was reported by 80.2% of patients who received at least 1 dose. Advantages reported for the Rebiject system included its convenience (53% of all patients), ease of use (25%), reduced trauma and pain (11% and 6%, respectively), and reduced local skin reactions (5%). No significant changes from baseline were observed regarding the frequency or severity of local reactions. Conclusions: During the 1-year observation of this small cohort, most patients considered the Rebiject system to be convenient, with a third of the patients feeling that the system was easier to use than conventional procedures. Rebiject was also associated with less pain and trauma in some patients. Use of Rebiject may facilitate EFN-beta-1a administration and may lead to an increase in compliance and adherence, thus increasing the effectiveness of treatment. [Lugaresi, Alessandra] Univ G dAnnunzio, Dept Oncol & Neurosci, Chieti, Italy; [Durastanti, Valentina; Millefiorini, Enrico] Univ Roma La Sapienza, Dept Neurol Sci, Rome, Italy; [Gasperini, Claudio] San Camillo Hosp, Dept Neurol, Rome, Italy; [Lai, Marina] Univ Cagliari, Binaghi Hosp, Multiple Sclerosis Ctr, Dept Cardiovasc & Neurol Sci, Cagliari, Italy; [Pozzilli, Carlo] Univ Roma La Sapienza, Azienda Osped S Andrea, Dept Neurol Sci, Rome, Italy; [Orefice, Giuseppe] Univ Naples Federico 2, Dept Neurol Sci, Naples, Italy; [Sotgiu, Stefano] Univ Sassari, Inst Clin Neurol, I-07100 Sassari, Italy; [Pucci, Eugenio] Macerata Hosp, UO Neurol, Macerata, Italy; [Ardito, Bruno] Hosp Miulli, Dept Neurol, Acquaviva delle Fonti, BA, Italy Lugaresi, A (reprint author), Osped Clin SS Annunziata, Neurol Clin, Via Vestini, I-66013 Chieti, Italy. lugaresi@unich.it 17 9 9 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0362-5664 CLIN NEUROPHARMACOL Clin. Neuropharmacol. MAY-JUN 2008 31 3 167 172 10.1097/WNF.0b013e3181571a8e 6 Clinical Neurology; Pharmacology & Pharmacy Neurosciences & Neurology; Pharmacology & Pharmacy 311CU WOS:000256578600005 J Bruni, O; Ferri, R; Novelli, L; Finotti, E; Miano, S; Guilleminault, C Bruni, Oliviero; Ferri, Raffaele; Novelli, Luana; Finotti, Elena; Miano, Silvia; Guilleminault, Christian NREM sleep instability in children with sleep terrors: The role of slow wave activity interruptions CLINICAL NEUROPHYSIOLOGY English Article sleep terrors; parasomnias; cyclic alternating pattern; NREM sleep instability CYCLIC ALTERNATING PATTERN; FORENSIC IMPLICATIONS; NIGHT-TERRORS; SOMNAMBULISM; SLEEPWALKING; ADULTS; PARASOMNIAS; DELTA; AROUSAL; DEPRIVATION Objective: To evaluate NREM sleep instability, as measured by the cyclic alternating pattern (CAP), in children with sleep terrors (ST) vs. normal controls. Methods: Ten boys (mean age: 8.5 years, range 5-13) meeting the following inclusion criteria: (a) complaint of ST several times a month, (b) a history of ST confirmed by a third person, and (c) a diagnosis of ST according to the ICSD-2 criteria. Eleven age-matched control children with parental report of at least 8.5 h of nightly sleep, absence of known daytime consequences of sleep disorders were recruited by advertisement from the community. Sleep was visually scored for sleep macrostructure and CAP using standard criteria. Results: Sleep macrostructure showed only a significantly increased number of awakenings per hour and reduced sleep efficiency in ST subjects. CAP parameters analysis revealed several significant differences in ST vs. controls: an increase of total CAP rate in SWS, of A1 index in SWS and of the mean duration of A phases while B phases had a decreased duration, exclusively in SWS. The normalized CAP interval-distribution graphs showed significant differences in SWS with interval classes 10 <= i < 35 s higher in children with ST and intervals classes above 50 s higher in normal controls. Conclusions: Children with ST showed faster alternations of the amplitude of slow EEG bursts during SWS. This abnormally fast alternation of the EEG amplitude in SWS is linked to the frequent intrusion of CAP B phases interrupting the continuity of slow delta activity and could be considered as a neurophysiological marker of ST. Significance: This abnormal alternation of the EEG amplitude in SWS is associated with the occurrence of parasomnias and might be considered as a Deurophysiological marker of disorders of arousal. (c) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. [Bruni, Oliviero; Novelli, Luana] Univ Roma La Sapienza, Dept Dev Neurol & Psychiat, Ctr Pediat Sleep Disorders, I-00185 Rome, Italy; [Ferri, Raffaele] IRCCS, Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Sleep Res Ctr, Troina, Italy; [Finotti, Elena] Univ Padua, Dept Paediat, Padua, Italy; [Miano, Silvia] Univ Roma La Sapienza, S Andrea Hosp, Sleep Ctr, Dept Pediat, Rome, Italy; [Guilleminault, Christian] Stanford Univ, Sleep Med Program, Stanford, CA 94305 USA Bruni, O (reprint author), Univ Roma La Sapienza, Dept Dev Neurol & Psychiat, Ctr Pediat Sleep Disorders, Via Sabelli 108, I-00185 Rome, Italy. oliviero.bruni@uniroma1.it Bruni, Oliviero/A-4029-2008; Ferri, Raffaele/B-5439-2013 34 20 21 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 1388-2457 CLIN NEUROPHYSIOL Clin. Neurophysiol. MAY 2008 119 5 985 992 10.1016/j.clinph.2008.01.015 8 Clinical Neurology; Neurosciences Neurosciences & Neurology 298VW WOS:000255716200003 J Cafiero, C; Annibali, S; Gherlone, E; Grassi, FR; Gualini, F; Magliano, A; Romeo, E; Tonelli, P; Lang, NP; Salvi, GE Cafiero, C.; Annibali, S.; Gherlone, E.; Grassi, F. R.; Gualini, F.; Magliano, A.; Romeo, E.; Tonelli, P.; Lang, N. P.; Salvi, G. E. ITI Study Grp Italia Immediate transmucosal implant placement in molar extraction sites: a 12-month prospective multicenter cohort study CLINICAL ORAL IMPLANTS RESEARCH English Article extraction socket; immediate implants; guided bone; regeneration (GBR); tapered implants; transmucosal healing GUIDED TISSUE REGENERATION; TOOTH EXTRACTION; CLINICAL PROCEDURES; BONE; DOG; SOCKETS; PRINCIPLE; OUTCOMES Aim: To assess the clinical and radiographic outcomes of immediate transmucosal placement of implants into molar extraction sockets. Study design: Twelve-month multicenter prospective cohort study. Material and methods: Following molar extraction, tapered implants with an endosseous diameter of 4.8 mm and a shoulder diameter of 6.5 mm were immediately placed into the sockets. Molars with evidence of acute periapical pathology were excluded. After implant placement and achievement of primary stability, flaps were repositioned and sutured allowing a non-submerged, transmucosal healing. Peri-implant marginal defects were treated according to the principles of guided bone regeneration (GBR) by means of deproteinized bovine bone mineral particles in conjunction with a bioresrobable collagen membrane. Standardized radiographs were obtained at baseline and 12 months thereafter. Changes in depth and width of the distance from the implant shoulder (IS) and from the alveolar crest (AC) to the bottom of the defect (BD) were assessed. Results: Eighty-two patients (42 males and 40 females) were enrolled and followed for 12 months. They contributed with 82 tapered implants. Extraction sites displayed sufficient residual bone volume to allow primary stability of all implants. Sixty-four percent of the implants were placed in the areas of 36 and 46. GBR was used in conjunction with the placement of all implants. No post-surgical complications were observed. All implants healed uneventfully yielding a survival rate of 100% and healthy soft tissue conditions after 12 months. Radiographically, statistically significant changes (P < 0.0001) in mesial and distal crestal bone levels were observed from baseline to the 12-month follow-up. Conclusions: The findings of this 12-month prospective cohort study showed that immediate transmucosal implant placement represented a predictable treatment option for the replacement of mandibular and maxillary molars lost due to reasons other than periodontitis including vertical root fractures, endodontic failures and caries. [Lang, N. P.; Salvi, G. E.] Univ Bern, Dept Periodontol, Sch Dent Med, CH-3010 Bern, Switzerland; [Cafiero, C.] Univ Naples Federico 2, Dept Dent & Maxillofacial Sci, Naples, Italy; [Annibali, S.] Univ Roma La Sapienza, Sch Dent, Dept Oral Surg, Rome, Italy; [Grassi, F. R.] Univ Bari, Dept Dent & Surg, Bari, Italy; [Gherlone, E.] Univ San Raffaele, Milan, Italy; [Romeo, E.] Univ Milan, Dept Prosthodont, Dent Clin, Sch Dent, Milan, Italy; [Tonelli, P.] Univ Careggi, Dept Oral Surg, Florence, Italy Salvi, GE (reprint author), Univ Bern, Dept Periodontol, Sch Dent Med, Freiburgstr 7, CH-3010 Bern, Switzerland. giovanni.salvi@zmk.unibe.ch Lang, Niklaus/B-2154-2009 27 27 29 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 0905-7161 CLIN ORAL IMPLAN RES Clin. Oral Implant. Res. MAY 2008 19 5 476 482 10.1111/j.1600-0501.2008.01541.x 7 Dentistry, Oral Surgery & Medicine; Engineering, Biomedical Dentistry, Oral Surgery & Medicine; Engineering 288LZ WOS:000254989200007 J Marin, D; Brancatelli, G; Federle, MP; Lagalla, R; Catalano, C; Passariello, R; Midiri, M; Vilgrain, V Marin, D.; Brancatelli, G.; Federle, M. P.; Lagalla, R.; Catalano, C.; Passariello, R.; Midiri, M.; Vilgrain, V. Focal nodular hyperplasia: typical and atypical MRI findings with emphasis on the use of contrast media CLINICAL RADIOLOGY English Review BUDD-CHIARI-SYNDROME; HEPATOCELLULAR-CARCINOMA; PATHOLOGICAL CORRELATION; GADOBENATE DIMEGLUMINE; HEPATIC HEMANGIOMA; IMAGING FINDINGS; LIVER-LESIONS; ADENOMA; CT; APPEARANCE Focal nodular hyperptasia is a benign hypervascular hepatic tumour, frequently detected in asymptomatic patients undergoing imaging studies for unrelated reasons. Magnetic resonance imaging (MRI) generally allows a confident differential diagnosis with other hypervascular liver lesions, either benign or malignant. In addition, due to the recent development of hepatospecific MRI contrast agents, MRI concomitantly enables functional and morphological information to be obtained, thus providing important clues for the detection and characterization of focal nodular hyperplasia lesions. (C) 2007 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. [Marin, D.; Catalano, C.; Passariello, R.] Univ Roma La Sapienza, Dept Radiol Sci, I-00161 Rome, Italy; [Brancatelli, G.] Saverio Bellis IRCCS, Osped Specializzato Gastroenterol, Sezione Radiol, Bari, Italy; [Brancatelli, G.; Lagalla, R.; Midiri, M.] Univ Palermo, Inst Sci Radiol, Palermo, Italy; [Brancatelli, G.; Federle, M. P.] Univ Pittsburgh, Med Ctr, Dept Radiol, Pittsburgh, PA USA; [Vilgrain, V.] Hop Beaujon, Serv Radiol, Clichy, France Marin, D (reprint author), Univ Roma La Sapienza, Dept Radiol Sci, Viale Regina Elena 324, I-00161 Rome, Italy. danietemarin2@gmail.com 32 17 20 W B SAUNDERS CO LTD LONDON 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND 0009-9260 CLIN RADIOL Clin. Radiol. MAY 2008 63 5 577 585 10.1016/j.crad.2007.06.011 9 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging 296LT WOS:000255546700014 J Buttarelli, FR; Pellicano, C; Pontieri, FE Buttarelli, Francesca R.; Pellicano, Clelia; Pontieri, Francesco E. Neuropharmacology and behavior in planarians: Translations to mammals COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY English Review planarian; neural transmission; behavior; evolution ABSTINENCE-INDUCED WITHDRAWAL; DUGESIA-GONOCEPHALA S.L.; KAPPA-OPIOID WITHDRAWAL; NERVOUS-SYSTEM; SUPRACHIASMATIC HYPOTHALAMUS; COCAINE WITHDRAWAL; DRUG-ADDICTION; UV-LIGHT; DOPAMINE; SEROTONIN Planarians are the simplest animals to exhibit a body plan common to all vertebrates and many invertebrates, characterized by bilateral rather than radial symmetry, dorsal and ventral surfaces, and a rostrocaudal axis with a head and a tail, including specialized sense organs and an aggregate of nerve cells in the head. Neurons in planarian more closely resemble those of vertebrates than those of advanced invertebrates, exhibiting typical vertebrate features of multipolar shape, dendritic spines with synaptic boutons, a single axon, expression of vertebrate-like neural proteins, and relatively low spontaneously generated electrical activity. Here we report the most relevant contribution to the knowledge of the neuropharmacology of planarians, with particular reference to the behavioral consequences of the exposure to drugs acting on neural transmission. Neurochemtical and histochemical data indicate the presence of several neurotransmitter-receptor systems in planarians. Moreover, a variety of experimental studies characterized specific behavioral patterns of these animals following the exposure to drugs acting on neural transmission. There is also evidence of the interactions between discrete neurotransmitter-receptor systems in modulating behavior in planarians. Finally, the model has proved efficacy for investigating the neurotoxicology of the dopamine neurons, and for the initial screening of the neuroprotective potential of drugs. In conclusion, these findings indicate that interactions between discrete neurotransmitter-receptor systems occur very early along phylogerry, although they may have evolved from very fundamental behaviors, such as motor activity in planarian, to more complex and integrated functions in vertebrates. (c) 2008 Elsevier Inc. All rights reserved. [Buttarelli, Francesca R.; Pellicano, Clelia; Pontieri, Francesco E.] Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy Pontieri, FE (reprint author), Univ Roma La Sapienza, Dept Neurol Sci, Viale Univ, I-00185 Rome, Italy. francesco.pontieri@ospedalesantandrea.it 80 15 17 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 1532-0456 COMP BIOCHEM PHYS C Comp. Biochem. Physiol. C-Toxicol. Pharmacol. MAY 2008 147 4 399 408 10.1016/j.cbpc.2008.01.009 10 Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology 295XB WOS:000255506400001 J Dolcetta, IC; Vitolo, A Dolcetta, Italo Capuzzo; Vitolo, Antonio Gradient and Holder estimates for positive solutions of Pucci type equations COMPTES RENDUS MATHEMATIQUE French Article PARTIAL-DIFFERENTIAL EQUATIONS; VISCOSITY SOLUTIONS; INTERIOR We present some estimates for positive viscosity solutions of a class of fully non-linear elliptic equations including the extremal Pucci equations, generalizing some results for linear equations recently established by Y.Y. Li and L. Nirenberg. [Dolcetta, Italo Capuzzo] Univ Roma La Sapienza, Dipartimento Matemat, I-00185 Rome, Italy; [Vitolo, Antonio] Univ Salerno, Dipartimento Matemat & Informat, I-84084 Fisciano, SA, Italy Dolcetta, IC (reprint author), Univ Roma La Sapienza, Dipartimento Matemat, Ple A Moro 2, I-00185 Rome, Italy. capuzzo@mat.uniroma1.it; vitolo@unisa.it 8 1 1 ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PARIS 23 RUE LINOIS, 75724 PARIS, FRANCE 1631-073X CR MATH C. R. Math. MAY 2008 346 9-10 527 532 10.1016/j.crma.2008.03.004 6 Mathematics Mathematics 308SA WOS:000256409100010 J Dell'Olmo, P; Iovanella, A; Lulli, G; Scoppola, B Dell'Olmo, Paolo; Iovanella, Antonio; Lulli, Guglielmo; Scoppola, Benedetto Exploiting incomplete information to manage multiprocessor tasks with variable arrival rates COMPUTERS & OPERATIONS RESEARCH English Article multiprocessor task scheduling; semi-online algorithm; computational analysis ALGORITHMS In this paper a semi-online algorithm for scheduling multiprocessor tasks with partial information is proposed. We consider the case in which it is possible to exploit probabilistic information and use this information to obtain better solutions in comparison with standard non clairvoyant on-line algorithms. A wide computational analysis shows the effectiveness of our algorithm. Moreover, we also consider a test framework with a continuous generation of tasks in order to study the behavior of the proposed approach in real applications, which confirms the efficiency of our approach. (c) 2006 Elsevier Ltd. All rights reserved. Univ Roma La Sapienza, Dipartimento Stat Probabilita & Stat Appl, I-00185 Rome, Italy; Univ Roma Tor Vergata, Dipartimento Ingn Impresa, I-00133 