In the present paper we describe the synthesis of some dermorphin and deltorphin analogues beta-O- and alpha-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.
Dermorphin and deltorphin glycosilated analogs: synthesis and antinociceptive activity after systemic administration / Negri, Lucia; Lattanzi, Roberta; Tabacco, F.; Orru', L.; Severini, C.; Scolaro, B.; Rocchi, R.. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - STAMPA. - 42:(1999), pp. 400-404. [10.1021/jm9810699]
Dermorphin and deltorphin glycosilated analogs: synthesis and antinociceptive activity after systemic administration
NEGRI, Lucia;LATTANZI, Roberta;
1999
Abstract
In the present paper we describe the synthesis of some dermorphin and deltorphin analogues beta-O- and alpha-C-glycosylated on the C-terminal amino acid residue and report their opioid receptor affinity and selectivity as well as their analgesic potency after subcutaneous injection in mice.File allegati a questo prodotto
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