Long-term non-progressors (LTNP) are human immunodeficiency virus (HIV)-infected individuals characterized by the absence of disease, low viral loads and stable or even increasing CD4(+) T cell counts for prolonged periods of time. In these subjects, an HIV-specific immune response which is either stronger or directed against a wider array of viral epitopes than that seen in progressors, can be often detected. Here, we summarize the characteristics of HIV-specific CD4(+) and CD8(+) T cell responses in LTNP, and discuss how a highly effective T cell-mediated immune response against HIV might contribute to the establishment of this particular condition. (C) 2001 Elsevier Science B.V. All rights reserved.
The immunology of HIV-infected long-term non-progressors - a current view / Paroli, Marino; Antonella, Propato; Accapezzato, Daniele; Vittorio, Francavilla; Enrico, Schiaffella; Barnaba, Vincenzo. - In: IMMUNOLOGY LETTERS. - ISSN 0165-2478. - 79:1-2(2001), pp. 127-129. (Intervento presentato al convegno 3rd International Meeting on Immunological Correlates of Protection from HIV Infection and Disease tenutosi a LEVANTE, ITALY nel NOV 30-DEC 03, 2000) [10.1016/s0165-2478(01)00274-7].
The immunology of HIV-infected long-term non-progressors - a current view
PAROLI, Marino;ACCAPEZZATO, DANIELE;BARNABA, Vincenzo
2001
Abstract
Long-term non-progressors (LTNP) are human immunodeficiency virus (HIV)-infected individuals characterized by the absence of disease, low viral loads and stable or even increasing CD4(+) T cell counts for prolonged periods of time. In these subjects, an HIV-specific immune response which is either stronger or directed against a wider array of viral epitopes than that seen in progressors, can be often detected. Here, we summarize the characteristics of HIV-specific CD4(+) and CD8(+) T cell responses in LTNP, and discuss how a highly effective T cell-mediated immune response against HIV might contribute to the establishment of this particular condition. (C) 2001 Elsevier Science B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