Rome, Italy; Univ Milan, Dipartimento Informat Sistemist & Comunicaz, I-20126 Milan, Italy; Univ Roma Tor Vergata, Dipartimento Matemat, I-00133 Rome, Italy Dell'Olmo, P (reprint author), Univ Roma La Sapienza, Dipartimento Stat Probabilita & Stat Appl, Piazzale Aldo Moro 5, I-00185 Rome, Italy. paolo.dellolmo@uniromal.it; iovanella@disp.uniroma2.it; lulli@disco.unimib.it; scoppola@mat.uniroma2.it Iovanella, Antonio/J-9233-2012 Iovanella, Antonio/0000-0001-8147-3747 21 0 0 PERGAMON-ELSEVIER SCIENCE LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND 0305-0548 COMPUT OPER RES Comput. Oper. Res. MAY 2008 35 5 1589 1600 10.1016/j.cor.2006.09.005 12 Computer Science, Interdisciplinary Applications; Engineering, Industrial; Operations Research & Management Science Computer Science; Engineering; Operations Research & Management Science 233YK WOS:000251126000015 J Cabrini, L; Beccaria, P; Landoni, G; Biondi-Zoccai, GGL; Sheiban, I; Cristofolini, M; Fochi, O; Maj, G; Zangrillo, A Cabrini, Luca; Beccaria, Paolo; Landoni, Giovanni; Biondi-Zoccai, Giuseppe G. L.; Sheiban, Imad; Cristofolini, Marta; Fochi, Oliviero; Maj, Giulia; Zangrillo, Alberto Impact of impedance threshold devices on cardiopulmonary resuscitation: A systematic review and meta-analysis of randomized controlled studies CRITICAL CARE MEDICINE English Review impedance threshold devices; cardiopulmonary resuscitation; meta-analysis; systematic review; cardiac arrest; randomized trials HOSPITAL CARDIAC-ARREST; INSPIRATORY IMPEDANCE; PORCINE MODEL; VENTRICULAR-FIBRILLATION; VALVE; OUTCOMES Objectives: Vital organ hypoperfusion significantly contributes to the dismal survival rates observed with manual cardiopulmonary resuscitation after cardiac arrest. The impedance threshold device is a valve which reduces air entry into lungs during chest recoil between chest compressions, producing a potentially beneficial decrease in intrathoracic pressure and thus increasing venous return to the heart. This review provides an update on the impedance threshold device and underlines its effect on short-term survival. Data Source: MedCentral, CENTRAL, PubMed, and conference proceedings were searched (updated March 27, 2007). Authors and external experts were contacted. Study Selections: Three unblinded reviewers selected randomized trials using an impedance threshold device in cardiopulmonary resuscitation of nontraumatic out-of-hospital cardiac arrests. Four reviewers independently abstracted patient, treatment and outcome data. Data Extraction: A total of 833 patients from five high quality randomized studies were included in the analysis. Data Synthesis: Pooled estimates showed that the impedance threshold device consistently and significantly improved return to spontaneous circulation (202/438 [46%] for impedance threshold device group vs. 159/445 [36%] for control, relative risk [RR] = 1.29 [1.10-1.51], p = .002), early survival (139/428 [32%] vs. 97/433 [22%], RR = 1.45 [1.16-1.80], p = .0009) and favorable neurologic outcome (39/307 [13%] vs. 18/293 [6%], RR = 2.35 [1.30-4.24], p = .004) with no effect on favorable neurologic outcome in survivors (39/60 [65%] vs. 18/44 [41%]) nor an improved survival at the longest available follow up (35/428 [8.2%] vs. 24/433 [5.5%]). Conclusions: This meta-analysis of randomized controlled studies suggests that the impedance threshold device improves early outcome in patients with out-of-hospital cardiac arrest undergoing cardiopulmonary resuscitation. [Cabrini, Luca; Beccaria, Paolo] Univ Vita Salute San Raffaele, Dept Anesthesia & Intens Care Med, Milan, Italy; Ist Sci San Raffaele, Milan, Italy; [Landoni, Giovanni; Fochi, Oliviero; Maj, Giulia; Zangrillo, Alberto] Univ Vita Salute San Raffaele, Dept Cardiothorac Anesthesia & Intens Care, Milan, Italy; [Biondi-Zoccai, Giuseppe G. L.; Sheiban, Imad] Univ Turin, Div Cardiol, Turin, Italy; [Cristofolini, Marta] Osped Santa Chiara, Dept Anestesia & Intens Care, Trento, Italy Landoni, G (reprint author), Univ Vita Salute San Raffaele, Dept Anesthesia & Intens Care Med, Milan, Italy. landoni.giovanni@hsr.it 26 24 27 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 0090-3493 CRIT CARE MED Crit. Care Med. MAY 2008 36 5 1625 1632 10.1097/CCM.0b013e318170ba80 8 Critical Care Medicine General & Internal Medicine 297NJ WOS:000255623100035 J Barbarotto, E; Secchiero, P; Dasgupta, A; Fortina, P; Calin, GA; Hyslop, T Barbarotto, Elisa; Secchiero, Paola; Dasgupta, Abhijit; Fortina, Paolo; Calin, George A.; Hyslop, Terry MicroRNAs as New Players in the Genomic Galaxy and Disease Puzzles CTS-CLINICAL AND TRANSLATIONAL SCIENCE English Article microRNA; cancer; heart disease; miRNA gene expression CHRONIC LYMPHOCYTIC-LEUKEMIA; CAENORHABDITIS-ELEGANS; CARDIAC-HYPERTROPHY; GENE-EXPRESSION; IN-VIVO; MAMMALIAN MICRORNAS; CELL-PROLIFERATION; HEART-FAILURE; SMALL RNAS; C-ELEGANS MicroRNAs (miRNAs) are a large family of short, single-stranded, highly conserved noncoding RNAs involved in gene regulation that can regulate gene expression through sequence-specific base pairing with target messenger RNAs (mRNAs). miRNAs have been implicated in the development of a wide variety of cancers as well as heart disease and other diseases. This review describes the role of miRNAs in human disease, methodology for evaluating miRNA gene expression, and the potential role of miRNAs as therapeutic agents and targets for the treatment of disease. [Dasgupta, Abhijit; Hyslop, Terry] Thomas Jefferson Univ, Dept Pharmacol & Expt Therapeut, Div Biostat, Philadelphia, PA 19107 USA; [Barbarotto, Elisa; Secchiero, Paola] Univ Ferrara, Dept Morphol & Embryol, Ferrara, Italy; [Calin, George A.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA; [Calin, George A.] Univ Texas MD Anderson Canc Ctr, Dept Canc Genet, Houston, TX 77030 USA; [Fortina, Paolo] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Canc Biol, Philadelphia, PA 19107 USA; [Fortina, Paolo] Univ Roma La Sapienza, Dipartimento Med Sperimentale, I-00185 Rome, Italy Hyslop, T (reprint author), Thomas Jefferson Univ, Dept Pharmacol & Expt Therapeut, Div Biostat, Philadelphia, PA 19107 USA. thyslop@mail.jci.tju.edu 96 1 1 WILEY-BLACKWELL PUBLISHING, INC MALDEN COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA 1752-8054 CTS-CLIN TRANSL SCI CTS-Clin. Transl. Sci. MAY 2008 1 1 50 56 10.1111/j.1752-8062.2008.00028.x 7 Medicine, Research & Experimental Research & Experimental Medicine 532RR WOS:000272767700014 J Nicastri, E; Palmisano, L; Sarmati, L; D'Ettorre, G; Parisi, S; Andreotti, M; Buonomini, A; Pirillo, FM; Narciso, P; Bellagamba, R; Vullo, V; Montano, M; Di Perri, G; Andreoni, M Nicastri, Emanuele; Palmisano, Lucia; Sarmati, Loredana; D'Ettorre, Gabriella; Parisi, Saverio; Andreotti, Mauro; Buonomini, Annarita; Pirillo, Franca M.; Narciso, Pasquale; Bellagamba, Rita; Vullo, Vincenzo; Montano, Marco; Di Perri, Giovanni; Andreoni, Massimo HIV-1 residual viremia and proviral DNA in patients with suppressed plasma viral load (< 400 HIV-RNA cp/ml) during different antiretroviral regimens CURRENT HIV RESEARCH English Article REVERSE-TRANSCRIPTASE INHIBITOR; IMMUNOLOGICAL OUTCOMES; PROTEASE INHIBITORS; RANDOMIZED-TRIAL; INITIAL THERAPY; INFECTION; LOPINAVIR/RITONAVIR; COMBINATION; IMPACT; RESERVOIR Low levels of plasma viremia (below 50 copies/ml of HIV-1 RNA) can be detected in the majority of HIV+ subjects successfully treated with HAART. Aim of our study was to evaluate the impact of different antiretroviral regimens on this residual viremia and on proviral HIV-1 DNA in HAART-treated subjects with plasma HIV RNA < 400 cp/ml and no history of virological failure. To this purpose, a cross-sectional analysis of 319 HIV-positive patients on HAART with plasma HIV RNA < 400 cp/ml was performed. Subjects had been on HAART for a median of 3.6 years: the current regimen included two nucleoside reverse transcriptase inhibitors (NRTIs) plus a protease inhibitor (PI) in 104 (32.6%) cases, of which 73 treated with a boosted PI; two NRTIs plus a non-NRTI (NNRTI) were prescribed in 166 (52.2%) cases, and NRTIs-only in 49 cases (15.4%). Patients treated with PI had the lowest nadir CD4 cell count (237 +/- 191 cells/mu l) compared to patients treated with NNRTI (384 +/- 192 cells/mu l) or NRTIs-only (387 +/- 222 cells/mu l). Cell-associated HIV-1 DNA was measured in 231 subjects. Residual viremia was measured in 238 subjects with plasma HIV-1 RNA levels < 50 copies/ml. Multivariate analysis showed that the use of NNRTI was independently associated to low levels of residual viremia and high levels of HIV-1DNA, whereas the use of PI was independently associated to low levels of HIV-1 DNA. The better virological performance of NNRTI in terms of low residual viremia is consistent with specific literature data, whereas the greater impact of PI on the viral reservoirs is noteworthy and needs further investigations. [Nicastri, Emanuele; Narciso, Pasquale; Bellagamba, Rita] IRCCS Lazzaro Spallanzani, Ist Nazl Malattie Infett, I-00149 Rome, Italy; [Palmisano, Lucia; Andreotti, Mauro; Pirillo, Franca M.; Vullo, Vincenzo] Ist Super Sanita, I-00161 Rome, Italy; [Sarmati, Loredana; Buonomini, Annarita; Montano, Marco; Andreoni, Massimo] Univ Roma Tor Vergata, Dept Clin Infect Dis, Rome, Italy; [D'Ettorre, Gabriella] Univ Roma La Sapienza, Dept Clin Infect Dis, Rome, Italy; [Parisi, Saverio] Univ Padua, Dept Clin Infect Dis, Padua, Italy; [Di Perri, Giovanni] Univ Turin, Dept Clin Infect Dis, Turin, Italy Nicastri, E (reprint author), IRCCS Lazzaro Spallanzani, Ist Nazl Malattie Infett, Via Portuense 292, I-00149 Rome, Italy. nicastri@inmi.it Parisi, Saverio/C-6088-2009; palmisano, lucia/G-5577-2011; parisi, saverio/D-3115-2012 25 13 13 BENTHAM SCIENCE PUBL LTD SHARJAH EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES 1570-162X CURR HIV RES Curr. HIV Res. MAY 2008 6 3 261 266 10.2174/157016208784325010 6 Immunology; Infectious Diseases; Virology Immunology; Infectious Diseases; Virology 311RA WOS:000256616100010 J Campanella, L; Favero, G; Osinsky, SP; Sigan, AL; Tomassetti, M Campanella, Luigi; Favero, Gabriele; Osinsky, Sergey P.; Sigan, Andrej L.; Tomassetti, Mauro In vitro antioxidant capacity vs in vivo antimetastatic effect of anticancer cobalt complexes CURRENT PHARMACEUTICAL ANALYSIS English Review ANTITUMOR AGENTS; BIOSENSORS; WINES Four different methods were used to measure the "in vitro" antioxidant capacity of three cobalt complexes recently proposed as anticancer active principles: a new biosensor method and a new pulse voltammetric, or pulse polarographic method, together with two other methods - one fluorimetric and the other spectrophotometric. Results obtained using the different methods are discussed and compared with the anti-metastatic effect recently measured "in vivo" by Russian authors. The good correlation found between anti-tumoral and anti-metastatic activity ranking and in vitro antioxidant activity found by the new voltammetric method suggests interesting hypotheses based on the anti-tumoral effect of these complexes. [Campanella, Luigi; Tomassetti, Mauro] Univ Roma La Sapienza, Dept Chem, Rome, Italy; [Favero, Gabriele] Univ Roma La Sapienza, Dept Chem & Technol Studies Biol Act Subst, Rome, Italy; [Osinsky, Sergey P.] Natl Acad Sci Ukraine, Dept Modifying Agent Canc Therapy, Inst Expt Pathol Oncol & Radiobiol, Kiev, Ukraine; [Sigan, Andrej L.] Russian Acad Sci, Inst Organoelement Cpds, Lab BioactFluorineorgan Cpds, Moscow, Russia Tomassetti, M (reprint author), Univ Roma La Sapienza, Dept Chem, Rome, Italy. mauro.tomassetti@uniromal.it Favero, Gabriele/I-5596-2012 14 0 0 BENTHAM SCIENCE PUBL LTD SHARJAH EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES 1573-4129 CURR PHARM ANAL Curr. Pharm. Anal. MAY 2008 4 2 44 52 10.2174/157341208784246279 9 Pharmacology & Pharmacy Pharmacology & Pharmacy 309OC WOS:000256469100001 J Ajmone-Cat, MA; Cacci, E; Minghetti, L Ajmone-Cat, Maria Antonietta; Cacci, Emanuele; Minghetti, Luisa Non steroidal anti-inflammatory drugs and neurogenesis in the adult mammalian brain CURRENT PHARMACEUTICAL DESIGN English Review NSAID; neurogenesis; cyclooxygenase (COX); neural stem progenitor cells; inflammation ENDOTHELIAL GROWTH-FACTOR; NEURAL PROGENITOR CELLS; FOCAL CEREBRAL-ISCHEMIA; RAT DENTATE GYRUS; SEIZURE-INDUCED NEUROGENESIS; STATUS EPILEPTICUS SEVERITY; PROSTAGLANDIN E-2 SYNTHESIS; ACTIVATED PROTEIN-KINASE; NMDA RECEPTOR ACTIVATION; NECROSIS-FACTOR-ALPHA Non steroidal anti-inflammatory drugs (NSAIDs) are therapeutic agents of first choice for the treatment of inflammation, pain, and fever. Neuroscience research of the last decades has pointed out the important role of inflammation in the pathogenesis of several brain disorders, and epidemiological and experimental evidence has suggested a beneficial role of NSAIDs in both chronic and acute neuropathologies. More recently NSAIDs have gained further attention as potential tools to enhance neuroregenerative processes in the adult mammalian brain. The rational behind their use arises from the notion that inflammatory processes that accompany brain damage would exert a major detrimental effect on endogenous neurogenesis. However, inflammation and glial responses to acute or chronic injuries constitute a complex and multifaceted process by which, besides potentially harmful and cytotoxic activities, beneficial responses can be initiated in the attempt to re-establish the lost tissue integrity. The individuation of optimal timing and type of pharmacological intervention able to potentiate the beneficial aspects of inflammation rather than to suppress it as a whole, would allow the achievement of enhanced and successful regenerative responses. In the present article, we will review the current literature on the effects of NSAIDs on neurogenesis and briefly discuss the cellular or molecular mechanisms by which these drugs can modulate brain restorative processes. [Ajmone-Cat, Maria Antonietta] Ist Super Sanita, Dept Cell Biol & Neurosci, Sect Degenerat & Inflammatory Neurol Dis, I-00161 Rome, Italy; [Cacci, Emanuele] Univ Roma La Sapienza, Dept Cell & Dev Biol, I-00161 Rome, Italy Ajmone-Cat, MA (reprint author), Ist Super Sanita, Dept Cell Biol & Neurosci, Sect Degenerat & Inflammatory Neurol Dis, Viale Regina Elena 299, I-00161 Rome, Italy. ajcat@iss.it 122 11 11 BENTHAM SCIENCE PUBL LTD SHARJAH EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES 1381-6128 CURR PHARM DESIGN Curr. Pharm. Design MAY 2008 14 14 1435 1442 10.2174/138161208784480199 8 Pharmacology & Pharmacy Pharmacology & Pharmacy 311RW WOS:000256618300010 J Tiberti, C; Giordano, C; Locatelli, M; Bosi, E; Bottazzo, GF; Buzzetti, R; Cucinotta, D; Galluzzo, A; Falorni, A; Dotta, F Tiberti, Claudio; Giordano, Carla; Locatelli, Mattia; Bosi, Emanuele; Bottazzo, Gian Franco; Buzzetti, Raffaella; Cucinotta, Domenico; Galluzzo, Aldo; Falorni, Alberto; Dotta, Francesco Identiffication of tyrosine phosphatase 2((256-760)) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients - The Non-Insulin Requiring Autoimmune Diabetes (NIRAD) study 2 DIABETES English Article GLUTAMIC-ACID DECARBOXYLASE; IA-2 AUTOANTIBODY; EPITOPES; PHOSPHATASE; ANTIBODIES; PREDICTION; MELLITUS; PROTEIN; ONSET; IDDM OBJECTIVE-The presence of autoantibodies to islet antigens GAD and/or tyrosine phosphatase 2 (IA-2) in type 2 diabetic patients (latent autoimmune diabetes in adults [LADAI]) identifies subjects at high risk to develop insulin dependency. The aim of this study was to dissect humoral anti-IA-2 immune response in Caucasian LADA patients, identifying the most sensitive construct to evaluate IA-2 immunoreactivity and comparing LADA IA-2 epitope specificities to those found in type 1 diabetes. RESEARCH DESIGN AND METHODS-We analyzed 177 LADA and 978 type 2 diabetic patients with different disease duration, collected in a nationwide Italian survey, the Non-Insulin Requiring Autoimmune Diabetes (NIRAD) study aimed at assessing prevalence and characteristics of autoimmune diabetes in type 2 diabetic patients and 106 newly diagnosed type 1 diabetic