In the present study the authors have evaluated at tissue level the gene expression of IL-12, IL-2 and IL-4 to asses the functional phenotype of Tumour Infiltrating Lymphocytes. The distribution of lymphocytes present within the neoplastic tissue of breast, lung ad larynx carcinomas indicate that these neoplasms are able to induce predominantly Th1 heper lymphocytes.
INTERLEUKINE-12 RELATED CYTOKINE GENE EXPRESSION IN CARCINOMA OF THE BREST, LUNG AND LARYNX. A STUDY AT TISSUE LEVEL / Vitolo, Domenico; Ciocci, L; Ferrauti, P; Tiboni, F; Cicerone, E; Gallo, Andrea; DE VINCENTIIS, Marco; Baroni, Carlo. - In: CANCER DETECTION AND PREVENTION. - ISSN 0361-090X. - STAMPA. - 24 (5):(2000), pp. 422-434.