Insulin binding to isolated rat hepatocytes was studied during prenatal and postnatal life. Results show that in hepatocytes isolated from prenatal, postnatal and adult rat there is a constant increase in the number of insulin binding sites per cell, whereas the affinity of plasma membrane receptors for the hormonal ligand remains unaltered from prenatal to adult hepatocytes. Autoradiographic studies indicate a greater internalization of hormone during prenatal life and, taking into account the increase of cell size, suggest an unchanged surface density of receptor sites before and after birth. © 1981.

Insulin binding and internalization in rat hepatocytes during prenatal and postnatal life / Autuori, F.; Baldini, P.; Ciofi Luzzatto, A.; Conti, Laura; Dini, L.; Incerpi, S.; Luly, P.. - In: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. - ISSN 0304-4165. - STAMPA. - 678:1(1981), pp. 1-6.

Insulin binding and internalization in rat hepatocytes during prenatal and postnatal life

CONTI, Laura;L. Dini;
1981

Abstract

Insulin binding to isolated rat hepatocytes was studied during prenatal and postnatal life. Results show that in hepatocytes isolated from prenatal, postnatal and adult rat there is a constant increase in the number of insulin binding sites per cell, whereas the affinity of plasma membrane receptors for the hormonal ligand remains unaltered from prenatal to adult hepatocytes. Autoradiographic studies indicate a greater internalization of hormone during prenatal life and, taking into account the increase of cell size, suggest an unchanged surface density of receptor sites before and after birth. © 1981.
1981
(rat hepatocyte); development; insulin binding; internalization
01 Pubblicazione su rivista::01a Articolo in rivista
Insulin binding and internalization in rat hepatocytes during prenatal and postnatal life / Autuori, F.; Baldini, P.; Ciofi Luzzatto, A.; Conti, Laura; Dini, L.; Incerpi, S.; Luly, P.. - In: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. - ISSN 0304-4165. - STAMPA. - 678:1(1981), pp. 1-6.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/34113
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 17
  • ???jsp.display-item.citation.isi??? ND
social impact