patients (53 children, 53 adults). By radioimmunoassay, we analyzed humoral immunoreactivity to seven IA-2 constructs: IA-2(PTP(687-979)), IA-2((761-9G4)), IA-2((256-760)), IA-2(JM(601-630)), IA-2(IC(60-979)), IA-2(BDC(256-556:630-979)), and IA-2(FL(1-979)). RESULTS-IA-2((256-760)) fragment was identified as the marker with the highest sensitivity for detection of Immoral IA-2 immunoreactivity in LADA patients, identifying IA-2 autoantibodies in similar to 30% of GAD antibody (GADA)-positive LADA patients and in 3.4% of GADA-negative type 2 diabetic patients. LADA IA-2((256-760)) A positivity was associated with an increased frequency of autoimmune diabetes HLA-susceptible genotypes and with a higher risk for developing thyroid autoimmunity compared with autoantibody-negative type 2 diabetic patients. At disease diagnosis, adult-onset type 1 diabetic and LADA patients showed a lower IA-2 COOH-terminal immunoreactivity compared with childhood-onset type I diabetic patients. CONCLUSIONS-IA-2 immunoreactivity in LADA patients has thus far been underestimated, and IA-2((256-760)) autoantibody detection may represent a novel diagnostic tool for the identification of islet autoimmunity in these patients. [Tiberti, Claudio; Buzzetti, Raffaella] Univ Roma La Sapienza, Policlin Umberto I, Dept Clin Sci, I-00161 Rome, Italy; [Giordano, Carla; Galluzzo, Aldo] Univ Palermo, Dept Endocrinol, Palermo, Italy; [Locatelli, Mattia; Bottazzo, Gian Franco] Bambino Gesu Pediat Hosp, Inst Sci, Rome, Italy; [Bosi, Emanuele] Univ Vita Salute San Raffaele, Milan, Italy; [Bosi, Emanuele] Ist Sci San Raffaele, Milan, Italy; [Cucinotta, Domenico] Univ Messina, Dept Internal Med, Messina, Italy; [Falorni, Alberto] Univ Perugia, Dept Internal Med, I-06100 Perugia, Italy; [Dotta, Francesco] Univ Siena, Dept Internal Med Endocrine & Metab Sci & Biochem, I-53100 Siena, Italy Tiberti, C (reprint author), Univ Roma La Sapienza, Policlin Umberto I, Dept Clin Sci, Viale Policlin 155, I-00161 Rome, Italy. claudio.tiberti@uniroma1.it Falorni, Alberto/E-5747-2011; Dotta, Francesco/H-3788-2012 41 12 14 AMER DIABETES ASSOC ALEXANDRIA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA 0012-1797 DIABETES Diabetes MAY 2008 57 5 1276 1283 10.2337/db07-0874 8 Endocrinology & Metabolism Endocrinology & Metabolism 297PN WOS:000255628700018 J Grossi, M Grossi, Massimo Existence of radial solutions for an elliptic problem involving exponential nonlinearities DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS English Article exponential nonlinearities; Green's function; radial solutions Let us consider the problem {-Delta u + a(vertical bar x vertical bar)u = lambda e(u) in B-1, u = 0 on partial derivative B-1. (0.1) where B-1 is the unit ball in R-N, N >= 2, lambda > 0 and a(vertical bar x vertical bar) >= 0 is a smooth radial function. Under some suitable assumptions on the regular part of the Green function of the operator -u '' - N-1/ru+a(r)u, we prove the existence of a radial solution to (0.1) for lambda small enough. Univ Roma La Sapienza, Dipartimento Matemat, I-00185 Rome, Italy Grossi, M (reprint author), Univ Roma La Sapienza, Dipartimento Matemat, Ple A Moro 2, I-00185 Rome, Italy. grossi@mat.uniromal.it 5 0 0 AMER INST MATHEMATICAL SCIENCES SPRINGFIELD PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA 1078-0947 DISCRETE CONT DYN S Discret. Contin. Dyn. Syst. MAY 2008 21 1 221 232 12 Mathematics, Applied; Mathematics Mathematics 276DU WOS:000254122300010 J Ricotta, C; Godefroid, S; Celesti-Grapow, L Ricotta, Carlo; Godefroid, Sandrine; Celesti-Grapow, Laura Common species have lower taxonomic diversity - Evidence from the urban floras of Brussels and Rome DIVERSITY AND DISTRIBUTIONS English Article core-satellite species model; dominant-subordinate-transient species model; randomization; species pool hypothesis; taxonomic relatedness; urban ecology PLANT-COMMUNITIES; ECOLOGICAL COMMUNITIES; PHYLOGENETIC STRUCTURE; NATURAL COMMUNITIES; RICHNESS; PATTERNS; BIODIVERSITY; COEXISTENCE; MECHANISMS; EVOLUTION The species pool hypothesis claims that the large-scale regional species pool is the chief parameter in determining small-scale species richness through filtering of species that can persist within a community on the basis of their tolerance of the abiotic environment. Accordingly, different environmental conditions give rise to different species assemblages. From a taxonomic perspective, under the assumption of trait conservatism, co-occurring species that experience similar environmental conditions are likely to be more taxonomically similar than ecologically distant species. The next step consists in understanding how commonness and rarity of individual species produce the observed taxonomic diversity. In this paper, the importance of environmental filtering in regulating the taxonomic structure of rare and common plant species in the urban floras of Brussels (Belgium) and Rome (Italy) is tested. First, we computed the taxonomic diversity of the rare and common species of Brussels and Rome based on the branching topology of the Linnaean taxonomic trees. Next, using a randomization procedure, we determined whether the taxonomic diversity of the rare species was significantly higher than the diversity of the common species. Results show that, for both urban floras, common species that shape the community matrix and experience similar environmental conditions have a taxonomic diversity that is significantly lower than that of the rare species that represent a relatively incidental set of species of more 'disperse' origin. Finally, from a conservation/management perspective our results imply that, given their high taxonomic heterogeneity, the protection of rare species is a central issue for preserving high levels of diversity in urban areas. [Ricotta, Carlo; Celesti-Grapow, Laura] Univ Roma La Sapienza, Dept Plant Biol, I-00185 Rome, Italy; [Godefroid, Sandrine] Vrije Univ Brussels, Lab Gen Bot & Nat Management, B-1050 Brussels, Belgium Ricotta, C (reprint author), Univ Roma La Sapienza, Dept Plant Biol, Piazzale Aldo Moro 5, I-00185 Rome, Italy. carlo.ricotta@uniroma1.it 61 13 13 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1366-9516 DIVERS DISTRIB Divers. Distrib. MAY 2008 14 3 530 537 10.1111/j.1472-4642.2008.00467.x 8 Biodiversity Conservation; Ecology Biodiversity & Conservation; Environmental Sciences & Ecology 287WI WOS:000254946900009 J Tomei, MC; Annesini, MC Tomei, Maria Concetta; Annesini, Maria Cristina Biodegradation of phenolic mixtures in a sequencing batch reactor a kinetic study ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH English Article 3,4-dimethylphenol; 4-nitrophenol; biodegradation kinetics; Haldane equation; phenolic mixtures; SBR (sequencing batch reactor) ACCLIMATED ACTIVATED-SLUDGE; 4-NITROPHENOL BIODEGRADATION; P-NITROPHENOL; WASTE-WATER; MICROORGANISMS; DEGRADATION; REMOVAL; BACTERIA Goal, Scope and Background. In this study, attention was focused on substituted phenols because of their widespread presence in industrial effluents originating from many different sources: they are major constituents of wastewater from coal conversion processes, coke ovens, petroleum refineries and petrochemical industries, resin and fibreglass manufacturing and herbicide production. Moreover, for their characteristics of toxicity to humans and aquatic life (1 mgl(-1) is enough to detect the effects), they are included in the USEPA list of priority pollutants. Toxicity is higher in substituted phenols and is dependent on the nature and numbers of substituent groups. Objective of the present paper is to give a contribution to the modelling of phenolic mixture biodegradation by kinetic studies in which the different compounds are followed separately: this can be easily attained with an experimental apparatus such as the Sequencing Batch Reactor (SBR). Two substituted phenols, 4-nitrophenol (4NP) and 3,4-dimethylphenol (3,4DMP), were utilized as substrates and their degradation kinetics were investigated to evaluate the process parameters both in single compound and in mixture tests. Methods. Single compound and mixture kinetic tests have been carried out during the reaction phase of the working cycle of the SBR reactor. The single substrates and their mixture were utilized as sole carbon and energy sources. Moreover, in order to verify data reproducibility, all kinetic tests have been carried out in at least two replicates under the same operating conditions. Results and Discussion. Kinetic data showed the presence of substrate inhibition, to model this experimental evidence the Haldane equation, that is usually employed for substrate inhibited kinetics, was rearranged in a different form with parameters which have a precise meaning in relation to the process kinetics and, at the same time, make the integration procedure easier. The derivation of the equation is shown in an Appendix at the end of the paper. Kinetic parameters obtained are suitable for application. It was observed that the 4-nitrophenol removal rate in single compound tests is significantly higher than the 3,4-dimethylphenol removal rate in the whole range of investigated concentrations (up to 80 mg COD l(-1)). A faster 4-nitrophenol biodegradation was also observed in mixture tests. Moreover, it is worth noting that the two compounds were simultaneously degraded and no diauxic growth was observed. The comparison between single compound and mixture degradation kinetics showed that the 4-nitrophenol degradation rate was comparable in the two cases while a significantly beneficial effect (by increase by about 80% of the maximum removal rate) was detected for 3,4-dimethylphenol degradation in the mixture. Conclusions. Results of this study showed that the biodegradation kinetics of substituted phenols in mixture can be significantly different from that observed in single compound tests: in fact, the presence of a faster degradable compound (the 4NP) seems to exert a positive effect on the removal of a slower degradable compound (the 3,4DMP). The higher removal rate detected for 4NP, both in single compound and mixture tests, confirmed the key role of the biomass acclimatization in determining the biodegradation kinetics of xenobiotic compounds. The experimental approach and the original method applied for data analysis are of general validity and can be extended to the investigation of different classes of compounds. Recommendations and Perspectives. A relevant aspect related to the process applicability is the demonstrated possibility of easily adapting an enriched culture grown on a specific xenobiotic (in our case the 4NP) for the removal of similar single compounds or in mixtures. When biological process are considered for xenobiotic removal, this suggests a possible strategy of developing enriched cultures on target compounds that can be efficiently utilized on more complex matrices with reduced start up and acclimatization periods. [Annesini, Maria Cristina] Univ Roma La Sapienza, Dept Chem Engn, I-00184 Rome, Italy; [Tomei, Maria Concetta] CNR, Water Res Inst, I-00198 Rome, Italy Tomei, MC (reprint author), CNR, Water Res Inst, I-00198 Rome, Italy. tomei@irsa.cnr.it 23 5 6 SPRINGER HEIDELBERG HEIDELBERG TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY 0944-1344 ENVIRON SCI POLLUT R Environ. Sci. Pollut. Res. MAY 2008 15 3 188 195 10.1065/espr2007.12.470 8 Environmental Sciences Environmental Sciences & Ecology 305OK WOS:000256187500004 J Aytimur, G; Di Palma, L; Merli, C Aytimur, G.; Di Palma, L.; Merli, C. Experimental validation of a model describing the cycle of nitrogen in a Step Sludge Recirculation activated sludge system with denitrification ENVIRONMENTAL TECHNOLOGY English Article activated sludge; step sludge recirculation; denitrification; nitrogen cycle modeling; model validation WASTE-WATER TREATMENT; NUTRIENT REMOVAL PROCESS; STEADY-STATE MODEL; NO. 3; TREATMENT-PLANT; KINETICS; BIOMASS; NITRIFICATION; BIOFILM; NITRATE In this paper, a model describing the cycle of nitrogen in a Step Sludge Recirculation (SSR) reactor, was developed. The SSR reactor is a multistage, continuous stirred tank reactor where the recycled biomass is distributed over all stages. The SSR system provides a uniform treatment of the wastewater and high purification efficiency for both carbon and nitrogen removal. The objective of this work was to develop a mathematical model of the SSR system, based on the analysis of various parameters that are present in the system. The simplified form of the IWA-ASM model was adapted to include the carbon removal, nitrification and denitrification processes. For model validation, a SSR pilot plant fed with synthetic wastewater was operated for approximately four months. The experimental results show that the SSR system seems to be appropriate to attain maximum TOC and nitrogen removal with minimum sludge production. The proposed model seems to be capable of expressing the behavior of carbon removal, nitrification, denitrification and various microorganism species in a SSR configuration of a nitrogen cycle. When the experimental results were compared with those estimated by the proposed model, the model predictions matched well with the experimental results. [Aytimur, G.] Ege Univ, Dept Chem Engn, Fac Engn, TR-35100 Izmir, Turkey; [Di Palma, L.; Merli, C.] Univ Roma La Sapienza, Dept Chem Engn, I-00184 Rome, Italy Aytimur, G (reprint author), Ege Univ, Dept Chem Engn, Fac Engn, TR-35100 Izmir, Turkey. Di Palma, Luca/F-1183-2011 Di Palma, Luca/0000-0003-4838-7227 35 0 0 SELPER LTD, PUBLICATIONS DIV LONDON UNIT 55, 2 OLD BROMPTON ROAD, LONDON SW7 3DQ, ENGLAND 0959-3330 ENVIRON TECHNOL Environ. Technol. MAY 2008 29 5 591 601 10.1080/09593330801984688 11 Environmental Sciences Environmental Sciences & Ecology 316PD WOS:000256961300012 J Pucci, A; Brscic, E; Tessitore, E; Celeste, A; Crudelini, M; De Bernardi, A; Alberti, A; Biondi-Zoccai, G; Sheiban, I Pucci, A.; Brscic, E.; Tessitore, E.; Celeste, A.; Crudelini, M.; De Bernardi, A.; Alberti, A.; Biondi-Zoccai, G.; Sheiban, I. C-reactive protein and coronary composition in patients with percutaneous revascularization EUROPEAN JOURNAL OF CLINICAL INVESTIGATION English Article angiogenesis; coronary plaque; C-reactive protein; immunohistochemistry; macrophages; unstable angina UNSTABLE ANGINA-PECTORIS; HUMAN ENDOTHELIAL-CELLS; SMOOTH-MUSCLE; PLAQUE NEOVASCULARIZATION; ATHEROSCLEROTIC LESIONS; MYOCARDIAL-INFARCTION; TISSUE FACTOR; GROWTH-FACTOR; INFLAMMATION; RISK Background C-Reactive Protein (CRP) is considered a predictive factor for cardiovascular events and its serum levels have been shown to correlate with thin cap coronary plaques in sudden coronary death. Whether serum CRP levels are associated with in vivo atherothrombotic features is unclear. We thus analysed samples from coronary atherectomy specimens obtained during percutaneous coronary intervention. Materials and methods Patients with coronary artery disease undergoing directional atherectomy, distinguished by unstable versus stable coronary syndrome diagnosis, provided coronary specimens from culprit lesions. Assessment was conducted by means of conventional histology, morphometry and immunohistochemistry. Specific antibodies against erythrocyte-specific protein glycophorin A, endothelial and macrophage antigens were also used. Results There were 51 patients with unstable coronary disease and 47 patients with stable angina. Serum CRP levels >= 1 mg L-1 were detected in 24/98 patients, and were significantly associated with hypercellularity, macrophage infiltrates, neoangiogenesis and intraplaque haemorrhage (all P < 0.05). Furthermore, coronary plaques from patients with unstable angina contained larger atheromas, more hypercellular plaques, with abundant macrophages, neoangiogenesis and intraplaque haemorrhages and lesser fibrous tissue (all P < 0.05). Conclusions We observed a positive correlation between increased serum CRP levels and typical pathological features of complex atherothrombotic coronary disease, confirming in vivo the mechanistic role of CRP in coronary atherothrombosis. [Pucci, A.; Tessitore, E.; Celeste, A.; Crudelini, M.] ASO OIRM S Anna, Regina Margherita Hosp, Turin, Italy; [Brscic, E.; Alberti, A.] Villa Maria Pia Hosp, Turin, Italy; [De Bernardi, A.] Santa Croce Hosp, Moncalieri, Italy; [Biondi-Zoccai, G.; Sheiban, I.] Univ Turin, Turin, Italy Pucci, A (reprint author), ASO OIRM S Anna, Regina Margherita Hosp, Turin, Italy. 35 4 4 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 0014-2972 EUR J CLIN INVEST Eur. J. Clin. Invest. MAY 2008 38 5 281 289 10.1111/j.1365-2362.2008.01944.x 9 Medicine, General & Internal; Medicine, Research & Experimental General & Internal Medicine; Research & Experimental Medicine 283AZ WOS:000254610200001 J Vitarelli, A Vitarelli, Antonio Echocardiographic selection of candidates for cardiac resynchronization therapy: the lack of evidence! Reply EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY English Letter HEART-FAILURE; MECHANICAL DYSSYNCHRONY; PREDICTOR Univ Roma La Sapienza, Rome, Italy Vitarelli, A (reprint author), Univ Roma La Sapienza, Rome, Italy. vitar@tiscali.it 10 0 0 OXFORD UNIV PRESS OXFORD GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND 1525-2167 EUR J ECHOCARDIOGR Eur. J. Echocardiogr. MAY 2008 9 3 320 321 10.1093/ejechocard/jen02l 2 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 306CN WOS:000256226000004 J Annibaldi, A; Sajeva, A; Muscolini, M; Ciccosanti, F; Corazzari, M; Piacentini, M; Tuosto, L Annibaldi, Alessandro; Sajeva, Angela; Muscolini, Michela; Ciccosanti, Fabiola; Corazzari, Marco; Piacentini, Mauro; Tuosto, Loretta CD28 ligation in the absence of TCR promotes ReIA/NF-kappa B recruitment and trans-activation of the HIV-1 LTR EUROPEAN JOURNAL OF IMMUNOLOGY English Article CD28; HIV; NF-kappa B T-CELL-ACTIVATION; PERIPHERAL-BLOOD LYMPHOCYTES; PHOSPHATIDYLINOSITOL 3-KINASE; IMMUNOLOGICAL SYNAPSE; GENE-EXPRESSION; REPLICATION; TRANSCRIPTION; COSTIMULATION; SIGNAL CD28 is one of the most important co-stimulatory receptors necessary for full T lymphocyte activation. CD28 can act as a TCR-independent signalling unit by delivering specific signals which may induce HIV transcription and replication. However, the mechanisms by which CD28 regulates HIV expression remain largely unknovm. Here we show that the TCR-independent CD28 signals lead to the trans-activation of HIV-1 LTR in an NF-kappa B-dependent manner. In particular, we found that CD28 engagement by B7 induces the specific recruitment of ReIA/NF-kappa B subunit to the HIV-1 LTR promoter both in vitro and in ex vivo infected cells. The results obtained by mutating specific tyrosine residues within the CD28 cytoplasmic tail as well as by using LY294002 inhibitory drug evidenced that the recruitment and activation of the phosphatidylinositol 3-kinase/Akt signalling pathway is crucial in mediating CD28-induced HIV transcription through ReIA/NF-kappa B. [Annibaldi, Alessandro; Sajeva, Angela; Muscolini, Michela; Tuosto, Loretta] Univ Roma La Sapienza, Dept Cellular & Dev Biol, Rome, Italy; [Ciccosanti, Fabiola; Corazzari, Marco; Piacentini, Mauro] Natl Inst Infect Dis, Lab Cell Biol & Elect Microscopy, INMI, Rome, Italy; [Piacentini, Mauro] Univ Roma Tor Vergata, Dept Biol, Rome, Italy Tuosto, L (reprint author), Univ Roma La Sapienza, Dept Cellular & Dev Biol, Rome, Italy. loretta.tuosto@uniroma1.it Tuosto, Loretta/F-7017-2011 28 8 8 WILEY-V C H VERLAG GMBH WEINHEIM PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY 0014-2980 EUR J IMMUNOL Eur. J. Immunol. MAY 2008 38 5 1446 1451 10.1002/eji.200737854 6 Immunology Immunology 303XD WOS:000256073400028 J Parisi, V; Coppola, G; Ziccardi, L; Gallinaro, G; Falsini, B Parisi, V.; Coppola, G.; Ziccardi, L.; Gallinaro, G.; Falsini, B. Cytidine-5'-diphosphocholine (Citicoline): a pilot study in patients with non-arteritic ischaemic optic neuropathy EUROPEAN JOURNAL OF NEUROLOGY English Article cytidine-5-diphosphocholine; non-arteritic ischaemic optic neuropathy; pattern-electroretinogram; visual evoked potential VISUAL-EVOKED-POTENTIALS; CDP-CHOLINE; CYTIDINE-5'-DIPHOSPHOCHOLINE CITICOLINE; PATTERN ELECTRORETINOGRAMS; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; CEREBRAL-ISCHEMIA; GANGLION-CELLS; FOLLOW-UP Background and purpose: Our work evaluates visual function before and after treatment with cytidine-5-diphosphocholine (Citicoline) in patients with non-arteritic ischaemic optic neuropathy (NION). Methods: Twenty-six patients in which at least 6 months elapsed from NION, were randomly divided into two age-similar groups: 14 patients had Citicoline (Cebrolux-Tubilux, Italy, 1600 mg/diem for 60 days, followed by a 120-day period of wash out, days 60-180) (T-NION); 12 patients had no treatment during the same period (NT-NION). At day 180, in T-NION a second period of treatment (days 181-240) followed by a wash-out (days 241-360) was performed. Fourteen age-matched healthy subjects provided normative data. In all patients, pattern-electroretinogram (PERG), visual evoked potentials (VEPs) and visual acuity (VA) measurements were performed at baseline and at days 60 and 180. In T-NION, further measurements were achieved at days 240 and 360. Results: At baseline, NT-NION and T-NION patients showed abnormal PERGs and VEPs, and reduced VA, compared to controls. At the end of treatment (days 60 and 240), T-NION patients showed improvement (P < 0.01) of PERGs, VEPs parameters and VA, compared to pre-treatment values. After wash out, functional improvements persisted compared to baseline. No changes in NT-NION patients were observed. Conclusions: Our results suggest a beneficial effect of oral Citicoline in NION. [Parisi, V.; Coppola, G.; Ziccardi, L.; Gallinaro, G.] GB Bietti Eye Fdn, IRCCS, Dept Neurophysiol Vis & Neurophthalmol, I-00199 Rome, Italy; [Falsini, B.] Univ Cattolica Sacro Cuore, Dept Ophthalmol, Rome, Italy Parisi, V (reprint author), GB Bietti Eye Fdn, IRCCS, Dept Neurophysiol Vis & Neurophthalmol, Via Livenza 3, I-00199 Rome, Italy. vparisi@tin.it 53 5 5 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1351-5101 EUR J NEUROL Eur. J. Neurol. MAY 2008 15 5 465 474 10.1111/j.1468-1331.2008.02099.x 10 Clinical Neurology; Neurosciences Neurosciences & Neurology 283WJ WOS:000254666900014 J Coccia, ME; Rizzello, F; Cammilli, F; Bracco, GL; Scarselli, G Coccia, M. Elisabetta; Rizzello, Francesca; Cammilli, Fiamma; Bracco, Gian Luca; Scarselli, Gianfranco Endometriosis and infertility - Surgery and ART: An integrated approach for successful management EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY English Article endometriosis; infertility; IVF; laparoscopy; surgery IN-VITRO FERTILIZATION; MILD ENDOMETRIOSIS; WOMEN Objectives: Laparoscopy is considered the gold standard for treatment of endometriosis. In vitro fertilization and embryo transfer (IVF-ET) is often used to treat women with infertility associated with endometriosis. The objective of the study was to evaluate the pregnancy rate after surgical treatment and to assess whether a combined approach with laparoscopic surgery followed by IVF-ET can improve the "overall" pregnancy rate. Study design: A retrospective observational study was carried out on 107 infertile patients who underwent laparoscopic surgery for endometriosis and came at follow-up for a period of time between 1 and 11 years. Sixty-seven patients who did not become pregnant after surgery subsequently underwent IVF-ET. Results: The pregnancy rate achieved after the integrated laparoscopy-IVF approach was 56.1%. The pregnancy rate after surgery, was significantly lower (37.4%). The fecundity rate for spontaneous conceptions within 6 months of laparoscopy (23.2%) was significantly higher (P < 0.05) than for the following intervals. The cumulative fecundity in women older than 35 years was significantly lower than in younger women. Conclusions: In patients with endometriosis-associated infertility, surgery followed by IVF-ET is more effective than surgery alone. When patients fail to conceive spontaneously, after a maximum of 1 year from laparoscopic surgery, IVF should be suggested. (c) 2007 Elsevier Ireland Ltd. All rights reserved. [Coccia, M. Elisabetta; Rizzello, Francesca; Cammilli, Fiamma; Bracco, Gian Luca; Scarselli, Gianfranco] Univ Florence, Dept Gynaecol Perinatol & Human Reprod, I-50134 Florence, Italy Coccia, ME (reprint author), Via Ippolito Nievo 2, Florence, Italy. cocciame@tin.it 15 18 27 ELSEVIER IRELAND LTD CLARE ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND 0301-2115 EUR J OBSTET GYN R B Eur. J. Obstet. Gynecol. Reprod. Biol. MAY 2008 138 1 54 59 10.1016/j.ejogrb.2007.11.010 6 Obstetrics & Gynecology; Reproductive Biology Obstetrics & Gynecology; Reproductive Biology 329XQ WOS:000257904300011 J Mortelliti, A; Boitani, L Mortelliti, A.; Boitani, L. Inferring red squirrel (Sciurus vulgaris) absence with hair tubes surveys: a sampling protocol EUROPEAN JOURNAL OF WILDLIFE RESEARCH English Article PRESENCE; habitat fragmentation; detection probability; occupancy models; Italy ESTIMATING SITE OCCUPANCY; POPULATION-DENSITY; DETECTION PROBABILITIES; MAMMALS; FRAGMENTATION; SPACE Hair tubes are often used to monitor red squirrel in fragmented landscapes, where presence/absence data are gathered to determine its distribution and factors affecting it. Despite many applications and evaluation of this technique for density estimation, the reliability of absence data has been overlooked, as no rigorous statistical estimate has been attempted both on the survey duration and on the reliability of absences. Accurate determination of the duration of a survey (e.g. how many visits should be carried out to consider the species absent rather than non-detected) will affect total costs and number of monitored sites; moreover, false absences will bias the distribution estimates. By applying some recently developed occupancy models, we estimated detection probability and sampling size required to infer red squirrel absence. Application of this sampling and data analysis protocol allows to infer the species absence at a reasonable cost and thus to evaluate the reliability of a presence/absence dataset. [Mortelliti, A.; Boitani, L.] Univ Roma La Sapienza, Dept Anim & Human Biol, I-00185 Rome, Italy Mortelliti, A (reprint author), Univ Roma La Sapienza, Dept Anim & Human Biol, Viale Univ 32, I-00185 Rome, Italy. Alessio.Mortelliti@uniroma1.it 21 12 12 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 1612-4642 EUR J WILDLIFE RES Eur. J. Wildl. Res. MAY 2008 54 2 353 356 10.1007/s10344-007-0135-x 4 Ecology; Zoology Environmental Sciences & Ecology; Zoology 289ZB WOS:000255091300026 J Belli, P; Bernabei, R; Cappella, F; Cerulli, R; Danevich, FA; D'Angelo, S; Incicchitti, A; Kobychev, VV; Nagorny, SS; Nozzoli, F; Mokina, VM; Poda, DV; Prosperi, D; Tretyak, VI Belli, P.; Bernabei, R.; Cappella, F.; Cerulli, R.; Danevich, F. A.; D'Angelo, S.; Incicchitti, A.; Kobychev, V. V.; Nagorny, S. S.; Nozzoli, F.; Mokina, V. M.; Poda, D. V.; Prosperi, D.; Tretyak, V. I. Search for double-beta decay processes in (108)Cd and (114)Cd with the help of the low-background CdWO(4) crystal scintillator EUROPEAN PHYSICAL JOURNAL A English Article TABLES; ELEMENTS The search for double-beta processes in (108)Cd and (114)Cd was realized by using data of the low-background experiment with the CdWO(4) crystal scintillator at the Gran Sasso National Laboratories of the INFN. New improved half-life limits on double-beta processes were established, in particular T(1/2)(0 nu 2 epsilon)((108)Cd) >= 1.0(2.7) x 10(18) yr, T(1/2)(2 nu 2 beta)((114)Cd) >= 1.3(2.1) x 10(18) yr, and T(1/2)(0 nu 2 beta)((114)Cd) >= 1.1(2.5) x 10(21) yr at 90(68)% C.L. [Belli, P.; D'Angelo, S.; Nozzoli, F.; Tretyak, V. I.] Univ Roma Tor Vergata, Dipartimento Fis, I-00133 Rome, Italy; [Belli, P.; D'Angelo, S.; Nozzoli, F.; Tretyak, V. I.] Ist Nazl Fis Nucl, Sezione Roma Tor Vergata, I-00133 Rome, Italy; [Bernabei, R.; Incicchitti, A.; Prosperi, D.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [Bernabei, R.; Incicchitti, A.; Prosperi, D.] Ist Nazl Fis Nucl, Sezione Roma, I-00185 Rome, Italy; [Cappella, F.] Ist Nazl Fis Nucl, Lab Nazl Gran Sasso, I-67010 Assergi, AQ, Italy; [Danevich, F. A.; Kobychev, V. V.; Nagorny, S. S.; Poda, D. V.] MSP, Inst Nucl Res, UA-03680 Kiev, Ukraine Belli, P (reprint author), Univ Roma Tor Vergata, Dipartimento Fis, I-00133 Rome, Italy. rita.bernabei@roma2.infn.it Kobychev, Vladislav/B-3322-2008; Poda, Denys/G-8241-2011; Cerulli, Riccardo/G-9322-2012; Belli, Pierluigi/H-1942-2012; Incicchitti, Antonella/H-1885-2012; Cappella, Fabio/B-3483-2013 Kobychev, Vladislav/0000-0003-0030-7451; Poda, Denys/0000-0001-7238-7636; 17 29 29 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 1434-6001 EUR PHYS J A Eur. Phys. J. A MAY 2008 36 2 167 170 10.1140/epja/i2008-10593-6 4 Physics, Nuclear; Physics, Particles & Fields Physics 305KK WOS:000256177100007 J Chekanov, S; Derrick, M; Magill, S; Musgrave, B; Nicholass, D; Repond, J; Yoshida, R; Mattingly, MCK; Jechow, M; Pavel, N; Molina, AGY; Antonelli, S; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Bindi, M; Boscherini, D; Bruni, A; Bruni, G; Cifarelli, L; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Iacobucci, G; Margotti, A; Nania, R; Polini, A; Sartorelli, G; Zichichi, A; Bartsch, D; Brock, I; Hartmann, H; Hilger, E; Jakob, HP; Jungst, M; Kind, OM; Nuncio-Quiroz, AE; Paul, E; Renner, R; Samson, U; Schonberg, V; Shehzadi, R; Wlasenko, M; Brook, NH; Heath, GP; Morris, JD; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, JY; Ibrahim, ZA; Kamaluddin, B; Abdullah, WATW; Ning, Y; Ren, Z; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Gil, M; Olkiewicz, K; Stopa, P; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Lukasik, J; Przybycien, M; Suszycki, L; Kotanski, A; Slominski, W; Adler, V; Behrens, U; Blohm, C; Bonato, A; Borras, K; Ciesielski, R; Coppola, N; Drugakov, V; Fang, S; Fourletova, J; Geiser, A; Gladkov, D; Gottlicher, P; Grebenyuk, J; Gregor, I; Haas, T; Hain, W; Huttmann, A; Kahle, B; Katkov, II; Klein, U; Kotz, U; Kowalski, H; Lobodzinska, E; Lohr, B; Mankel, R; Melzer-Pellmann, IA; Miglioranzi, S; Montanari, A; Namsoo, T; Notz, D; Rinaldi, L; Roloff, P; Rubinsky, I; Santamarta, R; Schneekloth, U; Spiridonov, A; Szuba, D; Szuba, J; Theedt, T; Wolf, G; Wrona, K; Youngman, C; Zeuner, W; Lohmann, W; Schlenstedt, S; Barbagli, G; Gallo, E; Pelfer, PG; Bamberger, A; Dobur, D; Karstens, F; Vlasov, NN; Bussey, PJ; Doyle, AT; Dunne, W; Forrest, M; Saxon, DH; Skillicorn, IO; Gialas, I; Papageorgiu, K; Holm, U; Klanner, R; Lohrmann, E; Schleper, P; Schorner-Sadenius, T; Sztuk, J; Stadie, H; Turcato, M; Foudas, C; Fry, C; Long, KR; Tapper, AD; Matsumoto, T; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, AN; Boos, EG; Pokrovskiy, NS; Zhautykov, BO; Aushev, V; Borodin, M; Kozulia, A; Lisovyi, M; Son, D; de Favereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jimenez, M; Labarga, L; del Peso, J; Ron, E; Soares, M; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, BA; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, RK; Ermolov, PF; Gladilin, LK; Khein, LA; Korzhavina, IA; Kuzmin, VA; Levchenko, BB; Lukina, OY; Proskuryakov, AS; Shcheglova, LM; Zotkin, DS; Zotkin, SA; Abt, I; Buttner, C; Caldwell, A; Kollar, D; Schmidke, WB; Sutiak, J; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Pellegrino, A; Tiecke, H; Vazquez, M; Wiggers, L; Brummer, N; Bylsma, B; Durkin, LS; Lee, A; Ling, TY; Allfrey, PD; Bell, MA; Cooper-Sarkar, AM; Devenish, RCE; Ferrando, J; Foster, B; Korcsak-Gorzo, K; Oliver, K; Patel, S; Roberfroid, V; Robertson, A; Straub, PB; Uribe-Estrada, C; Walczak, R; Bellan, P; Bertolin, A; Brugnera, R; Carlin, R; Dal Corso, F; Dusini, S; Garfagnini, A; Limentani, S; Longhin, A; Stanco, L; Turcato, M; Oh, BY; Raval, A; Ukleja, J; Whitmore, JJ; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Cole, JE; Hart, JC; Abramowicz, H; Gabareen, A; Ingbir, R; Kananov, S; Levy, A; Smith, O; Stern, A; Kuze, M; Maeda, J; Hori, R; Kagawa, S; Okazaki, N; Shimizu, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Ota, O; Ri, YD; Ferrero, MI; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Costa, M; Ruspa, M; Fourletov, S; Martin, JF; Stewart, TP; Boutle, SK; Butterworth, JM; Gwenlan, C; Jones, TW; Loizides, JH; Wing, M; Brzozowska, B; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, RJ; Pawlak, JM; Tymieniecka, T; Ukleja, A; Zarnecki, AF; Adamus, M; Plucinski, P; Eisenberg, Y; Giller, I; Hochman, D; Karshon, U; Rosin, M; Brownson, E; Danielson, T; Everett, A; Kcira, D; Reeder, DD; Ryan, P; Savin, AA; Smith, WH; Wolfe, H; Bhadra, S; Catterall, CD; Cui, Y; Hartner, G; Menary, S; Noor, U; Standage, J; Whyte, J Chekanov, S.; Derrick, M.; Magill, S.; Musgrave, B.; Nicholass, D.; Repond, J.; Yoshida, R.; Mattingly, M. C. K.; Jechow, M.; Pavel, N.; Molina, A. G. Yaguees; Antonelli, S.; Antonioli, P.; Bari, G.; Basile, M.; Bellagamba, L.; Bindi, M.; Boscherini, D.; Bruni, A.; Bruni, G.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; De Pasquale, S.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A.; Sartorelli, G.; Zichichi, A.; Bartsch, D.; Brock, I.; Hartmann, H.; Hilger, E.; Jakob, H. -P.; Juengst, M.; Kind, O. M.; Nuncio-Quiroz, A. E.; Paul, E.; Renner, R.; Samson, U.; Schoenberg, V.; Shehzadi, R.; Wlasenko, M.; Brook, N. H.; Heath, G. P.; Morris, J. D.; Capua, M.; Fazio, S.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Tassi, E.; Kim, J. Y.; Ibrahim, Z. A.; Kamaluddin, B.; Abdullah, W. A. T. Wan; Ning, Y.; Ren, Z.; Sciulli, F.; Chwastowski, J.; Eskreys, A.; Figiel, J.; Galas, A.; Gil, M.; Olkiewicz, K.; Stopa, P.; Zawiejski, L.; Adamczyk, L.; Bold, T.; Grabowska-Bold, I.; Kisielewska, D.; Lukasik, J.; Przybycien, M.; Suszycki, L.; Kotanski, A.; Slominski, W.; Adler, V.; Behrens, U.; Blohm, C.; Bonato, A.; Borras, K.; Ciesielski, R.; Coppola, N.; Drugakov, V.; Fang, S.; Fourletova, J.; Geiser, A.; Gladkov, D.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Kahle, B.; Katkov, I. I.; Klein, U.; Koetz, U.; Kowalski, H.; Lobodzinska, E.; Loehr, B.; Mankel, R.; Melzer-Pellmann, I. -A.; Miglioranzi, S.; Montanari, A.; Namsoo, T.; Notz, D.; Rinaldi, L.; Roloff, P.; Rubinsky, I.; Santamarta, R.; Schneekloth, U.; Spiridonov, A.; Szuba, D.; Szuba, J.; Theedt, T.; Wolf, G.; Wrona, K.; Youngman, C.; Zeuner, W.; Lohmann, W.; Schlenstedt, S.; Barbagli, G.; Gallo, E.; Pelfer, P. G.; Bamberger, A.; Dobur, D.; Karstens, F.; Vlasov, N. N.; Bussey, P. J.; Doyle, A. T.; Dunne, W.; Forrest, M.; Saxon, D. H.; Skillicorn, I. O.; Gialas, I.; Papageorgiu, K.; Holm, U.; Klanner, R.; Lohrmann, E.; Schleper, P.; Schoerner-Sadenius, T.; Sztuk, J.; Stadie, H.; Turcato, M.; Foudas, C.; Fry, C.; Long, K. R.; Tapper, A. D.; Matsumoto, T.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Barakbaev, A. N.; Boos, E. G.; Pokrovskiy, N. S.; Zhautykov, B. O.; Aushev, V.; Borodin, M.; Kozulia, A.; Lisovyi, M.; Son, D.; de Favereau, J.; Piotrzkowski, K.; Barreiro, F.; Glasman, C.; Jimenez, M.; Labarga, L.; del Peso, J.; Ron, E.; Soares, M.; Terron, J.; Zambrana, M.; Corriveau, F.; Liu, C.; Walsh, R.; Zhou, C.; Tsurugai, T.; Antonov, A.; Dolgoshein, B. A.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S.; Dementiev, R. K.; Ermolov, P. F.; Gladilin, L. K.; Khein, L. A.; Korzhavina, I. A.; Kuzmin, V. A.; Levchenko, B. B.; Lukina, O. Y.; Proskuryakov, A. S.; Shcheglova, L. M.; Zotkin, D. S.; Zotkin, S. A.; Abt, I.; Buettner, C.; Caldwell, A.; Kollar, D.; Schmidke, W. B.; Sutiak, J.; Grigorescu, G.; Keramidas, A.; Koffeman, E.; Kooijman, P.; Pellegrino, A.; Tiecke, H.; Vazquez, M.; Wiggers, L.; Bruemmer, N.; Bylsma, B.; Durkin, L. S.; Lee, A.; Ling, T. Y.; Allfrey, P. D.; Bell, M. A.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Ferrando, J.; Foster, B.; Korcsak-Gorzo, K.; Oliver, K.; Patel, S.; Roberfroid, V.; Robertson, A.; Straub, P. B.; Uribe-Estrada, C.; Walczak, R.; Bellan, P.; Bertolin, A.; Brugnera, R.; Carlin, R.; Dal Corso, F.; Dusini, S.; Garfagnini, A.; Limentani, S.; Longhin, A.; Stanco, L.; Turcato, M.; Oh, B. Y.; Raval, A.; Ukleja, J.; Whitmore, J. J.; Iga, Y.; D'Agostini, G.; Marini, G.; Nigro, A.; Cole, J. E.; Hart, J. C.; Abramowicz, H.; Gabareen, A.; Ingbir, R.; Kananov, S.; Levy, A.; Smith, O.; Stern, A.; Kuze, M.; Maeda, J.; Hori, R.; Kagawa, S.; Okazaki, N.; Shimizu, S.; Tawara, T.; Hamatsu, R.; Kaji, H.; Kitamura, S.; Ota, O.; Ri, Y. D.; Ferrero, M. I.; Monaco, V.; Sacchi, R.; Solano, A.; Arneodo, M.; Costa, M.; Ruspa, M.; Fourletov, S.; Martin, J. F.; Stewart, T. P.; Boutle, S. K.; Butterworth, J. M.; Gwenlan, C.; Jones, T. W.; Loizides, J. H.; Wing, M.; Brzozowska, B.; Ciborowski, J.; Grzelak, G.; Kulinski, P.; Luzniak, P.; Malka, J.; Nowak, R. J.; Pawlak, J. M.; Tymieniecka, T.; Ukleja, A.; Zarnecki, A. F.; Adamus, M.; Plucinski, P.; Eisenberg, Y.; Giller, I.; Hochman, D.; Karshon, U.; Rosin, M.; Brownson, E.; Danielson, T.; Everett, A.; Kcira, D.; Reeder, D. D.; Ryan, P.; Savin, A. A.; Smith, W. H.; Wolfe, H.; Bhadra, S.; Catterall, C. D.; Cui, Y.; Hartner, G.; Menary, S.; Noor, U.; Standage, J.; Whyte, J. ZEUS Collaboration Diffractive photoproduction of dijets in ep collisions at HERA EUROPEAN PHYSICAL JOURNAL C English Article DEEP-INELASTIC SCATTERING; LUND MONTE-CARLO; CENTRAL TRACKING DETECTOR; ZEUS BARREL CALORIMETER; PARTON DISTRIBUTIONS; CROSS-SECTIONS; HADRON-COLLISIONS; JET FRAGMENTATION; VIRTUAL PHOTONS; HARD SCATTERING Diffractive photoproduction of dijets was measured with the ZEUS detector at the ep collider HERA using an integrated luminosity of 77.2 pb(-1). The measurements were made in the kinematic range Q(2) < 1 GeV(2), 0.20 < y < 0.85 and x(IP) < 0.025, where Q(2) is the photon virtuality, y is the inelasticity and x(IP) is the fraction of the proton momentum taken by the diffractive exchange. The two jets with the highest transverse energy, E(T)(jet), were required to satisfy E(T)(jet) > 7.5 and 6.5 GeV, respectively, and to lie in the pseudorapidity range -1.5 < eta(jet) < 1.5. Differential cross sections were compared to perturbative QCD calculations using available parameterisations of diffractive parton distributions of the proton. [Chekanov, S.; Derrick, M.; Magill, S.; Musgrave, B.; Nicholass, D.; Repond, J.; Yoshida, R.] Argonne Natl Lab, Argonne, IL 60439 USA; [Mattingly, M. C. K.] Andrews Univ, Berrien Springs, MI 49104 USA; [Jechow, M.; Pavel, N.; Molina, A. G. Yaguees] Humboldt Univ, Inst Phys, Berlin, Germany; [Antonelli, S.; Antonioli, P.; Bari, G.; Basile, M.; Bellagamba, L.; Bindi, M.; Boscherini, D.; Bruni, A.; Bruni, G.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; De Pasquale, S.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A.; Sartorelli, G.; Zichichi, A.] Univ Bologna, Bologna, Italy; [Kim, J. Y.] Chonnam Natl Univ, Kwangju, South Korea; [Ibrahim, Z. A.; Kamaluddin, B.; Abdullah, W. A. T. Wan] Univ Malaya, Kuala Lumpur 50603, Malaysia; [Ning, Y.; Ren, Z.; Sciulli, F.] Columbia Univ, Nevis Labs, New York, NY 10027 USA; [Chwastowski, J.; Eskreys, A.; Figiel, J.; Galas, A.; Gil, M.; Olkiewicz, K.; Stopa, P.; Zawiejski, L.] Polish Acad Sci, Henry Niewodniczanski Inst Nucl Phys, Krakow, Poland; [Adamczyk, L.; Bold, T.; Grabowska-Bold, I.; Kisielewska, D.; Lukasik, J.; Przybycien, M.; Suszycki, L.; Uribe-Estrada, C.] Univ Sci & Technol, AGH, Fac Phys & Appl Comp Sci, Krakow, Poland; [Kotanski, A.; Slominski, W.] Jagiellonian Univ, Dept Phys, Krakow, Poland; [Adler, V.; Fourletova, J.; Geiser, A.; Gladkov, D.; Goettlicher, P.; Grebenyuk, J.; Gregor, I.; Haas, T.; Hain, W.; Huettmann, A.; Kahle, B.; Katkov, I. I.; Klein, U.; Koetz, U.; Kowalski, H.; Lobodzinska, E.; Loehr, B.; Mankel, R.; Melzer-Pellmann, I. -A.; Miglioranzi, S.; Montanari, A.; Namsoo, T.; Notz, D.; Rinaldi, L.; Roloff, P.; Rubinsky, I.; Santamarta, R.; Schneekloth, U.; Spiridonov, A.; Szuba, D.; Szuba, J.; Theedt, T.; Wolf, G.; Wrona, K.; Youngman, C.; Zeuner, W.] Deutsch Elektronen Synchrotron DESY, D-22763 Hamburg, Germany; [Lohmann, W.; Schlenstedt, S.] Deutsch Elektronen Synchrotron DESY, Zeuthen, Germany; [Barbagli, G.; Gallo, E.; Pelfer, P. G.] Univ Florence, Florence, Italy; [Barbagli, G.; Gallo, E.; Pelfer, P. G.] Ist Nazl Fis Nucl, I-50125 Florence, Italy; [Bamberger, A.; Dobur, D.; Karstens, F.; Vlasov, N. N.; Bussey, P. J.] Univ Freiburg, Fak Phys, D-7800 Freiburg, Germany; [Bussey, P. J.; Doyle, A. T.; Dunne, W.; Forrest, M.; Saxon, D. H.; Skillicorn, I. O.] Univ Glasgow, Dept Phys & Astron, Glasgow, Lanark, Scotland; [Gialas, I.; Papageorgiu, K.] Univ Aegean, Dept Engn Management & Finance, Mitilini, Greece; [Holm, U.; Klanner, R.; Lohrmann, E.; Schleper, P.; Schoerner-Sadenius, T.; Sztuk, J.; Stadie, H.; Turcato, M.] Univ Hamburg, Inst Exp Phys, Hamburg, Germany; [Foudas, C.; Fry, C.; Long, K. R.; Tapper, A. D.] Univ London Imperial Coll Sci Technol & Med, High Energy Nucl Phys Grp, London, England; [Matsumoto, T.; Nagano, K.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Barakbaev, A. N.; Boos, E. G.] Natl Lab High Energy Phys, KEK, Inst Particle & Nucl Studies, Tsukuba, Ibaraki 305, Japan; [Aushev, V.; Borodin, M.; Kozulia, A.; Lisovyi, M.] Natl Acad Sci Ukraine, Inst Nucl Res, Kiev, Ukraine; [Aushev, V.; Borodin, M.; Kozulia, A.; Lisovyi, M.] Kiev Natl Univ, Kiev, Ukraine; [de Favereau, J.; Piotrzkowski, K.] Catholic Univ Louvain, Inst Phys Nucl, B-1348 Louvain La Neuve, Belgium; [Barreiro, F.; Glasman, C.; Jimenez, M.; Labarga, L.; del Peso, J.; Ron, E.; Soares, M.; Terron, J.; Zambrana, M.] Univ Autonoma Madrid, Dept Fis Teor, Madrid, Spain; [Corriveau, F.; Liu, C.; Walsh, R.; Zhou, C.] McGill Univ, Dept Phys, Montreal, PQ H3A 2T8, Canada; [Tsurugai, T.] Meiji Gakuin Univ, Fac Gen Educ, Yokohama, Kanagawa, Japan; [Antonov, A.; Dolgoshein, B. A.; Sosnovtsev, V.; Stifutkin, A.; Suchkov, S.] Moscow Engn Phys Inst, Moscow 115409, Russia; [Dementiev, R. K.; Ermolov, P. F.; Gladilin, L. K.; Khein, L. A.; Korzhavina, I. A.; Kuzmin, V. A.; Levchenko, B. B.; Lukina, O. Y.; Proskuryakov, A. S.; Shcheglova, L. M.; Zotkin, D. S.; Zotkin, S. A.] Moscow MV Lomonosov State Univ, Inst Nucl Phys, Moscow, Russia; [Abt, I.; Buettner, C.; Caldwell, A.; Kollar, D.; Schmidke, W. B.; Sutiak, J.; Grigorescu, G.] Max Planck Inst Phys & Astrophys, D-80805 Munich, Germany; [Grigorescu, G.; Keramidas, A.; Koffeman, E.; Kooijman, P.; Pellegrino, A.; Tiecke, H.; Vazquez, M.; Wiggers, L.] NIKHEF, Amsterdam, Netherlands; [Grigorescu, G.; Keramidas, A.; Koffeman, E.; Kooijman, P.; Pellegrino, A.; Tiecke, H.; Vazquez, M.; Wiggers, L.] Univ Amsterdam, Amsterdam, Netherlands; [Bruemmer, N.; Bylsma, B.; Durkin, L. S.; Lee, A.; Ling, T. Y.] Ohio State Univ, Dept Phys, Columbus, OH 43210 USA; [Allfrey, P. D.; Bell, M. A.; Cooper-Sarkar, A. M.; Devenish, R. C. E.; Ferrando, J.; Foster, B.; Korcsak-Gorzo, K.; Oliver, K.; Patel, S.; Roberfroid, V.; Robertson, A.; Straub, P. B.; Uribe-Estrada, C.; Walczak, R.] Univ Oxford, Dept Phys, Oxford, England; [Turcato, M.; Bellan, P.; Bertolin, A.; Brugnera, R.; Carlin, R.; Dal Corso, F.; Dusini, S.; Garfagnini, A.; Limentani, S.; Longhin, A.; Stanco, L.] Dipartimento Fis Univ, Padua, Italy; [Turcato, M.; Bellan, P.; Bertolin, A.; Brugnera, R.; Carlin, R.; Dal Corso, F.; Dusini, S.; Garfagnini, A.; Limentani, S.; Longhin, A.; Stanco, L.] Ist Nazl Fis Nucl, Padua, Italy; [Oh, B. Y.; Raval, A.; Ukleja, J.; Whitmore, J. J.] Penn State Univ, Dept Phys, University Pk, PA 16802 USA; [Iga, Y.] Polytech Univ, Sagamihara, Kanagawa, Japan; [D'Agostini, G.; Marini, G.; Nigro, A.] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; [D'Agostini, G.; Marini, G.; Nigro, A.] Ist Nazl Fis Nucl, Rome, Italy; [Cole, J. E.; Hart, J. C.] Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England; [Abramowicz, H.; Gabareen, A.; Ingbir, R.; Kananov, S.; Levy, A.; Smith, O.; Stern, A.] Tel Aviv Univ, Sch Phys, Raymond & Beverly Sackler Fac Exact Sci, IL-69978 Tel Aviv, Israel; [Kuze, M.; Maeda, J.] Tokyo Inst Technol, Dept Phys, Tokyo 152, Japan; [Hori, R.; Kagawa, S.; Okazaki, N.; Shimizu, S.; Tawara, T.] Univ Tokyo, Dept Phys, Tokyo 113, Japan; [Hamatsu, R.; Kaji, H.; Kitamura, S.; Ota, O.; Ri, Y. D.] Tokyo Metropolitan Univ, Dept Phys, Tokyo, Japan; [Ferrero, M. I.; Monaco, V.; Sacchi, R.; Solano, A.] Univ Turin, Turin, Italy; [Ferrero, M. I.; Monaco, V.; Sacchi, R.; Solano, A.] Ist Nazl Fis Nucl, I-10125 Turin, Italy; [Arneodo, M.; Costa, M.; Ruspa, M.] Univ Piemonte Orientale, Novara, Italy; [Fourletov, S.; Martin, J. F.; Stewart, T. P.] Univ Toronto, Dept Phys, Toronto, ON M5S 1A7, Canada; [Boutle, S. K.; Butterworth, J. M.; Gwenlan, C.; Jones, T. W.; Loizides, J. H.; Wing, M.] UCL, Dept Phys & Astron, London, England; [Brzozowska, B.; Ciborowski, J.; Grzelak, G.; Kulinski, P.; Luzniak, P.; Malka, J.; Nowak, R. J.; Pawlak, J. M.; Tymieniecka, T.; Ukleja, A.; Zarnecki, A. F.] Warsaw Univ, Inst Expt Phys, Warsaw, Poland; [Adamus, M.; Plucinski, P.] Inst Nucl Studies, PL-00681 Warsaw, Poland; [Eisenberg, Y.; Giller, I.; Hochman, D.; Karshon, U.; Rosin, M.] Weizmann Inst Sci, Dept Particle Phys, IL-76100 Rehovot, Israel; [Brownson, E.; Danielson, T.; Everett, A.; Kcira, D.; Reeder, D. D.; Ryan, P.; Savin, A. A.; Smith, W. H.; Wolfe, H.] Univ Wisconsin, Dept Phys, Madison, WI 53706 USA; [Bhadra, S.; Catterall, C. D.; Cui, Y.; Hartner, G.; Menary, S.; Noor, U.; Standage, J.; Whyte, J.] York Univ, Dept Phys, N York, ON M3J 1P3, Canada; [Spiridonov, A.] Inst Theoret & Expt Phys, Moscow 117259, Russia; [Szuba, D.] INP, Krakow, Poland; [Kitamura, S.] Tokyo Metropolitan Univ, Dept Radiol Sci, Tokyo, Japan; [Ciborowski, J.] Univ Lodz, PL-90131 Lodz, Poland; [Antonelli, S.; Antonioli, P.; Bari, G.; Basile, M.; Bellagamba, L.; Bindi, M.; Boscherini, D.; Bruni, A.; Bruni, G.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; De Pasquale, S.; Iacobucci, G.; Margotti, A.; Nania, R.; Polini, A.; Sartorelli, G.; Zichichi, A.] Ist Nazl Fis Nucl, I-40126 Bologna, Italy; [Bartsch, D.; Brock, I.; Hartmann, H.; Hilger, E.; Jakob, H. -P.; Juengst, M.; Kind, O. M.; Nuncio-Quiroz, A. E.; Paul, E.; Renner, R.; Samson, U.; Schoenberg, V.; Shehzadi, R.; Wlasenko, M.] Univ Bonn, Inst Phys, D-5300 Bonn, Germany; [Brook, N. H.; Heath, G. P.; Morris, J. D.] Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England; [Capua, M.; Fazio, S.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Tassi, E.] Univ Calabria, Dept Phys, I-87036 Cosenza, Italy; [Capua, M.; Fazio, S.; Mastroberardino, A.; Schioppa, M.; Susinno, G.; Tassi, E.] Ist Nazl Fis Nucl, Cosenza, Italy; [Son, D.] Kyungpook Natl Univ, Ctr High Energy Phys, Taegu, South Korea; [Barakbaev, A. N.; Boos, E. G.; Pokrovskiy, N. S.; Zhautykov, B. O.] Minist Educ & Sci Kazakhstan, Inst Phys & Technol, Alma Ata, Kazakhstan Chekanov, S (reprint author), Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA. tobias.haas@desy.de Wing, Matthew/C-2169-2008; IBRAHIM, ZAINOL ABIDIN/C-1121-2010; Fazio, Salvatore /G-5156-2010; WAN ABDULLAH, WAN AHMAD TAJUDDIN/B-5439-2010; Doyle, Anthony/C-5889-2009; Ferrando, James/A-9192-2012; Gladilin, Leonid/B-5226-2011; Levchenko, B./D-9752-2012; Proskuryakov, Alexander/J-6166-2012; Dementiev, Roman/K-7201-2012 Ferrando, James/0000-0002-1007-7816; Gladilin, Leonid/0000-0001-9422-8636; 73 23 23 SPRINGER NEW YORK 233 SPRING ST, NEW YORK, NY 10013 USA 1434-6044 EUR PHYS J C Eur. Phys. J. C MAY 2008 55 2 177 191 10.1140/epjc/s10052-008-0598-2 15 Physics, Particles & Fields Physics 301AC WOS:000255867700001 J Fanelli, F; Orgera, G; Bezzi, M; Rossi, P; Allegritti, M; Passariello, R Fanelli, Fabrizio; Orgera, Gianluigi; Bezzi, Mario; Rossi, Plinio; Allegritti, Massimiliano; Passariello, Roberto Management of malignant biliary obstruction: Technical and clinical results using an expanded polytetrafluoroethylene fluorinated ethylene propylene (ePTFE/FEP)-covered metallic stent after 6-year experience EUROPEAN RADIOLOGY English Article biliary; stricture; malignant; stent; covered FOLLOW-UP; COVERED WALLSTENTS; ENDOPROSTHESES To evaluate the efficacy and safety of an expanded polytetrafluoroethylene-fluorinated ethylene-propylene (ePTFE/FEP)-covered metallic stent in the management of malignant biliary obstruction. Eighty consecutive patients with malignant common bile duct strictures were treated by placement of 83 covered metallic stents. The stent-graft consists of an inner ePTFE/FEP lining and an outer supporting structure of nitinol wire. Clinical evaluation, assessment of serum bilirubin and liver enzyme levels were analyzed before biliary drainage, before stent-graft placement and during the follow-up period at 1, 3, 6, 9 and 12 months. Technical success was obtained in all cases. After a mean follow-up of 6.9 +/- 4.63 months, the 30-day mortality rate was 14.2%. Survival rates were 40% and 20.2% at 6 and 12 months, respectively. Stent-graft patency rates were 95.5%, 92.6% and 85.7% at 3, 6 and 12 months, respectively. Complications occurred in five patients (6.4%); among these, acute cholecystitis was observed in three patients (3.8%). A stent-graft occlusion rate of 9% was observed. The percentage of patients undergoing lifetime palliation (91%) and the midterm patency rate suggest that placement of this ePTFE/FEP-covered stent-graft is safe and highly effective in achieving biliary drainage in patients with malignant strictures of the common bile duct. [Fanelli, Fabrizio; Orgera, Gianluigi; Bezzi, Mario; Rossi, Plinio; Allegritti, Massimiliano; Passariello, Roberto] Univ Roma La Sapienza, Dept Radiol Sci, I-00161 Rome, Italy Fanelli, F (reprint author), Univ Roma La Sapienza, Dept Radiol Sci, Viale Regina Elena 324, I-00161 Rome, Italy. fabrizio.fanelli@uniroma1.it 20 17 17 SPRINGER NEW YORK 233 SPRING STREET, NEW YORK, NY 10013 USA 0938-7994 EUR RADIOL Eur. Radiol. MAY 2008 18 5 911 919 10.1007/s00330-008-0852-x 9 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging 286LW WOS:000254848400007 J Ji, H; Menini, S; Zheng, W; Pesce, C; Wu, X; Sandberg, K Ji, Hong; Menini, Stefano; Zheng, Wei; Pesce, Carlo; Wu, Xie; Sandberg, Kathryn Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17 beta-oestradiol regulation of renal pathology in renal wrap hypertension in rats EXPERIMENTAL PHYSIOLOGY English Article CONVERTING ENZYME-2; PROXIMAL TUBULES; AT(1) RECEPTOR; BLOOD-PRESSURE; UP-REGULATION; ACE2; KIDNEY; EXPRESSION; ESTROGEN; DISEASE 17 beta-Oestradiol (E(2))-mediated inhibition of angiotensin-converting enzyme (ACE) protects the E(2)-replete kidney from the progression of hypertensive renal disease. Angiotensin-converting enzyme 2 (ACE2), a homologue of ACE, counters the actions of ACE by catalysing the conversion of angiotensin II (Ang II) to angiotensin(1-7) [Ang(1-7)]. We investigated E(2) regulation of ACE2 in the renal wrap (RW) model of hypertension in rats. After 6 weeks on a high-sodium diet (4% NaCl), the activity of ACE2 was reduced in the renal cortex by 31%, which was mirrored by similar decreases in ACE2 protein (30%) and mRNA expression (36%) in the ovariectomized RW rat (RW-OVX); E(2) replacement prevented these effects. The RW-OVX rats exhibited greater renal injury, including 1.7-fold more tubulointerstitial fibrosis and 1.6-fold more glomerulosclerosis than E(2)-replete females (RW-Intact and RW-OVX+E(2)). Angiotensin(1-7) infusion prevented these exacerbating effects of ovariectomy on renal pathology; no differences in indicators of renal injury were observed between RW-OVX-Ang(1-7) and RW-Intact rats. These renal protective effects of Ang(1-7) infusion were not attributable to increased ACE2 activity or to changes in heart rate or body weight, since these parameters were unchanged by Ang(1-7) infusion. Furthermore, Ang(1-7) infusion did not attenuate renal injury by reducing mean arterial pressure (MAP), since infusion of the peptide did not lower MAP but rather caused a slight increase during a 6 week chronic treatment for Ang(1-7). These results suggest that E(2)-mediated upregulation of renal ACE2 and the consequent increased Ang(1-7) production contribute to E(2)-mediated protection from hypertensive renal disease. These findings have implications for E(2)-deficient women with hypertensive renal disease and suggest that therapeutics targeted towards increasing ACE2 activity and Ang(1-7) levels will be renal protective. [Ji, Hong; Zheng, Wei; Wu, Xie; Sandberg, Kathryn] Georgetown Univ, Ctr Study Sex Differences Hlth Aging & Dis, Washington, DC 20057 USA; [Menini, Stefano; Pesce, Carlo] Univ Genoa, DISTBIMO, Genoa, Italy Ji, H (reprint author), Georgetown Univ, Ctr Study Sex Differences Hlth Aging & Dis, 391 Bldg D,4000 Reservoir Rd NW, Washington, DC 20057 USA. jih@georgetown.edu Menini, Stefano/G-1130-2010 Menini, Stefano/0000-0001-7328-2385 47 28 28 WILEY-BLACKWELL MALDEN COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA 0958-0670 EXP PHYSIOL Exp. Physiol. MAY 1 2008 93 5 648 657 10.1113/expphysiol.2007.041392 10 Physiology Physiology 292SI WOS:000255286000017 J Bianchi, MM Bianchi, Michele M. Collective behavior in gene regulation: Metabolic clocks and cross-talking FEBS JOURNAL English Review circadian clock; cross-talk; cycles; ergodic system; message; metabolism; redox; synchronization; transcription dynamics; ultradian clock CIRCADIAN CLOCK; SACCHAROMYCES-CEREVISIAE; CONTINUOUS-CULTURE; CANDIDA-ALBICANS; DNA-REPLICATION; YEAST-CELLS; OSCILLATIONS; DYNAMICS; CYCLE; EXPRESSION Biological functions governed by the circadian clock are the evident result of the entrainment operated by the earth's day and night cycle on living organisms. However, the circadian clock is not unique, and cells and organisms possess many other cyclic activities. These activities are difficult to observe if carried out by single cells and the cells are not coordinated but, if they can be detected, cell-to-cell cross-talk and synchronization among cells must exist. Some of these cycles are metabolic and cell synchronization is due to small molecules acting as metabolic messengers. We propose a short survey of cellular cycles, paying special attention to metabolic cycles and cellular cross-talking, particularly when the synchronization of metabolism or, more generally, cellular functions are concerned. Questions arising from the observation of phenomena based on cell communication and from basic cellular cycles are also proposed. Univ Roma La Sapienza, Dept Cell & Dev Biol, I-00185 Rome, Italy Bianchi, MM (reprint author), Univ Roma La Sapienza, Dept Cell & Dev Biol, Ple Aldo Moro 5, I-00185 Rome, Italy. michele.bianchi@uniroma1.it 47 11 12 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1742-464X FEBS J FEBS J. MAY 2008 275 10 2356 2363 10.1111/j.1742-4658.2008.06397.x 8 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 292SF WOS:000255285700002 J Palumbo, MC; Farina, L; De Santis, A; Giuliani, A; Colosimo, A; Morelli, G; Ruberti, I Palumbo, Maria C.; Farina, Lorenzo; De Santis, Alberto; Giuliani, Alessandro; Colosimo, Alfredo; Morelli, Giorgio; Ruberti, Ida Collective behavior in gene regulation: Post-transcriptional regulation and the temporal compartmentalization of cellular cycles FEBS JOURNAL English Review metabolic cycle; oscillations; post-transcriptional regulation; RNA-binding proteins MESSENGER-RNA DECAY; SACCHAROMYCES-CEREVISIAE; PLASMODIUM-FALCIPARUM; YEAST; EXPRESSION; TRANSCRIPTION; STABILITY; PROTEIN; DEGRADATION; IDENTIFICATION Self-sustained oscillations are perhaps the most studied objects in science. The accomplishment of such a task reliably and accurately requires the presence of specific control mechanisms to face the presence of variable and largely unpredictable environmental stimuli and noise. Self-sustained oscillations of transcript abundance are, in fact, widespread and are not limited to the reproductive cycle but are also observed during circadian rhythms, metabolic cycles, developmental cycles and so on. To date, much of the literature has focused on the transcriptional machinery underlying control of the basic timing of transcript abundance. However, mRNA abundance is known to be regulated at the post-transcriptional level also and the relative contribution of the two mechanisms to gene-expression programmes is currently a major challenge in molecular biology. Here, we review recent results showing the relevance of the post-transcriptional regulation layer and present a statistical reanalysis of the yeast metabolic cycle using publicly available gene-expression and RNA-binding data. Taken together, the recent theoretical and experimental developments reviewed and the results of our reanalysis strongly indicate that regulation of mRNA stability is a widespread, phase-specific and finely tuned mechanism for the multi-layer control of gene expression needed to achieve high flexibility and adaptability to external and internal signals. [Palumbo, Maria C.; Colosimo, Alfredo] Univ Roma La Sapienza, Dept Physiol & Pharmacol, Rome, Italy; [Farina, Lorenzo; De Santis, Alberto] Univ Roma La Sapienza, Dept Comp & Syst Sci Antonio Ruberti, Rome, Italy; [Giuliani, Alessandro] Ist Super Sanita, Dept Environm & Primary Prevent, I-00161 Rome, Italy; [Morelli, Giorgio] Natl Res Inst Food & Human Nutr, Rome, Italy; [Ruberti, Ida] CNR, Inst Mol Biol & Pathol, Rome, Italy Farina, L (reprint author), Dipartimento Informat & Sistemist Antonio Ruberti, Via Ariosto 25, I-00185 Rome, Italy. lorenzo.farina@uniroma1.it De Santis, Alberto/F-6801-2011 38 11 12 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1742-464X FEBS J FEBS J. MAY 2008 275 10 2364 2371 10.1111/j.1742-4658.2008.06398.x 8 Biochemistry & Molecular Biology Biochemistry & Molecular Biology 292SF WOS:000255285700003 J Galandrini, R; Porpora, MG; Stoppacciaro, A; Micucci, F; Capuano, C; Tassi, I; Di Felice, A; Benedetti-Panici, P; Santoni, A Galandrini, Ricciarda; Porpora, Maria Grazia; Stoppacciaro, Antonella; Micucci, Federica; Capuano, Cristina; Tassi, Ilaria; Di Felice, Alessia; Benedetti-Panici, Pierlugi; Santoni, Angela Increased frequency of human leukocyte antigen-E inhibitory receptor CD94/NKG2A-expressing peritoneal natural killer cells in patients with endometriosis FERTILITY AND STERILITY English Article peritoneal NK cells; CD94/NKG2 receptors; endometriosis; HLA-E HLA-E; PELVIC ENDOMETRIOSIS; EXPRESSION; CD94/NKG2A; WOMEN; LYMPHOCYTES; INFECTION; DISEASE; BIOLOGY; FLUID Objective: To analyze the frequency of peritoneal natural killer (NK) cells expressing the human leukocyte antigen (HLA)-E receptor CD94/NKG2A in patients with endometriosis. Design: Case-control study. Setting: University hospital. Patient(s): Stage III and stage IV endometriosis, according to the revised American Society for Reproductive Medicine classification, was laparoscopically and histologically confirmed in I I and 9 patients, respectively; 13 subjects without endometriosis were selected for the control group. Intervention(s): Collection of peripheral venous blood, peritoneal fluid, endometriotic tissue, and normal endometrium in subjects undergoing laparoscopy. Main Outcome Measure(s): Surface expression levels of CD94/NKG2A and CD94/NKG2C were detected by three-color cytofluorometric analysis. Semiquantitative HLA-E messenger RNA expression analysis was performed in endometriotic lesions and in eutopic endometrium. NK cell-mediated cytotoxic activity toward HLA-E positive target, DT360 cell line, was also determined. Result(s): In women with endometriosis, the percentage of CD94/NKG2A-positive peritoneal NK cells was significantly higher than in the control group. The CD94/NKG2A ligand, HLA-E, was detected at high levels in endometriotic tissue as messenger RNA transcript. Target cells hearing HLA-E were resistant to NK cell-mediated lysis in a CD94/NKG2A-dependent manner. Conclusion(s): Increased expression of CD94/NKG2A in peritoneal NK cells may mediate the resistance of endometriotic tissue to NK cell-mediated lysis, thus contributing to the progression of the disease. [Galandrini, Ricciarda; Stoppacciaro, Antonella; Micucci, Federica; Capuano, Cristina; Tassi, Ilaria; Santoni, Angela] Univ Roma La Sapienza, Dept Expt Med, Sch Med, I-00161 Rome, Italy; [Galandrini, Ricciarda; Santoni, Angela] Univ Roma La Sapienza, Sch Med, Ist Pasteur Fdn Cenci Bolognetti, Rome, Italy; [Porpora, Maria Grazia; Di Felice, Alessia; Benedetti-Panici, Pierlugi] Univ Roma La Sapienza, Sch Med, Dept Gynecol Sci Perinatol & Child Hlth, Rome, Italy Galandrini, R (reprint author), Univ Roma La Sapienza, Dept Expt Med, Sch Med, Viale Regina Elena,324, I-00161 Rome, Italy. ricciarda.galandrini@uniroma1.it Porpora, Maria Grazia /G-3569-2010; Porpora, Maria Grazia /F-6745-2011 Porpora, Maria Grazia /0000-0001-5556-3933 30 3 3 ELSEVIER SCIENCE INC NEW YORK 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 0015-0282 FERTIL STERIL Fertil. Steril. MAY 2008 89 3 1490 1496 10.1016/j.fertnstert.2007.05.018 7 Obstetrics & Gynecology; Reproductive Biology Obstetrics & Gynecology; Reproductive Biology 303XW WOS:000256075500027 J Bogialli, S; D'Ascenzo, G; Di Corcia, A; Lagana, A; Nicolardi, S Bogialli, Sara; D'Ascenzo, Giuseppe; Di Corcia, Antonio; Lagana, Aldo; Nicolardi, Simone A simple and rapid assay based on hot water extraction and liquid chromatography-tandem mass spectrometry for monitoring quinolone residues in bovine milk FOOD CHEMISTRY English Article fluoroquinolones; milk; hot water extraction; liquid chromatography-tandem mass spectrometry ANALYTICAL STRATEGIES; CONFIRMATORY ASSAY; ANTIBIOTICS; FOOD; PRODUCTS; MASTITIS; CATTLE; AGENTS A rapid, specific and sensitive procedure for determining residues of eight widespread used quinolone antimicrobials in bovine milk is presented. The method is based on the matrix solid-phase dispersion technique with hot water as extractant followed by LC/MS/MS. The entire sample treatment did not take more than 40 min. Hot water appeared to be an efficient extracting medium, since absolute recoveries of the analytes in milk were 77-90%. The method proved to be robust as matrix effects did not affect significantly the accuracy of the method, as evidenced by analyzing six different batches of milk. Using norfloxacin as surrogate analyte, the accuracy of the method at three different spike levels of the analytes in milk was 93-110% with RSDs not larger than 10%. On the basis of a S/N of 10, estimated LOQs of this method range from 0.3 to 1.5 ng/ml, well below the tolerance levels of quinolones in milk set by the European Union. (C) 2007 Elsevier Ltd. All rights reserved. [Bogialli, Sara] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy Bogialli, S (reprint author), Univ Roma La Sapienza, Dipartimento Chim, Piazza Aldo Moro 5, I-00185 Rome, Italy. sara.bogialli@uniromal.it Lagana, Aldo/F-7390-2010; bogialli, sara/A-8677-2013; Nicolardi, Simone/K-1698-2013 19 37 41 ELSEVIER SCI LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND 0308-8146 FOOD CHEM Food Chem. MAY 1 2008 108 1 354 360 10.1016/j.foodchem.2007.10.044 7 Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics Chemistry; Food Science & Technology; Nutrition & Dietetics 260TM WOS:000253033300045 J Carbonaro, M; Maselli, P; Dore, P; Nucara, A Carbonaro, Marina; Maselli, Paola; Dore, Paolo; Nucara, Alessandro Application of Fourier transform infrared spectroscopy to legume seed flour analysis FOOD CHEMISTRY English Article Fourier transform infrared spectroscopy; secondary structure; heat treatment; legume proteins BETA-LACTOGLOBULIN; SECONDARY STRUCTURE; STORAGE PROTEINS; DIGESTIBILITY RELATIONSHIP; ANGSTROM RESOLUTION; VICIA-FABA; GLOBULINS; BOVINE; CONFORMATION; SUPERFAMILY The secondary structure of legume (Phaseolus vulgaris L. and Lens culinaris L.) proteins was investigated by studying the amide I infrared absorption band in whole seed flours, before and after dry heating and autoclaving thermal treatments. The analysis procedure, set up on 7S and different model proteins, shows that the content of beta-sheet structures in lentil is higher than in common bean (47% vs. 32%). The dry heating does not appreciably affect secondary structures in lentil, while it causes a reduction of beta-sheets (to 13%), an increase of aggregates, and the appearance of random coil structures in common bean. The autoclaving treatment produces high amounts of aggregates in both legumes. However, in lentil, random coil structures are lower than in common bean and some beta-sheet structures are still detectable. These results indicate that multimeric heat-induced complexes of legume proteins have a high stability because of the high content in beta-sheet structures, in particular in lentil, which may adversely affect protein utilization. (C) 2007 Elsevier Ltd. All rights reserved. [Carbonaro, Marina] Ist Nazl Ric Alimenti & Nutr, I-00178 Rome, Italy; [Maselli, Paola; Dore, Paolo; Nucara, Alessandro] Univ Roma La Sapienza, INFM, Dipartimento Fis, I-00185 Rome, Italy Carbonaro, M (reprint author), Ist Nazl Ric Alimenti & Nutr, Via Ardeatina 546, I-00178 Rome, Italy. carbonaro@inran.it 33 22 23 ELSEVIER SCI LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND 0308-8146 FOOD CHEM Food Chem. MAY 1 2008 108 1 361 368 10.1016/j.foodchem.2007.10.045 8 Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics Chemistry; Food Science & Technology; Nutrition & Dietetics 260TM WOS:000253033300046 J Araghipour, N; Colineau, J; Koot, A; Akkermans, W; Rojas, JMM; Beauchamp, J; Wisthaler, A; Mark, TD; Downey, G; Guillou, C; Mannina, L; Van Ruth, S Araghipour, Nooshin; Colineau, Jennifer; Koot, Alex; Akkermans, Wies; Rojas, Jose Manuel Moreno; Beauchamp, Jonathan; Wisthaler, Armin; Maerk, Tilmann D.; Downey, Gerard; Guillou, Claude; Mannina, Luisa; Van Ruth, Saskia Geographical origin classification of olive oils by PTR-MS FOOD CHEMISTRY English Article chemometrics; olive oil; origin classification; PTR-MS; PLS-DA RESOLUTION GAS-CHROMATOGRAPHY; MASS-SPECTROMETRY; VOLATILE COMPOUNDS; QUALITY; AROMA; EXTRACTION; HEADSPACE The volatile compositions of 192 olive oil samples from five different European countries were investigated by PTR-MS sample head-space analysis. The mass spectra of all samples showed many masses with high abundances, indicating the complex VOC composition of olive oil. Three different PLS-DA models were fitted to the data to classify samples into 'country', 'region' and 'district' of origin, respectively. Correct classification rates were assessed by cross-validation. The first fitted model produced an 86% success rate in classifying the samples into their country of origin. The second model, which was fitted to the Italian oils only, also demonstrated satisfactory results, with 74% of samples successfully classified into region of origin. The third model, classifying the Italian samples into district of origin, yielded a success rate of only 52%. This lower success rate might be due to either the small class set, or to genuine similarities between olive oil VOC compositions on this tight scale. (C) 2007 Elsevier Ltd. All rights reserved. [Araghipour, Nooshin; Beauchamp, Jonathan; Wisthaler, Armin; Maerk, Tilmann D.; Van Ruth, Saskia] Leopold Franzens Univ Innsbruck, Inst Ionenphys & Angew Phys, A-6020 Innsbruck, Austria; [Araghipour, Nooshin; Colineau, Jennifer; Koot, Alex] Wageningen UR, RIKILT, Inst Food Safety, NL-6700 AE Wageningen, Netherlands; [Akkermans, Wies] Wageningen UR, NL-6700 AA Wageningen, Netherlands; [Rojas, Jose Manuel Moreno; Guillou, Claude] European Commiss Joint Res Ctr, Inst Hlth & Consumer Protect, Phys & Chem Exposure Unit, BEVABS, I-21020 Ispra, Italy; [Downey, Gerard] TEAGASC, Ashtown Food Res Ctr, Dublin 15, Ireland; [Mannina, Luisa] Univ Molise, Dept STAAM, I-86100 Campobasso, Italy; [Mannina, Luisa] CNR, Inst Chem Methodol, Monterotondo Staz, I-00016 Rome, Italy Van Ruth, S (reprint author), Leopold Franzens Univ Innsbruck, Inst Ionenphys & Angew Phys, Technikerstr 25, A-6020 Innsbruck, Austria. Saskia.vanRuth@wur.nl Downey, Gerard/G-5840-2011 Downey, Gerard/0000-0002-6633-1270 27 29 29 ELSEVIER SCI LTD OXFORD THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND 0308-8146 FOOD CHEM Food Chem. MAY 1 2008 108 1 374 383 10.1016/j.foodchem.2007.10.056 10 Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics Chemistry; Food Science & Technology; Nutrition & Dietetics 260TM WOS:000253033300048 J Familiari, G; Heyn, R; Relucenti, M; Sathananthan, H Familiari, Giuseppe; Heyn, Rosemarie; Relucenti, Michela; Sathananthan, Henry Structural changes of the zona pellucida during fertilization and embryo development FRONTIERS IN BIOSCIENCE English Review human oocyte; electron microscopy; glycoprotein matrix; ovulation; fertilization; human embryo SCANNING-ELECTRON-MICROSCOPY; IN-VITRO FERTILIZATION; POLARIZED-LIGHT MICROSCOPY; EGG EXTRACELLULAR COAT; HUMAN-SPERM; HUMAN OOCYTES; ULTRASTRUCTURAL OBSERVATIONS; MAMMALIAN FERTILIZATION; CORTICAL GRANULES; ACROSOME REACTION The zona pellucida (ZP) is a unique extracellular coat surrounding the maturing oocyte, during ovulation, fertilization, and early embryo development. It is formed by three/four glycoproteins. Ultrastructural data obtained with transmission (TEM) and scanning electron microscopy (SEM) were compared with molecular data on the glycoproteins network from ovulation to blastocyst formation. Molecular models are quite different to the morphology obtained with TEM, which shows a microfibrillar architecture, or with SEM, which shows a spongy or smooth surface. The saponin-ruthenium red-osmium tetroxide-thiocarbohydrazide technique allows to show the ZP real microfilamentous structure and the related functional changes. These results support an ultrastructural supramolecular model, more similar and comparable to molecular models related with the glycoprotein network. A detailed mapping of single mammalian ZP proteins and their relationship within the supramolecular architecture of the zona matrix would clearly supply insights into the molecular basis of sperm-egg recognition. Differences in ZP glycoproteins among mammals do not affect structural morphology; further studies are needed to clarify the relationships between ultrastructural and molecular organizations. [Familiari, Giuseppe; Heyn, Rosemarie; Relucenti, Michela] Univ Roma La Sapienza, Lab Electron Microscopy Pietro M Motta, Dept Anat, I-00161 Rome, Italy; [Sathananthan, Henry] Monash Univ, MIMR, Clayton, Vic 3800, Australia Familiari, G (reprint author), Univ Roma La Sapienza, Lab Electron Microscopy Pietro M Motta, Dept Human Anat, Via Alfonso Borelli 50, I-00161 Rome, Italy. giuseppe.familiari@uniroma1.it Relucenti, Michela/I-2377-2012 132 17 17 FRONTIERS IN BIOSCIENCE INC MANHASSET C/O NORTH SHORE UNIV HOSPITAL, BIOMEDICAL RESEARCH CENTER, 350 COMMUNITY DR, MANHASSET, NY 11030 USA 1093-9946 FRONT BIOSCI Front. Biosci. MAY 2008 13 6730 6751 10.2741/3185 22 Biochemistry & Molecular Biology; Cell Biology Biochemistry & Molecular Biology; Cell Biology 301GS WOS:000255885000265 J Iorio, A; Oliovecchio, E; Morfini, M; Mannucci, PM; Contino, L; Accorsi, A; Ciavarella, N; Schiavoni, M; Scaraggi, FA; Rodorigo, G; Valdre, L; Targhetta, R; Tagariello, G; Radossi, P; Musso, R; Cultrera, D; Muleo, G; Iannacaro, P; Biasioli, C; Testa, S; Alatri, A; Vincenzi, D; Scapoli, G; Morfini, M; Molinari, AC; Boeri, E; Caprino, D; Delios, G; Girotto, M; Mariani, G; Lapecorella, M; Carloni, MT; Cantori, I; Mannucci, PM; Santagostino, E; Gringeri, A; Federici, AB; Marietta, M; Pedrazzoli, P; Di Minno, G; Coppola, A; Perricone, C; Schiavulli, M; Rocino, A; Berrettini, M; Zanon, E; Mancuso, G; Siragusa, S; Malato, A; Saccullo, G; Tagliaferri, A; Rivolta, F; Iorio, A; Oliovecchio, E; Ferrante, F; Dragani, A; Rossi, A; Mancino, A; Albertini, P; Macchi, S; D'Inca, M; De Rossi, G; Luciani, M; Landolfi, R; Mazzucconi, MG; Santoro, C; Piseddu, G; Schinco, PC; Rossetti, G; Barillari, G; Feola, G; Gandini, G; Franchini, M; Castaman, G Iorio, A.; Oliovecchio, E.; Morfini, M.; Mannucci, P. M.; Contino, Laura; Accorsi, Arianna; Ciavarella, Nicola; Schiavoni, Mario; Scaraggi, Francesco Antonio; Rodorigo, Giuseppina; Valdre, Lelia; Targhetta, Roberto; Tagariello, Giuseppe; Radossi, Paolo; Musso, Roberto; Cultrera, Dorina; Muleo, Gaetano; Iannacaro, Piergiorgio; Biasioli, Chiara; Testa, Sophie; Alatri, Adriano; Vincenzi, Daniele; Scapoli, Gianluigi; Morfini, Massimo; Molinari, Angelo Claudio; Boeri, Elio; Caprino, Daniela; Delios, Grazia; Girotto, Mauro; Mariani, Guglielmo; Lapecorella, Mario; Carloni, Maria Teresa; Cantori, Isabella; Mannucci, Pier Mannuccio; Santagostino, Elena; Gringeri, Alessandro; Federici, Augusto B.; Marietta, Marco; Pedrazzoli, Paola; Di Minno, Giovanni; Coppola, Antonio; Perricone, Corrado; Schiavulli, Michele; Rocino, Angiola; Berrettini, Mauro; Zanon, Ezio; Mancuso, Giacomo; Siragusa, Sergio; Malato, Alessandra; Saccullo, Giorgia; Tagliaferri, Annarita; Rivolta, Franca; Iorio, Alfonso; Oliovecchio, Emily; Ferrante, Francesca; Dragani, Alfredo; Rossi, Agostino; Mancino, Antonino; Albertini, Patrizia; Macchi, Silvia; D'Inca, Marco; De Rossi, Giulio; Luciani, Matteo; Landolfi, Raffaele; Mazzucconi, Maria Gabriella; Santoro, Cristina; Piseddu, Gavino; Schinco, Pier Carla; Rossetti, Gina; Barillari, Giovanni; Feola, Giulio; Gandini, Giorgio; Franchini, Massimo; Castaman, Giancarlo Assoc Italian Hemophilia Ctr Italian registry of haemophilia and allied disorders. Objectives, methodology and data analysis HAEMOPHILIA English Article haemophilia; registry; von Willebrand's disease DATA-COLLECTION; UK; POPULATION; MUTATIONS; MORTALITY; AIDS; CARE; IDENTIFICATION; EPIDEMIOLOGY; PROGRESSION National haemophilia registries are powerful instruments to support health care and research. A national registry was established in Italy by the Ministry of Health until 1999. Since 2003 the Italian Association of Haemophilia Centres (AICE) started a new programme aiming at building up the Italian Registry of Haemophilia and Allied Disorders. The AICE identified an expert panel to steer the registry. A computer software to assist patient management was developed and all the AICE-affiliated haemophilia treatment centres (HTC) were prompted to adopt it. Twice a year a predefined set of anonymized data is centralized and merged into a national database. Duplicated entries are managed through a confidentiality sparing mechanism. The database covers sociodemographic, clinical, laboratory and treatment data. A subset of data are shared with the Ministry of Health (Istituto Superiore di Sanita,ISS).Overall, data were collected six times by 43 of 49 HTC; 41 centres updated their patients' records up to December 2006. The database contains 6632 unique records, 442 of them referring to dead patients. Database growth and missing data clearance showed a constantly positive trend over time. The database has collected records of the following alive patients - haemophilia A: 1364 severe, 398 moderate and 935 mild; haemophilia B: 231 severe, 138 moderate and 204 mild; von Willebrand's disease: 1208 type 1, 346 type 2 and 96 type 3. Inhibitor patients were 296 (of which 194 high responders and 65 low responders).The Italian registry run by AICE adds to the list of the available national haemophilia registries and is intended to establish treatment guidelines and foster research projects in Italy. [Iorio, A.] Univ Perugia, Hemophilia Ctr, I-06131 Perugia, Italy; [Ciavarella, Nicola; Schiavoni, Mario] Bari Polclin, Bari, Italy; [Scaraggi, Francesco Antonio] Univ Bari, I-70121 Bari, Italy; [Mancuso, Giacomo] Osped Bambini Brescia, Palermo, Italy; [Siragusa, Sergio; Malato, Alessandra; Saccullo, Giorgia] Univ Palermo, I-90133 Palermo, Italy Iorio, A (reprint author), Univ Perugia, Hemophilia Ctr, I-06131 Perugia, Italy. iorioa@unipg.it Coppola, Antonio/J-1846-2012 43 29 29 WILEY-BLACKWELL HOBOKEN 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 1351-8216 HAEMOPHILIA Haemophilia MAY 2008 14 3 444 453 10.1111/j.1365-2516.2008.01679.x 10 Hematology Hematology 295GT WOS:000255463700005 J Ince, H; Valgimigli, M; Petzsch, M; De Lezo, JS; Kuethe, F; Dunkelmann, S; Biondi-Zoccai, G; Nienaber, CA Ince, H.; Valgimigli, M.; Petzsch, M.; De Lezo, J. Suarez; Kuethe, F.; Dunkelmann, S.; Biondi-Zoccai, G.; Nienaber, C. A. Cardiovascular events and re-stenosis following administration of G-CSF in acute myocardial infarction: systematic review and meta-analysis HEART English Article COLONY-STIMULATING FACTOR; ENDOTHELIAL PROGENITOR CELLS; HEMATOPOIETIC STEM-CELLS; CORONARY-ARTERY-DISEASE; ISCHEMIC-HEART-DISEASE; NEOINTIMAL HYPERPLASIA; INTRACORONARY INFUSION; CARDIAC MYOCYTES; CONTROLLED-TRIAL; CLINICAL-TRIAL Background: Because of the recently published results of the MAGIC study there is confusion as to whether administration of granulocyte-colony stimulating factor (GCSF) after acute myocardial infarction (MI) should be regarded as a potentially harmful treatment. This meta-analysis of appropriate clinical studies is intended to show the impact of G-CSF given after MI on aggravated incidence of coronary re-stenosis or progression of coronary lesions. Methods: We used a fixed effects model based on the Mantel-Haenszel method to combine results from the different trials. These studies provided the basis for the current analysis comprising 106 patients of whom 62 were subjected to G-CSF treatment. Results: Minimum lumen diameter (MLD) measured immediately after percutaneous coronary intervention (PCI) was similar in both groups with a diameter stenosis of 12.3% (SD 9.5%) in the G-CSF group and 10.3% (8.5%) in the control group (p=0.32). At follow-up, both MLD and percentage stenosis were not different between G-CSF-treated and control patients. Subsequently, averaged late lumen loss revealed similar results and no differences between groups (p= 0.11), and neither stent thrombosis nor re-infarction in either group. Conclusions: The current meta-analysis of clinical reports fails to justify an elevated risk for coronary restenosis after PCI in acute MI or adverse events following G-CSF in the setting of MI when used after state of the art treatment in carefully conducted clinical protocols. [Ince, H.; Petzsch, M.; Dunkelmann, S.; Nienaber, C. A.] Univ Hosp Rostock, Div Cardiol, Sch Med, Dept Med, D-18057 Rostock, Germany; [Valgimigli, M.] Univ Ferrara, Cardiovasc Inst, I-44100 Ferrara, Italy; [Biondi-Zoccai, G.] Univ Turin, Div Cardiol, Turin, Italy; [De Lezo, J. Suarez] Univ Hosp Reina Sofia, Cordoba, Spain; [Kuethe, F.] Univ Hosp, Dept Internal Med, Jena, Germany Nienaber, CA (reprint author), Univ Hosp Rostock, Div Cardiol, Sch Med, Dept Med, Ernst Heydemann Str 16, D-18057 Rostock, Germany. nienaber@med.uni-rostock.de 42 19 19 B M J PUBLISHING GROUP LONDON BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND 1355-6037 HEART Heart MAY 2008 94 5 610 616 10.1136/hrt.2006.111385 7 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 288EP WOS:000254969300023 J Mocroft, A; Kirk, O; Aldins, P; Chies, A; Blaxhult, A; Chentsova, N; Vetter, N; Dabis, F; Gatell, J; Lundgren, JD Mocroft, A.; Kirk, O.; Aldins, P.; Chies, A.; Blaxhult, A.; Chentsova, N.; Vetter, N.; Dabis, F.; Gatell, J.; Lundgren, J. D. EuroSIDA Study Group Loss to follow-up in an international, multicentre observational study HIV MEDICINE English Article loss to follow-up; survival; vital status HIV-INFECTED PATIENTS; ANTIRETROVIRAL TREATMENT; BASE-LINE; COHORT; RATIONALE; MORTALITY; THERAPY; DESIGN; IMPACT; AIDS Objective The aim of this work was to assess loss to follow-up (LTFU) in EuroSIDA, an international multicentre observational cohort study. Methods LTFU was defined as no follow-up visit, CD4 cell count measurement or viral load measurement after 1 January 2006. Poisson regression was used to describe factors related to LTFU. Results The incidence of LTFU in 12 304 patients was 3.72 per 100 person-years of follow-up [95% confidence interval (CI) 3.58-3.86; 2712 LTFU] and varied among countries from 0.67 to 13.35. After adjustment, older patients, those with higher CD4 cell counts, and those who had started combination antiretroviral therapy all had lower incidences of LTFU, while injecting drug users had a higher incidence of LTFU. Compared with patients from Southern Europe and Argentina, patients from Eastern Europe had over a twofold increased incidence of LTFU after adjustment (incidence rate ratio 2.16; 95% CI 1.84-2.53; P < 0.0001). A total of 2743 patients had a period of > 1 year with no CD4 cell count or viral load measured during the year; 743 (27.1%) subsequently returned to follow-up. Conclusions Some patients thought to be LTFU may have died, and efforts should be made to ascertain vital status wherever possible. A significant proportion of patients who have a year with no follow-up visit, CD4 cell count measurement or viral load measurement subsequently return to follow-up. [Mocroft, A.] UCL Royal Free & Univ Coll Med Sch, Royal Free Ctr HIV Med, London NW3 2PF, England; [Kirk, O.; Lundgren, J. D.] Univ Copenhagen, Panum Inst, Copenhagen HIV Programme, DK-2200 Copenhagen, Denmark; [Aldins, P.] Infectol Ctr Lativa, Riga, Latvia; [Chies, A.] Ist Super Sanita, I-00161 Rome, Italy; [Blaxhult, A.] Swedish Inst Infect Dis, Solna, Sweden; [Chentsova, N.] Kyiv Ctr AIDS, Kiev, Ukraine; [Vetter, N.] Pulmol Zentrum Stadt Wien, Vienna, Austria; [Dabis, F.] Univ Victor Segalen, INSERM, ISPED, Unite 593, Bordeaux, France; [Gatell, J.] Hosp Clin Barcelona, Barcelona, Spain Mocroft, A (reprint author), UCL Royal Free & Univ Coll Med Sch, Royal Free Ctr HIV Med, Royal Free Camous,Rowland Hill St, London NW3 2PF, England. a.mocroft@pcps.ucl.ac.uk Mocroft, Amanda/C-1527-2008; Phillips, Andrew/B-4427-2008; Mocroft, Amanda/G-8748-2011; SHCS, int. coll. B/G-4090-2011; SHCS, all/G-4072-2011 Phillips, Andrew/0000-0003-2384-4807; 16 27 27 WILEY-BLACKWELL PUBLISHING, INC MALDEN COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA 1464-2662 HIV MED HIV Med. MAY 2008 9 5 261 269 10.1111/j.1468-1293.2008.00557.x 9 Infectious Diseases Infectious Diseases 285QD WOS:000254790400001 J Ferrandina, G; Bonanno, G; Pierelli, L; Perillo, A; Procoli, A; Mariotti, A; Corallo, M; Martinelli, E; Rutella, S; Paglia, A; Zannoni, G; Mancuso, S; Scambia, G Ferrandina, G.; Bonanno, G.; Pierelli, L.; Perillo, A.; Procoli, A.; Mariotti, A.; Corallo, M.; Martinelli, E.; Rutella, S.; Paglia, A.; Zannoni, G.; Mancuso, S.; Scambia, G. Expression of CD133-1 and CD133-2 in ovarian cancer INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER English Article CD133 antigen; ovarian cancer; stem cells EPITHELIAL STEM-CELLS; PROSPECTIVE IDENTIFICATION; AC133; LINES; MARKER Cancer stem cells have been isolated from several solid tumors including prostate, colon, liver, breast, and ovarian cancer. Stem cells isolated from nervous system and prostate express CD133 antigen, which is widely used to isolate hematopoietic stem and progenitor cells. The aims of this study were to investigate the expression of the CD133-1 and CD133-2 epitopes in primary ovarian tumors and to biologically characterize CD133(+) ovarian cancer cells, also according to clinicopathologic parameters. Tissue specimens were obtained at primary surgery from 41 ovarian carcinomas; eight normal ovaries and five benign ovarian tumors were also collected. Flow cytometry with monoclonal antibodies against CD133-1 and CD133-2 epitopes was employed. FACS (fluorescence activated cell sorting) analysis enabled the selection of CD133(+) cells, whose epithelial origin was confirmed by immunofluorescence analysis with monoclonal anti-cytokeratin 7. CD133(+) cells gave rise to a 4.7 +/- 0.9-fold larger number of colonies than that documented in CD133(-) population (P < 0.001). Moreover, CD133(+) cells showed an enhanced proliferative potential compared to CD133(-) cells. The percentages of C13133-1- and C13133-2-expressing cells were significantly lower in normal ovaries/benign tumors with respect to those in ovarian carcinoma. Both the percentages of CD133-1- and C13133-2-expressing cells were significantly lower in omental metastases than in primary ovarian cancer (P = 0.009 and 0.007 for CD133-1- and C13133-2-expressing cells, respectively). There seems not to be any difference in the distribution of the percentage of C13133-1- and C13133-2-expressing cells according to clinicopathologic parameters and response to primary chemotherapy. CD133-1 and CD133-2 may be useful in order to select and enrich the population of CD133(+) ovarian tumor cells, which are characterized by a higher clonogenic efficiency and proliferative potential. [Ferrandina, G.; Bonanno, G.; Perillo, A.; Procoli, A.; Mariotti, A.; Corallo, M.; Martinelli, E.; Paglia, A.; Mancuso, S.] Univ Cattolica Sacro Cuore, Gynecol Oncol Unit, I-00168 Rome, Italy; [Ferrandina, G.; Scambia, G.] Univ Cattolica Sacro Cuore, Dept Oncol, Campobasso, Italy; [Pierelli, L.] ASL Viterbo, Immunohaematol & Transfus Serv, Viterbo, Italy; [Rutella, S.] Univ Cattolica Sacro Cuore, Dept Haematol & Blood Transfus, I-00168 Rome, Italy; [Zannoni, G.] Univ Cattolica Sacro Cuore, Inst Human Pathol, I-00168 Rome, Italy Ferrandina, G (reprint author), Univ Cattolica Sacro Cuore, Gynecol Oncol Unit, Largo A Gemelli 8, I-00168 Rome, Italy. gabriella.ferrandina@libero.it 34 77 84 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1048-891X INT J GYNECOL CANCER Int. J. Gynecol. Cancer MAY-JUN 2008 18 3 506 514 10.1111/j.1525-1438.2007.01056.x 9 Oncology; Obstetrics & Gynecology Oncology; Obstetrics & Gynecology 303QI WOS:000256055200018 J Furlanello, F; Lupo, P; Pittalis, M; Foresti, S; Vitali-Serdoz, L; Francia, P; De Ambroggi, G; Ferrero, P; Nardi, S; Inama, G; De Ambroggi, L; Cappato, R Furlanello, Francesco; Lupo, Pierpaolo; Pittalis, Mario; Foresti, Sara; Vitali-Serdoz, Laura; Francia, Pietro; De Ambroggi, Guido; Ferrero, Paolo; Nardi, Stefano; Inama, Giuseppe; De Ambroggi, Luigi; Cappato, Riccardo Radiofrequency catheter ablation of atrial fibrillation in athletes referred for disabling symptoms preventing usual training schedule and sport competition JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY English Article atrial fibrillation; catheter ablation; athletes; sport eligibility PULMONARY VEINS; CARDIAC REHABILITATION; CARDIOVASCULAR-DISEASE; CONSENSUS DOCUMENT; PHYSICAL-ACTIVITY; RECOMMENDATIONS; EXERCISE; PARTICIPATION; INFLAMMATION; INITIATION Catheter Ablation of Atrial Fibrillation in Athletes. Introduction: Atrial fibrillation (AF) may occasionally affect athletes by impairing their ability to compete, and leading to noneligibility at prequalification screening. The impact of catheter ablation (CA) in restoring full competitive activity of athletes affected by AF is not known. The aim of our study was to investigate the effectiveness of CA of idiopathic AF in athletes with palpitations impairing physical performance and compromising eligibility for competitive activities. Methods and Results: Twenty consecutive competitive athletes (all males; 44.4 +/- 13.0 years) with disabling palpitations on the basis of idiopathic drug-refractory AF underwent 46 procedures (2.3 +/- 0.4 per patient) according to a prospectively designed multiprocedural CA approach that consolidates pulmonary veins (PV) isolation through subsequent steps. Preablation, effort-induced AF could be documented in 13 patients (65%) during stress ECG and significantly reduced maximal effort capacity (176 +/- 21 W), as compared with patients with no AF during effort (207 +/- 43 W, P < 0.05). At the end of CA protocol, which also included ablation of atrial flutter (AFL) in 7 patients, 18 (90.0%) patients were free of AF and two (10.0%) reported short-lasting (minutes) episodes of palpitations during 36.1 +/- 12.7 months follow-up. Compared with preablation, postablation maximal exercise capacity significantly improved (from 183 +/- 32 to 218 +/- 20 W, P < 0.02). All baseline quality of life (QoL) parameters pertinent to physical activity significantly improved (P < 0.05) at the end of CA protocol. All athletes obtained reeligibility and could effectively reinitiate sport activity. Conclusions: AF, alone or in combination with AFL, may significantly impair maximal effort capacity thereby limiting competitive performance. Multiple PV isolation proved very effective in these patients to restore full competitive activity and allow reeligibility. [Furlanello, Francesco; Lupo, Pierpaolo; Pittalis, Mario; Foresti, Sara; Vitali-Serdoz, Laura; Francia, Pietro; De Ambroggi, Guido; Ferrero, Paolo; De Ambroggi, Luigi; Cappato, Riccardo] Univ Milan, Policlin San Donato, IRCCS, Arrhythmia & Electrophysiol Ctr, I-20097 San Donato Milanese, Italy; [Inama, Giuseppe] Osped Maggiore Crema, Crema, Italy; [De Ambroggi, Luigi] Univ Milan, I-20122 Milan, Italy Cappato, R (reprint author), Univ Milan, Policlin San Donato, IRCCS, Arrhythmia & Electrophysiol Ctr, Via Morandi 30, I-20097 San Donato Milanese, Italy. riccardo.cappato@grupposandonato.it 27 18 18 BLACKWELL PUBLISHING OXFORD 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND 1045-3873 J CARDIOVASC ELECTR J. Cardiovasc. Electrophysiol. MAY 2008 19 5 457 462 10.1111/j.1540-8167.2007.01077.x 6 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 295OW WOS:000255484800005 J Agricola, E; Galderisi, M; Mele, D; Ansalone, G; Dini, FL; Di Salvo, G; Gallina, S; Montisci, R; Sciomer, S; Di Bello, V; Mondillo, S; Marino, PN Agricola, Eustachio; Galderisi, Maurizio; Mele, Donato; Ansalone, Gerardo; Dini, Frank Loyd; Di Salvo, Giovanni; Gallina, Sabina; Montisci, Roberta; Sciomer, Susanna; Di Bello, Vitantonio; Mondillo, Sergio; Marino, Paolo Nicola Echocardiographic Study Grp Mechanical dyssynchrony and functional mitral regurgitation: pathophysiology and clinical implications JOURNAL OF CARDIOVASCULAR MEDICINE English Article cardiac resynchronization therapy; functional mitral regurgitation; ventricular dyssynchrony CARDIAC-RESYNCHRONIZATION THERAPY; ACUTE MYOCARDIAL-INFARCTION; CHRONIC HEART-FAILURE; LEFT-VENTRICULAR DYSFUNCTION; INTRAVENTRICULAR-CONDUCTION DELAY; BUNDLE-BRANCH BLOCK; DOPPLER-ECHOCARDIOGRAPHIC EVIDENCE; EXERCISE-INDUCED CHANGES; DILATED CARDIOMYOPATHY; ISCHEMIC CARDIOMYOPATHY Functional mitral regurgitation (FMR) is a common finding in patients with ischemic or nonischemic dilated cardiomyopathy as a complication of left ventricular (LV) dysfunction and remodeling associated with a fibrotic remodeling response of mitral leaflets to abnormal valvular loading. Although mitral valve tenting is the main determinant of FMR, clinical and experimental observations suggest that intraventricular delay could be a potential co-determinant of FMR. LV dyssynchrony can potentially contribute to FMR by several mechanisms, such as creating an uncoordinated regional LV mechanical activation in segments supporting the papillary muscles, determining diastolic mitral regurgitation, reducing the sphincteric function of the mitral annulus, and decreasing the efficiency of LV contraction and closing forces. Cardiac resynchronization therapy has been demonstrated to reduce FMR with correction of some of the underlying pathophysiological mechanisms. The present review article focuses on the role of mechanical dyssynchrony as a pathophysiological determinant of FMR, and on the potential role of cardiac resynchronization therapy as a therapeutic option for treatment of FMR in patients with severe heart failure and advanced LV dysfunction. [Agricola, Eustachio] Hosp San Raffaele, IRCCS, Div Noninvas Cardiol, I-20132 Milan, Italy Agricola, E (reprint author), Hosp San Raffaele, IRCCS, Div Noninvas Cardiol, Via Olgettina 60, I-20132 Milan, Italy. agricola.eustachio@hsr.it 70 2 4 LIPPINCOTT WILLIAMS & WILKINS PHILADELPHIA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA 1558-2027 J CARDIOVASC MED J. Cardiovasc. Med. MAY 2008 9 5 461 469 9 Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology 315BX WOS:000256854000003 J Dimopoulos, P; Herdoiza, G; Palombi, F; Papinutto, M; Pena, C; Vladikas, A; Wittig, H Dimopoulos, Petros; Herdoiza, Gregorio; Palombi, Filippo; Papinutto, Mauro; Pena, Carlos; Vladikas, Anastassios; Wittig, Hartmut Non-perturbative renormalisation of Delta F=2 four-fermion operators in two-flavour QCD JOURNAL OF HIGH ENERGY PHYSICS English Article renormalization group; lattice gauge field theories; lattice QCD QUARK MASS RENORMALIZATION; LATTICE QCD; PRECISE DETERMINATION; MATRIX-ELEMENTS; COMPUTATION; IMPROVEMENT; SYMMETRY; FLAVORS Using Schrodinger Functional methods, we compute the non-perturbative renormalisation and renormalisation group running of several four-fermion operators, in the framework of lattice simulations with two dynamical Wilson quarks. Two classes of operators have been targeted: (i) those with left-left current structure and four propagating quark fields; (ii) all operators containing two static quarks. In both cases, only the parity-odd contributions have been considered, being the ones that renormalise multiplicatively. Our results, once combined with future simulations of the corresponding lattice hadronic matrix elements, may be used for the computation of phenomenological quantities of interest, such as B-K and B-B (the latter also in the static limit). [Dimopoulos, Petros] Univ Roma Tor Vergata, Ist Nazl Fis Nucl, Sez Roma Tor Vergata, I-00133 Rome, Italy; [Herdoiza, Gregorio] DESY, Theory Grp, D-15738 Zeuthen, Germany; [Palombi, Filippo; Papinutto, Mauro] CERN, Dept Phys, Div TH, CH-1211 Geneva, Switzerland; [Pena, Carlos] Univ Autonoma Madrid, CSIC C16, Inst Fis Teor, E-28049 Madrid, Spain; [Pena, Carlos] Univ Autonoma Madrid, Dept Fis Teor C11, E-28049 Madrid, Spain; [Vladikas, Anastassios] Univ Roma Tor Vergata, Dipartimento Fis, Ist Nazl Fis Nucl, Sez Roma Tor Vergata, I-00133 Rome, Italy; [Wittig, Hartmut] Johannes Gutenberg Univ Mainz, Inst Kernphys, D-55099 Mainz, Germany Dimopoulos, P (reprint author), Univ Roma Tor Vergata, Ist Nazl Fis Nucl, Sez Roma Tor Vergata, Via Ricerca Sci 1, I-00133 Rome, Italy. petros.dimopoulos@roma2.infn.it; gregorio.herdoiza@desy.de; filippo.palombi@cern.ch; mauro.papinutto@cern.ch; carlos.pena@uam.es; tassos.vladikas@roma2.infn.it; wittig@kph.uni-mainz.de 36 0 0 INT SCHOOL ADVANCED STUDIES TRIESTE VIA BEIRUT 2-4, I-34014 TRIESTE, ITALY 1126-6708 J HIGH ENERGY PHYS J. High Energy Phys. MAY 2008 5 065 26 Physics, Particles & Fields Physics 312JA WOS:000256664400065 J Giampietri, C; Petrungaro, S; Musumeci, M; Coluccia, P; Antonangeli, F; De Cesaris, P; Filippini, A; Marano, G; Ziparo, E Giampietri, Claudia; Petrungaro, Simonetta; Musumeci, Marco; Coluccia, Pierpaolo; Antonangeli, Fabrizio; De Cesaris, Paola; Filippini, Antonio; Marano, Giuseppe; Ziparo, Elio c-Flip overexpression reduces cardiac hypertrophy in response to pressure overload JOURNAL OF HYPERTENSION English Article heart; hypertrophy; transgenic animal model IN-VIVO; INHIBITORY PROTEIN; TRANSGENIC MICE; RETINOIC ACID; WALL STRESS; EXPRESSION; APOPTOSIS; DEATH; HEART; PROLIFERATION Objective Activation of Fas signaling has been associated with the development of cardiomyocyte hypertrophy. In the present study, we investigated the effects of increased expression of c-Flip, a natural modulator of Fas receptor signaling, in a mouse model of cardiac growth response to pressure overload. Methods A transgenic mouse overexpressing c-Flip in the heart was generated in FVB/N strain. Echocardiographic, hemodynamic, histological and molecular analyses were carried out under basal conditions and after transverse aortic constriction (TAC)-induced pressure overload. Results Overexpression of c-Flip in ventricular heart tissue was functionally silent under basal conditions affecting neither cardiac morphology nor basal cardiac function. Transgenic mice were then subjected to pressure overload by TAC procedure. Under such conditions, c-Flip transgenic mice showed normal left ventricular function with a significantly reduced left ventricular hypertrophy compared with wild-type mice and reduced induction of the cardiac "fetal'' gene programme. Further, analysis of intracellular signaling pathways indicated that c-Flip overexpression reduced phosphorylation of both the glycogen synthase kinase 3 beta (GSK3 beta) and Akt as compared with controls. Finally, the reduction of the TAC-induced hypertrophy was not accompanied by significant apoptosis increase. Conclusion Altogether, these findings indicate c-Flip as a key regulator of the cardiac response to ventricular pressure overload.